Two new studies provide new insights for treating cardiogenic shock, a rare and life-threatening condition where the heart stops pumping enough blood. The studies confirm the accuracy of the SCAI shock stage classification system and show that early use of mechanical circulatory support improves patient outcomes.
New Army-funded synthetic biology research has enabled the manipulation of micro-compartments in cells, potentially leading to breakthroughs in bio-manufacturing. The study could inform new ways to design medicine, synthetic cells and nano-reactors for nanotechnology applications.
Two compounds, (-)-geosmin and 3-methyl-1H-indole, are found to be primary contributors to the musty and moldy scents of cocoa beans. Measuring their amounts within cocoa beans could help detect off-putting scents and flavors.
Researchers at INRS discovered a compound that alleviates some neurological symptoms of CHARGE syndrome, a rare genetic disorder affecting 1 in 10,000 newborns. The treatment targets GABAergic neurons and shows therapeutic effects on both neurological and behavioral symptoms.
Recent study reveals significant strengthening of tropical Pacific western boundary currents (WBCs) over the past six decades, primarily driven by temperature change. The WBCs' intensification is attributed to a strengthening of trade winds in the western Pacific Ocean.
A two-step prognostic test can predict patient response to SARS-CoV-2 infection, guiding therapeutic choices before severe symptoms appear. The test combines a disease risk factor score with antibodies produced early in the infection.
A large meta-analysis of 17,687 individuals with diabetes found that those with more advanced diabetes have a higher risk of death from SARS-CoV-2. Men and older adults with diabetes were particularly at increased risk.
The Society for Cardiovascular Angiography and Interventions has released updated consensus guidelines on best practices in cardiac catheterization laboratories. The new recommendations focus on patient-centered approaches, staff qualifications, and quality metrics to optimize outcomes. The document covers topics such as pre-procedure ...
A new study suggests the P.1 variant is 1.7-2.4 times more transmissible than non-P1-lineages and evades 10-46% of immunity gained from previous infections. This has led to difficulties in controlling outbreaks in Brazil, particularly in Manaus.
Researchers have developed hybrid materials that combine hydrogels and metal-organic frameworks (MOFs) to optimize water harvesting technologies for various environments. These materials have the potential to provide a sustainable source of water in arid conditions, as well as improve energy efficiency in air conditioning systems.
Researchers found virtual reality (VR) effective in assessing balance and improving postural control in older adults. VR systems can differentiate healthy from balance-impaired individuals and provide a more natural and relevant testing environment.
A review of over 500 academic papers found that wasps are valuable for agriculture, providing biocontrol services worth $416 billion annually. Wasps also contribute to pollination, visiting 960 plant species, including those dependent on them for reproduction. Their venom and saliva have medicinal properties.
Researchers at UCSF have engineered smart immune cells effective against solid tumors, overcoming hurdles for immunotherapies. The new approach may be ready for clinical trials in the near future, offering hope for patients with previously untouchable cancers.
Adolescents who experience early puberty are more likely to drink alcohol, with peer drinking and parental permissiveness contributing to this risk. Early maturing girls are particularly vulnerable, with a higher likelihood of binge drinking and substance use disorders.
During the pandemic, a 70% decrease was observed in heart attack patients seeking care, with those receiving treatment experiencing more severe symptoms due to delays. The study underscores the importance of early treatment and public education on cardiac care.
A new compound AAZ-A-154 has been identified with potential to act on beneficial pathways in the brain without hallucinogenic effects. The discovery was made possible by a genetically encoded fluorescent sensor called psychLight that screens for hallucinogenic potential.
A team of scientists discovered that microorganisms in the subseafloor are active and adaptable, able to survive on low-carbon conditions. They use carbon dioxide as a building block without converting it into organic carbon first.
A study has found that sperm development is linked to testicular cancer in men. Germ cells that fail to undergo sex-specific differentiation and retain pluripotent features are more likely to transform into cancer cells.
A recent study found a causal genetic link between coffee consumption and cardio health, suggesting that genetics play a role in regulating safe levels of caffeine. People with high blood pressure are more likely to avoid or limit their caffeine intake.
A team of scientists has re-evaluated the forest harvesting trends in Europe, finding that an abrupt increase of 69% reported by a previous study was incorrect. Instead, they found a more modest 6% increase in forest harvests over the same period.
