A study on experimental microneedle painkiller patches in pigs has shown that the drug concentrations reached only about 2 micrograms per liter, which is 1,500 times less than the required effective dose. The patches work better on the neck than the ear and have shown safety and tolerability.
The Illinois Grainger Engineers have developed a reconfigurable slow-light platform for on-chip photonic engineering, which enables high spectral resolution features. This technology has the potential to be used for classical and quantum applications such as quantum memory, single photon storage, and exotic structures.
New research reveals biochar's impact on autotrophic soil microbes that fix carbon dioxide through the Calvin cycle. In paddy soils, these microbes are active capturing carbon dioxide, while in upland soils, microbial biomass and labile carbon pools play a larger role.
Research by Li-Mei Chen finds that digital tools provide measurable benefits for caregivers and persons living with dementia, improving self-efficacy, emotional well-being, and social connectedness. However, equity gaps remain due to limited access to culturally adapted and inclusive technologies.
Researchers at the University of Illinois developed a machine learning approach to analyze diffraction patterns and capture an alloy's microstructure in unprecedented detail. This method accelerates alloy property prediction by orders of magnitude, enabling rapid fundamental understanding of structure properties in metals.
A new study reveals that Normalized Mutual Information (NMI), a widely used metric for algorithm performance, can produce biased results. The researchers developed an asymmetric, reduced version of the mutual information metric to eliminate biases and improve comparison across fields.
The study pooled data from 90 previously published research papers, standardizing 162 different phenotypes, including life events, traits, or choices. The researchers found five large groups of personality profiles, each characterized by distinct patterns of neuroticism, extraversion, and sociability.
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
A new method using hyperspectral imaging and deep learning enables rapid, non-destructive estimation and visualization of lettuce pigment content. This allows for efficient physiological assessment and supports precision agriculture.
Researchers used AI to study covert attention and found emergent properties in artificial neural networks, including new neuron types with response properties never highlighted before. The findings have implications for our understanding of the human brain and its ability to process information.
Researchers developed a non-invasive OCT scanner to measure environmental stress in plants. The device reveals internal structural changes caused by ozone exposure, enabling early detection of deficiencies or stress-induced changes.
A team of researchers uncovered a surprising physical mechanism explaining how isolated filaments form knots in fluids under strong gravitational forces. The discovery provides insight into polymer dynamics, with implications for understanding DNA behavior, designing soft materials, and nanomaterials fabrication.
Developed by U-M and Penn, the robots can sense and respond to their surroundings, operate for months, and cost just a penny each. They have applications in monitoring cell health and aiding manufacturing.
Scientists identify targeting B-cells as a promising strategy to improve liver cancer immunotherapy. Researchers found that tumor-associated B-cells suppress T-cell activity, allowing cancer cells to escape immune attacks.
Scientists have discovered a way to efficiently transfer electrical current through specific materials at room temperature, unlocking extraordinary electronic behaviors. The breakthrough hinges on applying high pressure to certain materials, strengthening electron interactions that may refine tomorrow's technologies.
Researchers have discovered that iron oxide minerals like ferrihydrite employ different chemical strategies to grab and hold onto various types of organic molecules, making them powerful carbon traps. This study provides new insight into how these minerals in soils trap carbon for decades or centuries.
A study highlights how social media is transforming neurosurgical education, collaboration, and case consultations globally. Platforms like Neurosurgery Cocktail have democratized neurosurgical knowledge, supporting high-level discourse among experts.
The BRIDGE Program provides coordinated support across disease types to address the rising issue of early-onset cancer, offering fertility counseling, genomic testing, and community education. The program also fuels research into tumor biology and outcomes for younger patients affected by cancer.
Mosses have been found to remove metals from water by utilizing the help of their microbial symbionts. The key to this process is the cooperation between the moss and its endophytes, which enhance metal tolerance. Mosses from polluted environments were found to host more beneficial microbes that facilitate metal removal.
Researchers have created a novel synthetic enzyme that efficiently converts CO2 into formic acid, opening up new possibilities for biotechnological production of valuable chemicals and fuels. The enzyme, FAR, tolerates high concentrations of formate and is stable in both living cells and cell-free systems.
Researchers at the University of Kansas Biodiversity Institute and Natural History Museum uncovered a slipup from decades ago: the misidentification of a poison frog specimen from Peru used as a holotype. After discovering the error, they corrected it by re-examining data and field notes. The frog in question has since been reclassifie...
