Researchers developed a plyometric-based high-intensity interval training (Plyo-HIIT) program to preserve muscle while reducing fat in children aged 9-12. The 16-week program showed promise in improving muscle-to-fat ratio, prioritizing metabolic health over weight reduction.
The updated expert consensus offers a practical roadmap for recognizing and treating childhood nocturnal enuresis, emphasizing symptom-based classification, individualized first-line treatment, and management of daytime urinary symptoms. The framework aims to provide more standardized, individualized, and family-centered care.
A comprehensive review of surgery for necrotizing enterocolitis (NEC) in premature infants highlights the importance of preserving functional bowel, reducing long-term complications, and supporting survival with better quality of life. Emerging perioperative tools and risk scores may improve assessment and recovery.
Researchers develop biodegradable film using rapeseed-processing residues, combining chitosan with phenolic extracts and silver nanoparticles to protect fresh food from moisture, oxygen, and microorganisms. The film showed improved structural durability, active preservation, and rapid environmental degradation.
Researchers found that an electrostatic field slows pork glycolysis during near-freezing storage by preserving glycogen and adenosine triphosphate (ATP), limiting lactate accumulation, and altering muscle protein structure. This approach could offer a new route to maintaining fresh pork quality.
A new genetic framework, Behçet's spectrum disorders (BSD), maps out diverse inflammatory conditions united by shared immune pathways. The two-tiered classification aids in early recognition and genetic screening for children with unexplained fevers and gut inflammation.
A comprehensive review reveals a crucial role of CHD proteins in regulating gene activity during heart development. The study identifies specific members of the protein family linked to different stages of cardiac development, providing a unifying framework for understanding congenital heart defects.
A new study found that hunger increases the immediate liking and physiological arousal triggered by sweetness, not just its calorie content. Long-term non-nutritive sweetener consumers exhibit heightened activity in a brain region linked to self-control, suggesting these sweeteners may help manage hedonic appeal.
Global newborn mortality from birth asphyxia and trauma has declined, but progress is slowing in low- and middle-income countries, particularly in sub-Saharan Africa. Countries with lower scores on human development indices experienced slower mortality declines, highlighting the need for targeted investments to close the equity gap.
A new review suggests that immune checkpoint inhibitors can help selected patients with hepatocellular carcinoma (HCC) shrink or stabilize tumors before transplantation, increasing transplant eligibility. However, the therapy also carries a risk of rejection, highlighting the need for precise timing and patient selection.
Pre-retrieval imaging is revolutionizing liver transplantation by improving graft selection, reducing uncertainty, and supporting better surgical planning. Imaging modalities like ultrasound, CT, and MRI offer distinct strengths and limitations in evaluating liver graft quality, vascular anatomy, and biliary variants.
A longitudinal study found that higher screen viewing time during infancy and school-entry age was associated with poorer academic performance and weaker working memory. The study suggests that the timing of screen exposure may be as important as the amount of screen time itself.
A study of Indonesian upper secondary special schools found that entrepreneurship education often remains within protected school settings, with limited opportunities for students with disabilities to develop pricing, marketing, and customer engagement skills. The authors suggest that inclusive entrepreneurship education should move be...
A study by Zhejiang University researchers reveals that TATA box-binding protein-associated factor 1 (TAF1) acts as a context-dependent molecular switch regulating ferroptosis in cancer cells. In <em>TP53</em>-mutant tumors, TAF1 promotes nGPX4 degradation, increasing ferroptosis susceptibility. Conversely, in <em>TP53</em>-wild-type t...
A remotely operated AI algorithm has identified the critical view of safety (CVS) in pediatric patients, detecting when all safety criteria were met and issuing real-time alerts. This approach combines AI with teleconferencing for potential new intraoperative guidance without requiring specialized hardware.
The review highlights the potential of vision and vision-language foundation models in ophthalmology, achieving strong diagnostic performance and adaptability with limited labeled data. However, challenges such as algorithmic bias, overfitting, and limited interpretability remain to be addressed for real-world adoption
A new analysis of nearly 400 young participants found that those starting a healthy lifestyle program in spring showed weaker improvement than those beginning in summer, autumn, or winter. The study suggests that school calendars, daily routines, and long holiday breaks can impact treatment success.
