A team of researchers discovered a long intergentic non-coding RNA molecule, lincPRKD, that may provide a new target to prevent and treat gastric cancer. The study aims to determine how often this molecule is activated in gastric cancers and test whether it can be used for early detection.
Researchers at Case Western Reserve University and University Hospitals will test EsoCheck and EsoGuard technologies to detect Barrett's Esophagus, a precursor to esophageal cancer. The goal is to improve detection in an at-risk population with limited endoscopy resources.
Researchers at Case Western Reserve University found that manufactured separation materials don't function as intended due to blocked pores, leading to inefficient and expensive separations. Single-molecule microscopy technique revealed the behavior of individual molecules, allowing for predictive performance and design improvements.
Researchers at Case Western Reserve University developed a method to detect inflammation using antibodies, potentially leading to blood tests for disease-specific biomarkers. The breakthrough also holds promise for drug discovery.
Researchers at Case Western Reserve University have identified a protein called NF-kB c-Rel as intensifying psoriasis symptoms when activated by immune signals. The study found that c-Rel plays a major role in psoriasis inflammation and that its absence alleviates skin inflammation.
Four Case School of Engineering faculty members, A. Bolu Ajiboye, Christine Duval, Burcu Gurkan, and Steve Majerus, received the Presidential Early Career Award for Scientists and Engineers from the US government. The award recognizes their exceptional talent, dedication, and impact in their respective research fields.
Boron-doped diamonds exhibit plasmons, allowing electric fields to be controlled on a nanometer scale, for advanced biosensors and nanoscale optical devices. This discovery could pave the way for new types of biomedical and quantum optical devices.
A new AI model will analyze combined data from calcium-scoring CT scans, clinical risk factors, and demographics to identify high-risk patients. The project aims to accurately predict cardiovascular events, including heart failure, and provide personalized treatment options.
A new study has identified genetic and demographic factors that increase the risk of developing age-related macular degeneration (AMD). The research found a significant difference in AMD risk between European and non-European descent populations, highlighting the importance of diverse ancestry groups in understanding this condition.
Researchers at Case Western Reserve University have made a groundbreaking discovery about the molecular switches within the estrogen receptor protein that contribute to breast cancer. The study's findings offer new tools and ideas for developing more effective treatments for this devastating disease.
Researchers at Case Western Reserve University have discovered a potential target for treating drug-resistant malaria, PfNCR1, a cholesterol-managing protein. A compound known as MMV009108 can physically block the transporter, preventing it from doing its job and potentially killing the parasite.
Researchers at Case Western Reserve University have developed high-performance, low-cost zinc-sulfur batteries with enhanced energy capacity, improved conductivity and stability. These advancements address long-standing safety concerns and enable smaller, longer-lasting designs.
Gary E. Wnek and Arnold Caplan recognized for their pioneering work in polymer science and stem-cell biology, respectively. Their research has generated significant economic impact and improved quality of life through inventions and innovations.
Researchers from Case Western Reserve University discovered a large cavern in Manot Cave that was used as a gathering space for rituals, possibly enhancing social cohesion. The site features an engraved rock with a turtle-shell design, contemporaneous with some of the oldest cave paintings in France.
A new study from Case Western Reserve University found that 71% of respondents had brokered a drug transaction in the past month, highlighting the importance of social networks in facilitating access to illegal substances. Peer-brokered sales are also linked to increased demand and expansion of the narcotics trade.
Alianza Americas co-founder Oscar Chacón will be awarded the 2025 Inamori Ethics Prize for his tireless advocacy on immigrant rights and economic justice. He has been recognized for his compassion and humanity in raising awareness about global challenges and promoting human dignity.
Researchers at Case Western Reserve and Mass Eye and Ear aim to prevent hearing loss by protecting inner-ear cells from damage caused by noise exposure. They will study the effects of calcium overload on cochlear hair cells and identify novel therapeutic targets to treat acquired hearing loss.
