The study identified 97 potential therapeutic targets for SFJD, with 27 key targets involved in antiviral, anti-inflammatory, and immune regulation effects. Molecular docking results showed strong interactions between core active ingredients and these targets.
A recent study by Flinders University researchers challenged the common assumption that autistic adults are more prone to criminal exploitation due to difficulties in reading others' intentions. The study found that verbal intelligence and Theory of Mind were critical factors influencing vulnerability to crime, not autism diagnosis.
A new study found that early aortic valve intervention in patients with asymptomatic severe aortic stenosis and myocardial fibrosis did not reduce the incidence of all-cause death or unplanned aortic stenosis hospitalization. However, it did show benefits in reducing emergency hospitalizations and preventing symptom development.
Researchers found that thalattosuchian sinuses reduced during semi-aquatic phases and then diminished further as they became fully aquatic. This allowed them to develop extracranial sinuses, which might have helped drain salt glands and alleviate 'encrustation' problems.
A new study reveals that naturally occurring iron minerals can oxidise arsenite, making it less harmful to humans. The breakthrough has the potential to improve water and food safety globally, particularly in regions with high levels of arsenic pollution.
A remarkable clinical and metabolic response is reported in a metastatic BRAF V600E-mutated glomangiosarcoma treated with encorafenib and binimetinib. The combination of BRAF and MEK inhibitors achieves a long-lasting complete morpho-metabolic response in the patient.
The US Department of Defense has awarded $514,000 to study the efficacy of gene editors in treating Duchenne Muscular Dystrophy. Researchers will explore non-viral options for delivering gene therapy through 'self-delivering' gene editors, aiming to improve safety and efficacy.
Researchers at Seoul National University have developed ultra-low power neuromorphic hardware capable of performing AI computations with significant accuracy and efficiency. The technology relies on hybrid organic-inorganic materials and enables uniform ion movement across the surface, leading to high-performance neuromorphic devices.
Researchers discovered five distinct grain boundary structures composed of different arrangements of icosahedral cage units, enabling dense packing of iron atoms. The formation of these quasicrystalline-like phases can be used to tailor material behavior and make materials more resilient against degradation processes.
A systematic review found that exposure to social media posts depicting ideal muscular male bodies is directly linked to a negative body image and greater odds of resorting to anabolic-androgenic steroid use. Men are also under pressure to be physically strong, which is intrinsically linked to masculinity.
A new study reveals that couples living with rheumatoid arthritis who engage in joint problem-solving and emotional support experience lower depression and anxiety. The research highlights the importance of dyadic coping in improving relationship quality and patient well-being.
Rice University researchers developed an electrochemical reactor to reduce energy consumption in direct air capture. The new design has achieved industrially relevant rates of carbon dioxide regeneration and offers flexibility, scalability, and lower capital costs.
Researchers developed an AI model that can identify and measure aggressive prostate cancer lesions with high accuracy. The model's estimates of tumor size were associated with the likelihood of cancer recurrence or metastasis.
The ECLIPSE trial found that routine orbital atherectomy had similar outcomes as conventional balloon angioplasty before stent implantation. Procedural complications were largely similar between groups, with no reduction in target vessel failure.
A novel ratiometric fluorescent probe was synthesized to detect native human albumin (HA) activity in patients with hepatitis B cirrhosis and hepatocellular carcinoma. Native HA activity levels were significantly higher in low albumin groups, correlating with increased severity of liver disease.
Astronomers can now analyze powerful space explosions more efficiently using a novel model developed by Syracuse University physicist Eric Coughlin. The model helps track the evolution of shockwaves generated during these events, enabling researchers to infer properties such as energy. Coughlin's research will aid in the detection and ...
Twelve healthcare innovators have been shortlisted for the Global Healthcare Innovation Competition, with seven candidates selected for the 'Young Innovators' category. The competition aims to nurture transformative health solutions, providing a platform for innovators to develop and scale their ideas.
Radiologists who had access to questionnaire information during MRI interpretation achieved a near statistically perfect agreement with spine specialists. This improved diagnostic accuracy and confidence, avoiding diagnostic discrepancies between radiologists and spine specialists.
Researchers from Peking University have identified a new compound, C7, that retains the therapeutic effect of obeticholic acid without causing itch. The study reveals the molecular mechanism of bile acids activating hX4 to induce cholestatic itch, offering hope for more effective and comfortable liver disease treatments.
A new study by University of Technology Sydney researchers challenges the Infinite Monkey Theorem, finding it unlikely a monkey can type out Shakespeare's works before the universe ends. With around a 5% chance, even an increased number of monkeys would not produce the Bard's entire works.
