The CIP2A protein regulates DNA repair during cell division and influences tumor response to radiotherapy. It controls Polθ activity and maintains its recruitment to damaged DNA sites through interaction with PP2A.
A new porous material has been developed to detect and adsorb copper ions, with a detection limit of 40.76 nM and a high adsorption capacity of 1902 mg/g. The material shows specific fluorescent recognition and cooperative adsorption capabilities, enabling efficient heavy metal monitoring and pollution treatment.
Researchers developed a Mo alloy with high strength, good ductility, and excellent thermal stability at high temperatures, overcoming conventional dispersion-strengthened Mo alloys' limitations. The alloy retained stable mechanical properties after long-term annealing at 1000 °C.
A high-entropy electrode has been developed to improve the efficiency of green hydrogen production through anion-exchange membrane water electrolysis. The electrode, containing five metal elements, demonstrated excellent oxygen evolution performance and long-term stability in tests.
Researchers at Hefei Institutes of Physical Science achieved record pulse energies with a laser diode-pumped Er,Pr:GYAP laser operating at 2.7 μm. The crystal helps improve laser performance, expanding the emission range and reducing energy losses. The laser produced high-energy pulses with Q-switched operation.
Researchers found that magnetotactic bacteria AMB-1 extended lifespan by 43.39% and improved neurological function and intestinal integrity in aged worms. AMB-1 reduced iron accumulation and lipid peroxidation levels, suppressing ferroptosis and aging-related pathways.
Researchers found that nanosecond laser-driven proton FLASH radiotherapy effectively kills cancer cells while minimizing damage to normal cells. The study showed that this new irradiation method preserves mitochondrial structure and function, reducing ferroptosis and stress responses in healthy tissues.
Researchers developed a low-noise magnetic sensor that improves weak-field detection, leveraging spin-texture dynamics to break the sensitivity–noise limitation. The anomalous Hall magnetic sensor achieved a magnetic-field detectivity of 15.7 nT/√Hz at 1 Hz, nearly one order of magnitude better than conventional ferromagnetic materials.
Researchers developed a highly crystalline three-dimensional graphitic carbon tube grid that improves filtering supercapacitor performance, offering potential for compact and efficient electronic devices. The new material shows faster coupled electron and ion transport and strong high mass loading capabilities.
A research team has developed a new strategy to regulate quantum states in layered materials by precisely tuning atomic layer movement. This approach enables the design of superlattices and regulation of electronic properties through structural engineering.
The study reveals the detailed structure of an RNA–DNA hybrid G-quadruplex, showing unique arrangement and unusual structural state. The findings suggest that RDQs may participate in regulating interactions between RNA and DNA in cells, protecting telomeres and maintaining genome stability.
A new membrane-based approach for treating high-salinity brines has been developed, utilizing thermoresponsive ionic liquids as recoverable draw solutes. The system achieves stable operation under high-salinity conditions and can be regenerated using low-grade heat.
A flavonoid-based fluorescent dye combined with whey protein creates a supramolecular probe that rapidly detects phoxim pesticide concentrations in solution. The system shows good selectivity and response, making it suitable for on-site screening in food safety and environmental monitoring.
A new method combining FTIR spectroscopy with machine learning improves gas concentration estimation in complex industrial conditions.
Researchers stabilize B31-type MnSe0.5Te0.5 phase with superconductivity driven by pressure-induced Jahn-Teller distortions. The team's chemical strategy enables the emergence of superconductivity at lower pressures.
A miniaturized spectroradiometer based on VIPA technology achieves high spectral resolution for atmospheric water vapor profiling. The system enables researchers to visualize water vapor distribution across the atmosphere, layer by layer.
A research team at Hefei Institutes of Physical Science, Chinese Academy of Sciences, has realized a superconducting diode effect that preserves time-reversal symmetry in NbSe2 homojunctions. The device was built using a solid-state proton gating technique to form n–n, p–n and p–p junctions, all operating under zero magnetic field.
