A research team at Case Western Reserve University is developing a non-invasive oral cancer test that can diagnose the disease in minutes. The test uses a simple oral swab and measures the ratio of two naturally occurring peptides, offering a promising alternative to current biopsy methods.
A new study reveals frequent gene-swapping among microbes in Arctic soils, influencing carbon cycling and microbial adaptation. The findings suggest that these 'hitchhiker' genes can affect basic cellular processes, helping microbes survive in a changing environment.
A new study predicts rising temperatures will dramatically increase heat-related heart disease in the US by 200% by 2050. Southern states are projected to see the largest increases, driven by high heart disease burdens, fast temperature rises, and poverty.
The Jack, Joseph and Morton Mandel Foundation has made a historic commitment of $125 million to Case Western Reserve University, the largest in their history. The investment will fund four focus areas: new humanities building, student scholarships, leadership initiatives, and ethical technological innovation.
Artificial platelets have been developed that remain stable and effective after a year at room temperature and two months at high temperatures. This technology could enable direct injection of synthetic platelets into bone marrow to treat life-threatening bleeding in remote areas or disaster zones.
Researchers at Case Western Reserve University will use AI and machine learning to analyze over 1,800 potential genes that have been identified as suitable new targets for treating Alzheimer's disease. The goal is to deliver a prioritized list of genetically validated drug targets to pharmaceutical developers and clinicians.
Researchers have identified a critical molecular mechanism that shuts down the heart's repair system after cardiac arrest, leaving it unable to recover. The study aims to develop new treatments for devastating medical conditions such as heart attack and stroke during major surgery.
A nationwide study of community health centers found that these clinics consistently provided high levels of continuous care during the COVID-19 pandemic. However, the study revealed significant gaps in care continuity along racial, ethnic, economic, and demographic lines.
A new study found that popular vitamin B3 derivatives, commonly taken by cancer patients to manage chemotherapy side effects, can actually make cancer cells more resistant to treatment. This means that supplements like NMN, NR, and NAM may be undermining treatment in critical ways.
Paul Tesar, a Case Western Reserve University neuroscientist, has been elected as an AAAS Fellow for his distinguished contributions to translational neuroscience. His research has helped elucidate the role of oligodendrocytes in neurological disease and develop regenerative therapies for multiple sclerosis and pediatric leukodystrophies.
Researchers at Case Western Reserve University are working on sustainable packaging solutions to reduce food spoilage and plastic pollution. The team is developing advanced nanocomposite materials that can help food stay fresh longer while reducing environmental impact.
Researchers at Case Western Reserve University have developed a new therapy called OSM CAR-T that successfully attacks osteosarcoma tumors in mouse models. This treatment harnesses the body's immune system to fight cancer, potentially offering better outcomes with fewer side effects than traditional chemotherapy.
Researchers at Case Western Reserve University developed a strategy using ultrasound-activated nanobubbles to break down tumor barriers, making tumors softer and more penetrable to treatment-bearing molecules and immune cells. This breakthrough could fast-track therapy to clinical trials for solid tumors like prostate cancer.
Case Western Reserve researchers create a new type of electrolyte that improves the safety and efficiency of flow batteries, enabling large-scale energy storage. The breakthrough could lead to advancements in solar farms, power grids, data centers, and other applications.
A breakthrough study has discovered a genetic defect that weakens the esophageal lining, making it vulnerable to acid damage. The discovery offers new hope for esophageal cancer patients and provides a potential screening tool for family members at high risk of developing the condition.
Researchers at Case Western Reserve University identified a link between gut bacteria and neurodegenerative diseases like ALS and FTD. They discovered that certain bacterial sugars cause immune responses that kill cells, paving the way for new treatments.
Researchers at Case Western Reserve University have made a breakthrough in HIV treatment by enhancing NK cells to better fight HIV infections. The study shows that lab-enhanced NK cells can reduce the viral reservoir enough to allow long-term immunological control of HIV without daily antiretroviral medications.
