A new study found that nearly one in five babies in Brazil were born 'small' and at increased risk of mortality. The researchers identified six 'small vulnerable newborn' phenotypes, which showed the highest mortality risk was 62 times greater than full-term babies.
In the NRG-LU001 clinical trial, adding metformin to concurrent chemoradiation did not improve one-year progression-free survival (PFS) in patients with locally advanced non-small cell lung cancer. The study found nearly identical overall survival rates between the two groups.
This study analyzed data from 10 recent flu seasons to examine the rates of influenza-associated hospitalizations, intensive care unit (ICU) admissions, and in-hospital deaths among different racial and ethnic groups. The findings highlight disparities in flu-related healthcare outcomes across various populations.
A study by UC Davis found that teens who have lived in poverty experience higher levels of cortisol, a hormone measuring stress. Boosting families out of poverty may protect them from later health problems, depression, and suicide risk.
The International Vaccine Institute (IVI) has initiated a Phase II/III clinical trial for the Bharat Biotech Chikungunya vaccine candidate BBV87, evaluating its safety and immunogenicity in healthy adults across five countries. The study aims to develop an affordable vaccine with the aim of achieving WHO prequalification.
Researchers from ETU LETI and Institute of Highly Pure Biopreparations proposed a new-generation biochip for multiparametric express-testing using molecular recognition and direct fluorimetry. The device selectively detects cardiac markers without fluorescent labels, reducing background fluorescence to 30%.
Researchers at Tata Institute of Fundamental Research used extreme magnetic pulses to create large-scale spin patterns, potentially useful for terahertz frequency range electronic devices. The induced spin patterns are robust and stay 'arrested' for up to ten days.
In a breakthrough study, scientists found an 'unconventional' incommensurate spin-density wave order at the q = 2kF fundamental wavevector in YbAlO3 under finite magnetic fields. This mechanism is similar to Fermi surface nesting observed in metals and leads to multiple coherent scattering of fermions.
A US study published in Journal of Health Communication found that emphasizing individual health risks from COVID-19 leads to higher vaccine acceptance among participants. The researchers also discovered that loss framing was slightly more effective than positive gain framing, suggesting cultural and personal factors may play a role.
A new study from the University of Georgia found that college students who were physically active before starting university remained so, while those with low motivation to exercise gained significant weight. The researchers recommend teaching children the importance of exercise and healthy eating habits.
A study published in Autism Research investigated over 925,000 births in Denmark, Finland, and Sweden, finding that delayed pregnancies by 2.5 to three years reduced the sibling's risk of autism diagnosis by up to nine percent
Stabilizing the NO signaling pathway has been achieved through the use of zinc complexes, which can bind to thionitrite and perthionitrite anions. This breakthrough reveals the importance of these intermediates in cellular communication, shedding light on their roles in vasodilation and cell protection.
The study found that cycling accidents account for 81% of sports-related traumatic spine injuries, followed by skiing and snowboarding accidents. The research highlights the importance of implementing safety measures to prevent these types of injuries.
A new study from the University of Surrey found that keeping car windows open while wearing a mask is best for reducing Covid-19 risk in cars. However, this approach also increases occupants' exposure to toxic air pollution particles. The optimal balance is running air conditioning on ambient mode with windows closed.
A research study is being conducted to understand muscle fatigue in older adults, with a focus on its effects on mobility and daily activities. The study aims to develop a new metric called fatigability to assess an individual's change in performance and perceived effort in response to standardized activity.
Scientists challenge existing thinking on opioid tolerance and respiratory depression, proposing a new balanced approach to developing safer analgesics. They found that arrestin-3 engagement limits tolerance development but does not exacerbate respiratory depression.
A global study found that patients with recent or current COVID-19 infection are at a higher risk of developing dangerous blood clots during surgery. The study also revealed that having a venous thromboembolism clot increases the risk of death within 30 days by five times.
Researchers developed a precise stopwatch to count single photons, enhancing imaging technologies like forest mapping and disease diagnosis. The new time lens technology improves photon timing resolution by orders of magnitude.
A preclinical study found that age-related decline in two sirtuin enzymes alters mitochondrial dynamics, weakening cardiac contractions in response to ischemia-reperfusion injury. Boosting SIRT1/SIRT3 levels may help protect against such injuries, potentially reducing heart attack complications and deaths.
