A team of researchers led by Texas A&M University has discovered Atlantic herring possess exceptionally high diversity in their MHC class II genes, a group of immune genes involved in recognizing pathogens. This diversity is shaped by natural selection driven by the evolutionary
Researchers have developed an ultracompact gene activation tool called TIGRa, which can target multiple genes simultaneously and is smaller than CRISPR-based tools. TIGRa was tested in a mouse model and showed promising results in treating retinal degenerative conditions, including glaucoma.
Researchers at Yale University have discovered two ancient, extinct giant tortoise lineages using a new combination of computational tools. The findings can aid conservation efforts in the Galapagos archipelago by unlocking the genetic diversity of extinct species.
Researchers developed new guidelines to study molecular biomarkers associated with stroke recovery. The recommendations aim to identify biological signals that can help clinicians determine the most effective therapies for each patient at the right moment. The guidelines also emphasize the importance of creating national biomarker cent...
Researchers discovered how tumors interact with the body to grow and spread, revealing a new target for cancer therapy. Metadherin, a protein encoded by the MTDH gene, mediates this metabolic-immune crosstalk, supporting tumor growth and metastasis.
Researchers at Texas A&M University are working on a project to develop a mobile and efficient drilling system that combines faster drilling technology, real-time rock analysis, and artificial intelligence to identify valuable minerals in real time. This project aims to reduce the time needed to evaluate potential deposits of rare eart...
The researcher will investigate how infected cells live and die, and what chemical signals they release to surrounding cells. This work could lead to better antiviral drugs and virus-based cancer treatments.
A new Concordia study suggests that reducing fast fashion's environmental impact can be achieved through changes in manufacturing, transportation, and consumer use. By producing fewer garments, designing them with longevity in mind, and cutting back on air freight, the fashion industry can achieve significant environmental benefits.
Researchers developed SOT-MRAM, a fast and energy-efficient memory tech, to address AI's increasing energy needs. The technology can reduce energy consumption by up to 5x, making it suitable for edge devices and applications where power is limited.
A new study identifies a distinct population of lung vein cells that contribute to scar tissue formation, a process known as fibrosis, in diseases like pulmonary fibrosis. The researchers found that targeting a specific signaling pathway can prevent lung scarring and inflammation.
A new study found that nearly 20% of eligible adults in Medicaid expansion states are at risk of losing health coverage due to insufficient or inconsistent work hours. Women, unmarried people, and those with limited education are disproportionately affected.
Two new research chairs at UVic will focus on improving climate-ready ocean stewardship and prevention-focused health research. Elliott Hazen will lead efforts to identify early ecosystem warning signals and collaborate with Indigenous communities to support climate-responsive ocean stewardship. David Almeida will establish a digital a...
A new study from the University of Georgia found that Joro spiders eat different insects and a wider variety than native orb weavers, suggesting they don't compete for food. However, Joros are still taking up physical space, but can often be found alongside native spiders in their webs.
Cyclin D1, a protein linked to cancer, paradoxically promotes chronic inflammation in non-proliferating senescent cells, which can lead to age-related disease. Research suggests that targeting cyclin D1 may be a promising strategy to reduce inflammation and promote healthier aging.
A new theranostic pair, 68Ga/177Lu-NYM096, shows excellent tumor uptake in clear cell renal cell carcinoma lesions and demonstrates early evidence of tumor response in patients. The radiotracer can identify tumors and deliver targeted radiotherapy, mitigating toxicity issues common with treatment.
A warming tropical pool has temporarily slowed Antarctic ice loss by triggering a Rossby wave train and reorganizing moisture transport, resulting in a 695 billion-ton mass gain. This phenomenon, linked to tropical warm-pool warming, demonstrates the complex interactions between atmospheric circulation and ice sheet mass changes.
The American Academy of Neurology launches BrainHealth.com, a public resource providing expert-reviewed information, tools, and stories for brain health. The website offers evidence-based guidance and practical resources for individuals to make informed choices for their brain health at every stage of life.
Thomson Reuters developed a frontier AI model named Thomson that rivals big foundation models with a $40 million development cost. The approach allows organisations to build and deploy frontier AI systems without major frontier labs' resources, addressing governments' and companies' need for sovereign AI systems.
Researchers found that impaired peroxisomal function can increase insulin secretion while promoting insulin oxidation and disrupting pancreatic beta cell maturity. Healthy peroxisomes play a role in protecting insulin from oxidative modification and degradation, and helping beta cells maintain their specialized characteristics.
