A recent Amsterdam UMC study found that a quick initial shock with a defibrillator can significantly improve survival rates in patients who have suffered a cardiac arrest. Every minute of delay reduces the chance of survival by 6%, with 93% of cases successfully terminated if given within six minutes.
Research reveals that lumbosacral vertebrae region stimulation significantly elevates low blood pressure, unlike cervical or upper thoracic stimulation. This approach offers a non-invasive therapeutic intervention to regulate cardiovascular function in SCI patients.
Researchers found a bovine H5N1 virus isolated from an infected worker to be transmissible and lethal in mice and ferrets, with limited efficiency. The virus is susceptible to certain antiviral drugs, including favipiravir and baloxavir marboxil.
Scientists have successfully imaged superspreader fibrils in the brain tissue of Alzheimer's patients, shedding light on their role in spreading the disease. The study, published in Science Advances, uses advanced imaging techniques to visualize the fibrils' formation and spread.
Researchers at Hokkaido University discovered unique lipids in sorghum that have anti-diabetic and anti-inflammatory properties. The study suggests that incorporating sorghum into diets could promote cardiovascular health, reduce inflammation, and enhance metabolic health.
A team of researchers at the University of Illinois has developed a multimode propulsion system that integrates both chemical high-thrust mode and electric low-thrust mode, resulting in reduced fuel consumption and increased flexibility. The system uses the same propellant for both modes, saving mass and volume.
A new study published in JCOM identified the characteristics of polarized scientific digital messages, proposing a system to codify and characterize polarized discourses. The research found that simplifying and presenting scientific information as unquestionable can limit critical thinking and hinder scientific progress.
A new study from Karolinska Institutet reveals a decline in heart failure mortality in Sweden over the last 20 years. Despite improvements, the prognosis for heart failure patients remains concerning, with 25% of those diagnosed in 2022 dying within a year.
New RSV vaccines have been found to be highly effective in preventing severe respiratory illness and hospitalizations, with an 80% efficacy rate. However, vaccination rates remain low, especially among older adults, highlighting the need for better understanding of risk factors and improved healthcare provider education.
The Atlantic Marine Energy Center (AMEC) will develop new research projects, infrastructure, and educational programs using the funding. Lehigh University will lead two research projects focused on tidal turbine blades and real-time stable marine energy microgrid power management.
Researchers found that pig skin attached to underlying tissue reduced damage from puncture by about 60% at slower speeds and 73% at higher speeds compared to the same tissue without skin. Synthetic skin offered less protection, reducing the damage by less than 40% at slower speeds and less than 30% at higher speeds.
A machine learning model predicts soil behavior during earthquakes, identifying areas vulnerable to liquefaction and providing contour maps for safer construction sites. The study uses geological data to create detailed 3D maps of soil layers, improving prediction accuracy by 20%.
Osaka University researchers develop a new method for long-range enhancement of fluorescence and Raman signals using Ag nanoislands protected with column-structured silica layers. This leads to an astonishing ten-million-fold increase in signal strength, making it ideal for sensitive biosensing applications.
Researchers used genomic technology to study Marjolin's ulcer, a rare and highly aggressive skin cancer that grows on chronic burn wounds. The study reveals insights into how keratinocytes switch their function to become cancerous, creating a fertile environment for tumor cells to grow and spread.
Researchers developed a screening technique to filter out low-quality data in wearable sensors, improving the performance of smartwatches for noninvasive blood glucose estimation. The approach enhances accuracy by discarding data with high phase errors and approximating missing values.
A new guide provides a roadmap for developing cell-penetrating peptide clusters to deliver lifesaving treatments across biological barriers. The clusters could improve patient outcomes dramatically by allowing minimum doses of treatments, reducing toxicity.
A 10-week break from resistance training had little effect on maximum strength but did affect muscle size. Maximum strength was better preserved than muscle size during the break. With regular progressive training, gym-goers can quickly regain pre-break levels of strength and muscle size.
Researchers at Terasaki Institute have developed simvastatin-loaded nanoparticles to target adipose tissue inflammation, promoting fat tissue browning and weight loss. The treatment effectively inhibits obesity-related inflammation, controlled white fat production, and demonstrated strong anti-inflammatory effects.
A new study published in JAMA Pediatrics reveals that 30% of parents with a very low birth weight baby have had to make an employment decision due to their child's health and ongoing care needs. Having a medically complex baby often forces parents to consider leaving their job, impacting their health insurance plans and networks.
Scientists use modern technology to analyze ancient ochre samples, revealing the material's origin and history. This helps them understand how human cognition and social networks developed alongside early technological innovations.
