A new study reveals that pre-cancerous blood cells can actively reshape the bone marrow environment, creating conditions that favor their growth and increasing the risk of blood cancer. By targeting the aging bone marrow environment, scientists may be able to slow down or prevent blood cancers before they arise.
Researchers at JAX-NYSCF will create and share human stem cell models to better understand Parkinson's disease development. The team aims to create a shared platform of rigorously validated models, data, and protocols to accelerate therapeutic discovery.
A preclinical study using precision gene editing targets and corrects the root cause of Dravet syndrome, a rare form of childhood epilepsy. The approach demonstrates significant success in treating the disease, including improved survival rates and reduced seizures.
Scientists corrected a genetic disease of the liver in mouse models and human patient cells using gene editing, building a foundation for a potential new therapy for Zellweger spectrum disorder. The breakthrough restored function of the liver and peroxisomes, reducing toxic buildup.
A recent study from The Jackson Laboratory has identified dozens of unexpected genes strongly linked to type 2 diabetes. These genes are key to cell death and vitamin A metabolism, suggesting the disease depends on expression changes that can be targeted for treatment.
Researchers created a CRISPR-based tool to pinpoint genes the cancer turns off, restoring a key cancer-fighting gene in leukemia. The study found that blocking KDM4 enzymes can regain expression of the tumor-suppressor gene ZBTB7A, reducing leukemia burden while leaving normal blood formation largely unaffected.
Mark Adams, a leading expert in genomics, has been elected an AAAS Fellow for his groundbreaking work in DNA sequencing and genome mapping. His pioneering efforts have laid the foundation for modern precision medicine.
Researchers have developed a painless skin patch that samples key immune cells from the skin, offering a new way to monitor immune health. The device detects inflammatory signals and collects immune cells without invasive procedures.
Researchers identified specific genetic variations contributing to blood pressure, cholesterol, blood sugar, and other complex human traits. By rapidly testing hundreds of thousands of DNA sequences, they created high-resolution maps of DNA variant activity, revealing new insights into disease risk prediction and therapy development.
A team of researchers from The Jackson Laboratory and the University of Pennsylvania have discovered that specialized neurons in the brain's hypothalamus play a crucial role in signaling the body to start the recovery process after exercise. These neurons, which express a protein called steroidogenic factor-1 (SF1), become active for a...
The JAX-NYSCF Collaborative and GSK are working together to develop human cellular models of neurodegenerative diseases. This collaboration aims to generate disease-relevant cellular models that can help scientists understand the underlying biology of neurodegenerative conditions like Alzheimer's disease.
The combined organization aims to accelerate research and improve patient outcomes through advanced predictive platforms. The new engine will help scientists uncover disease mechanisms earlier and translate discoveries into therapies with a higher likelihood of success.
The Jackson Laboratory's CARDIOVERSE project uses AI, stem cells, and genetic variation to predict drug safety before human trials. The initiative aims to reduce cardiotoxicity and improve patient stratification in clinical trials.
A new study on artificial reproductive technologies found that mice conceived with IVF have slightly increased rates of DNA errors compared to those conceived naturally. The researchers discovered a 30% increase in new single-nucleotide variants, which are unlikely to be harmful.
The acquisition unifies genetics and stem cell research expertise to accelerate discovery and translate science into therapies. Researchers will gain access to advanced platforms, including the NYSCF Global Stem Cell Array, to study disease mechanisms and test treatments.
Researchers developed an unusual therapy using a cocktail of antibodies that protected mice from nearly every strain of influenza, including avian and swine variants. The therapy did not allow viral escape, even after repeated exposure in animals.
Researchers have found a strong link between abnormal changes in retinal blood vessels and increased risk of Alzheimer's disease. The study, published in Alzheimer's & Dementia, suggests that routine eye exams could potentially reveal early signs of the condition.
Researchers have identified a previously unknown molecular mechanism behind chemoresistance in acute myeloid leukemia (AML), a type of blood cancer. The study found that a protein called RUNX1C plays a key role in this process, and blocking its activity with RNA-targeting tools can improve chemotherapy's effectiveness.
A study analyzing 249 individuals reveals disrupted interactions between the gut microbiome, immune system, and metabolism in ME/CFS patients. Biomarkers linked to symptoms such as sleep disturbances, headaches, and fatigue provide hope for future diagnostic tools.
A team of scientists has decoded hidden DNA variations that influence digestion, immune response, and muscle control. The study maps genomic variation across ancestries with a breadth and resolution never before achieved.
Scientists successfully edited DNA directly in the brain to correct ultra-rare genetic mutations causing alternating hemiplegia of childhood. The technique improved symptoms and survival rates in mice, with implications for treating other rare genetic diseases.
Scientists developed mouse models that survive premature death, enabling pre-clinical testing of alternating hemiplegia of childhood (AHC), a devastating neurological disorder. The research reveals how different mutations can lead to distinct outcomes in AHC and sets the stage for developing gene editing therapies.
Patients with mitochondrial diseases face serious health issues, and a new study reveals that damaged mitochondria put the immune system on overdrive, leading to severe infections. The researchers identified specific molecules that could be targeted with new treatments to protect this vulnerable population.
Aging-associated mutations in the Dnmt3a gene boost mitochondria power in blood stem cells, leading to clonal hematopoiesis. New mitochondrial-targeting drugs show promise in treating age-related illnesses by selectively weakening mutated cells without impacting normal ones.
Researchers have found a way to reactivate the body's natural ability to destroy excess cancer proteins by introducing synthetic RNA fragments that increase poison exon inclusion. This discovery could lead to game-changing therapies for aggressive cancers such as triple-negative breast cancer and certain brain tumors.
