Case Western Reserve University researcher Farren Briggs has been awarded $1.2 million to identify biomarkers for more accurate MS diagnoses. The goal is to monitor disease activity and progression, ultimately improving treatment outcomes.
A new study aims to identify diabetic donors whose corneas are suitable for transplant surgery, a crucial step in addressing growing demand for the procedure. The Diabetes Endothelial Keratoplasty Study will explore the impact of donor and recipient diabetes on outcomes and inform eye-banking and surgical practices.
Case Western Reserve researchers have identified a potential new approach to controlling epileptic seizures by stabilizing the sodium channel through neddylation. This finding, published in The Journal of Clinical Investigation, offers hope for future research and potential drug development to prevent epilepsy.
A new study by Case Western Reserve University researchers highlights the need for improved access to Medicaid waivers for families affected by autism spectrum disorder. The study found that having a Medicaid waiver and high school enrollment were key predictors of youth with autism and their families using available services.
Researchers used ultra-high field MRI to map the brains of people with Down syndrome, detecting subtle differences in hippocampal structure and function. The study provides insight into how subregions of the hippocampus are connected to other brain areas.
A team of researchers has developed AI tools to predict which lung cancer patients will respond to immunotherapy, with the goal of improving patient outcomes and reducing costs. The study uses machine learning algorithms to analyze tissue scan patterns and identify previously unseen indicators that can inform treatment decisions.
Researchers at Case Western Reserve University developed a novel transdermal mixture of terbinafine and clotrimazole to combat Candida auris, a highly resistant fungus. The study found that this formulation can effectively reduce the presence of C. auris on skin and prevent its spread.
The Mt. Sinai Health Care Foundation has awarded a $1 million challenge grant to the Case Western Reserve University School of Medicine's Department of Pharmacology. The grant will support recruitment and retention of exceptional faculty, as well as bridge funding for promising early-stage research.
A new technique for sampling and testing cells from Barrett's esophagus patients can detect specific chromosomal alterations, including the presence of esophageal adenocarcinoma. The approach combines esophageal brushing with massively parallel sequencing to provide an accurate assessment of disease stages and identify high-risk patients.
Researchers at Case Western Reserve University have determined the structure of protein fibrils linked to Lou Gehrig's disease and other neurodegenerative disorders. The findings provide clues on how toxic proteins clump and spread between nerve cells in the brain, potentially leading to the development of new treatments.
A team of bioethicists and scientists proposes a cautious, stepwise approach to studying human embryos beyond the 14-day limit, potentially unlocking insights into early development disorders and therapies for infertility. The proposed research aims to serve important goals that cannot be adequately met by other means.
The Cleveland African American Prostate Cancer Project aims to reduce health disparities by increasing prostate cancer screening among African American men. The project will develop and implement a comprehensive, sustainable program to screen for prostate cancer using barbershops as community hubs.
A new study found adults with Down syndrome are roughly three times more likely to die from COVID-19 than the general population. The study's results have implications for preventive and clinical management of COVID-19 patients with Down syndrome, highlighting the need to prioritize individuals with this genetic condition for vaccination.
Researchers at Case Western Reserve University have found a way to measure the kinetics of proteins that bind to RNA, shedding light on gene function regulation in diseases like cancer and neurodegenerative disorders. This discovery could lead to new therapeutic strategies targeting RNA-protein interactions.
A study found patients with dementia twice as likely to contract COVID-19 and experience worse outcomes. African Americans with dementia faced a near-threefold higher risk of infection. The researchers emphasized the need for strategies balancing safety from COVID-19 with protection from social isolation and health-related harms.
Scientists at Case Western Reserve University have discovered biomarkers using AI analysis of simple tissue scans to predict which lung cancer patients will be harmed by immunotherapy. This new work builds on previous research that used AI and machine learning to identify patients who will benefit from the treatment.