Researchers from Binghamton University and Harvard Medical School are using computer modeling and advanced imaging to study brain folding and growth in fetuses. They hope to understand the underlying mechanism of how brains form and how early weeks affect later life.
A new Rutgers-led study finds that people who believe leisure activities are a waste of time tend to enjoy them less. The research suggests that attitudes towards leisure can impact its enjoyment and even mental health.
University of South Australia researchers create a computer vision system to detect premature babies' faces and vital signs from digital cameras, outperforming electrocardiogram machines. The technology has the potential to replace contact-based sensors, reducing skin tearing and infections.
A team of scientists used low-cost sensor networks to map pollution exposure in real-time during the 2018 Kīlauea Volcano eruption. The study provided highly granular estimates of human exposure to fine particulate matter and sulfur dioxide gas, enabling communities to make informed decisions about their health.
Researchers at the University of Queensland discovered that stingless bees produce a rare, healthy sugar called trehalulose, which is not found in other honey or as a major component in other food. Stingless bees convert sucrose to trehalulose and produce honey rich in trehalulose in their gut.
Researchers at Osaka University have developed a new method for detecting single DNA molecules directly from individual cells, eliminating the need for subsequent steps. The 3D-integrated nanopore allows for efficient delivery of released DNA molecules to the sensing zone, enabling robust detection and analysis.
Researchers found that nurse home visits for low-income mothers resulted in significant reductions in maternal and child mortality, including external causes of death and preventable causes. The study's findings support the benefits of Nurse-Family Partnership programs in improving pregnancy outcomes and child health.
A recent study found that telehealth medication abortions were safe and effective during the COVID-19 pandemic. The researchers examined data from patients who underwent telehealth abortion procedures and found that they had similar outcomes to in-person procedures.
Researchers at Albert Einstein College of Medicine and City University of New York Graduate School of Public Health and Health Policy have been awarded a five-year, $14.5 million grant from the National Institutes of Health to continue leading and expand their research on HIV treatment and care in five Central African nations. The effo...
Researchers explored optimizing disease control in prisons using rapid tests, identifying the optimal strategy to minimize costs and reduce infection. The study found that switching between full and no testing depends on various parameters, including contagion rates and test sensitivity.
Scientists from KIT have investigated the behavior of iridium oxide catalysts under dynamic conditions using X-ray absorption spectroscopy. The study reveals highly unexpected structural modifications connected to a stabilization of the catalyst at high voltages, contributing to more efficient and sustainable green hydrogen production.
A study found that climate change and drought are shifting the range of infectious disease in forests suffering from white pine blister rust disease. The disease expanded its range into higher-elevation forests while contracting it in lower elevations, where conditions were too hot and dry.
Medically-supervised pediatric obesity treatment is associated with improved psychosocial health and reduced symptoms of depression, anxiety, and eating disorders. However, access to supervised weight management services is limited in the US, with fewer than 50 facilities available.
Researchers found increased capillary blood flow in mice brains during REM sleep, indicating a possible role of adenosine A2a receptors in brain refreshing. This unique state may be crucial for waste removal from the brain, which is associated with Alzheimer's disease development.
The robotic white cane system combines depth data with a 2D floor plan map to reduce pose estimation errors. It features a novel 'robotic roller tip' interface that allows for automatic mode-switching, making it easier for visually impaired users to navigate.
Researchers have discovered a room-temperature transition between 1D and 2D electrical conduction states in topological crystals of bismuth and iodine. The material's electronic behavior changes at a transition temperature around 80 degrees Fahrenheit.
Researchers developed scale model structures that can predict storm damage to wood-frame buildings, using LiDAR technology to track damage progression. The study's findings suggest that elevated structures are more resilient to wave loading and surge forces than on-grade models.
Research team investigates urbanization's impact on farmland bird communities in Bangalore, India, finding that urbanization homogenizes bird species, eliminating insect-eating birds essential for pest control. The study highlights the importance of preserving biodiversity to maintain ecosystem resilience and food production systems.
Researchers have found that viruses like hepatitis B and C do not always kill infected cells, but instead cause long-term changes. These changes can affect genes related to cell division and metabolism, potentially contributing to increased risk of liver cancer in cured patients.
