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Regenstrief Institute


Psychological comorbidity in patients presenting to the emergency department with low-risk chest pain and anxiety

A new study found that low-risk chest pain patients frequently experience severe anxiety and other treatable comorbidities, such as depression and somatization. Cognitive Behavioral Therapy (CBT) and prescription medications are effective in managing these conditions, improving patient outcomes and reducing unnecessary ED visits.

SourceRegenstrief Institute·JournalAcademic Emergency Medicine·DateSep 25, 2025

Creating user personas to represent the needs of dementia caregivers supporting medication management at home

A recent study developed three distinct caregiver personas: Checklist Cheryl, Social Sam, and Responsive Rhonda. These personas embody different approaches to medication management, varying in organization, technology use, collaboration, and response to challenges. The study found that caregivers employ diverse strategies blending tech...

SourceRegenstrief Institute·JournalJMIR Aging·DateSep 11, 2025

American Geriatrics Society unveils updated alternatives to potentially harmful medications for older adults

The American Geriatrics Society has released an update to its list of safer pharmacologic options and non-pharmacologic treatments for common conditions in frail and aging populations. The new guidelines offer a comprehensive suite of alternatives, including cognitive behavioral therapy and lifestyle changes, for conditions such as ins...

SourceRegenstrief Institute·JournalJournal of the American Geriatrics Society·DateAug 18, 2025

Assessing pain, anxiety and other symptoms of nursing home residents unable to speak for themselves

Researchers have revamped a symptom assessment instrument to address pain, anxiety, and other symptoms of nursing home residents who are cognitively impaired. The new tool reliably captures physical and emotional distress, well-being, and end-of-life symptoms, providing guidance for expanding palliative care services in nursing homes.

SourceRegenstrief Institute·JournalInternational Journal of Geriatric Psychiatry·DateMar 12, 2025

JAMA study integrates palliative and dementia care for patients and caregivers

The IN-PEACE randomized clinical trial integrated palliative care with state-of-the-art dementia care, cutting in half emergency department visits and hospitalizations among participants. This innovative approach benefited African American individuals and those with lower incomes the most, offering cost savings to the healthcare system.

SourceRegenstrief Institute·JournalJournal of the American Medical Association·DateJan 29, 2025

Telephone therapy reduces fatigue interference with activities, mood and cognition for metastatic breast cancer survivors

A study demonstrates the effectiveness of telephone-delivered acceptance and commitment therapy in reducing fatigue's interference with functioning and improving quality of life for metastatic breast cancer survivors. The remote intervention showed promise in reducing sleep interference, leading to improved sleep quality and a greater ...

SourceRegenstrief Institute·JournalJournal of Clinical Oncology·DateJan 21, 2025

Big data, real world, multi-state study finds RSV vaccine highly effective in protecting older adults against severe disease, hospitalization and death

A multi-state study published in The Lancet found the RSV vaccine to be highly effective in protecting older adults against severe disease, hospitalization, and death. The vaccine provided approximately 80% protection against these outcomes, including severe disease and ICU admission.

SourceRegenstrief Institute·JournalThe Lancet·DateOct 17, 2024

Addressing the geriatric healthcare workforce shortage

A new study presents an innovative curriculum for nursing students, exposing them to geriatric care early in their training with the goal of increasing interest in specializing in care for older adults. The curriculum uses virtual standardized patients, providing a higher level of training and covering knowledge, attitudes, and skills.

SourceRegenstrief Institute·JournalJournal of the American Geriatrics Society·DateOct 1, 2024

Waiting is the hardest part: Medical field should address uncertainty for cancer patients under active surveillance

Patients with low-risk cancers undergoing active surveillance experience anxiety caused by uncertainty, a problem that persists even after diagnosis, leading to negative responses such as fear and avoidance of decision-making. Medical interventions are needed to address this anxiety and improve patient-centered care.

SourceRegenstrief Institute·JournalJAMA Oncology·DateSep 16, 2024

New study examines use of opioids for chronic cough

A recent study found that 20% of patients with chronic cough received an opioid prescription, with older patients and those with Medicaid insurance more likely to be prescribed these drugs. The research team hopes to explore alternative treatment options to reduce reliance on opioids for chronic cough care.

SourceRegenstrief Institute·JournalTherapeutic Advances in Respiratory Disease·DateAug 22, 2024

Promoting healthy teen romantic relationships to reduce risk of unintended pregnancies and sexually transmitted infections

A new multi-site randomized-controlled study evaluates an innovative healthy relationships program for teens. The study found the program may have influenced abstinence but not relationship communication, highlighting the need for tailored program components to address unique environmental contexts.

SourceRegenstrief Institute·JournalJournal of Adolescent Health·DateAug 8, 2024

Bringing data to life: New interactive dashboard provides analysis and visualization of sickle cell disease prevalence and burden in an entire state

The Indiana Sickle Cell Dashboard presents interactive visualizations of the disease's prevalence and burden across an entire state, offering a comprehensive picture of those living with sickle cell. The dashboard provides rates per 100,000 population, allowing for comparisons between states or areas around the world.