Researchers have developed a novel framework for comparing and contrasting oscillations across different mechanisms, enabling better understanding of brain waves, heartbeats, and other stochastic oscillations. This breakthrough could lead to new insights into neurological disorders such as Parkinson's disease and atrial fibrillation.
A study by Case Western Reserve University researchers found that traditional coaching approaches can hinder growth by focusing on immediate problems. Instead, they recommend helping individuals develop a clear vision of their ideal self, leading to increased positive emotion, openness to new ideas, and sustained intrinsic motivation.
Researchers at Case Western Reserve University found that a protein called Slingshot Homolog-1 (SSH1) stops Nrf2 from carrying out its protective biological activity, leading to the decline of brain defense in Alzheimer's disease. Genetically eliminating SSH1 increases Nrf2 activation and slows the development of oxidative damage.
A new study by researchers at Case Western Reserve University found that US military veterans living in historically discriminatory 'redlined' areas had a higher risk for heart attacks and other cardiovascular issues. The study used data from 80,000 veterans with pre-existing cardiovascular disease, revealing a 14% increased likelihood...
Researchers at Case Western Reserve University have identified a panel of long intergenic non-coding RNAs that are
A team of scientists has successfully used synthetic platelets to treat a genetic condition that prevents blood from clotting, known as Von Willebrand disease. This breakthrough treatment could provide new hope for millions of people affected by the disorder, which affects up to 1% of the US population.
Researchers discovered how zebrafish use their hair cells to detect movement, a discovery that sheds light on the mechanisms of human hearing and balance. The study's findings suggest that the structure and function of zebrafish hair cells are nearly identical to those found in humans.
Researchers from Case Western Reserve University suggest that the length of the prehistoric fish Dunkleosteus terrelli was greatly exaggerated. The study proposes a new method to estimate the size based on the head, which is consistent among living fishes and smaller relatives. According to this method, Dunkleosteus was only 11-13 feet...
Researchers at Case Western Reserve University used AI to analyze vast amounts of biomedical knowledge and electronic health records. The study found that ketamine improved remission rates among patients with cocaine-use disorders by two to four times. While promising, additional clinical trials are needed to fully assess ketamine's po...
Researchers examined factors that led to discriminatory lending decisions in Ohio's 1930s loan applications, finding neighborhoods with Black families were 40 times more likely to be redlined. The study highlights ongoing consequences of racist policies, including poverty and life-expectancy disparities.
Researchers at Case Western Reserve University will conduct high-speed experiments with a projectile hitting a wall of water at 9,000 mph to study the effects on water and potential applications for national defense. The project aims to accurately predict damage from hypersonic vehicles and missiles.
Patients with cocaine and opioid use disorders are at higher risk of developing endocarditis after COVID-19 infection, according to new research. The study found a significant increase in endocarditis cases among these patients, highlighting the need for increased screenings.
Researchers at Case Western Reserve University are developing a new treatment for Candida auris, a multidrug-resistant yeast that causes serious infection and death. The five-year NIH grant will enhance an antifungal drug developed by SCYNEXIS to prevent the spread of the fungus.
A team led by CWRU law and medicine faculty will examine the ethics of 'nudging' in biomedical research, using accepted public health practices to recruit participants. The study aims to understand how nudging techniques influence consent and decision-making in medical trials.
Women are more susceptible to Alzheimer's disease due to higher expression of the enzyme ubiquitin-specific peptidase 11 (USP11), which drives increased accumulation of tau protein in brain nerve cells. Researchers hope to develop new neuroprotective medicines based on this finding.
The researchers will conduct multimodal imaging of 100 human vagus nerves using high-resolution technologies, providing unprecedented data on the vagus nerve's organization. This work aims to improve the safety and effectiveness of existing vagus nerve therapies, offering potential for novel neuromodulation therapies.