A new study suggests that existing drugs for multiple sclerosis may not be effective due to toxic blood leaks in the brain. Researchers have identified a promising alternative treatment option that could improve myelin repair, even in the presence of these harmful elements.
Researchers explored wind turbine dynamics under simultaneous wind and earthquake excitation, finding a coupling effect between aerodynamic damping and blade stiffness. This knowledge can guide seismic design of wind turbines and inform determination of wind-earthquake combinations.
Adolescents in the US showed stable overall drug use rates during the first six months of the COVID-19 pandemic, but nicotine and prescription misuse increased, while alcohol use decreased. The study monitored 7,842 adolescents and found heightened stress, depression, and anxiety associated with youth substance abuse.
Scientists developed new imaging and machine-learning methods to discover water-use efficiency traits in crops. The approach identified key links between microscopic anatomy and physiological performance, revealing the genetic basis of variation in stomata patterning.
Referral guidelines for nephrology care are shifting towards identifying patients at higher risk of kidney failure. A study using Veterans Health Administration data found that referring patients with a two-year risk of kidney failure above 1% would identify those at highest median risk.
The $3 million grant aims to study the effect of climate change, globalization and infrastructure development on the Arctic region. The project will examine interactions among social systems, natural environment and built environment in Yamal, northern Russia.
Scientists have developed stable peptide mimics called peptoids to treat viruses and prevent infections. Peptoids, such as those tested against SARS-CoV-2 and HSV-1, could one day cure or prevent many kinds of infections, including COVID-19.
A new study found that individuals infected with COVID-19 are most contagious two days before and three days after developing symptoms. Asymptomatic primary cases were also more likely to transmit the virus to close contacts, but only if they were exposed shortly before or after symptom onset.
Anjana Bhat is studying the prevalence and relationship of motor problems in children with ASD. Her research aims to alter the Diagnostic and Statistical Manual of Mental Disorders definition of ASD by including motor impairments.
A new study found that an early warning system for sepsis improved patient outcomes by alerting healthcare providers to administer antibiotics sooner. The system, implemented in the emergency department, resulted in increased survival rates and reduced hospital stays for patients with sepsis.
Carnivorous animals lack key genes needed to detect and respond to infection, making them asymptomatic carriers of disease-causing pathogens. This can lead to the formation of undetected disease reservoirs that can mutate and become a risk to human health.
Research from the University of Florida found that COVID-19 vaccination significantly increases antibodies against SARS-CoV-2 in breast milk, providing passive immunity to newborns. The study suggests that vaccinated mothers can help protect their babies from COVID-19 illness.
New research from Portland State University suggests that Allosaurus, a large carnivorous dinosaur, acquired most of its calories by scavenging on sauropod carcasses. The study's agent-based model and morphological analysis support this hypothesis, challenging 150 years of established thought about Allosaurus' ecological role.
Researchers have helped fill gaps in the rhino evolutionary family tree by analyzing genomes of living and extinct species, finding that African and Eurasian lineages separated 16 million years ago and that low genetic diversity is a natural state for rhinoceroses, not a consequence of recent population declines
A new WVU study found that psychological capital, including self-efficacy, optimism, hope, and resiliency, can help employees cope with the stress of working during a pandemic. Workers who used adaptive coping strategies fared better, but those relying on maladaptive behaviors experienced higher levels of stress.
Student researchers at the University of Cincinnati developed artificial intelligence to train robots to work together to move a couch around obstacles and through a narrow door. The robots successfully completed the task 95% of the time in simulations, with nearly equal success without re-training.
A study published in the Journal of Clinical Investigation has identified an enzyme called secreted phospholipase A2 group IIA as a key mechanism driving COVID-19 severity. The enzyme is found to be associated with increased mortality rates, particularly when its levels are high, and could provide a new therapeutic target for reducing ...
Recent studies suggest that cosmic rays, originating from supernova remnants and pulsars, have a significant impact on galactic dynamics and star formation. The streaming instability triggered by cosmic rays in the interstellar medium can create plasma waves that heat and scatter gas, influencing the formation of planets and stars.
