Researchers have discovered a small RNA molecule that plays a key role in controlling cholesterol production and the development of heart disease. The molecule, tsRNA-Glu-CTC, was found to boost SREBP2 activity, leading to higher cholesterol levels and increased risk of atherosclerosis.
A large-scale study found that individuals with ADHD are at higher risk of being convicted of crimes compared to those without ADHD. Relatives of individuals with ADHD also show increased risk, even if they themselves do not have ADHD. Early identification and treatment of ADHD in high-risk families may help mitigate these risks.
A new modeling study suggests that regular testing for sexually transmitted infections (STIs) can successfully reduce their spread, even if individuals on PrEP engage in riskier behavior. The paradoxical findings highlight the importance of careful surveillance data interpretation when evaluating public health interventions.
A blood test may help doctors identify which patients with colon cancer can benefit from anti-inflammatory medication and chemotherapy after surgery. The test measures circulating tumor DNA levels, and high-risk patients who test positive see improved survival rates when taking celecoxib with chemotherapy.
Stanford engineers develop an AI framework called MetaChat, which rapidly accelerates metasurface design using computational tools and self-reflective AI assistants. This enables rapid solving of optics-related problems, such as designing metal lenses that can focus different wavelengths of light.
A £1.4 million funding has been secured by the University of Stirling to explore tissue remodelling processes in salmon, with a focus on reducing mortality linked to gill and skin health issues. The research will deliver practical tools for fish health and productivity while enhancing sustainability in the Scottish aquaculture industry.
Researchers discovered that SUMO E1 enzyme activity drives lens fibrosis, while its inhibition with ML792 disrupts SMAD4 SUMOylation and subsequent TGFβ2-induced fibrotic transformation. This study establishes a novel SUMOylation-SMAD4 regulatory axis in ocular fibrosis.
A study from UMBC reveals a conserved RNA-protein interaction as a promising target for broad-spectrum enterovirus antivirals. The researchers found that a fusion protein called 3CD recruits proteins to assemble the replication complex, and targeting this interface could lead to universal drugs.
In a groundbreaking discovery, researchers at the Technion and Shanghai Jiao Tong University found that photons can emerge with
A new study using mice found that surviving cells compensate for cell death by sprouting extra branches to promote recovery in the visual brain system. However, female mice showed delayed or incomplete repair compared to males. This suggests a compensatory mechanism following brain injury that differs between sexes.
Researchers develop a method to tune thermal conductivity in thin films using femtosecond lasers, achieving unprecedented throughput and nanoscale resolution. The technique enables laboratory-scale precision and industrial-scale production of phononic nanostructures.
The book explores three phases of defense: internationalizing rights, criticizing global inequality, and securing legitimacy. It engages with new scholarship and bridges political philosophy and global inequality studies, providing a nuanced history of human rights.
A new study led by UniSC has pinpointed areas and times when large seabirds like the Antipodean albatross are most at risk of injury or death from fishing longlines. The researchers identified winter hotspots in a latitudinal band near the Tropic of Capricorn, where juvenile and female birds face the highest risk.
A study analyzed large-scale human ChIP-seq data to identify unmeasured transcription factor-tissue/cell type pairs, revealing significant gaps in current knowledge. These findings indicate that essential regulatory mechanisms may have been overlooked, emphasizing the need for strategic prioritization of measurement targets.
A novel diagnostic approach enables rapid detection of both antibiotic resistance and high virulence in Klebsiella pneumoniae, a microorganism driving the global antibiotic resistance crisis. This breakthrough could support timely, targeted therapy and strengthen infection-control strategies in healthcare settings.
A single 20-30 minute online course can improve young adults' tolerance of uncertainty, leading to reduced anxiety and depression. The course, which took less than half an hour to complete, showed lasting effects on mental health even a month after completion.
Researchers at Drexel University and UMass Chan Medical School have developed a gene therapy approach that silences and replaces disease-causing genes in mice with hereditary spastic paraplegia. The treatment prevents nerve breakdown and symptoms, offering a potential cure for the rare disease. Studies suggest that the therapy could be...
Agrivoltaics systems can significantly augment quality of life for farmworkers by providing shelter from the sun, cooler drinking water, and reduced fatigue. Researchers found that these systems can reduce wet bulb globe temperature by up to 5.5 degrees Celsius, making them a crucial tool in protecting farmworkers from heat stress.
A new study published in Frontiers in Human Neuroscience reveals that a visual training program called Perceptual Attention Therapy (PATH) produces rapid improvements in reading, attention, memory, and executive function after concussion. PATH addresses underlying visual timing deficits before strengthening specific cognitive skills.