Researchers aim to develop scalable, modular manufacturing platform for growing new tissues from component parts, accelerating their fabrication and use. The goal is to assemble functional constructs that restore or improve damaged tissues or whole organs.
Researchers at Case Western Reserve University found that chronic daily stress was beneficial against a second injury, inducing formation of immune cells called TLOs which protected against intestinal inflammation. The study also revealed an association between stressed mice and increased production of cytokines IL-23 and IL-22.
A new study found that children infected with COVID-19 have a substantially higher risk of developing type 1 diabetes, with a 72% increase in new diagnoses in the six months following COVID diagnosis. Pediatricians and families should be alert for symptoms of diabetes following COVID.
A recent study published in the journal Gut found that gay men are more than twice as likely to develop inflammatory bowel disease (IBD) than heterosexual men who engage in high-risk sexual activity. The study's lead author notes that this finding will open a new field of research into gastrointestinal inflammatory conditions.
New research reveals dramatic variations in cancer mortality across the US, highlighting the importance of considering location-based risk factors for public health interventions. The study finds that certain behavioral risk factors, such as obesity and smoking, have varying levels of impact depending on geographic region.
Researchers at Case Western Reserve University have identified the structure of protein fibrils linked to a hereditary form of human prion disease, revealing the mechanism for interspecies transmission. The study suggests that disease transmission between species can be predicted based on structural information.
Researchers at Case Western Reserve University found wide genetic variation in SARS-CoV-2 viruses among 360 patients, showing that all individual infections include multiple variants of the virus. The study highlights the importance of examining variations that are historically considered noise to better understand how these genetic ch...
A study by Case Western Reserve University has identified a promising path to developing therapies for esophageal tumors. The research team linked the TGFβ-pathway, a cell signaling mechanism, to tumor development and found that a protein-coding gene called HNF4α is a predictive biomarker of cancer.
A team of researchers at Case Western Reserve University has discovered a cell signaling pathway responsible for the development of esophageal adenocarcinomas. The Ephrin B2 (EphB2) Tyrosine kinase pathway is activated during cancer growth and regulates the behavior of normal esophageal cells, making it an attractive therapeutic target.
Researchers discovered a new prion structure using electron microscopy, revealing key similarities and differences between distinct strains. This finding could lead to better understanding of how shape variations affect disease outcomes.
A new study found that COVID-19 booster shots significantly increase neutralizing antibodies in nursing home residents and their caregivers, offering improved protection against Omicron variants. This research highlights the importance of booster vaccinations for vulnerable populations, including those living at home.
Researchers at Case Western Reserve and University of Washington develop AI-3D collaboration to gain insights into highly aggressive prostate cancer. The collaboration aims to provide a new view and understanding of prostate cancer cells using light sheet microscopy.
Researchers at Case Western Reserve University developed an AI tool that analyzes routine tissue biopsy images to predict response to immunotherapy in lung and gynecologic cancers. The study found that the AI consistently predicted clinical outcomes, including survival, for three common immunotherapies.
A team of researchers identified a group of interneurons in the spinal cord required for heat sensation and found a signaling pathway that contributes to heat hypersensitivity. Their study may lead to more effective treatment for chronic, pathological pain.
Researchers at Case Western Reserve University discovered that altering macrophage metabolism influences their relationship with T cells, suppressing tumor growth and reducing overall tumor size. The study found PERK protein's involvement in key metabolic pathways and identified a potential clinical drug inhibitor to target it.
Researchers have identified a key protein molecule that plays a major role in the accumulation of brain cholesterol, triggering Alzheimer's disease. The peptide inhibitor ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
A new study suggests that children under 5 infected with Omicron have a lower risk of severe health outcomes compared to those infected with the Delta variant. The study found that Omicron is 6-8 times more infectious than Delta, but resulted in fewer hospitalizations and mechanical ventilation cases.
Researchers at Case Western Reserve University discovered nearly twice as many men with cancer among those living with HIV compared to those without the virus. The study emphasizes the need for continued use of antiretroviral therapies and HPV vaccination to address known risk factors.