Researchers at Rice University developed a material that uses light to break down PFAS and other contaminants. The covalent organic framework (COF) material, grown directly onto a hexagonal boron nitride film, requires only light to activate its photocatalytic reactions.
Two new studies show how climate shapes the behavior, communication, and genome evolution of ants and their social parasites, leading to adaptation in this long-standing conflict. Climate influences aggression, chemical profiles, and genetic strategies in both hosts and parasites, with varying responses across different climates.
A new framework uses weather indicators to estimate how quickly a travel ban may start to lose effectiveness. The approach could inform targeted interventions before storms hit and preserve emergency measures' legitimacy while keeping people safer. It was developed after analyzing two Buffalo storms in late 2022.
A comparative study of 117 mammal species found that reproductive suppression increases lifespan by an average of ten percent. The study suggests that blocking reproduction allows more energy to be directed towards longevity, with significant effects observed in various mammalian groups.
A major new study from University of Limerick analysing almost six million person-years of data has revealed that personality traits are linked to longevity and risk of death. The research highlights that personality is likely associated with risk of death through an influence on a range of health behaviours and biological processes.
A randomized controlled trial found that lipoic acid had a small beneficial effect on slowing brain atrophy in people with progressive multiple sclerosis. However, it did not improve walking speed as the primary clinical outcome. The study suggests that lipoic acid may be worth further investigation for its potential benefits.
Tiny particles called extracellular vesicles (EVs) play a major role in hormone circulation and access to the brain. Exercise stimulates this process, causing EV-bound hormones like POMC to cross the blood-brain barrier more efficiently.
Researchers at Aarhus University equip artificial cells with tiny motors mimicking the bacterium's actin polymerization mechanism, creating a functional internal skeleton and network of protein filaments. The study demonstrates how motion and structural organization can emerge in synthetic systems.
Researchers at Penn State develop high-speed platform to produce synthetic brochosomes, complex nanostructures that make insects invisible to predators. The breakthrough enables next-gen camouflage, sensors and other advancements for humans.
Scientists discovered 14 new species of denitrifying endosymbionts in wastewater, which contribute to nitrate removal and help hosts generate energy. However, one species produces nitrous oxide, a potent greenhouse gas, with widespread global distribution.
Researchers at the University of Minnesota Medical School identified a key protein called GDF3 that drives inflammatory responses in older adults. The study showed that GDF3 signals through SMAD2/3, inducing permanent changes in the genome and increasing inflammatory cytokines.
A new study demonstrates a one-two punch approach to combatting drug-resistant tuberculosis by pairing rifampicin with AAP-SO2, which exploits the weaknesses of resistant bacteria. The combination effectively kills more bacteria than either drug alone, increasing potency and reducing resistance.
Severe microcephaly and oligodendrocyte loss were observed in a cynomolgus monkey with an ASPM knockout, resulting from complete loss of all protein isoforms. This study highlights the critical role of ASPM in gliogenesis and underscores the importance of oligodendrocytes in primate cortical expansion.
Researchers at Ludwig-Maximilians-Universität München identify two mechanisms of chemical interface damping, crucial for determining plasmon energy loss. The study opens opportunities for light-driven catalysis, sensing technologies, and energy-efficient chemical processes.
Researchers developed a new computational approach to unite two long-divided scientific perspectives in understanding materials. The method reveals how transport properties emerge from quantum effects in materials, correctly modeling challenging test cases such as hydrogen chains and p–n junctions.
New York state's K-12 enrollment declined by more than 250,000 students over the past decade, while charter schools saw a nearly tripled enrollment and homeschooling rates doubled. The decline is largely attributed to an aging population and shifting educational trends.
Researchers developed IPENS, an AI-powered 3D tool for non-invasive trait evaluation in plants. The system achieves high accuracy and efficiency, enabling rapid generation of accurate 3D trait data.
This study identifies CLK1 as a key player in PARPi resistance and demonstrates that its inhibition can restore PARPi sensitivity in ovarian cancer. By targeting CLK1, researchers aim to develop a new therapeutic strategy for overcoming PARPi resistance.
A dual-UAV color correction method improves crop remote sensing accuracy by over 70%, aligning image color with ground-truth measurements and enabling more precise phenotyping and agricultural decision-making. The technology offers a scalable pathway for reliable high-throughput applications in precision agriculture.
A new method uses machine learning and flow cytometry to detect contaminated bathing water, providing faster and more complete answers on water safety. The method has several advantages, including being open-source and able to detect changes in entire bacterial communities.