A new study used the 2023 Texas-Louisiana heat wave as a test case to establish processes for evaluating extreme weather events. The researchers found that the heat wave was directly related to climate change and will see even hotter heat waves in the future.
Jeah Jung is studying long-term care integration for dually eligible individuals with Alzheimer's disease and related dementias. She examines the effect of integrating medical services with long-term care through Medicare Advantage plans on health outcomes.
The University of Michigan School of Public Health and Institute for Firearm Injury Prevention will evaluate a community-led, school-based secure firearm storage campaign in Michigan. The study aims to assess the impact on attitudes, norms, and behaviors among adults and prevent adolescent firearm violence.
A new study found a significant rise in malaria risk in northern Kenya, particularly due to higher rainfall and temperature creating ideal mosquito breeding conditions. The study emphasizes the need for targeted, region-specific malaria strategies that account for seasonal and climate differences.
Research from Thomas Jefferson University and Esperanza Health Center aims to overcome healthcare disparities by developing short, accessible videos to teach patients how to use health portals. The study identified key obstacles, including limited digital literacy, language barriers, and lack of trust in telehealth platforms.
A new study from the MIT Center for Collective Intelligence found that combining humans and AI can be effective in certain tasks, such as creative ones like summarizing social media posts or generating new content. However, human-AI combinations often underperform compared to AI alone in decision-making tasks. The researchers suggest t...
A new study finds that volcanic eruptions triggered a sudden and devastating cooling event, causing mass extinctions in the Triassic period. The research contradicts previous theories that suggested increased carbon dioxide led to warming temperatures.
Research shows that animals, including humans, can become less sociable as they age to avoid diseases and parasites. This phenomenon, known as social ageing, may bring benefits, such as reduced competition and increased safety.
A research team led by University of Nebraska–Lincoln materials scientists has discovered a new MXene material with p-type properties and increasing conductivity under illumination. The discovery enables complex structures where complementary MXenes are used together to achieve new electronic functionalities.
The study demonstrates the exceptional efficiency of layered high-entropy sulfides in boosting electrocatalytic performance for hydrogen evolution reaction. The introduction of molybdenum into the composition creates a unique layered structure that increases the material's surface area and enhances its catalytic efficiency.
A pilot study by NCCN Cancer Center demonstrates the usability of HERC in advancing equitable cancer care delivery, with all participating sites strongly agreeing on its applicability. The tool features 19 practice evaluation and change recommendations to address disparity and bias in care delivery.
Research led by a firefighter co-author sheds light on polycyclic aromatic hydrocarbons' affinity for DNA and ability to evade repair, highlighting potential health risks. The study's findings could inform public policy and accelerate the development of safer chemicals.
The KIMS research team developed a multi-band electromagnetic wave absorption material less than 0.5mm thick, absorbing over 99% of electromagnetic waves from various frequency bands. This technology resolves secondary interference issues and enhances the reliability of wireless communication devices.
A recent study suggests that enhanced Arctic sea-ice melting during the Last Interglacial period led to significant cooling in northern Europe. The researchers used sediment cores and geochemical tracers to reconstruct past ocean conditions, highlighting the importance of feedback mechanisms in the climate system.
A new study reveals that Oriental hornets are the only animals capable of consuming high concentrations of alcohol chronically without ill effects. The research found that the hornets metabolize alcohol rapidly and show no signs of intoxication or illness, even after consuming high amounts.
A new study found that psilocybin significantly reduced OCD-like behaviors and tic-like head-body twitches in genetically modified mice. The research provides hope for new treatments for these conditions and may offer benefits for patients who have not responded to current therapies.
A new study reveals that magicians are willing to share their own trick techniques, but not those invented by others or deceased individuals. They believe it's acceptable to reveal secrets for good causes, such as enhancing wellbeing or scientific research, and that mass online tutorials have reduced the need for traditional secrecy.
Researchers discovered a stable lithium isotope fractionation mechanism in Qinghai Lake, indicating minimal Li cycling. The lake's Li reserves are expected to increase over time, providing insights into paleoclimate history.
A recent study on global giant cicadas reveals an aerial evolutionary arms race between Palaeontinidae and birds. The research suggests that the rise of birds imposed greater predation pressure on insects, driving the evolution of more advanced flight capabilities in late Palaeontinidae.
Researchers studied an isolated population of sparrows on Lundy Island and found that older birds tend to have fewer friends, similar to humans. The study suggests that there is no 'evolutionary pressure' to maintain social connections in older age, leading to a decline in friendships.
A new prognostic model accurately predicts short-term mortality in ACLF patients, offering improved clinical decision-making. The Model for end-stage liver disease-complication score demonstrated superior predictive accuracy and robustness in external cohorts.