This study found that parental screen-time modeling, mealtime screen use, and bedroom screen use were associated with higher odds of adolescents playing mature-rated video games later. In contrast, parental monitoring and screen-time limits were linked to lower odds of mature-rated gaming and less total gaming time.
A 12-week integrated cognitive-motor exercise program reduced core ADHD symptoms in children, producing stronger improvements in inhibitory control and immediate working memory compared to aerobic exercise alone. The combined training also eased inattention and hyperactivity-impulsivity, improving key executive functions.
Researchers from Zhejiang University found that inhaling citrus essential oils promotes relaxation-related autonomic activity, enhances brain rhythms associated with positive emotions, and reduces stress and tension. The study identified four key mood-enhancing molecules: d-limonene, linalool, α-terpineol, and geranial.
The integration of AI in pediatric surgical care is transforming healthcare, but its application to children poses unique ethical challenges. Key findings highlight the need for transparent and accountable AI systems that prioritize patient safety, autonomy, and fairness.
A new roadmap for newborn screening combines genetic sequencing with traditional biomarker-based testing to enhance early detection of treatable neonatal disorders. The framework covers 154 disease-associated genes across 67 inherited metabolic disorders, reducing false positives and false negatives while accelerating diagnosis and int...
Even after successful surgical intervention, progressive liver fibrosis remains common in biliary atresia, with fibrotic injury evolving over time. Advanced imaging and AI-assisted histological analyses reveal that ductular reaction plays a key role in matrix remodeling and disease progression.
Melatonin's short-term effectiveness is well-documented for children with neurodevelopmental disorders, but its long-term safety and efficacy remain uncertain. In contrast, evidence for typically developing children is sparse, highlighting the need for better regulation and stronger guidance on melatonin use.
A large national survey reveals nearly a third of students started drinking before age 13, with higher rates in rural areas and boys. The study highlights the need for targeted prevention strategies addressing early exposure, social contexts, and vulnerable subgroups to curb underage drinking's long-term impact.
A new synthesis of seismic research shows that AI combined with physical principles is rapidly transforming how scientists image the Earth's shallow and crustal structures. The study highlights the need for physics-guided AI frameworks that balance computational efficiency with interpretability.
Recent advances in CAR-NK cell therapy have expanded its applicability across hematological malignancies, solid tumors, autoimmune diseases, and infectious conditions. CAR-NK cells offer a unique balance between efficacy and safety, with potential applications in cancer and immune-related diseases.
Recent advances in maternal vaccines and long-acting monoclonal antibodies have broadened the scope of RSV prevention, reducing disease burden and improving infant survival outcomes. The expert panel concludes that both strategies demonstrate strong benefit–risk profiles when used appropriately.
A recent survey of pediatric surgeons reveals that AI adoption is hindered by ethical concerns over accountability, informed consent, and data protection. Despite potential benefits, only one-third of respondents have used AI in clinical practice, with most focusing on tasks like literature searches.
A new electrolyte design, LiPF₆–PC–TFMB, offers exceptional stability in high-voltage lithium-ion batteries, maintaining 78.8% capacity over 600 cycles and significantly reducing heat release and oxygen evolution. The TFMB-based electrolyte improves cathode interfaces and mitigates safety hazards.
A new interpretable machine learning framework predicts syngas composition in biomass-plastic co-gasification, identifying key factors controlling product distribution. The model supports improved syngas quality, reduced experimental workload, and more efficient process optimization.
Researchers developed a persistent luminescence nanoprobe to detect H₂O₂ in real samples, overcoming background fluorescence interference. The probe's high selectivity and reproducibility make it suitable for food safety monitoring, environmental inspection, and biomedical assays.
A metabolomics study found galangin accelerates yeast sedimentation and promotes premature flocculation in beer fermentation. Researchers identified galangin as a key promoter of yeast aggregation and propose strategies to improve fermentation control.