Researchers used glacial isostatic adjustment modeling to reconstruct the Antarctic Ice Sheet before the Last Glacial Maximum, revealing a thickened ice sheet that depressed the continent and generated high sea levels. The study aims to improve understanding of ice-sheet response to climate changes.
A new University of Michigan study analyzes 20 potential uses of captured carbon dioxide, ranking them by climate benefit. Only four pathways have a greater than 50% likelihood of generating a net climate benefit. The researchers found that using CCU to make products like concrete and chemicals could help reduce emissions.
Researchers have identified a potential advantage of weakened SARS-CoV-2 variants as immunogens, sparking interest in their use for live-attenuated vaccines. The variants, which emerge rapidly during cell culture propagation, show resistance to subsequent infection with both the parental strain and emerging variants.
A new gene ZFP541 has been discovered by researchers at Kumamoto University to control the completion of meiosis in spermatogenesis. The study found that ZFP541 plays an essential role in regulating meiosis and is expressed in late meiotic prophase, binding to regulatory regions of meiosis-related genes.
The Iñupiaq people's seal hunting season has shrunk by about one day per year over the past 17 years due to sea ice decline. This reduction in flexibility affects hunters' ability to prepare and hunt, as they now have less time to adapt to changing conditions.
Researchers at Berkeley Lab and UC Berkeley capture the first direct image of quantum spin liquid particles, called spinons and chargons. The discovery advances research on quantum computing and exotic superconductivity.
Researchers use super-resolution infrared imaging combined with X-ray fluorescence nano-imaging to study amyloid toxicity on a subcellular level. They found that the distribution of trace elements in neurons is related to molecular mechanisms of Alzheimer's disease, offering new insights into preventing neuronal damage.
A low-cost prototype breathing device designed for poorer-resourced healthcare settings has shown promising results in a pilot trial involving healthy volunteers. The device provides continuous positive airway pressure (CPAP) therapy and operates with oxygen concentrators, which are commonly used in low-pressure systems.
Researchers from Carnegie Mellon University and the University of Pittsburgh conducted a study on three Rhesus monkeys, finding that their performance declined by up to 25% when offered a jackpot reward. The team also discovered a link between sensory motor processing and emotional processing in the monkeys' brains.
A novel CT scan-based approach detects changes in lung tissue indicating emphysema and airway constriction in patients with asthma. This finding may explain why conventional anti-inflammatory treatments are ineffective in some asthmatics, paving the way for personalized management of the disease.
Moderate online engagement helps stressed teens cope better than those who avoid digital technology or overuse it. This 'Goldilocks' effect suggests that just the right amount of online support provides short-term relief from daily stressors.
Researchers at Duke University Medical Center identified a mechanism where breast cancer cells use cholesterol to develop tolerance to stress, allowing them to resist ferroptosis and proliferate. This finding highlights the importance of lowering cholesterol in preventing cancer progression and offers new approaches for treatment.
A reservoir of genes allowing sorghum to adapt to environmental stresses has been identified from 13 contrasting genomes. This genetic diversity is valuable for breeders, enabling them to improve crop yield and resilience. The analysis, led by the University of Queensland, provides unprecedented insights into the genome's dynamic nature.
A study published in Marketing Letters found that analytical thinkers are more likely to undergo plastic surgery, while holistic thinkers are more forgiving of imperfections. The researchers suggest taking a holistic approach to consider the long-term impact of procedures on one's life.
Researchers at the University of Texas at Dallas have produced large, high-quality bismuth iodide crystals that demonstrate the existence of weak topological insulators. The crystals undergo a phase transition into a novel structure at room temperature, altering their electronic properties.
A new effort at the University of Kansas aims to design course modules to train students in building and maintaining more secure computer hardware. The work is supported by a $400,000 grant from the National Science Foundation's SaTC program.
Researchers have discovered that the TRPV4 gene plays a crucial role in regulating cartilage growth, which could lead to more effective treatments for osteoarthritis and other cartilage diseases. The study also suggests that TRPV4 may be used to accelerate stem cell differentiation for bioengineering cartilage.
The prevalence of type 1 and type 2 diabetes among US children and teens rose significantly from 2001 to 2017. Researchers estimated an increase in diabetes cases across all age groups during this period, with the largest increases seen among younger populations.