Researchers are using AI to improve treatment outcomes for patients with oral squamous cell carcinomas by predicting which patients need chemotherapy, radiation, or surgery. The project aims to develop a more precise and personalized approach to cancer care.
Child care programs in Ohio have shown low COVID-19 infection rates due to clear guidelines, streamlined reporting, and high compliance among workers and families. The study recommends maintaining capacity, developing a supply chain for PPE, standardizing communication, and expanding workforce pipelines.
A team of international scientists detected an external field effect in over 150 galaxies, challenging the dark matter hypothesis and supporting modified Newtonian dynamics (MOND). The findings suggest that MOND's gravity at low accelerations is stronger than predicted by Newtonian understanding.
Researchers at Case Western Reserve University have discovered a new pathway in Alzheimer's disease that could lead to earlier and more effective treatments. The Drp1-HK1-NLRP3 pathway plays a key role in disrupting normal brain cell function, leading to cognitive deficits and degeneration of white matter.
A Case Western Reserve University study found that children exposed to domestic violence need tailored interventions, including emotional and coping skills education. Service providers highlighted the need for increased trauma-informed care and better collaboration among agencies.
A study published in Proceedings of the National Academy of Sciences reveals that liquid-liquid phase separation facilitates tau protein aggregation, a hallmark of neurodegenerative disorders. The researchers discovered a novel regulatory mechanism involving different variants of tau protein, which may influence disease clinical outcomes.
A new study reveals that brain cell dysfunction in low oxygen is caused by the body's protective response system, which ultimately impairs brain cell function. Researchers have identified a class of drugs that can overcome this damage and restore brain-stem cell function.
The HAMRC will investigate novel approaches to characterize lung cancer epidemiology, somatic mutation burden, and the relationship between HIV-1 infection and accelerated aging. The team aims to develop diagnostic computational imaging algorithms to discern lung cancer from respiratory infections.
Researchers at Case Western Reserve University aim to create quicker diagnostic tests for dementia with Lewy bodies and Parkinson's disease dementia using non-traditional tissue samples. The new method could enable doctors to diagnose patients earlier and more easily, improving patient care.
Researchers from Case Western Reserve University are developing a hand-held device that can non-invasively detect oral cancer by analyzing the ratios of two key proteins. The device aims to reduce the need for painful biopsies and provide an accurate diagnostic alternative, especially in resource-poor settings.
The researchers will investigate how long-term care residents transmit and cope with the disease, aiming to identify asymptomatic cases and develop new therapeutic strategies for vulnerable populations. They also seek to understand the epidemiology, transmission, and immunology of COVID-19 in nursing homes.
A team of researchers at Case Western Reserve University has identified new biomarkers in the blood that can indicate damage to brain tissue, which could help emergency clinicians quickly recognize minor strokes. The discovery has the potential to reduce delays in treatment and improve patient outcomes.
A Case Western Reserve University researcher is working to enhance genomic privacy protections using a $1.2 million NIH grant. He plans to identify weaknesses in the genomic data sharing network and develop more complex algorithms to protect against potential threats.
Researchers at Case Western Reserve University are developing a novel technique using nanotechnology to wake up 'cold' tumors, allowing immune cells to locate and neutralize them. The approach aims to improve treatment outcomes for metastatic breast cancer patients by combining nanotechnology with immunotherapy.
Scientists have discovered that a small fraction of carbonate melt is present throughout the Earth's mantle, storing a large mass of carbon. This finding sheds light on seismology and its connection to climate change.
Researchers at Case Western Reserve University have developed a new class of metalenses that can be reconfigured using liquid crystals, allowing for the creation of flexible and tunable lenses. This innovation holds promise for revolutionizing optics and enabling new scientific and technological endeavors.
Researchers at Case Western Reserve University found that hydroxychloroquine is not effective in preventing COVID-19 in patients with lupus and rheumatoid arthritis. The study, which analyzed data from over 159 patients, suggests that HCQ may not be active against the SARS-CoV-2 virus in humans.