Case Western Reserve University has received a $1.5 million grant to study vaginal bacterial infections, which are linked to preterm birth, gynecological malignancies, and sexually transmitted diseases. The researchers aim to identify effective treatments and prevent recurrences.
David Gerdes, a distinguished physics scholar, will lead the College of Arts and Sciences at Case Western Reserve University. He has focused on promoting faculty, modernizing curriculum, and expanding research opportunities for undergraduates during his tenure as department chair at the University of Michigan.
Researchers at Case Western Reserve University have discovered a new target for treating atherosclerosis by identifying an inflammation-reducing molecule called itaconate. This finding may lead to the development of a new therapeutic approach that mimics the beneficial effects of a low-fat diet without requiring drastic lifestyle changes.
Astronomers at Case Western Reserve University have questioned the long-held standard model for galaxy formation, instead suggesting that modified gravity theories may be responsible. The James Webb Space Telescope's data suggests large and bright galaxies formed rapidly, contradicting predictions of dark matter's role.
A 15-year study of an ancient ecosystem in Bolivia provides a comprehensive view of the Earth's past, revealing warmer temperatures and lower elevation. The team found fossils of diverse animals and plants, reconstructing the site as a dry forest or wooded savanna with palms and bamboos.
Researchers at Case Western Reserve University are studying a new approach to treat multiple sclerosis, focusing on toxic astrocytes that contribute to nerve-cell damage. They aim to develop medicines that prevent the formation of these cells and promote brain repair.
Researchers found that patients taking semaglutide had a significantly lower risk of developing Alzheimer's disease compared to those on other anti-diabetic medications. The study suggests potential benefits for preventing neurodegeneration and neuroinflammation.
A new study from Case Western Reserve University reveals how ethnic Tibetan women thrive in low-oxygen environments, with unique blood and heart traits enhancing oxygen delivery. The research provides valuable insights into human adaptation to extreme environments and offers clues about future environmental challenges.
A new study from Case Western Reserve University found that patients taking semaglutide had a significantly lower risk of opioid overdose compared to those on other anti-diabetic medications. The research suggests semaglutide could be a potential new treatment for opioid use disorder and preventing overdoses.
A new study led by Case Western Reserve University finds a significant increase in suicidality among Black youth on Chicago's South Side, attributing it to factors such as bullying, community violence, and neglectful parenting. The study also identifies authoritarian parenting as a protective factor against suicidality.
Researchers used mathematical modeling to calculate the likelihood of successfully scheduling a meeting based on several factors. As the number of participants grows, the probability of scheduling a successful meeting decreases sharply, with a critical point where the likelihood drops significantly.
Researchers at Case Western Reserve University discovered that ecological interactions between resistant cells and their ancestors play a pivotal role in reducing the costs of resistance. This finding has significant implications for understanding cancer evolution and developing innovative treatment strategies.
Researchers at Case Western Reserve University will test a possible breakthrough drug for inherited retinal disease, which may prevent blindness in patients with various genetic mutations. The study aims to advance the technology to FDA-regulated clinical trials and potentially expand the application of the Bax-inhibiting therapeutic.
Researchers from CWRU and NJIT have made a significant breakthrough in understanding how the body adapts to COVID-19 infection. The study suggests a potential link between elevated hemoglobin levels and the body's response to the virus, shedding light on the enigmatic phenomenon of silent hypoxemia.
Scientists at Case Western Reserve University have discovered that the rotation curves of galaxies remain flat for millions of light years, defying expectations and challenging traditional understanding of cosmology. This finding suggests that dark matter may not exist or that alternative gravity theories could explain this phenomenon.
Researchers at Case Western Reserve University have developed a new method for target DNA sequence amplification, testing and analysis known as AMPLON. This technique offers an alternative to the previously accepted PCR method, allowing for more applications in medical diagnosis and expanding scientific innovation.