The U.S. Preventive Services Task Force recommends screening for prediabetes and type 2 diabetes, particularly in high-risk individuals. The guidelines aim to detect and prevent these conditions through early detection and intervention.
A study found that white lupin plants can rejuvenate arsenic-contaminated soils by releasing compounds that bind metals, potentially offering a sustainable remediation method. The research used advanced chemical profiling to identify the root chemicals involved in this process.
A new study suggests that China's policies in Xinjiang, including enforced birth control and internment camps, could result in a significant loss of life among the Uyghur population. The research estimates that up to 4.5 million lives could be lost by 2040 if current policies continue.
Researchers study mosses and find unique centriole assembly process, with a 'unique symmetry break' that allows for regulation. This discovery provides insights into centriole development across the tree of life and has implications for our understanding of evolution.
A team of researchers has created a bioink that can reduce toxicity and improve cell survival, enabling the fabrication of clinically relevant human-scale organs. The development paves the way for regenerative medicine applications.
Researchers at Osaka University have successfully created a 3D-bioprinted structured Wagyu beef-like meat alternative using stem cells isolated from Wagyu cows. The new technology mimics the complex texture of real Wagyu beef, allowing for customizable fat and muscle components in cultured meat.
Research from the University of Pennsylvania suggests that certain proteins have evolved to reduce biased chromosome inheritance, potentially avoiding mistakes and birth defects. The study found a parallel pathway suppressing selfish chromosomes, indicating an evolutionary arms race.
Recent progresses of silicon/2DM PDs are reviewed for their potential applications in various functional photonic integrated circuits. The article discusses the operation mechanisms, device configurations, and application scenarios of these photodetectors.
Researchers at the University of Houston have developed a smartwatch technology that can monitor and help lower stress levels by detecting changes in skin conductance response. The device sends reminders to listen to relaxing music when stress is detected, forming a closed-loop system.
A study of 282,271 European ancestry participants found 26 genetic regions associated with increased preference for high-fat foods. The research also identified specific subtypes of neurons responsive to protein, fat, or carbohydrate, which may explain individual differences in food choice behavior.
The New Roots for Restoration Biology Integration Institute aims to integrate plant traits, communities, and the soil ecosphere to advance restoration of natural and agricultural ecosystems. The project seeks to understand how root traits influence plant interactions with each other and with the soil.
A recent NIH-funded study found that the overall rate of drug use among 10-14 year-olds remained stable during the 2020 COVID-19 pandemic, with adolescents experiencing stress and hardship being most likely to use substances. The study also detected shifts in substance types, with alcohol use declining and nicotine use increasing.
A study found that young Black athletes recovered faster from sports-related concussions, returning to school sooner and experiencing less impact on daily activities. In contrast, White athletes took longer to recover, with changes in sleep patterns and increased risk of post-concussion depression.
Researchers have identified several small molecules responsible for coffee's mouthfeel, including melanoidin compounds and caffeoylquinic acid. These compounds can be used to tune processing and roasting conditions for specialty coffees.
A review article published in the Endocrine Society's journal Endocrinology predicts a peak in population numbers in 2064 followed by a 50% drop by the end of the century. Stress from less quality social interactions is believed to suppress sperm count, ovulation, and sexual activity, contributing to declining reproduction rates.
Researchers identified physical binding sites for cholesterol in GIRK channels, which play a role in neurodegenerative diseases. The study provides structural insights into how cholesterol alters channel function, paving the way for drug development.
A study from Linköping University found that the tumour-inhibiting gene TET2 is silenced in most cases of acute lymphoblastic leukemia (ALL) in children. The gene can be reactivated by treatment with an existing drug, 5-azacytidine, suggesting a targeted therapy for ALL in children.
A study found that transcranial stimulation can increase the benefits of aerobic exercise and improve gait in Parkinson's patients. The treatment uses a weak current delivered by electrodes placed over specific brain regions, activating the pre-frontal cortex.
A new study found that increasing childhood cardiorespiratory fitness can reduce the adverse effects of metabolic syndrome traits on atherosclerosis. The researchers discovered a two-way connection between arterial health and fat mass, with healthy arteries associated with higher fat mass in children.
