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Science News for August 23, 2021


Study could lead to new treatments for neuroblastoma

Researchers have identified a new potential treatment for neuroblastoma by targeting the ALT mechanism, which is responsible for chemotherapy resistance. The study found that activating ATM kinase at telomeres promotes chemotherapy resistance in ALT neuroblastoma and suggests a cancer-specific approach to treating this disease.

SourceTexas Tech University Health Sciences Center·JournalScience Translational Medicine·TypeExperimental study·DateAug 23, 2021

World First: Smaller than a speck of dust, voltage like a AAA battery - Smallest biosupercapacitor provides energy for biomedical applications

Researchers have created the smallest microsupercapacitors to date, which can function in artificial blood vessels and provide an energy source for tiny sensor systems. The biosupercapacitor has a volume of 0.001 mm3 and delivers up to 1.6 V supply voltage.

SourceChemnitz University of Technology·JournalNature Communications·TypeExperimental study·DateAug 23, 2021

Eight predictors of upper gastrointestinal bleeding after heart attack

Researchers at Karolinska Institutet have identified eight primary factors that increase the risk of upper gastrointestinal bleeding after heart attack. The study, published in European Heart Journal - Cardiovascular Pharmacotherapy, found that smoking, blood pressure, and blood glucose are among the new predictors.

SourceKarolinska Institutet·JournalEuropean Heart Journal - Cardiovascular Pharmacotherapy·TypeObservational study·DateAug 23, 2021

No swimming? Molecule regulating sperm motility discovered

Researchers from Osaka University identified SPATA33 as a key regulator of sperm motility, which will aid in developing fast-acting male contraceptives. The study also clarified the mechanism by which SPATA33 controls sperm motility, shedding light on the cause of male infertility.

SourceOsaka University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 23, 2021

Watch this slow but deadly tortoise hunt a baby bird

Researchers captured footage of a tortoise attacking and killing a tern chick on Frégate Island. The tortoise approached the chick with its jaws open, suggesting it was an experienced hunter. This unusual behavior challenges previous assumptions about tortoises' diets and hunting habits.

SourceCell Press·JournalCurrent Biology·TypeObservational study·DateAug 23, 2021

Wildfire smoke exposure during pregnancy increases preterm birth risk

A Stanford University study suggests that wildfire smoke exposure during pregnancy increases the risk of preterm birth, with as many as 7,000 extra births attributed to this factor between 2007 and 2012. The research highlights the need for investment in prescribed burns, mechanical thinning, or other efforts to reduce extreme wildfires.

SourceStanford University·JournalEnvironmental Research·TypeData/statistical analysis·DateAug 23, 2021

Tree rings from old growth Douglas-firs on the Oregon Coast show evidence of 1700 tsunami

A study published in Natural Hazards and Earth System Sciences analyzed tree rings from old-growth Douglas-firs on the Oregon Coast, revealing reduced growth following the 9.0 earthquake and subsequent tsunami in 1700. The findings confirm modeling of the quake's reach and provide insight into the impact of tsunamis on trees.

SourceOregon State University·JournalNatural Hazards and Earth System Sciences·DateAug 23, 2021

New study in regenerative medicine identifies RNA released from damaged cells act as the signal to initiate repair after injury

A new study from Monash University has identified RNA released from damaged cells as a signal to initiate repair in the nervous system. The research found that blocking or enhancing this recruitment of immature neurons halted or sped up neural circuit recovery, demonstrating their power in boosting neural repair.

SourceMonash University·JournalDevelopmental Cell·TypeExperimental study·DateAug 23, 2021

Overcoming false optical activity

Researchers discovered false optical activity in Raman spectroscopic analysis of vitamin B12 and its derivatives, leading to misinterpretations of data. The phenomenon was attributed to circular dichroism and can be computationally modeled or adapted to measurement methods.

SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateAug 23, 2021

Turning the tables into touchscreens

Scientists at Nara Institute of Science and Technology create a projected touchscreen system using just one camera and projector, eliminating the need for additional detectors. The system uses slope disparity gating to capture touch data with high efficiency, enabling portable projection systems for large interactive displays.

SourceNara Institute of Science and Technology·JournalIEEE Access·TypeImaging analysis·DateAug 23, 2021

T. rex’s jaw had sensors to make it an even more fearsome predator, new digital study finds

A new digital study has found that Tyrannosaurus rex's jaw had nerve sensors enabling it to better detect and eat its prey. The researchers used computed tomography to analyze the distribution of neurovascular canals in a fossil mandible, revealing complex branching patterns similar to those of modern-day crocodiles and birds.

SourceTaylor & Francis Group·JournalHistorical Biology·TypeComputational simulation/modeling·DateAug 23, 2021

A “helping hand”: Intervention for early cancer screening in patients with mental illness

Researchers from Okayama University conducted a randomized trial to assess the benefits of interventions for early cancer screening in patients with schizophrenia. The study found that 47.1% of counseled patients underwent colorectal cancer screening, compared to 11.8% of those receiving only usual treatment.