Researchers from Zhejiang University analyzed crucial factors influencing crystallization in blade-coated perovskite films. The study identifies interconnected factors controlling crystal nucleation, grain evolution, and defect distribution.
The study identifies biliary atresia splenic malformation syndrome (BASM) as the most prevalent syndromic form of biliary atresia, associated with polysplenia, situs inversus, and vascular anomalies. Genetic analyses highlight PKD1L1 and CFC1 pathways involved in nodal signaling and cardiac development.
Researchers have identified promising molecular targets for acute pancreatitis treatment, focusing on intracellular calcium overload and mitochondrial dysfunction. Experimental studies show that blocking calcium influx channels and enhancing cellular protection may transform AP therapy.
Recent research highlights advances in precision medicine and multidisciplinary management for pancreatitis, including improved fluid resuscitation strategies and novel molecular therapies. Gene-based treatments like SPINK1 gene therapy show promise in reversing fibrosis and improving quality of life for patients.
Exercise now considered a key component of asthma management, with aerobic, resistance, and flexibility training recommended. Wearable devices and home spirometry monitor lung function and exercise intensity for personalized plans.
A national registry has tracked nearly 4,000 patients with biliary atresia since 1989, showing that combined surgery and liver transplantation can extend survival well into adulthood. The study highlights the transformative power of nationwide data collection in reshaping treatment strategies.
A large population-based study in Western Australia found that nearly one in four CALD children displayed vulnerabilities in at least one key developmental domain. The findings emphasize the importance of culturally sensitive education policies, stronger language support, and better collaboration to address these disparities.
Researchers found that curdlan reduces cooking time from three hours to one, strengthens texture, and improves stability in pineapple jam. Consumer panels reported no loss in taste or overall appeal.
A new AI-powered solution enables robots to navigate without a map by training them to evaluate visual richness and avoid collisions. The approach combines deep reinforcement learning with real-time feedback from RGB-D camera input and ORB-SLAM2, achieving improved navigation success rates in simulated tests.
Pediatric MRI innovations sharpen clinical lens for early disorder identification, making experience safer and more comfortable. AI-powered analysis and silent scanning enable deeper insights into lifelong cognitive and emotional health.
Researchers mapped 176 real-world NFT security incidents and identified critical vulnerabilities across platforms and protocols. A multilayered NFT security reference framework pinpoints common vulnerabilities, assesses detection challenges, and proposes a clear path forward for safeguarding the Web3 ecosystem.
Researchers develop a groundbreaking, non-destructive method to monitor oyster health by analyzing heartbeat patterns using high-resolution image processing. The technique tracks vitality loss through cardiac activity and biochemical markers, providing a sensitive and real-time tool for seafood quality assurance.
A scoping review highlights Europe's fragmented efforts in biliary atresia screening, calling for a unified approach that merges effective tools with innovation. The review assesses three major screening strategies: stool color cards, serum bilirubin testing, and biochemical profiling, emphasizing the potential of digital apps and AI-p...
A scoping review highlights Europe's fragmented approach to biliary atresia screening, citing inconsistent practices and parental unawareness. The authors advocate for a unified approach merging cost-effective tools with innovation to ensure timely diagnoses and improved outcomes.
Researchers have developed a simplified one-shot synthesis technique to transform gold nanocubes into consistently sized 35 nm nanospheres, overcoming the technical hurdle of uniform size and shape manufacturing. The approach delivers high-quality nanospheres ideal for biomedical applications like rapid pathogen detection.
A new study explores how generative AI models with different dimensional outputs support combinational creativity. Expert designers applied each AI type to six combinational tasks, revealing distinct divisions of labor: LLMs excel in early idea generation, while image and 3D models shine in visualization and prototyping.
Researchers have developed a hyperspectral imaging technique that can detect microplastics in soil with impressive accuracy, paving the way for faster and non-invasive monitoring methods. The MCT-HSI system has been shown to achieve over 93% detection accuracy across tested levels of microplastic concentrations.