Scientists at Case Western Reserve University have discovered how quickly certain pre-cancerous lesions can form on the DNA of our skin when exposed to sunlight, a finding that could lead to more effective prevention methods. The research reveals that these mutations can form in as little as three picoseconds after exposure to UV light.
Researchers aim to reduce bleeding time for soldiers on the battlefield by developing synthetic platelet substitutes that can be easily transported and stored. The technology, which involves freeze-drying artificial platelets into a powder, could potentially address blood shortages and improve treatment outcomes in emergency situations.
A recent study by Case Western Reserve University reveals a correlation between states' voting patterns in the 2016 presidential election and decreases in health insurance coverage. States classified as 'red' had the highest uninsured rates, while 'blue' states saw a decrease of over 7.6 million uninsured adults.
Scientists have discovered a new approach to treating Pelizaeus-Merzbacher disease by targeting toxic proteins that prevent myelin production. The treatment, which uses antisense oligonucleotides, reduced symptoms and extended lifespan in laboratory studies.
Researchers discovered an overabundance of KLK6 protein can produce skin inflammation in psoriasis, while normalizing its level can eliminate it. They also found that KLK6 plays a key role in damaging joints and bones in people with the disorder.
A new study by Case Western Reserve University economist Mark Votruba found that involuntary job loss leads to a dramatic increase in criminal behavior. Displaced workers experienced a 20% increase in criminal charges the year after being laid off, as well as decreased earnings and full-time opportunities.
A new study by Case Western Reserve University found that nearly 94% of defendants in Cuyahoga County drug court have been exposed to trauma, with many suffering from post-traumatic stress disorder (PTSD) symptoms. The research suggests a need for increased trauma-informed care and possibly specialized, gender-specific support.
Researchers used AI to analyze digitized images of cancer tissues and found critical variations between black and white male patients, which could improve care for black patients with prostate cancer. The study suggests that there are biological differences in the disease that cannot be explained by other disparities.
Researchers at Case Western Reserve University and Cleveland Clinic have developed a new method to determine the relative life expectancy of glioblastoma patients using AI, MRI scans, and genomic analysis. This approach identifies patients who could benefit from experimental clinical trials.
Researchers at Case Western Reserve University have developed a new method to preserve donated kidneys using a drug that generates S-nitrosothiols, restoring flow-through and reducing resistance. This could extend the number and quality of kidneys available for transplant, saving more people with end-stage renal disease.
A new drug called Myeliviz has been approved for its first human trials to aid multiple sclerosis (MS) diagnoses. The drug targets and binds to myelin, allowing for its imaging by a PET scanner, potentially providing earlier and more accurate diagnoses.
Researchers have identified a new protein called 'aggregatin' that accumulates in brain plaques and may be linked to Alzheimer's disease progression. Suppressing this protein could lead to future treatments aimed at slowing the disease's advance.
Researchers at Case Western Reserve University developed a new screener to quickly identify children exposed to violence and trauma. The 22-question tool is designed for minimally trained staff to refer children to necessary assessment and treatment services.
Researchers at Case Western Reserve University have discovered a crucial connection between interleukin-1α and gut microbiome function in a mouse model of Crohn's disease. Blocking this protein reduces intestinal inflammation severity, with effects comparable to steroids, which are the current gold standard treatment.
Case Western Reserve University researchers found that virtual training increased middle-school educators' ability to recognize suicidal behavior. The training, Kognito At-Risk simulation, also covers bullying and other topics, highlighting the importance of comprehensive mental health education.
Scientists at Case Western Reserve University have identified a critical role for the Cullin 3 gene in brain development, contributing to autism spectrum disorders (ASD) and schizophrenia. The discovery sheds light on the mechanisms underlying these complex conditions, potentially paving the way for new treatments.
A study published in Cancer Immunology Research uses AI to analyze changes in CT scans before and after immunotherapy treatment, predicting patient response. The researchers found that textural changes, not just tumor size, are a better indicator of therapy effectiveness.