Researchers developed new guidelines to study molecular biomarkers associated with stroke recovery. The recommendations aim to identify biological signals that can help clinicians determine the most effective therapies for each patient at the right moment. The guidelines also emphasize the importance of creating national biomarker cent...
Researchers developed a risk calculator that estimates short-term risk of diabetes complications using routine health data. The tool analyzes insurance claims and electronic health record data to provide monthly, encounter-level risk estimates.
Researchers analyzed data from over 9,300 cases of diarrhea in Africa, finding that climate change affects disease risk, but factors like vaccination and access to transportation can reduce impact. Climate drivers vary by pathogen and location, with temperature being key in Kenya and rainfall in Mali and The Gambia.
A new study found that 5% of hospitalized adults with firearm injuries developed bacterial infections, with the majority occurring during initial hospitalization. Patients undergoing surgeries involving the head, neck, spine, liver, or lower abdomen faced the highest risk of developing bacterial infections.
Dr. Enrico Novelli leads a newly launched network to expand access to care for patients with sickle cell disease across Maryland. He brings expertise in SCD and blood vessel biology, as well as global efforts to strengthen hematology care.
Bradley A. Maron, MD, a renowned clinical cardiologist and researcher, has been appointed as the new editor-in-chief of Circulation. He will focus on strengthening and expanding the legacy of the journal, introducing new editorial features to publish high-quality cardiovascular science and medicine.
Jacques Ravel has been recognized for his foundational contributions to understanding the human vaginal microbiome, its links to pregnancy outcomes and susceptibility to infection. His work also laid the groundwork for live biotherapeutics designed to shape the vaginal microbiome in ways that could improve pregnancy outcomes.
Researchers have identified a protein called cathepsin B that can prevent CAR T-cells from tearing off fragments from cancer cells, allowing them to stay active longer and fight cancer more effectively. This breakthrough could lead to improved durability and outcomes for patients with recurrent or difficult-to-treat blood cancers.
The University of Maryland School of Medicine is establishing a new Center for Combat Casualty Care with a $1 million state grant. The center will include a sensitive compartmented information facility and train military clinicians in the development of new medical tools and treatments.
A new dual vaccine against Lassa fever and rabies has been shown to be safe and induce immune responses against both viruses. The vaccine could potentially streamline delivery in settings where access is limited, reducing the need for separate vaccination efforts.
The center is the first in the region to offer TCR-T therapy, an FDA-approved treatment targeting proteins inside cancer cells. Patients with chemotherapy-resistant synovial sarcoma can now access this novel cellular therapy.
A five-minute session of proximal intercessory prayer significantly reduced pain and anxiety in primary care patients compared to a music control group. The study suggests that in-person intercessory prayer may offer a practical complement to conventional care for underserved populations.
The University of Maryland School of Medicine has received a $2.9 million federal grant to establish an advanced microscopy facility, enabling researchers to study cellular processes with nanoscale precision. The facility will house cutting-edge instruments like the MINFLUX microscope, which can visualize molecular events in brain cell...
New research has found that immature red blood cells can import heme from surrounding cells, overcoming long-standing assumptions about heme and red blood cells. This discovery could lead to new therapeutic approaches for inherited genetic blood disorders such as β-thalassemia.
The Marlene and Stewart Greenebaum Family Foundation donated $5.5 million to the University of Maryland Greenebaum Comprehensive Cancer Center to fund groundbreaking scientific research and compassionate cancer care. The funds will support innovative treatments, including immunotherapies, and strengthen support for cancer survivors.
Researchers developed an immune-capable 'cervix-on-a-Chip' model to study sexually transmitted infections (STIs), enabling a more accurate understanding of these conditions and the potential for better treatments. The model replicated key aspects of human biology, including the cervical microenvironment, microbiomes, and immune system.
Researchers uncover distinct patterns of Indigenous and European ancestry in urban Peruvian population, challenging common categorizations. The study's findings hold significant implications for precision medicine and health disparities among Latin Americans.
The University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center has been awarded a $3 million National Cancer Institute Career Development Award to support early-career oncology researchers focused on improving cancer outcomes for patients from diverse backgrounds. The program, called Advancing Oncology Research C...
Researchers created a pioneering database to map neocortical development across species using multiomic data from 188 studies. They discovered that humans take longer than mice to reach full molecular maturity, and gene regulation plays a key role in brain disorders.
Researchers at the University of Maryland School of Medicine discovered 25 distinct vaginal microbiome types, challenging the long-standing view of a simplified
A new experimental intranasal spray, INNA-051, will be tested in a randomized Phase 2 trial to determine its safety and effectiveness in reducing illness from respiratory viruses. The study aims to enroll 1,100 healthy adults at increased risk of upper respiratory virus infections.
A new review study led by the University of Maryland School of Medicine identifies genetic ancestry as a key component of assessing head and neck cancerous tumors. The research found that ancestry, rather than self-identified race, was a stronger predictor of genetic differences between tumors.
Researchers developed a smartphone-based assessment approach to detect improvements in daytime insomnia symptoms, detecting treatment effects more powerfully than traditional methods. The new method leverages real-time, multimethod assessment and shows potential for personalizing sleep medicine care.
A new study published in JAMA Network Open found that older adults living in economically disadvantaged neighborhoods spend significantly fewer days at home after a hip fracture. The researchers analyzed Medicare data and found that people in the most deprived areas spent about 23 fewer days at home compared to those in less disadvanta...
Manhattan E. Charurat, Ph.D., MHS has been invested as the Homer and Martha Gudelsky Distinguished Professor in Medicine at the University of Maryland School of Medicine. He is recognized for his scientific contributions and dedication to global health equity.