Researchers discovered that a protein called VGLUT plays a key role in regulating sex differences in brain vulnerability to age-related dopamine neuron loss. Higher levels of VGLUT were found in female neurons, correlating with greater resilience to neurodegeneration and mobility deficiencies.
Researchers characterized how electronic states depend on local chemical composition in a compound containing iron, tellurium, and selenium. They discovered that low iron concentration leads to superconductivity and distinct magnetic correlations, while high tellurium concentration creates a topological surface state.
The article discusses the critical role of Texas Biomed in the development of the Pfizer COVID-19 vaccine through preclinical testing. Scientists tested two mRNA vaccine candidates in rhesus macaques, showing high effectiveness in protecting against SARS-CoV-2, and highlighting the importance of rapid therapy and vaccine development.
A new study found that fatty acid supplements may protect children with high cholesterol from heart disease by increasing their blood levels of healthy omega-3 fatty acids. The researchers discovered that an EPA supplement improved the lipid profile in the blood, reducing the risk of coronary artery disease and promoting healthy aging.
Researchers have made new discoveries about fetal liver cells that could help make liver cell transplants more effective. Fetal liver cells can multiply and maintain function for long periods when used in transplants, but adult liver cells do not share this ability.
Researchers found that four hepatitis C drugs boost remdesivir's efficacy by up to tenfold in cell cultures. This combination therapy may provide an immediate treatment for unvaccinated individuals or those with waning immunity. The study aimed to develop an oral drug that inhibits SARS-CoV-2 like remdesivir.
Cities with well-connected job networks and high employment diversity are more resilient to economic shocks, according to a study. The researchers found that cities with limited job connectivity, such as the size of a city, have higher unemployment rates during economic crises.
A Phase 2b trial will test Dalbavancin for safety and efficacy in treating complicated S. aureus bacteremia in hospitalized adults. The study aims to validate a dalbavancin regimen of one dose a week for two weeks, potentially leading to a shorter and less invasive treatment.
Researchers found that combining remdesivir with four HCV drugs boosts its antiviral activity by up to 10 times. This combination therapy could be a game changer for patients with COVID-19 who are not vaccinated or have waned immunity.
A study of oak forests in European Russia has provided new insights into the region's climate change. Researchers developed a classification system based on the Braun-Blanquet method, identifying two new associations and demonstrating the uniqueness of steppe oak forests compared to xero-mesophytic European oak forests.
Researchers developed a neural implant that monitors brain activity in multiple areas simultaneously. The study reveals two-way communication between the hippocampus and cerebral cortex during learning and memory formation, tied to sharp-wave ripples.
Researchers discovered silicon's strongest nonlinearity, allowing for extremely weak beams to be used in photonic applications. This breakthrough could lead to the production of silicon processors with built-in light beam control capabilities.
Research from University of Gothenburg shows Brexit may change EU cooperation structure, with neighboring countries and similar ideologies taking precedence. After the referendum, member states with similar economic and political systems have stronger partnerships.
The USPSTF reaffirms its recommendation of screening for high blood pressure in adults 18 years or older, highlighting the condition's significant impact on cardiovascular health. Regular screenings are crucial for early detection and effective management of hypertension.
A new genus and species of hadrosaur, Yamatosaurus izanagii, has been identified in Japan, revealing insights into the herbivores' migration from Asia to North America. The discovery also highlights an evolutionary step as dinosaurs transitioned from bipedalism to quadrupedalism.
Researchers made a precise measurement of the lead nucleus's neutron skin, revealing it's thicker than expected. This thickness has implications for the physical processes in neutron stars and their size.
Engineers can now determine material properties like stress and strain from images of their internal structure, reducing computational complexity. The AI-powered approach uses computer vision and machine learning to generate estimates in real-time.
A new protein, AIF3, is produced in the brain after a stroke and triggers cell death, providing a potential therapeutic target for preventing or delaying neurodegenerative diseases. Defective splicing of AIF leads to its production, causing mitochondrial dysfunction and cell death.
A new study resolves the horned crocodile's evolutionary relationships, placing it on a separate branch of the crocodile family tree. The research suggests that modern crocodiles likely originated in Africa, contradicting previous scientific thinking.
Researchers found that sanguinarine, a natural compound, reduces cell viability and growth in triple-negative breast cancer cells. The treatment activated different genes in cells from African American ancestry, suggesting potential therapeutic benefits for this population.