Researchers directly observed Meissner effect in 2D van der Waals superconductors, providing evidence of superconductivity in low-dimensional systems. The study used a new high-sensitivity method to detect magnetic signals in ultrathin samples.
A new peptide agonist, beta01, has been designed to target the kappa opioid receptor with high efficacy and reduced β-arrestin signaling, offering improved safety profiles for chronic pain and pruritus treatment. The study demonstrates a structure-based rational design approach for biased KOR agonists.
Researchers developed a synergistic strategy using glutathione additives to improve the efficiency and stability of inverted perovskite solar cells. The approach enhances charge transport, reduces energy loss, and strengthens structural stability, resulting in high power conversion efficiency and operational stability.
The study introduces a phenotype-aware contrastive learning framework that leverages self-supervised learning on large-scale sequence datasets. BCRInsight accurately deconvolves B-cell subset compositions from bulk BCR-seq data, achieving an AUROC of 0.962 in antibody paratope prediction.
A new multimodal neural network model, MM-LHRNet, enhances atmospheric CO2 retrieval using laser heterodyne radiometry by doubling accuracy while tripling speed. The model achieves a retrieval standard deviation of 0.49 ppm and precision of 0.11%, outperforming traditional methods.
Researchers analyzed 32 years of global observations to identify eight daily patterns of aerosol optical depth (AOD) variability. These patterns are linked to land surface conditions and aerosol types, suggesting local environments play a significant role in shaping AOD behavior.
A new drug candidate, IHMT-15137, has been discovered to target key proteins involved in chemotherapy resistance. The compound blocks BMX activity, disrupting downstream signals and reducing E2F1 levels, making cancer cells more sensitive to treatment.
A research team developed a high-performance laser-based Three-Dimensional methane gas cloud imaging telemetry system. The system enables accurate measurement of emissions, supporting more efficient monitoring and control of pipeline networks.
A research team at Hefei Institutes of Physical Science developed a low-temperature solution-processing strategy for fabricating CuInS2 thin-film solar cells with an efficiency up to 12.28%, outperforming previous records.
The study reveals a nearly isotropic upper critical field in trilayer nickelate La4Ni3O10-δ under high pressure, unlike most layered superconductors. This unusual feature arises from the combined effect of two types of electronic states that balance out to lead to an overall nearly isotropic superconducting response.
A team of researchers has solved the long-standing structural puzzle of γ-N2 using a combination of high-pressure experiments and first-principles calculations. The study reveals that γ-N2 adopts a monoclinic P21/c structure containing two nitrogen molecules per unit cell.
The study uncovered how affibody Aff6 specifically recognizes different photoexcitation states of photosensitive protein DrBphP in the red/far-red optogenetic system MagRed. Key interactions between Aff6 and DrBphP, including aromatic and allosteric effects, were identified as crucial for state-specific recognition.
A new integrated plasma regime has been demonstrated in a metal-wall environment, achieving partial divertor detachment, an ELM-free H-mode, and high pedestal performance. This regime was sustained on a minute-scale and offers a potential solution to managing extreme heat loads on divertor plates while maintaining plasma stability.
A new catalyst, 3D Ce–Co3O4, was developed to improve the efficiency and durability of chlor-alkali electrolysis. The catalyst features a unique active site configuration that enhances Cl– adsorption and suppresses lattice-oxygen corrosion.
Researchers developed a coordination-unsaturated copper single-atom nanozyme that exhibits dual enzyme-like activities, mimicking peroxidase and glutathione peroxidase. The unsaturated Cu-N2 configuration induces high-spin electron density, enhancing H2O2 adsorption and accelerating electron transfer.
Researchers identified a natural compound, Timosaponin AIII, that selectively eliminates CAR-T regulatory T cells, enhancing CAR-T cell potency and preventing relapse. TAIII restored CAR-T function, increased killing ability, and improved patient-derived CAR-T cells in lymphoma models.