A new NASA-led study finds that the Earth's far northern permafrost region has become a net contributor to global warming due to methane emissions. The thawing permafrost is releasing stored carbon as greenhouse gases, shifting the region from being a sink to a source of warming.
A UTEP student has developed an innovative method to desalinate water, which converts over 90% of salt water to fresh water. The new technique, called salt-free electrodialysis metathesis, uses ion exchange membranes and electrical currents to separate salt from water.
Scientists at Max Planck Institute for Dynamics and Self-Organization created a navigation system for artificial microswimmers, enabling control over their movement using electric fields and flow. The system generates various motility patterns, including adhesion to channel walls or centerline motion.
The study found a significant decrease in the percentage of adolescents reporting current marijuana use, from 23.1% in 2011 to 15.8% in 2021. Marijuana use was most prevalent among 12th graders, with a notable decline in usage rates across all grades.
A study found that nearly one-third of individuals from Ghana and Nigeria carry APOL1 variants that significantly increase the risk of chronic kidney disease. The researchers also discovered that having a single copy of the APOL1 gene increases the risk by 18%, while two copies increase it by 25%.
A study found that up to 50.7% of Medicare beneficiaries with modest incomes may not have sufficient funds to cover out-of-pocket costs associated with a single hospital stay. This financial precarity is more prevalent among Black and Hispanic beneficiaries, those with lower education levels, and those with multiple chronic conditions.
Researchers develop novel mathematical formalization, the quantitative omnigenic model (QOM), to understand how mutations affect diseases. The QOM combines state-of-the-art genome analysis with biological insights to explain polygenic diseases.
A new intervention will be developed by University of South Australia researchers to help young people with chronic childhood arthritis overcome barriers to physical activity and mental wellbeing. The VITAL Project aims to validate, understand, and empower activity in people with Juvenile Idiopathic Arthritis, reducing pain invalidatio...
The school aims to implement evidence-based practice and reduce antibiotic misuse in pediatric populations. The PCORI funding will support work with physicians, families, and providers to delay unnecessary antibiotics.
Researchers at Rensselaer Polytechnic Institute have developed a novel compound to treat dry age-related macular degeneration and Stargardt disease, both blindness-causing diseases. The compound has shown therapeutic potential in slowing down disease progression and preserving vision.
Researchers have developed a machine learning-based approach to detect keyhole pores in laser powder bed fusion (LPBF) metal 3D printing, achieving over 90% accuracy. The method uses simple light and sound sensors to monitor the printing process and accurately detect defects with a temporal resolution of 0.1 milliseconds.
A groundbreaking study introduces a novel mass spectrometry imaging approach to detect and quantify microplastics in biological samples, offering critical insights into their distribution and potential impacts on ecosystems and human health. The technique provides high-resolution spatial analysis of microplastic chemical compositions w...
Researchers at the University of Rochester developed a new liquid biopsy method called CAD-LB, which uses ultrathin membranes to easily identify EVs for rapid diagnosis. The method holds promise for diagnosing cancer quickly and affordably, as well as assessing therapy progress.
A new co-culture system uses photosynthetic microorganisms to remove waste products and enhance muscle cell growth, resulting in a 30% reduction of lactate and over 90% reduction of ammonia. This innovation provides a low-cost, sustainable alternative to animal serum for cultured meat production.
Researchers have developed a highly efficient alkaline membrane electrolyser that approaches the performance of established PEM electrolysers. The use of inexpensive nickel compounds replaces costly and rare iridium, leading to significant advancements in understanding fundamental catalysis mechanisms.
Scientists have discovered a crucial protein called DMT1 that enables single-celled malaria parasites to use iron, essential for survival and reproduction. Blocking this protein may lead to effective antimalarial drugs.
A new study calls for a 'child rights' approach to age assurance online, emphasizing the need for robust evaluation, consultation with children, and protection of their privacy and civil rights. The research identifies serious concerns related to age assurance methods, including inadequate protections against online harm and exploitation.
A recent study published in JAMA Network Open found that 84% of adults with congenital heart disease reported good or better health-related quality of life, despite complex CHD. However, participants with complex CHD were less likely to meet physical activity guidelines and reported mood disorders.
A new study found that 90% of countries with biodiversity conservation policies fail to specify individual and group behavioural changes, despite the critical role they play in making a real difference. Researchers suggest that clear policy specification on behaviour change is essential to boost effectiveness.
A new deep learning model predicts protein conformational changes by leveraging a large-scale database of protein dynamics. The PATHpre model demonstrates robust predictive capabilities across proteins with varying sequence lengths, revealing new insights into protein function and regulation.