SourceOkayama University·JournalActa Psychiatrica Scandinavica·TypeRandomized controlled/clinical trial·DateAug 23, 2021

Making patient care easier: Self-powered diaper sensors that monitor urine sugar levels

Researchers from Tokyo University of Science developed a self-powered diaper sensor that monitors urine sugar levels, providing an alternative biomarker for blood sugar monitoring. The sensor uses a biofuel cell powered by glucose in the urine, detecting sugar levels within 1 second and simplifying caretaking tasks.

SourceTokyo University of Science·JournalACS Sensors·TypeExperimental study·DateAug 23, 2021

Cutting “edge”: A tunable neural network framework towards compact and efficient models

Researchers at Tokyo Institute of Technology developed a tunable neural network framework that achieves high accuracy and efficiency for sparse CNNs. The new architecture employs a Cartesian-product MAC array and pipelined activation aligners to enable dense computing of sparse convolution, resulting in better resource utilization.

SourceTokyo Institute of Technology·TypeExperimental study·DateAug 23, 2021

New discovery pinpoints the ‘golden window’ for IVF success

Researchers at RMIT University have discovered a Teflon-like molecule on the womb's surface that decreases at a certain point in the menstrual cycle, opening the 'golden window' for pregnancy success. This finding could lead to improved IVF success rates and potentially treat underlying causes of infertility.

SourceRMIT University·JournalFertility and Sterility·TypeExperimental study·DateAug 23, 2021

Rise and fall of water blisters offers glimpse beneath Greenland’s thick ice sheet

A Princeton University-led research team discovered that water blisters on the surface of Greenland's high-elevation ice sheet can estimate transmissivity, a property characterizing the efficiency of water networks between ice and bedrock. The study found that transmissivity can increase by two orders of magnitude during the summer mel...

SourcePrinceton University·JournalNature Communications·TypeExperimental study·DateAug 23, 2021

Understanding how elephants use their trunk

A multidisciplinary team of scientists studied the elephant trunk's kinematic versatility, revealing a toolkit of 20 basic movements that combine to produce complex behaviors. The researchers identified a mathematical law governing the trunk's velocity, similar to human hand-drawing movements.

SourceUniversité de Genève·JournalCurrent Biology·TypeExperimental study·DateAug 23, 2021

Pusan National University researchers shed light on the early development of rice seeds

A team of scientists led by Assistant Professor Lae-Hyeon Cho identified a single mutation in the gene that codes for cytidine triphosphate synthase (CTPS), an enzyme crucial for early endosperm development. The study showed that overexpressing CTPS in genetically modified rice plants results in a larger endosperm, opening up opportuni...

SourcePusan National University·JournalPlant Biotechnology Journal·TypeExperimental study·DateAug 23, 2021

How to double voter turnout and increase representation during local elections

A new study by UC San Diego researchers finds that moving local elections to on-cycle races increases voter turnout and makes the electorate more representative of the population, particularly in terms of race, age, class, and partisanship. The study analyzed California elections over an eight-year period and found significant effects ...

SourceUniversity of California - San Diego·JournalAmerican Political Science Review·DateAug 23, 2021

Common workflows for computing material properties with various quantum engines

Researchers have developed a common workflow interface for various quantum codes, enabling accurate predictions of system properties and promoting the wider use of density-functional theory. The interface allows users to optimize structures using any code without defining parameters, providing reusable results.

SourceNational Centre of Competence in Research (NCCR) MARVEL·Journalnpj Computational Materials·DateAug 23, 2021

Surrey student makes a discovery that could improve the reliability of future smart electronics

A University of Surrey undergraduate has developed a method to suppress hot-carrier effects in devices, leading to more reliable performance and increased power efficiency. This breakthrough uses a multimodal transistor architecture, which could enable high-performance amplifiers for environmental and biological sensor applications.

SourceUniversity of Surrey·JournalAdvanced Electronic Materials·TypeComputational simulation/modeling·DateAug 23, 2021

Statistics say large pandemics are more likely than we thought

A new study estimates the intensity and frequency of extreme novel pandemics, finding that large pandemics like COVID-19 are relatively likely due to growing risks. The study suggests that a pandemic similar in scale to COVID-19 is likely within 59 years, highlighting the need for adjusted perceptions of pandemic risks.

SourceDuke University·JournalProceedings of the National Academy of Sciences·TypeData/statistical analysis·DateAug 23, 2021

Mathematical model predicts best way to build muscle

A mathematical model developed by researchers at the University of Cambridge can predict the optimum exercise regime for building muscle. The model takes into account individual physiology and optimizes exercise regimes based on user input, promising to maximize athletes' potential.

SourceUniversity of Cambridge·JournalBiophysical Journal·TypeComputational simulation/modeling·DateAug 23, 2021

A novel function of noncoding RNA in senescence and cancer

Researchers discovered that noncoding RNA derived from pericentromeric repetitive sequences upregulates SASP-like inflammatory gene expression by disturbing chromatin interactions. hSATII RNA is highly detectable in cancer cells and supports tumor development via small EVs, highlighting a new role in age-related pathologies.