A study by North Carolina State University found that surface waters in eastern North Carolina were more likely to face dual contamination from human and swine waste after Hurricane Florence. The presence of Arcobacter, a pathogen not associated with human or swine fecal markers, was also discovered.
A Mount Sinai study found significant inequalities among low-risk births, with Black and Hispanic infants experiencing higher rates of unexpected complications. Hospital quality was identified as a key contributor to these disparities, with lower-quality hospitals serving more Black and Hispanic women.
A recent study from University of Cambridge and Addenbrooke's Hospital found that most patients infected with COVID-19 in hospitals contracted it from other patients rather than healthcare workers. The research highlights the importance of regular screening for asymptomatic patients and proper use of face masks.
Scientists have created a system dubbed "NanoporeTERs" allowing cells to express themselves in a whole new light. These new reporter proteins can detect multiple protein expression levels and shed new light on biological systems, enabling deeper analysis than before.
Researchers use radiochronometry and forensic methods to determine the age and origins of Heisenberg and Diebner cubes. The findings will help train international border guards and nuclear forensics researchers to detect nuclear material.
A new TB prevention regimen for HIV-positive individuals has shown promising results, with 90.4% completing the three-month course compared to 50.5% of those on a six-month daily treatment. The study suggests that this shorter approach is as safe and effective as the standard treatment.
A new study asked over 470 firefighters about their recovery methods in extreme heat, finding that simple strategies like finding shade and drinking water are often used. The research suggests potential for better cooling and recovery protocols to improve firefighter safety and performance.
Gastrointestinal stroma tumors (GIST) are rare cancers that can be problematic to detect and treat. Researchers have identified the mutational drivers for GIST in the stomach and found a potential drug therapy, temozolomide, which showed promising results in treating patients with specific mutations.
New research published in PNAS suggests that community-based monitoring can improve water management in rural Costa Rica by reducing groundwater extraction and improving water quality. The program, which used a smartphone application and WhatsApp, showed modest but significant effects after one year.
Researchers at Karlsruhe Institute of Technology have developed a record-breaking lithium-metal battery with an energy density of 560 Wh/kg, retaining 88% capacity after 1000 cycles. The battery features a nickel-rich cathode and a dual-anion ionic liquid electrolyte, which significantly improves stability.
The number of people living with hypertension has doubled from 331 million in 1990 to 626 million women and 652 million men in 2019. Despite being diagnosable and treatable, nearly half of those with hypertension remain unaware or untreated.
Researchers found that wood vinegar and tar fraction in bio-oil produced from hazelnut shells pyrolysis at 400 C to 1,000 C contain high concentrations of phenolic substances, which contribute to their antioxidant activity. The study suggests using these fractions as a potential renewable energy source.
The USPSTF has lowered the recommended starting age of screening for type 2 diabetes from 40 to 35. Screening is now recommended for adults with prediabetes or type 2 diabetes, particularly those aged 35-70 who are overweight or obese. This recommendation aims to detect and treat these conditions earlier.
Researchers at the University of Southampton have identified a unique change in B cells that allows them to receive signals from molecules called lectins, enabling tumor growth. This discovery could pave the way for new treatments and early cancer detection methods.
A Korean research team developed an electrode pre-treatment solution to minimize initial Li ion loss in graphite-silicon oxide composite anodes. The process enabled a full cell to exhibit near-ideal energy density, with negligible Li loss.
Researchers at UEA developed a new method for measuring carbon uptake by Arctic plants, providing insights into the impact of climate change on this process. This study reduces uncertainties in previous assessments and investigates the influence of environmental factors on carbon uptake.
A new study published in the Journal of Gerontology finds that engaging in diverse daily activities is associated with a diverse set of emotions. Individuals who regularly participated in a broad range of activities experienced more diverse positive emotions, particularly those between ages 33-44.
High-intensity focused ultrasound (HIFU) technology is being explored for its potential to destroy cancerous tumours while minimizing damage to healthy tissue. Researchers at the University of Waterloo have made significant progress in understanding how HIFU works on a cellular level, paving the way for future clinical trials.
A new study found that early socialization of dairy calves does not negatively affect their behavior, performance, or health, and may even benefit their early-life health by reducing scours. Calves housed in pairs after birth showed greater comfort with pen-mates and a reduced risk of diarrhea.