Researchers developed an atomic-column-resolved EMCD method to image antiferromagnetic order at the atomic scale. This technique detects chiral reversal signals from individual atomic columns, revealing microscopic magnetic structures.
A team of scientists developed a novel dual antisite defect strategy to introduce defects into chalcopyrite-based thermoelectric materials. This approach enabled the material to conduct electricity more efficiently while blocking heat, leading to a record peak ZT value of 2.03 at 873 K.
The study reveals two distinct types of unusual low-energy quasiparticle states in CsV3Sb5, including a zero-bias conductance peak within the superconducting gap and Kondo resonance peaks that break mirror symmetries of the kagome lattice.
A new technique called Differential Photoacoustic Stimulated Raman Spectroscopy (DPA-SRS) enables high-sensitivity hydrogen detection at concentrations as low as 1 ppm under atmospheric pressure. The DPA-SRS system achieved a minimum detection limit of 0.65 ppm for hydrogen.
Researchers developed high-performance catalytic membranes using MXene nanosheets and microfiltration techniques, achieving efficient removal of emerging contaminants like antibiotics from pharmaceutical wastewater. The membranes showed improved stability, antifouling performance, and permeation flux, cutting treatment costs by over 30%.
Researchers developed a programmable plasmonic ring biosensor, MetaRing, to rapidly identify paclitaxel sensitivity in breast cancer patients. The platform achieved deterministic nanoparticle assembly and surface-enhanced Raman spectroscopy for rapid molecular analysis.
Researchers propose a universal mechanism for deterministic electrical control of collinear antiferromagnets, overcoming a long-standing bottleneck in antiferromagnetic spintronics. Asymmetric spin torque enables reliable flip of the Néel vector, making controlled data writing possible.
A new Metal–Organic Framework (MOF)-based material efficiently removes fluoride ions from water while providing real-time visual detection. This breakthrough overcomes limitations of conventional methods by integrating removal and monitoring processes.
An antiferromagnetic kagome semimetal heterostructure exhibits unconventional, damped oscillatory magnetoresistance in low-field regimes. Real-space magnetic force microscopy reveals topological magnetic textures that directly correlate with anomalous transport behavior.
Researchers successfully generated electrically controllable magnetic hopfions in a chiral magnet, representing a significant advancement in topological soliton research. The team's findings also revealed that the hopfions exhibit unconventional dynamics and transport behavior linked to their three-dimensional topology.
Researchers developed a fast, multi-platform compatible detection network that can detect gas leaks in three dimensions. The system achieves real-time detection at over 25 frames per second and provides accurate 3D reconstruction within 200 milliseconds.
Gradient-engineered cathode materials exhibit improved cycling stability and rate performance, demonstrating high capacity and strong long-term durability. The composition gradient strategy precisely regulates internal stress distribution and electronic structure, suppressing undesirable oxygen-related side reactions.
A research team from Hefei Institutes of Physical Science grew a high-entropy garnet-structured oxide crystal, achieving enhanced laser performance at 2.8 μm. The material demonstrated strong potential as a gain medium for mid-infrared ultrashort-pulse lasers.
Researchers provide new insights into how uncertainty propagation affects tokamak equilibrium reconstruction. They found reliable reconstruction requires controlled accuracy range for core diagnostic inputs and improved precision in midplane data.
Researchers discovered that magnetotactic bacteria can resist and detoxify lead, a highly toxic heavy metal pollutant. The bacteria use different strategies to handle lead, including adsorption on cell surfaces or absorption into cells.
A research team developed a novel amino-nitrogen–guided pore-engineering strategy to enhance sodium-ion transport and relieve interlayer confinement in hard carbon anodes. The process enables high initial efficiency, strong reversible capacity, and long-term cycling stability even under extreme conditions.
A team of researchers has discovered a high-energy-density barocaloric effect in Ag₂Te₁₋ₓSₓ, a plastic superionic conductor. The material produces a reversible volumetric entropy change of 0.478 J·cm⁻³·K⁻¹ under moderate pressure, surpassing most known inorganic materials.