A retrospective study found that patients treated with semaglutide, an active ingredient in Wegovy and Ozempic, had a 50-56% decrease in the initiation and re-occurrence of alcohol-use disorder. The study, published in Nature Communications, provides preliminary evidence for the potential benefit of semaglutide in treating AUD.
A new study reveals that granular materials exhibit universal and non-universal features in their vibrational spectra, shedding light on the propagation of sound through these mysterious materials. The research provides a statistical understanding of the spectra, linking them to random matrix theory.
Researchers at Case Western Reserve, UNC/NCSU, and Pitt aim to develop an injectable nanotechnology that mimics platelet function to stabilize blood clots in traumatic injuries. The technology has the potential to stop hemorrhage and improve survival rates in emergency situations.
Researchers from Case Western Reserve University found that common household chemicals harm oligodendrocytes, specialized cells that generate protective insulation around nerve cells. This discovery suggests a previously unrecognized risk factor for neurological diseases like multiple sclerosis and autism spectrum disorders.
Researchers warn of a growing problem with severe fungal infections, resulting in over 150 million cases annually and 1.7 million fatalities globally. The emergence of multidrug-resistant fungal species, such as Candida auris and Trichophyton indotineae, poses a significant threat to patient outcomes.
A team at Case Western Reserve University has identified a key protein regulator that, when inhibited, can prevent the formation of harmful astrocytes. Administering medications that specifically target this protein may prevent the development of dangerous astrocytes and increase nerve cell survival in mouse models.
Researchers found that combining chemotherapy drugs triggers 'cell blasters' to kill cancer, leading to longer survival rates in patients with tumors having increased NETs. The study's novel discovery paves the way for designing new cancer treatments.
A recent study by Case Western Reserve University researchers found that Black teenagers who are more involved in religious activities are less likely to engage in delinquent behavior. The study suggests that religiosity acts as a protective factor for positive behavioral outcomes.
Scientists at Case Western Reserve University identified a novel enzyme, SCAN, which attaches nitric oxide to proteins, including the receptor for insulin action. Blocking this enzyme protects from diabetes, suggesting it may be a cause of the disease.
Researchers found that GLP-1 RAs significantly reduced the incidence of colorectal cancer in patients with diabetes, compared to those treated with other anti-diabetic drugs. The study's findings support the need for clinical trials to determine whether these medications could prevent one of the deadliest types of cancers.
A new study published in Cell Host & Microbe concludes that even people with the protective Duffy-silent blood type can still become infected with malaria. The research suggests that the parasite may have found alternative ways to infect red blood cells, raising questions about how to combat this type of malaria.
Researchers Reshmi Parameswaran and Carlos Subauste at Case Western Reserve University have received funding for their work on finding new treatments for B-cell cancer and diabetic retinopathy, a leading cause of blindness. They aim to develop more effective cell therapies and inhibitors to treat these diseases.
Researchers at CWRU's Trauma Center have developed a model called CoHealing to mitigate on-the-job stress for educators. The study found that with support and psychoeducation, teachers can ease symptoms of burnout, stress, and secondary traumatic stress disorder.
Researchers find evidence supporting Modified Newtonian Dynamics (MOND) as an alternative to Planet Nine hypothesis. MOND predicts precise orbital clustering in the outer solar system, which could be indicative of a modified law of gravity at play.
Case Western Reserve University and University Hospitals researchers will focus on understanding the molecular and genetic factors that trigger Barrett's esophagus development and progression to esophageal cancer. The goal is to translate discoveries into effective prevention and treatments for patients, reducing cancer mortalities.
A team of researchers at Case Western Reserve University has identified a genetic defect in Caveolin-3 that increases the risk of developing esophageal adenocarcinoma. The discovery could lead to early screening, lifestyle modifications, and targeted treatments for individuals with a family history of the disease.
Researchers at Case Western Reserve University have identified a new function of the key protein LSD1 that leads to cancer and other diseases. They found that degrading LSD1 rather than just short-circuiting its catalytic activity could be more effective in slowing or stopping cancer growth.