Researchers are studying the male role in early pregnancy loss, focusing on paternal epigenetics and its impact on fertility and pregnancy. By analyzing sperm from bulls with high and low fertility, the team aims to understand how nongenetic changes to DNA affect embryo development and gene regulation.
Researchers have created a high-resolution functional map of human immune cells, revealing intricate circuits that govern health and disease. The dataset provides a powerful framework for designing cancer immunotherapies and treating autoimmune conditions, and serves as a foundation for AI models of biology.
Researchers developed fluorescent molecules that allow imaging of DNA inside living cells at unprecedented resolution, and in preserved cells, close to the width of the double helix. The team tested the probes on cancer patients and found DNA to be noticeably looser and more spread out in tumours.
Researchers have mapped how the immune response in people with sepsis changes over time, revealing three distinct immune states. This finding could lead to targeted treatments for sepsis patients, as the immune state doesn't match the clinical stage of sepsis.
Digital tools are transforming clinical research, public health readiness, healthcare institutions, and consumer choices. Citizen science initiatives using mobile apps are also growing, with three types of citizen science identified: with-the-people, by-the-people, and for-the-people.
Researchers have identified a subset of B cells known as atypical memory cells as the primary precursors of autoantibody-producing cells during SARS-CoV-2 infection. These cells adopt a markedly different biological program, leading to increased autoantibody production. The study provides new insight into how viral infections can trigg...
A study found that higher breastfeeding intensity is associated with more favorable early postpartum lipid profiles among women with prior gestational diabetes. Greater breastfeeding intensity may be linked to a more favorable early cardiometabolic profile in these women.
A team led by Professor Paulin Straughan is studying how urban design and infrastructure influence physical activity, mobility, and social participation among older adults. The goal is to create a sustainable approach to wellbeing-management through
A new generation of intelligent decision support methods and software tools will be developed to enhance supply chain resilience, optimize healthcare operations, and strengthen emergency response coordination. The HOPE project aims to create a lasting area of excellence in human-centered AI, serving as a trusted partner for government,...
A recent study aims to evaluate the effectiveness of Healthier SG in cancer screening, focusing on improving systems and boosting habits. The research seeks to address knowledge gaps in evidence-based planning for Singapore's preventive care agenda.
Researchers found that reef fish exposed to motorboat noise as embryos and juveniles grow smaller and have impaired survival skills. The study suggests that limiting motorboat traffic near reefs during breeding season may help preserve coral reefs.
Researchers developed a Mo alloy with high strength, good ductility, and excellent thermal stability at high temperatures, overcoming conventional dispersion-strengthened Mo alloys' limitations. The alloy retained stable mechanical properties after long-term annealing at 1000 °C.
Kajetan Fijalkowski developed a method for determining electrical resistance without an external magnetic field, opening up new possibilities for future measurement systems. This achievement contributes to the foundations of metrology and has implications for linking different electrical units.
A new study from the University of Copenhagen and Nordsjællands Hospital found a 75% reduction in hospital admissions among infants aged 0-5 months in Denmark following the rollout of an RSV vaccine for pregnant women. This significant decline suggests that the vaccine is effective in reducing the burden of severe RSV disease.
Researchers from the Max Planck Institute for Solar System Research have determined Mercury's surface silicon dioxide content with greater accuracy, finding it up to 25% less abundant than previously thought. This suggests the volcanic rocks on Mercury formed from more deeply melted mantle material than previously assumed.
Researchers at Ludwig-Maximilians-Universität München identify a molecular mechanism enabling single-celled parasites to move and invade host cells through lysine methylation. This regulatory layer connects signaling, cytoskeletal activation, and mechanical force, offering a promising starting point for drug development.
Researchers developed a plyometric-based high-intensity interval training (Plyo-HIIT) program to preserve muscle while reducing fat in children aged 9-12. The 16-week program showed promise in improving muscle-to-fat ratio, prioritizing metabolic health over weight reduction.
Researchers have developed a programmable directional photonic spiking neuron based on a non-Hermitian silicon microresonator. The device, called DRUM, can emit spikes in one direction while remaining inactive in the other, reducing unwanted crosstalk and enabling true directional interaction.
The Plant Journal has transitioned to gold open access, removing paywalls and making its research freely available. This change is part of the Society for Experimental Biology's strategy to support the plant science community and ensure discoveries reach the widest audience.
Researchers developed a new approach to multi-camera identity tracking by combining camera geometry and visual appearance. The method achieved high IDF1 scores on benchmarks, demonstrating improved tracking continuity across different environments, but highlighted limitations in detecting people in severe occlusion.