Neoliensinine, a tribenzylisoquinoline alkaloid, has potent anti-T-CM activity and induces TUBA1B-mediated STING degradation via the lysosomal pathway. This promotes lysosome-dependent cell death in T-CM cells.
Researchers have identified Tapt1 as a key gene in maintaining the balance between protein synthesis and degradation, crucial for normal brain development. The study reveals that Tapt1, along with its partner Suco, ensures proper neural stem cell proliferation and differentiation.
Researchers at Nagoya University created a new aluminum alloy series optimized for high strength and heat resistance through 3D printing. The study used low-cost elements to produce recycling-friendly materials that can operate at elevated temperatures, leading to lighter vehicles and reduced emissions.
TBX4 plays a central role in regulating mesenchymal-epithelial communication during organogenesis. It also has significant implications in respiratory medicine, orthopedics, and oncology.
A new study identifies a distinctive brain activity pattern in children with ADHD, which may be modified using non-invasive brain stimulation and cognitive training. The pattern, known as aperiodic EEG activity, reliably distinguished children with ADHD from their peers.
The University of Oklahoma researcher is working on a project using inverse design techniques and AI to create advanced materials that can quickly switch between conductive and insulating states. The goal is to reduce uncertainty in the discovery process and create a scalable material-design methodology.
A new study identifies miR-101a as a critical suppressor of chondrocyte hypertrophy, reducing Cox-2 expression and attenuating structural damage in an OA mouse model. This highlights miR-101a's potential as a therapeutic candidate for osteoarthritis intervention.
A study found that Streptococcus suis serotype 2 collagenase-like protease enhances virulence and tissue colonization, promoting BBB destruction and increased permeability. The protein also induced apoptosis in brain microvascular endothelial cells and infiltrated immune cells into the brain after infection.
According to a recent survey by the Physicians Committee for Responsible Medicine, nearly half of US adults resolve to start a new diet in 2026. More than 80% say cost is an important factor when choosing a weight-loss plan. Despite evidence that plant-based diets are effective and less expensive, only 6% plan to try this approach. Res...
A Harvard-designed bio-logger captures high-fidelity audio of sperm whale codas, which are later analyzed by machine learning models to uncover structured communication. Recent results show that sperm whales have their own alphabet and use vowels and diphthongs in their language.
Researchers discover RFP's role in adipogenesis, a process that forms fat-storing cells. The study found that high RFP levels promote easy fat cell formation and weight gain, while low levels resist weight gain.
Researchers review how haplo-HSCT overcomes HLA barriers to restore immune homeostasis, with up to 30% GVHD rates reduced. Donor immune cells can be re-educated to accept recipients' bodies as 'self', highlighting a process of immune remodeling.
A new technique using thermal desorption GC/MS on human dental calculus detects minute millet consumption in medieval Ukraine, revealing subtle dietary practices. This approach opens up a new way to detect species-specific plant consumption and provides insights into medieval communities' dietary histories.
A UBC-led study found that COVID-19 vaccination significantly reduces hospitalization, intensive care admission, and preterm birth risks for pregnant women. Vaccination is associated with lower risks even as the virus evolved from Delta to Omicron variants.
The Alps are expected to reach a peak loss rate of 2,000-4,000 glaciers per year by 2033-2041, with only 110 glaciers remaining in Central Europe by 2100. Regions like the Rocky Mountains and Andes will also experience significant glacier losses.
A new white paper by biostatistician Professor Jeffrey S. Morris analyzes the multicomponent US vaccine safety monitoring system, including VAERS and other components. The study suggests improvements to enhance the system's effectiveness and sustain a robust safety monitoring infrastructure.
A new NYU study found that supporting parents with infants during pediatric check-ups leads to better academic skills in elementary school, particularly for families in poverty. The Smart Beginnings model combines play and reading activities to foster cognitive development.
Researchers discovered that a bacterium isolated from Japanese tree frogs has complete tumor-eliminating properties. The study found that this bacterium attacks cancer through two mechanisms, selectively accumulating in tumors and evading the immune system.
Researchers identify S-nitrosylation of USP16 as a key driver of cardiac injury after coronary microembolization. This process disrupts antioxidant regulation by destabilizing KDM1A, leading to impaired GSH synthesis and worsened oxidative damage.
Researchers at Mayo Clinic have developed a smartwatch-based alert system that signals parents to intervene in children with emotional and behavioral disorders, reducing tantrum duration by an average of 11 minutes. The system uses physiological stress signals detected by the smartwatch to prompt parental intervention.