A new 'Take a Break KIDS' edition helps children manage stress through simple one- to three-minute activities, leveraging color-coded practices and QR codes for digital resources. This card deck supports the development of lifelong skills for stress management and emotional regulation.
A team of researchers has discovered a potential new target for treating Parkinson's disease by blocking the interaction between toxic proteins that damages brain cells. The treatment, CS2, improves mobility and cognitive performance in various study models, including human brain tissue and mice models.
Researchers at Case Western Reserve University have developed a new treatment for advanced prostate cancer that targets the PSMA protein. The treatment, called PSMA-1-DOTA, has been shown to effectively reduce salivary gland damage and eliminate severe side effects associated with current therapies.
A new study by Case Western Reserve University and University Hospitals found that financial factors are the strongest predictors of participation in cancer research studies. The researchers recommend addressing practical challenges like transportation, childcare, and lost wages to make clinical trials more inclusive.
A new six-month study aims to gather data on the prevalence and effects of nail fungus in athletes, with potential benefits for military personnel and others at risk from repetitive foot trauma. The research will provide insights into prevention, diagnosis, and treatment strategies for this condition.
Researchers at Case Western Reserve University improved electrode performance in brain-computer interfaces by delivering anti-inflammatory drugs directly to the site of implantation using platelet-inspired nanoparticles. The breakthrough has potential applications for treating various diseases involving inflammation and vascular injury.
Researchers found that treatment within one week of a serious head injury can reduce the risk of developing Alzheimer's disease. A study analyzing health records from over 100 million US patients showed a significant reduction in Alzheimer's risk at three and five years for those who received immediate treatment.
A new study reveals that Dunkleosteus was an oddball among ancient armored fishes, with a cartilage-heavy skull and unexpected feeding behavior. The research places Dunkleosteus in proper evolutionary context, highlighting the diversity of arthrodire groups.
The National Institutes of Health has awarded a $2.5 million Phase II Small Business Innovation Research (SBIR) grant to Case Western Reserve University to develop medical technology that can track specific cells in the body, including cancer cells. This technology aims to enhance the ability to locate therapeutic cells or diseased cells.
Case Western Reserve University researchers created advanced computer analysis tools to study DNA's 3D structure, allowing for more accurate understanding of gene interactions. The new software can help scientists analyze lower-quality data and discover potential treatment strategies for genetic diseases.
Case Western Reserve University researchers discovered pseudo leukotrienes, which may be the dominant players in the inflammatory cascade that causes disease. The findings open new avenues for treating asthma and other inflammatory diseases.
A new study led by Suchitra Nelson aims to advance previous research on two less-invasive options for treating and preventing cavities. The study focuses on older adults living in subsidized housing with limited access to dental care, using Silver Diamine Fluoride (SDF) and Atraumatic Restorative Treatment (ART).
A recent study published in JAMA Ophthalmology found that corneas from donors with diabetes are just as effective for surgery as those without the disease. The results suggest that the number of corneas available for transplant worldwide could be significantly increased, improving outcomes for patients seeking sight-restoring transplants.
A study by researchers at Case Western Reserve University found that teaching patients to better understand social cues through targeted training programs can be more effective than traditional approaches. The study identified the crucial role of social inference skills in determining functional recovery from early schizophrenia.
Scientists have discovered that gray tree frogs prepare for winter by responding to shorter days rather than colder temperatures, allocating energy resources unnecessarily. This 'ecological trap' could affect critical behaviors like breeding cycles and migration patterns in species adapted to seasonal cues.
A new study by researchers at Case Western Reserve University found that senior citizens prioritize social activities and inclusiveness over health. The study, which analyzed responses from over 388,000 patients aged 65 and older, also found that independence and family togetherness are important priorities for older adults.
Researchers identified how HIV enters dormant state in infected cells, allowing the virus to hide from immune system and current treatments. This finding challenges decades of scientific assumptions and opens a new approach to possibly eliminating the deadly virus.