A new study suggests that children with cerebral palsy born very preterm may need closer nutritional and rehabilitation monitoring due to higher risks of undernutrition and functional impairments. The study found that gestational age should be considered when assessing nutrition and rehabilitation needs in children with cerebral palsy.
Researchers identified a critical postnatal window in which excessive FGFR2 signaling drives coronal craniosynostosis by reducing GLI1+ progenitors and promoting abnormal osteogenesis. Restoring suture patency or RA signaling rescues structural and neurocognitive abnormalities.
The robots use torsion to store elastic energy and release it all at once, causing them to jump and repeat the process as long as they are exposed to infrared light. Design changes can control the movement, such as jumping forward or leaping vertically.
Researchers have developed a heat-driven, elastocaloric cooling system that leverages waste heat and solar energy for sustainable cooling. The system achieves a temperature difference of 4°C on the component level, demonstrating its feasibility.
Researchers at the Max Planck Institute for Polymer Research have identified the electrical charge of droplets as a new factor contributing to surface corrosion. Charged droplets can puncture coatings like Teflon, causing damage and reducing durability.
A new trial has found that implanting an ICD in patients with mild-to-moderate heart dysfunction can reduce sudden cardiac death, particularly in younger patients. This breakthrough has the potential to save lives and expand treatment options for patients who previously were not eligible for ICDs.
Researchers have demonstrated that nano-antennas can enhance the fluorescence of proteins in living human and other mammalian cells, allowing for faster and more precise monitoring of electrical signals in the brain. This discovery adds a new tool for revealing electrical signals in the brain, using nanotechnology and genetic engineering.
Researchers at the Max Delbrück Center have developed a search engine, Malva, to analyze single-cell RNA data, enabling rapid analysis of millions of cells worldwide. Malva simplifies the task of wading through data from thousands of experiments and provides insights into RNA biology, cancer, and disease mechanisms.
Researchers developed a dual-threshold approach for measuring tumor volume on PET/CT, showing higher total lesion volume associated with shorter overall survival and time to treatment failure. FAPI PET/CT improved detection of ovarian cancer spread, while CD8-targeted PET tracked immune response in lung cancer.
Researchers at Tsinghua University Press review Pt-based catalysts for the reverse water-gas shift reaction, highlighting the importance of structurally defined active centers and defect-anchored single atoms. The study identifies priorities for future research, including improved stabilization of single-atom and sub-nanometer Pt species.
Researchers developed high-performance flexible thermoelectric generators with planar and multilayer-stacked structures, overcoming material flexibility and mechanical stability challenges. The devices achieved high energy conversion capabilities and demonstrated practical potential for wearable thermoelectric energy harvesting.
A new coating developed by Professor Zhang Yuxin's team achieves long-term adaptive anti-corrosion for magnesium alloys, overcoming the limitations of traditional epoxy resins. The coating combines a hierarchical composite system to provide both long-term barrier protection and on-demand release of corrosion inhibitors.
A collaborative research team has successfully upcycled phosphine waste into high-value electrocatalysts for hydrogen evolution, a critical process for a hydrogen economy. The catalyst achieves exceptional performance in water splitting, making hydrogen production spontaneous and thermodynamically favorable.
Researchers have developed a concentration-gradient strategy to stabilize cell voltage for high-yield formate production via CO2 electroreduction. The strategy uses a concentration gradient to offset the voltage increase caused by cation migration, resulting in stable operation for up to 30 hours. This breakthrough enables efficient gr...
A new study found that off-equatorial Pacific warming halted La Niña development by inducing equatorial westerly wind anomalies, breaking the Bjerknes feedback. Climate models have been improved by refining ensemble forecasting frameworks to fully integrate off-equatorial ocean signals.
The updated expert consensus offers a practical roadmap for recognizing and treating childhood nocturnal enuresis, emphasizing symptom-based classification, individualized first-line treatment, and management of daytime urinary symptoms. The framework aims to provide more standardized, individualized, and family-centered care.
Dr. Sebastian Spethmann joins JMIR Cardio as Editor-in-Chief, bringing expertise in heart failure, cardiomyopathies, and digital health. He aims to integrate digital advancements into routine clinical care, enhancing cardiovascular health systems and patient outcomes.
Researchers from SWPS University found that mimicry in social interactions doubles tobacco consumption and makes quitting difficult. The study showed that when participants mimicked the smoker's movements, they were more likely to smoke and less likely to quit.
Insilico Medicine leaders will share AI-driven insights at key tech events, including LEAP 2026 and the UBS China A-Share Conference. The company will discuss how AI drug discovery is reshaping R&D paradigms, enhancing efficiency and innovation value.