A new study by University of Maryland researchers found that Black patients with aggressive leukemia have lower survival rates and are more likely to die from the disease compared to white patients. The disparity is attributed to younger age at diagnosis rather than genetic differences, according to Dr. Shella Saint Fleur-Lominy.
Dr. Mintz brings exceptional clinical care, research, and education expertise to the role. He will lead transformative initiatives in perioperative operations, improving financial performance, employee satisfaction, quality, safety, and patient experience.
Gerald M. Wilson, PhD, joins UMSOM as Chair of Biochemistry and Molecular Biology, bringing expertise in RNA biochemistry and cancer mechanisms. He aims to strengthen departmental capabilities and foster collaboration to advance research, education, and service.
A new report from the University of Maryland School of Medicine presents a five-year data model demonstrating how a state-funded, multidisciplinary care approach can improve health outcomes and quality of life for adults with autism spectrum disorder (ASD) and other neurodevelopmental disorders. The study found that this model can serv...
The University of Maryland School of Medicine will expand its MD program class size from 175 to 200 students over five years. This initiative aims to address the projected nationwide shortage of physicians, with projections indicating a need for up to 84,000 additional doctors by 2036.
Researchers at the University of Maryland School of Medicine have identified a bacterial enzyme called zmpB that can cause fatal heart complications in people infected with pneumonia. The enzyme potentiates the invasion of Streptococcus pneumoniae into the heart, leading to damage and potentially life-threatening outcomes.
A clinical trial found a nearly 40% increase in overall survival for glioblastoma patients treated with focused ultrasound and chemotherapy. The study also showed that liquid biopsy tests can detect cancer biomarkers, which are closely concordant with patient outcomes.
A study published in Science Translational Medicine reveals that overactive plasmacytoid dendritic cells contribute to continuous immune inflammation and weaken antiviral T cell function. Reducing these cells or combining with an immune checkpoint inhibitor can restore antiviral T cell function and shrink the viral reservoir.
A new paper by University of Maryland School of Medicine researcher David Gorelick proposes six core competencies for medical students to know about cannabis before entering practice. The competencies address clinical utility, risks, legal landscape, and scientific evidence around medical cannabis.
Stuart S. Martin, PhD, has been appointed Chair of the Department of Pharmacology & Physiology at UMSOM, bringing over 20 years of success in advancing basic science research efforts and developing new drug therapies. His groundbreaking discovery of microtentacles on cancer cells promises to lead to new life-extending therapies.
Researchers at the University of Maryland School of Medicine have reported encouraging results from an early phase clinical trial of an intranasal influenza vaccine. The study found that the vaccine triggered a broad immune response, including higher levels of protective antibodies and better ability to kill infected cells.
A new monoclonal antibody has shown dose-dependent full protection against the malaria parasite with minimal side effects. Researchers found that a single injection of the antibody could provide months-long protection, offering a fundamentally different way to prevent infection before it starts.
A Phase 1 clinical trial has successfully tested a new vaccine against typhoid fever and invasive non-typhoidal Salmonella, demonstrating strong immune responses in healthy adults. The vaccine triggered balanced immune defenses and showed potential for whole-body protection against Salmonella.
Paul N. Staats, MD, has been appointed Chair of the University of Maryland School of Medicine's Department of Pathology, overseeing clinical services to multiple hospitals and laboratories. He will drive partnerships and expand outpatient laboratory services.
Dr. Andreea Creanga, a leading maternal health expert, joins the University of Maryland School of Medicine as Chair of the Department of Epidemiology and Public Health. She will oversee initiatives in bioinformatics, data science, and maternal health.
Stefan Kappe, a leading expert in genetic engineering of parasites, has been appointed as the new Director of the Center for Vaccine Development and Global Health at UM School of Medicine. He will focus on developing genetically engineered live-attenuated pathogens to combat malaria infection.
Researchers from the University of Maryland School of Medicine have developed a reliable measurement for opening the blood-brain barrier using focused ultrasound. By analyzing acoustic emissions signals generated by circulating microbubbles, they found that this method can predict blood-brain barrier opening in patients with glioblasto...
A new study uses generative AI to quickly scan notes in electronic medical records and identify high-risk patients with potential H5N1 avian influenza exposure. The model detected 76 patients with high-risk exposures, including 14 confirmed cases of recent bird flu exposure.
Researchers developed a new engineered protein-based therapy called RcoM-HBD-CCC, which acts like a sponge to soak up carbon monoxide from the blood. The therapy was tested on mice and showed promising results, clearing half of the carbon monoxide in the blood in less than a minute.
A new review highlights the critical need for standardized long-term medical care for gun violence survivors, who suffer physical, neurological, psychological, and social consequences. The review provides guidance for primary care physicians, psychiatrists, and rehabilitation specialists to manage survivors' long-term care.
A groundbreaking single-day study on Crete's soil microbiome has provided new insights into the environmental factors influencing microbial diversity. The researchers identified several key drivers, including soil moisture and nutrient availability, which can inform strategies for preserving biodiversity.
Researchers developed a software fueled by genomics to predict cancer cell behavior, combining genomics technologies with computational modeling. The new 'grammar' enables communication between biology and code, allowing scientists to build digital representations of multicellular biological systems and simulate diseases like cancer.
Dr. Machado brings scientific expertise, clinical leadership, and mentorship to the Department of Medicine at UMSOM. He will advance research impact, enhance clinical excellence, and shape the future of academic medicine.
Researchers investigate cannabis-based treatment to improve quality of care for hospice-eligible patients with dementia. A clinical trial will test T2:C100, a drug containing THC and CBD, to determine its effectiveness in reducing agitation.
Dr. Deanna L. Kelly has been named Director of the Maryland Psychiatric Research Center, building on her expertise in schizophrenia treatments and nutrition. She continues to advance personalized treatment options, including effective medications and innovative dietary interventions.