A team led by Case Western Reserve University discovered the novel repair properties of Gasdermin B protein, promoting restoration of epithelial layers and effective wound-healing. The findings have significant implications for designing therapeutics to enhance wound repair in various organs.
Case Western Reserve University researchers create nanoparticles that generate a protein mesh to stabilize blood clots and reduce blood loss. The technology could help save lives by rapidly stabilizing clots to reduce blood loss from traumatic injuries.
A new study published in the Journal of the American Medical Association finds that those who received the Moderna COVID-19 mRNA vaccine have a lower risk of experiencing 'breakthrough' COVID-19 cases compared to recipients of the Pfizer-BioNTech mRNA vaccine. The study also found that Moderna recipients were less likely to be hospital...
A research team led by Youwei Zhang discovered a new protective function of the protein 53BP1 in preserving DNA structure. This mechanism involves liquid-liquid phase separation, allowing 53BP1 to stabilize proteins at condensed DNA regions, maintaining genome stability and preventing diseases like cancer and premature aging.
A recent study by researchers at Case Western Reserve University found that Candida tropicalis fungus can trigger chronic inflammation in the gut microbiome of Crohn's disease patients. This imbalance of fungi and bacteria can create a predisposition to inflammatory bowel disease.
Researchers used AI tools to analyze tissue samples from 439 patients with head and neck cancers, identifying those who could benefit from reduced radiation therapy. The study aims to improve treatment decisions for patients, reducing side effects and improving quality of life.
A research team led by Case Western Reserve University has discovered a link between misshapen tau protein and accelerated cognitive decline in Alzheimer's disease, potentially leading to more accurate prognoses. The study found distinct populations of highly potent TAU seed conformers in rapidly progressing cases.
Researchers at Case Western Reserve University are developing an AI tool to analyze medical images and determine which rectal cancer patients require surgery. By using radiomics and machine learning techniques, the team hopes to identify patients who can avoid invasive surgery and opt for chemotherapy or radiation therapy instead.
Researchers found that high levels of MYO10 induce chronic inflammation, reducing T cell function, but also increasing immune response. This led to improved outcomes with immune checkpoint blockade therapy for certain tumors.
Researchers co-led by Jonathan L. Haines are conducting a comprehensive analysis of genetic data from over 100,000 people worldwide to better understand the condition. The study aims to uncover the genetic architecture of age-related macular degeneration and its impact on diverse populations.
A team of researchers at Case Western Reserve University has developed an AI-powered tool that can accurately predict which COVID-19 patients will need a ventilator to breathe. The tool, trained on CT scans from nearly 900 patients, shows an impressive 84% accuracy rate in identifying patients who require breathing assistance.
A new study found that an early warning system for sepsis improved patient outcomes by alerting healthcare providers to administer antibiotics sooner. The system, implemented in the emergency department, resulted in increased survival rates and reduced hospital stays for patients with sepsis.
Researchers at Case Western Reserve University have successfully imaged lethal prions using cryo-electron microscopy, providing atomic-level data on their structure and assembly. This breakthrough offers a new premise for understanding and targeting these currently untreatable diseases.
Researchers at Case Western Reserve University will study the genomics of Alzheimer's disease in people of African heritage across the US. The study aims to address the lack of diversity in existing genetic research and identify novel risk factors for the disease.
A global team led by Case Western Reserve University's Beverly Saylor will investigate how ecological factors influenced the evolution of early human ancestors using advanced technology. The project aims to gain a more granular understanding of two fossil sites in Ethiopia and their distinct records of the human genus' early predecessors.
Case Western Reserve University researchers have identified structural elements on human prions that drive their replication in the brain. This breakthrough could lead to a new strategy to stop Alzheimer's disease and other neurodegenerative disorders, as scientists explore ways to bind to these sites to block progression.