SourceJapanese Foundation For Cancer Research·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 23, 2021

Survival strategy of starving spruces trees: The critical role of reserves

Trees continue to form reserves even during long periods of starvation, contrary to the assumption that they only form when photosynthetic conditions are favorable. As CO2 starvation progresses, trees stabilize their reserve levels and divert resources to storage, allowing them to survive climate extremes.

SourceMax-Planck-Gesellschaft·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateAug 23, 2021

Bringing order to chaotic bubbles can make mining more sustainable

Researchers at Columbia University School of Engineering and Applied Science have developed a new technique to structure chaotic bubbles, enabling more efficient separation of useful metals from useless particles. This method uses vibrations to control the motion of bubbles, leading to reduced energy and water usage in mining.

SourceColumbia University School of Engineering and Applied Science·JournalProceedings of the National Academy of Sciences·DateAug 23, 2021

TSIM: A model for telehealth

The Telehealth Service Implementation Model (TSIM) offers a comprehensive approach to developing and sustaining successful telehealth programs. TSIM addresses key challenges such as provider and patient engagement, technical, financial, regulatory, and administrative burdens.

SourceMedical University of South Carolina·JournalTelemedicine Reports·TypeExperimental study·DateAug 23, 2021

Moving emergency care patients to other hospital departments prone to high mishap rate

A recent study at a large Australian hospital found nearly 4 out of 10 patient transports to be marred by incidents, including limb entrapment, collisions, and issues with infusion pumps. Patient agitation was also a common factor in these mishaps, highlighting the need for improved transport training and preparation.

SourceBMJ Group·JournalEmergency Medicine Journal·TypeObservational study·DateAug 23, 2021

CUNY SPH and the NYC Health Department to study long-acting antiretroviral therapy for HIV

The APPLI study aims to assess the perceptions and preferences of people living with HIV on long-acting injectable antiretroviral therapies. The study will explore how to support adherence and integrate these therapies into Ryan White HIV care settings, potentially improving health outcomes for those struggling with daily oral medicati...

Would we still have severe thunderstorms over North America if the Gulf of Mexico were filled in with land?

A Purdue University study suggests that the eastern half of the US is a hotspot for severe thunderstorms due to high terrain, while the Gulf of Mexico plays a relatively weak role. Removing the Gulf would shift storm patterns eastward into Illinois and reduce them over southern Texas.

SourcePurdue University·JournalJournal of Climate·TypeComputational simulation/modeling·DateAug 23, 2021

Volcanism drove rapid ocean deoxygenation during the time of the dinosaurs

Research from UBC and HKU Earth scientists reveals that massive volcanism played a key role in triggering oceanic anoxia, with CO2-induced environmental warming creating 'dead zones' over short timescales. The findings provide important insights into the sensitivity of the Earth system to global biogeochemical cycles and marine biology.

SourceUniversity of British Columbia·JournalGeology·TypeExperimental study·DateAug 23, 2021

Scientists develop brain organoids with complex neural activity

Researchers at UCLA developed brain organoids that mimic human brain structure and function, allowing for the study of neurological disorders like Rett syndrome. The organoids showed organized waves of activity similar to those found in living brains and responded to treatment with an experimental drug.

SourceUniversity of California - Los Angeles Health Sciences·JournalNature Neuroscience·TypeExperimental study·DateAug 23, 2021

Reversal of lung fibrosis in mouse model suggests a novel therapeutic target for pulmonary fibrosis

Researchers reverse lung fibrosis in a mouse model using Bcl-2 inhibitor ABT-199, suggesting a novel therapeutic target to treat idiopathic pulmonary fibrosis. The study finds that monocyte-derived macrophages play a key role in fibrosis progression and that targeting the Cpt1a-Bcl-2 interaction modulates apoptosis resistance.

SourceUniversity of Alabama at Birmingham·JournalCell Death and Differentiation·TypeExperimental study·DateAug 23, 2021

Delayed care for juvenile new-onset type 1 diabetes

A Swedish study found that 43% of children with new-onset type 1 diabetes did not receive hospital treatment on the same day as primary care contact. Delayed care can lead to life-threatening conditions like diabetic ketoacidosis. Improved awareness and rapid treatment are crucial for preventing complications.

SourceUniversity of Gothenburg·JournalPediatric Diabetes·TypeCase study·DateAug 23, 2021

The Hobbit’s bite gets a stress test

A study on Homo floresiensis found its bite could exert around 1300 Newtons of force, comparable to modern humans and some extinct cousins. This suggests that the Hobbit might have been at greater risk of facial bone strain or dislocation when biting hard foods.

SourceDuke University·JournalInterface Focus·TypeComputational simulation/modeling·DateAug 23, 2021

Shorter weekly course of rifapentine-isoniazid associated with much higher treatment completion rates compared to longer daily course

A randomized trial found that a shorter course of rifapentine-isoniazid therapy resulted in significantly higher treatment completion rates compared to a longer daily course. The findings suggest that this regimens can be more effective for preventing tuberculosis disease in individuals with HIV, particularly in high-transmission areas.

SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateAug 23, 2021