Researchers from JAX used mice with different genetic backgrounds to identify factors influencing eye aging, leading to a better understanding of age-related eye diseases. The study found that genetics play a key role in retinal aging and predicts common age-related eye diseases.
Researchers at The Jackson Laboratory have created an atlas of how healthy breast tissue ages, revealing key cellular and molecular changes that may contribute to breast cancer development. The study found that epithelial cells lose their job descriptions, becoming more prone to malignancy, while stromal cells lose their specialized id...
Researchers at JAX have successfully alleviated symptoms of multiple sulfatase deficiency using a combination of gene therapy and bone marrow transplantation. The studies, conducted in mice, offer new hope to children with the disease and provide insights into common genetic diseases.
Scientists at The Jackson Laboratory have identified the CAST/EiJ mouse as a highly susceptible model for studying severe COVID-19. This genetically pure background allows researchers to investigate the virus's impact without artificial receptor modifications, mirroring human responses. Initial trials using antiviral treatments show pr...
The JAX-Allentown partnership launches an AI-powered home-cage monitoring system to enhance preclinical research efficiency and improve translatability. The Envision platform captures digital measures of mouse behavior and physiology, promoting animal welfare and superior data quality.
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study immune cell interactions. The approach reveals that interactions between immune cells in the vicinity of breast cancer or melanoma can predict immune responses and patient outcomes.
Scientists have developed a new method using artificial intelligence to design thousands of DNA switches that can activate or repress genes in specific cell types. This approach could revolutionize gene therapy and biotechnology by allowing precise control over gene expression in the body.
A new study published in Science reveals that the salivary amylase gene (AMY1) may have first duplicated more than 800,000 years ago, seeding genetic variation that shapes human digestion of starchy foods. This early duplication allowed for increased starch-digesting efficiency and may have played a role in human adaptation to new diets.
A recent study by The Jackson Laboratory reveals that reducing calorie intake can significantly extend the lifespan of mice, with the most robust animals living the longest. However, the researchers found that losing weight on these diets had a negative impact on lifespan in humans.
Studies discovered that DNA sequence changes associated with diabetes predisposition alter pancreatic cell stress response, leading to reduced insulin production and increased cell death. The findings point toward a druggable target, MAP3K5, which may help prevent or treat type 2 diabetes in high-risk individuals.
The new funding supports the first-of-its-kind single-cell mass spectrometer in Maine and one of the first in the country. Researchers can now analyze proteins and metabolites from individual cells, providing unprecedented detail into disease mechanisms.
Researchers at JAX propose using genetically diverse mice and cell-based assays to better predict human responses to drugs and diseases. This approach has shown remarkable improvements in mimicking human diseases, offering a significant improvement over standardized but limited mouse and cellular models.
Researchers at Jackson Laboratory have developed a non-intrusive method to accurately and continuously measure mouse body mass using computer vision. This approach reduces stress associated with traditional weighing techniques, improving data accuracy and reproducibility.
A team of researchers has developed a comprehensive ranking of genes and proteins involved in Alzheimer's disease, providing a roadmap for more targeted research and drug discovery. The study integrates findings from multiple fields and identifies thousands of potential therapeutic targets.
Scientists at the Jackson Laboratory created a mouse model for late-onset Alzheimer’s disease by introducing genetic variants associated with the illness into mice. They used transcriptomics to analyze brain tissue and identify key biological signatures, paving the way for testing new therapeutics.
Researchers discovered that sodium valerate supplementation can dramatically reduce binge drinking behavior and blood ethanol concentration in mice. The study highlights the potential therapeutic role of sodium valerate in reducing excessive alcohol use.
A study published in Blood reveals that hematopoietic stem cells in the bone marrow of genetically identical middle-aged mice aged differently. The team found that subtle changes in the bone marrow microenvironment and two growth factors, Kitl and Igf1, correlated with age-associated molecular programs in the stem cells.
A study published in Genetics in Medicine found that workplace genetic testing led to increased health behavior changes and follow-up with healthcare professionals among employees who received test results indicating elevated cancer or heart disease risk. Employees with negative test results reported feeling reassured about their healt...
Researchers at The Jackson Laboratory discovered a cascade of molecules that help coordinate the attack of cytotoxic T-cells on tumors. Elevated levels of IL-3 reenergize these cells, signaling them to resume detecting and destroying tumors, with rare basophils playing a key role in this process.
Researchers at The Jackson Laboratory have developed new laboratory-grade research mouse strains that better reflect human genetic variation. These wild-derived strains, detailed in PLoS Genetics, introduce millions of novel genetic variants and provide a powerful resource for modeling human traits and diseases.
A study by the Maine Cancer Genomics Initiative (MCGI) found that 17% of patients received genome-matched treatment, resulting in a 31% reduced mortality rate within one year. However, only 9% participated in clinical trials, highlighting the need to improve access and delivery of precision oncology care.
JAX researchers develop platform to mimic genetic diversity in humans, allowing for precise modeling of disease mechanisms and therapeutic targets. The platform enables direct comparison between mouse and human cells, providing molecular insights into autism, intellectual disability, and other neurodevelopmental disorders.
Researchers have characterized the rapid series of events transforming a fertilized cell into a living being, highlighting rapid changes in genetic activity post-birth. The study's findings underscore the speed at which newborns must adapt to extrauterine life and offer insights into long-term physiology and health outcomes.
Researchers have assembled the complete sequences of 43 human Y chromosomes from around the globe, revealing extensive complexity and variation. The study provides an unprecedented understanding of the Y chromosome's structure and function, shedding light on its role in human health and disease.
A panel of genetically diverse mice has been created to accurately model the variable human response to SARS-CoV-2 infection. The mice exhibit different levels of disease severity, ranging from asymptomatic to lethal, and can help scientists discover biomarkers of disease severity and evaluate countermeasures.