Researchers in China have created a highly efficient desalination device powered by solar energy that can remove salt from seawater, producing freshwater. The device uses a titanium-containing layer and special paper to absorb sunlight and condense water vapor.
Researchers develop new technique to hyperpolarize and purify fumarate for MRI, offering cost-effective and convenient way to track metabolism in real-time. The method has potential applications in monitoring tumor responses to therapy and imaging acute kidney injuries.
Laura Miettinen's research highlights the importance of self-reflection and collective discussions in developing music teachers' intercultural competence. Her study recommends strengthening music teacher education programmes to foster critical thinking and collaboration among educators.
The International Culture Collection of Vesicular Arbuscular Mycorrhizal Fungi will be relocated to the University of Kansas due to a grant from the National Science Foundation. WVU researchers will duplicate the collection and send it to Jim Bever at KU for cultivation, with the goal of sustaining cultures in perpetuity.
Researchers at Argonne National Laboratory have created a new 2D superconductor that forms at the interface of an oxide insulator, enabling high-temperature superconductivity and raising fundamental questions about its properties. The discovery could lead to breakthroughs in quantum information processing and quantum sensing.
African mangrove populations exhibit high genetic diversity, with distinct populations separated by ocean currents and facilitated by connectivity. The study highlights the importance of conservation efforts to protect these ecosystems and their unique biodiversity.
Researchers at RMIT University have developed a new bioreactor technology to create artificial super stool for treating chronic gut infections. The innovation aims to overcome the limitations of donor-derived faecal microbiota transplantation (FMT), an established life-saving therapy.
A new study predicts that ignoring climate change will lead to life-threatening heatwaves in the region, with temperatures reaching up to 56 degrees Celsius and affecting 600 million people. The research team recommends immediate climate change mitigation measures to avoid such extreme events.
A new stem cell therapy strategy has shown promising results in treating intestinal bowel disease in premature infants. The treatment uses human placental-derived stem cells to repair damage caused by the disease and promote healing of the intestinal barrier.
Researchers investigate renin-angiotensin system genes in brain region associated with traumatic memory processing, potentially leading to improved fear memory and reduced CVD risk. Current treatment options for PTSD are limited, but this study offers new insights into therapeutic targets.
Researchers at NIST and VCU have developed a new approach to building better 'nanopore' biosensors by measuring the energy required for molecules to interact with these sensors. This laser-based heating method enables faster and more accurate measurements, potentially revolutionizing disease detection and treatment.
Researchers analyzed COVID-19 vaccination data and found no significant association between mRNA vaccines and facial paralysis. The study suggests that compared to other viral vaccines, mRNA COVID-19 vaccines do not display a signal of facial paralysis.
A study tracking young people from Switzerland found that those who experienced bullying or aggression had a marked increase in violent fantasies. The likelihood of these thoughts increased with the number of forms of mistreatment, with boys more prone to violent thinking overall.
Researchers at HI-SEAS analog lunar habitat in Hawaii use spacesuits to explore lava tubes, mimicking conditions on the moon and Mars. The study aims to improve methods and suits for future astrobiology research.
Researchers developed a non-intrusive Bio-Monitor shirt to track astronauts' health during spaceflight, providing continuous measurements of heart rate, breathing rate, and physical activity. The study found significant reductions in physical activity during spaceflight, highlighting the potential for early warning systems.
Researchers have found a link between certain blood types and increased risk of diseases such as kidney stones, pregnancy-induced hypertension, and bleeding conditions. A study scanning health data on over five million people revealed new connections and confirmed previously reported associations.
A new approach to solving multiagent decision making problems using agent-by-agent optimization leads to reduced computational complexity, performing at par with standard rollout algorithms. The result is a dramatic reduction in computation cost with linear growth in computation with the number of agents.
Researchers found elevated levels of specific biomarkers in COVID-19 patients, particularly those with comorbidities like high blood pressure and diabetes. These findings suggest that non-invasive urine analysis could predict which individuals are at risk of developing severe disease.
Researchers developed a link discovery method using terahertz radiation, enabling the detection of non-line-of-sight (NLOS) paths in wireless communications. The study reveals that transmitters with strong angular dispersion can exploit NLOS links to provide faster connectivity.
Researchers at the University of South Australia have designed a dragonfly-inspired drone that boasts superior aerodynamic performance. The drone's unique body shape and long abdomen mimic those of the insect, allowing it to hover, cruise, and perform aerobatics with ease.