Researchers at KIER develop technology to separate current collectors from spent battery cathode materials, regenerating materials to near-pristine condition. The process uses diethylene glycol solution, enabling complete separation and simultaneous regeneration of cathode materials.
A new study highlights the impact of coastal freshening on the giant amphipod species Paraceradocus miersi, which lose salts, gain water, and suffer gill damage in diluted waters. The research warns that continued freshening may pose a significant threat to many marine invertebrates and reshape the global ocean's communities.
Researchers identified a compound, PF-04457845, that slows ALS progression in mice, with potential as a therapeutic option. The compound targets N-acyl taurines, which correlate with ALS progression, and has been proven safe in humans.
Research suggests that insects struggle with hypoxia and hypobaria at higher elevations, limiting their ability to pollinate and survive. Insects with aquatic larval stages and high energy demands are particularly affected, highlighting the need for targeted conservation strategies.
A Swedish study found that short-term exposure to cold spells and higher ambient temperatures increased the risk of heart failure hospitalization within days. The study highlights the need for time-sensitive management and more urgent response strategies during heatwaves.
The new ESC Guidelines on cardiac rehabilitation emphasize its benefits for patients with various heart conditions, improving heart health and reducing the risk of cardiac events. The guidelines also highlight the importance of individualized programs, patient-centered care, and cost-effectiveness.
The 2026 ESC Guidelines on heart failure introduce significant changes, including a staging approach and removal of the mildly reduced ejection fraction phenotype. New recommendations focus on prevention, early treatment, and patient education, with updated therapies for specific patient populations.
A universal definition of myocardial infarction has been developed to improve diagnosis and treatment. The new definition considers the underlying cause of the MI and aligns with established approaches to clinical evaluation.
Researchers at EPFL's POWERlab have developed a new class of GaN transistor that can withstand nearly 4 kilovolts before breaking down, maintaining low resistance and reducing energy losses. This innovation is crucial for efficient power conversion in AI data centers and renewable energy systems.
A research team at the Wyss Institute has engineered bacteria to produce higher amounts of siderophores, molecules that extract iron from silicate minerals, speeding up rock weathering and removing CO2 from the atmosphere. This process has the potential to be implemented at industrial scales, offering a new climate-regulating strategy.
The new guidelines aim to increase kidney function and urine albumin testing in patients with CVD, identifying at-risk patients and prescribing targeted treatments. Early use of RAS inhibitors and SGLT2 inhibitors, alongside statin-based therapy, is particularly important in slowing CKD progression and reducing cardiovascular events.
Optical convolution computation enables parallel light propagation and multiplexing for faster and more energy-efficient computing systems. The review organizes the field into two paradigms: definition-based and theorem-based, which leverage mathematical principles to implement convolution operations in the physical domain.
A randomized trial found that patients with atrial fibrillation at intermediate risk of stroke experienced a 69% lower risk of adverse events with oral anticoagulants compared to no treatment. The study also showed a lower incidence of ischemic stroke with anticoagulant therapy.
The CARDIO-TTRansform trial investigated eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy, but failed to meet its primary endpoint. The study found that eplontersen reduced circulating serum TTR, but had no significant impact on cardiovascular mortality and recurrent cardiovascular events in the overall popula...
A tailored strategy shortened antibiotic duration by two weeks in patients with left-sided infective endocarditis, with no compromise on safety. The study found that rates of primary relapse were low, and most were easily managed with reinitiation of antibiotics.
Researchers propose a new understanding of moral distress that links ethical awareness with clinician well-being, organizational culture, and patient care. The framework offers a clearer foundation for future research, suggesting that moral distress may sometimes be a sign of strong ethical awareness rather than personal weakness.
The ACACIA-HCM trial showed aficamten significantly improves symptom burden and exercise capacity in patients with symptomatic non-obstructive hypertrophic cardiomyopathy. Clinically meaningful improvements were documented for the first time in this relatively common form of inherited heart disease.
ICDs did not improve overall primary endpoint but showed benefit in younger patients (under 70) with a 72% reduction in sudden cardiac death. In contrast, older patients did not derive benefit from ICDs.
A University of Helsinki research group has discovered a weakness in aggressive breast cancer cells that can be exploited, targeting the MYC protein's metabolic grip. By inhibiting energy production and glutamine uptake, researchers were able to slow breast cancer growth in mice, paving the way for new and personalised treatments.
Researchers developed a machine learning-based time-to-event model that outperformed existing staging systems in predicting mortality and heart failure hospitalization in transthyretin amyloid cardiomyopathy patients. The model showed promise for individualized prognosis in contemporary clinical care.