Behavioral health spending in the US increased significantly between 2017 and 2022, reaching 40% of child health spending. This shift is associated with high family financial burdens due to expanded access to services and supports through insurance coverage and clinician availability.
Pediatric behavioral health spending surged to $41.8 billion in 2022, representing 40% of total children's health expenditures, and families faced mounting out-of-pocket costs, increasing at more than twice the rate of other medical expenses.
A case-crossover study found that air conditioning in nursing homes reduces mortality among older adults during extreme heat. The study suggests that AC provision may be crucial for preventing mortality in congregate care settings.
The study found that behavioral health care accounted for $41.8 billion of overall health spending in 2022, with families paying an average of $2.9 billion out-of-pocket. The costs have grown more than twice as fast as other types of medical care, with telehealth visits increasing by 99% per year.
This study found that vaccination before and during COVID-19 diagnosis in pregnancy significantly lowers the risk of severe maternal illness and premature birth. The results suggest that COVID-19 vaccination plays a crucial role in protecting pregnant individuals from serious health complications associated with the virus.
Research found that breast cancer flattens corticosterone release in mice, reducing quality of life and increasing mortality. Disruptions to diurnal rhythms have been linked to stress responses like insomnia and anxiety in cancer patients.
Researchers created particle-like vortex knots in chiral nematic liquid crystals and discovered they can be reversibly switched between different knotted forms using electric pulses. The study provides a physical testbed for mathematical ideas, opening possible new routes toward knot-based electro-optic and photonic technologies.
AI is becoming increasingly used in peer review, with 53% of reviewers now utilizing AI tools to enhance research quality and trust. The study highlights significant untapped potential for AI to support rigor, reproducibility, and deeper methodological insight.
A randomized clinical trial found digital cognitive behavioral therapy to be significantly beneficial for adults with generalized anxiety disorder. The treatment provided sustained benefits and has the potential for public health impact due to its accessibility.
Researchers created a metric to quantify lattice flexibility and studied how it impacts proton transport. They ranked the importance of seven features, including hydrogen bond length and oxygen sublattice flexibility, finding that these are critical for efficient proton conduction.
John Holdren, a Harvard University professor and former OSTP director, has been awarded the 2026 AIP Karl Taylor Compton Medal for his scientific leadership in engaging the public and promoting sound governmental policies. The medal recognizes his contributions to physics through statesmanship in science.
A new study by McGill University researchers found that fine particles in air pollution are associated with higher levels of a biomarker linked with autoimmune diseases. The findings add to mounting evidence that air pollution affects more than heart and lung health, potentially affecting the whole body.
The study presents a comprehensive roadmap for building an integrated GGBEO to meet the United Nations' Sustainable Development Goals and advance climate science. The system would integrate regional and global ground-based in situ and remote sensing systems, marine, and airborne observational data.
A new six-month study aims to gather data on the prevalence and effects of nail fungus in athletes, with potential benefits for military personnel and others at risk from repetitive foot trauma. The research will provide insights into prevention, diagnosis, and treatment strategies for this condition.
Researchers at Penn and UMich created microscopic swimming machines that can independently sense and respond to their surroundings, operate for months, and cost just a penny each. The robots are powered by light and can be programmed to move in complex patterns, sense local temperatures, and adjust their paths accordingly.
A major international study reveals significant disparities in childhood cancer survival rates worldwide. The global average is just 37% survival rate, while high-income countries boast an 80% rate. Better monitoring and investment in healthcare are critical to achieve the WHO's goal of at least 60% survival by 2030.
A new hybrid approach combines neural perception and acoustic feature learning to detect acoustic targets with high accuracy. The system leverages neuroanatomical priors, confidence-driven fusion, and streaming-mode validation to achieve robust performance.
A new science reporting guide has been published to help aspiring journalists in Bulgaria cover scientific topics. The guide offers crucial principles and skills to ensure daily work benefits the public and holds the scientific enterprise accountable.
The Lundquist Institute's second-generation fungal vaccine candidate, VXV-01, is moving forward in development after securing a $40 million NIH/NIAID contract. The vaccine aims to elicit robust immunity against opportunistic and hospital-associated pathogens.
Eight SwRI hydrogen projects funded by ENERGYWERX will evaluate new technology and existing infrastructure for a hydrogen-powered future. The projects, conducted at SwRI's Metering Research Facility, aim to improve energy infrastructure and support the use of clean-burning fuel.
A new guide aims to improve science journalism in Turkey, providing practical advice and insights from contemporary scientists. The Balkan Network of Science Journalists has published the first Turkish science journalism guidebook, highlighting the importance of high-quality reporting in a rapidly changing field.