Researchers at Case Western Reserve and the Cleveland VA are conducting a clinical trial to test sensory-enabled neural-controlled prostheses developed since 2015. The study will enroll 12 people with upper-limb amputation to compare standard prosthetic arms and hands to the sensory-enabled neural-controlled prostheses.
A team of scientists at Case Western Reserve University has discovered a built-in 'brake' that controls when key brain cells mature, which appears to stay on too long in multiple sclerosis. This brake is essential for healthy brain development but gets stuck in MS, leaving the cells unable to repair damage.
Researchers have identified a key synergistic role for two epigenetic markers involved in programming cell fate. Turning off these markers causes genes to over-activate, disrupting normal cell development. This discovery may indicate a new target for treating some types of leukemia with drugs already in clinical trials for other cancers.
Researchers at Case Western Reserve University have made a breakthrough discovery that could lead to new treatments for patients with spinal cord injuries who struggle to breathe on their own. The study identified a subset of interneurons in the brain and spinal cord that can boost breathing when faced with physiological challenges.
A study using stem cells from ALS patients identified a potential new target for treatment: the integrated stress response. The researchers found that blocking this stress response can reverse damage in lab-grown motor neurons, providing a promising proof-of-concept for future therapeutic strategies.
Researchers at Case Western Reserve University developed a computational method and tool to identify genes and genetic changes causing complex diseases. Their new approach allows doctors to detect and treat cardiometabolic diseases earlier in their development, identifying new genes that were previously overlooked.
Case Western Reserve University researchers have developed an environmentally safer type of plastic that can be used for wearable electronics, sensors, and other electrical applications without fluorine. The new material exhibits tunable ferroelectricity and flexibility, making it suitable for various electronic uses.
Researchers at Case Western Reserve University have received an NSF CAREER Award to develop synthetic DNA nanoparticles with potential applications in gene therapy. The program aims to study how these particles behave inside cells and potentially design therapeutics for genetic diseases.
A new study published in Epilepsy & Behavior found that a self-management program for people with epilepsy can reduce health complications, improve mood, and enhance quality of life. The program, called SMART, features remote training sessions and written resource materials to help participants manage their condition.
Researchers at Case Western Reserve University found that semaglutide lowers the risk of dementia in people with type 2 diabetes. The study, published in the Journal of Alzheimer's Disease, suggests T2D patients taking semaglutide had a significantly lower risk of developing dementia compared to other antidiabetic medications.
Researchers at Case Western Reserve University have developed a new device called CAPGLO that uses magnets to isolate disease-fighting T cells, making CAR T cell therapy potentially less expensive and more accessible. The technology aims to reduce the cost of immunotherapy from thousands to just hundreds of dollars.
Researchers have discovered a new drug that protects the blood-brain barrier, preventing neurodegeneration and cognitive impairment in Alzheimer's disease. The drug targets an enzyme that damages the BBB, which is also affected in traumatic brain injury and aging.
Computer scientist An Wang receives a $1M NSF CAREER grant to leverage cloud computing resources for efficient machine learning model training. Environmental engineer Bridget Hegarty receives a grant to develop safe and effective biocontrol for water systems using bacteriophages.
A new study from Case Western Reserve University finds that a global shortage of essential nutrient omega-3 polyunsaturated fatty acids is linked to rising overall health risks. The researchers suggest increasing production and reducing intake of harmful omega-6 fatty acids to lower disease risk.
Scientists have long believed that cells respond to stress in a linear chain of events, but a new study reveals a more complex 'split-integrated stress response' that can be fine-tuned depending on the type and intensity of stress. This flexibility could lead to new targets for treating cancer and neurodegenerative diseases.
A team of researchers found bacteria linked to the gut in the brains of mouse models implanted with microelectrodes, breaching the blood-brain barrier. The discovery highlights the need for permanent strategies to prevent bacterial invasion from implanted devices, which can contribute to inflammation and reduced device performance.