A recent study by Stanford Medicine suggests that new blood-based colon cancer screening tests are effective for people who shun traditional methods. However, if too many switch to the new tests, colorectal cancer death rates may rise due to reduced detection of early cancers and precancerous polyps.
Researchers develop a novel edge-highlighting visualization technique to improve the clarity of complex 3D structures, revealing sharp edges and intricate details. The technique, tested on real 3D point cloud data, offers interactive rendering speeds and enhances depth perception.
A new study shows that preventing F-actin accumulation in the brains of aging fruit flies can maintain cellular recycling, extend lifespan and improve cognitive function. This discovery may offer a promising direction for developing interventions to promote healthier aging in humans.
Researchers at Nationwide Children's Hospital found prenatal cannabis exposure associated with poorer thinking skills and behaviors like impulse control and aggression in preschool-aged children. The study supports existing clinical recommendations against cannabis use during pregnancy due to potential health risks.
The USTC team found that positive NBEs occur during convective uplift, while negative NBEs occur during downdraft phase. This discovery suggests a new model where convection modulates charged layers within the cloud, governing cloud-top discharge intensity.
A new training algorithm called ternarized gradient BNN (TGBNN) enables learning capabilities for binarized neural networks (BNNs) on IoT edge devices. The proposed MRAM-based CiM architecture achieves faster convergence and matching accuracy with regular BNNs.
The SPINNING project successfully demonstrated the entanglement of two registers of six qubits each over 20m distance with high fidelity. The spin-photon-based quantum computer achieved lower error rates than superconducting Josephson junctions, outperforming prominent models like Eagle and Heron.
A recent study found that endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) provided sufficient tissue for identifying actionable genetic aberrations in patients with advanced non-small cell lung cancer. Liquid biopsy samples were also analyzed and compared to EBUS-TBNA results, demonstrating similar findings.
Researchers at USTC have developed a new type of soft gripper using porous magnetic silicone elastomer. This design enhances the gripper's ability to grip heavy objects while maintaining gentleness and flexibility, opening up new possibilities for biomedical and scientific applications.
Researchers are analyzing RNA and DNA amplification in breast cancer cases to identify potential biomarkers. Funding will support the study from September 2024 to March 2025.
A USTC team proposes a new type of battery using Martian atmospheric components, achieving higher energy density and longer stable cycling than previous designs. The battery has been validated in actual Martian conditions, paving the way for future space missions.
A new study by Rice University researchers found that invasive plants reshape soil microbial communities across the US, making them more uniform and disrupting ecological balance. The study highlights the critical belowground effects of invasive plants on soil health and biodiversity.
A new study by the University of Exeter found that public participation is key to enhancing urban living conditions and environmental decision-making in China. The research suggests that smaller local projects tend to have higher levels of public engagement, while larger initiatives often experience minimal involvement.
Researchers at TUM developed a new protective layer for zinc anodes, addressing issues like zinc dendrites and hydrogen formation. The layer enables efficient zinc ion flow through nano-channels, extending battery lifespan by hundreds of thousands of cycles.
Researchers have identified a genetic signature that can predict neonatal sepsis in newborns before symptoms appear, allowing for earlier recognition and life-saving treatment. The discovery has the potential to improve healthcare outcomes in lower- and middle-income countries where neonatal sepsis is most prevalent.
A collaborative study by University of Pennsylvania researchers found that an increase in Airbnbs in London led to higher rates of robbery, burglary, theft, and violence. The study suggests that Airbnbs provide opportunities for crimes, particularly against tourists or vacant properties.
Researchers have identified a unique multidomain enzyme capable of catalysing two separate reactions, cyclization and hydroxylation, on a single peptide substrate. This breakthrough discovery opens the possibility of developing innovative drug molecules with potential therapeutic applications for life-threatening infections and cancer.
Researchers found a highly pathogenic H5N1 strain isolated from a dairy worker that killed all infected ferrets, but the worker experienced mild symptoms and recovered. The study suggests that this particular strain may have died out and has not been detected in nature since.
A new study presents a cutting-edge catalog of banana diversity, tracing the ancestral origins of various cultivars using innovative genomic techniques. The catalog reveals that some locally appreciated banana groups are not single clones, opening perspectives for diversification.
Researchers at Princeton University developed a new technology inspired by bird feathers, which improves flight performance and prevents stalling. The covert-inspired flaps deploy in response to changes in airflow, offering an inexpensive and lightweight method to increase flight performance without complex machinery.