Researchers at UT Health Sciences Center have developed an AI-enhanced platform called ENRICH, which leverages advanced analytics with community-based human support to reduce treatment interruptions and improve cancer outcomes. The program identifies patients at highest risk for interruption and deploys targeted support resources.
Researchers at USC Dornsife College of Letters, Arts and Sciences discovered that neurons can rapidly adjust their signaling using a fast, physical mechanism. This system relies on structural cues rather than electrical signals to maintain balance between neurons, which is essential for muscle control, learning, and overall brain health.
Researchers found that mitochondrial RNA can leak into healthy tissue, triggering inflammation and scarring. Inhibiting certain proteins enables mitochondrial RNA to escape, leading to less inflammation and healthier liver tissue.
A study found that CTCF's regulatory mechanism is more complex than previously thought, with loop-independent functions playing a dominant role in the acute degradation system. CTCF selectively stabilizes chromatin remodelers and binds to specific regions upstream of target genes to activate transcription.
The five-year partnership aims to equip Hiroshima University researchers with new open policies, promoting transparency and accessibility in their work. The collaboration will also provide practical guidance on open publishing pathways and encourage reform of the research evaluation system.
A new AI model, SegPPD-FS, detects plant pests and diseases in real-world environments with minimal annotated samples. It outperforms existing methods in pixel-level detection, achieving gains of up to 1.00% mIoU and demonstrating strong performance on objects of varying scales.
A University of Houston chemist has received a nearly $2M grant to develop molecular blueprints for controlling how molecules change shape and reactivity upon absorbing light. This research could lead to breakthroughs in storing and using chemical energy, as well as designing materials that change when exposed to light.
New research found that Zestimate boosts efficiency in the residential real estate sector while benefiting lower-income neighborhoods. The algorithm helps alleviate uncertainty about property values, leading to increased buyer surplus and seller profit by an average of 5.94% and 4.36%, respectively.
A team of researchers developed an algae-derived asphalt binder that improves moisture resistance, flexibility, and self-healing behavior in asphalt, potentially extending pavement life. Substituting 1% of the petroleum-based binder with algae-based binder could cut net carbon emissions from asphalt by 4.5%.
A novel phenotyping platform has identified a major QTL and candidate gene GmWRKY58 linked to drought resilience in soybean. The low-cost platform uses automated load-cell weighing devices to record pot weight, estimating transpiration rates and detecting key traits such as stress recognition time point and decrease under stress.
The Icahn School of Medicine at Mount Sinai is advancing women's health through cutting-edge research and compassionate care, with a focus on addressing knowledge gaps and promoting seamless treatment journeys. The institution joins the Milken Institute's Women's Health Network to bring its expertise in clinical excellence, research in...
UTHealth Houston, in collaboration with UTMB Health, will lead a $50 million two-year ibogaine clinical trial to evaluate its effect on patients suffering from addiction, traumatic brain injury, and behavioral health conditions. The trial aims to advance ibogaine research for improving behavioral health outcomes across Texas.
A new study by the University of Washington found that households redeeming higher amounts of popular WIC food categories are less likely to drop out of the program. The research identified a link between increased redemption rates and lower risk of discontinuation, with fruits, vegetables, eggs, and whole milk being key categories.
Researchers at Johns Hopkins Medicine report a significant reduction in HIV-infected CD4+ T immune cells after chemotherapy treatment. This finding may be an early step toward a more practical HIV cure, as the virus relies on frequent proliferation to persist in the body.
Young Caribbean manta rays swim with groups of fish, creating small ecosystems that support a variety of marine species. The study found that four families of teleost fish regularly associate with young mantas, including remoras and jacks.
Fermilab appoints Norbert Holtkamp as its new director, bringing extensive scientific expertise to lead the lab's ambitious projects, including LBNF-DUNE. Holtkamp has managed large-scale scientific projects globally, ensuring the success of critical experiments and inspiring the next generation of researchers.
Combocat integrates miniaturized drug dispensing with machine learning to efficiently uncover promising drug combinations. The platform's capabilities were published in Nature Communications, demonstrating its potential for scaling up drug combination screening.
A study by Swansea University found that higher-ranking baboons get less and more fragmented rest at night compared to lower-ranked troop mates. This disruption is caused by the baboons' social bonds and dominance, leading to increased influence on each other's behavior.
The UC3M's new supercomputer is a state-of-the-art facility designed to support research and development projects requiring high-performance computing. The system features over 11,500 CPU cores and 42 GPUs, enabling the processing of large volumes of data and complex numerical simulations.