This study identifies the hsa_circ_0001726/miR-140-3p/KRAS axis as a key regulator in hepatocellular carcinoma (HCC) progression and lenvatinib resistance. The axis is involved in promoting cell proliferation and migration, and is also linked to overall survival in HCC patients.
Researchers used 16 years of radar weather data to monitor bird migration patterns from Tasmania to northern Queensland, finding millions of birds migrate each year. The study revealed unique patterns, including variation in migration direction, timing, and intensity compared to Northern Hemisphere birds.
A new Oxford study assesses 152 animal species across various taxonomic groups, finding that more social species live longer, have longer generation times, and longer reproductive windows. Sociality's benefits outweigh its costs, with species displaying increased resilience as a group.
A collaborative team developed CShaperApp to segment and analyze Caenorhabditis elegans embryo morphologies, providing a user-friendly platform for researchers. The software offers modular functions for image segmentation, analysis, and result visualization, allowing users to adaptively retrain models or process external datasets.
Researchers at Tohoku University developed a synthesis method to control the surface structure of small metal particles, improving their catalytic activity for hydrogen evolution. The new approach, combining gold and platinum, achieves higher catalytic activity than conventional catalysts.
Researchers have discovered that ASCL1 is essential to the transformation of adenocarcinoma into neuroendocrine prostate cancer, a deadly form of the disease. Disabling the ASCL1 gene can prevent this transition, but only if done early in the disease progression.
A new framework called Engine Repair Theory uses self-assembling organelles derived from neural stem cells to restore mitochondrial energy homeostasis and mitigate oxidative stress. The study demonstrates an increase in ATP production and reduced cell damage, offering a promising approach for treating neurodegenerative conditions.
New phase 3 clinical trials show potential for improving kidney health outcomes with targeted therapies, such as pegcetacoplan and semaglutide. These studies have the potential to revolutionize kidney care and treatment.
Researchers have developed a novel gene therapy called PS-002, which targets podocytes and blocks complement activation to treat IgA nephropathy. In mouse models, treatment with PS-002 reduced signs of kidney dysfunction and lowered complement deposition, while in pigs, it resulted in elevated gene expression without safety issues.
A 48-week follow-up study found that TMF treatment did not significantly affect blood lipid profiles in patients with chronic hepatitis B. Lipid indices remained stable, regardless of baseline characteristics.
A study analyzed Photosystem I P700 chlorophyll a apoprotein A2 from Chlorella vulgaris, identifying up to 17 distinct bioactivities, including antibacterial, anti-inflammatory, and hypotensive effects. The peptides were found to be non-toxic and likely non-allergenic.
A meta-analysis found that individuals carrying the AA genotype at TLR10 rs10004195 locus have a significantly elevated risk of H. pylori infection. This association may be used to assess future risk and provide personalized health guidance.
A Phase 3 trial of clazakizumab, a monoclonal antibody targeting interleukin-6, failed to demonstrate efficacy in treating chronic active antibody-mediated kidney transplant rejection. The study, which recruited 350 patients, showed no significant improvement in kidney function at week 52.
A cohort study reveals that AATD patients with COPD have a unique liver transcriptomic profile, with upregulated pathways related to fibrosis and inflammation. Histopathological analysis confirms higher levels of fibrosis and hepatocellular damage in these individuals.
A phase 2 clinical trial found imlifidase to be more effective than plasmapheresis in reducing donor-specific antibodies by 97% compared to 42%. The investigational drug achieved maximum DSA depletion in 15 hours, outperforming the standard treatment.
A study found MALDI-TOF mass spectrometry to be highly sensitive and specific for diagnosing onychomycosis in patients with nail psoriasis, distinguishing it from nail psoriasis without infection. The technique's accuracy was comparable to conventional methods, making it a promising tool for clinical diagnosis.
Researchers uncover new insights into protein signal transduction, revealing key details about GRB2 and SOS1's role in passing signals. They discovered differences in the domains' dynamics and binding affinities, providing a more detailed mechanism for liquid-liquid phase separation.
This study investigates the use of carbonic anhydrase IX (CAIX) as a diagnostic marker for distinguishing pleural mesothelioma from non-small cell lung carcinoma (NSCLC). CAIX expression is found to be highly sensitive and specific in detecting pleural epithelioid mesothelioma, comparable to or better than existing mesothelial markers.
Recent studies from China's Chang'e-4 and Chang'e-5 missions have revealed diverse lunar soil compositions, including iron-rich high-Ca pyroxene and impact-induced weathering. These findings provide valuable information for future lunar explorations.