Triple-negative breast cancer often responds well to treatment, but 'persister' cells can reform a tumour, leading to relapse. A shared transcriptional programme determines which genes are active or not, with the FOSL1 protein playing a central role in resistance.
A research team has identified a molecule that can prevent the onset of peripheral neuropathies caused by chemotherapy, which are common and persistent neurological complications. The molecule promotes cellular energy production and nerve cell resilience, reducing painful symptoms without affecting cancer treatment.
Scientists have discovered how to generate an electron gas by illuminating a material made of layers of oxides, enabling light-controlled electronic components. This breakthrough could lead to applications in spintronics and quantum computing, with potential energy savings of up to a third of electrical contacts on computer processors.
The M-Cube associated research laboratory combines micron-level visualization tools with precise mineralogical and geochemical analyses to identify new avenues for optimizing the mining cycle. The collaboration aims to reduce the environmental impact of uranium mining sites and better understand the mobility of radioactive descendants.
Researchers uncover pierced shells and pigments from Châtelperronian period, indicating a genuine workshop for jewellery manufacture. The findings suggest long-distance trade networks or significant human mobility, shedding new light on cultural variability of the time.
Research confirms bidirectional relationship between long COVID and menstrual disorders, with symptoms intensifying during perimenstrual phases. The study suggests an inflammatory reaction as the underlying cause, paving the way for new therapeutic prospects tailored to women.
A study by the CNRS-led research team highlights the key role of Tat, a viral protein that blocks autophagy, promoting Mycobacterium tuberculosis survival and multiplication. Restoring autophagy mechanism could lead to innovative therapeutic strategies for better protection against tuberculosis in HIV-positive patients.
Researchers found that human selection and environmental changes led to a synchronous evolution of domestic and wild animal body sizes over the past 7,000 years. However, in recent centuries, human impact has intensified, causing wild species to shrink while domestic animals have grown larger.
Scientists have designed a nanobody made from llama antibodies to activate a glutamate receptor involved in neural activity, improving cognitive function in mouse models of schizophrenia. Peripheral administration has shown promise as a new therapeutic strategy for treating the condition.
Researchers found that agro-pastoral activities increased soil erosion rates 4-10 times faster than natural formation over 3,800 years. The study reveals the degradation of high-altitude soil first, followed by medium- and low-altitude soils with agricultural development.
Astrocytes, long-neglected brain cells, are found to modulate behavioral flexibility and whole-body metabolism in mice with obesity. Researchers from CNRS and Université Paris Cité discovered that manipulating astrocytes in vivo can correct cognitive changes and influence metabolism.
Researchers analyzed data from 253 primate populations to quantify male-female dominance. They found diverse power relations across species, contradicting previous assumptions about male dominance.
The Vera C. Rubin Observatory has unveiled the first images of the sky obtained with its LSST camera, a 3200-megapixel resolution car-sized camera that can photograph 45 times the area of the full moon in just three nights. The high-definition images will provide unprecedented views of the southern sky and reveal faintest and furthest-...
The James Webb Space Telescope has captured the direct image of a previously unknown exoplanet, TWA 7 b, located within a disk of rocky debris and dust. The exoplanet is ten times lighter than previously captured ones and more similar to Earth than gas giants.
The new Jean Zay supercomputer in France has increased its AI dedicated resources fourfold to 125.9 petaflops, offering free access for thousands of research projects and start-ups. The upgraded machine is expected to accelerate French and European power in artificial intelligence.
Scientists develop a new class of small molecules that activate ferroptosis, a process triggering cell death in cancer cells with high metastatic potential. These molecules show promise in treating breast, pancreatic, and sarcoma cancers resistant to standard chemotherapy.
A new recycling process for silicones has been developed, reducing environmental impacts by bringing materials back to an earlier state. The chemical recycling method gives direct access to high-quality silicone materials without loss of properties, making it a game-changer for the sector.
Researchers at CNRS have discovered that chemical intermediates of the citric acid cycle can form spontaneously in interstellar ice. This finding suggests that the raw materials necessary for life could be present in space and potentially delivered to Earth.
A French study found that chronic exposure to the fungicide tebuconazole impairs offspring growth and survival in farmland birds. Sparrow chicks exposed to realistic concentrations of tebuconazole showed reduced growth and doubled mortality rates, particularly females.
Researchers have detected unprecedentedly large organic molecules on Mars, containing up to 12 consecutive carbon atoms. These findings provide valuable insights into the planet's potential for life and pave the way for future interplanetary science missions.
Researchers developed a predictive model showing peat bogs can offset 14% of future CO2 emissions through microalgae's photosynthesis. Peatlands store over 30% of the Earth's soil carbon, estimated to be between 500-1000 gigatons.
Researchers from CNRS found that applying a mixture of sunscreen and insect repellent simultaneously decreases UV protection. The study used skin biopsies and computer tool analysis to measure the stress response of skin cells to radiation.
Research teams at Alcal'Hylab joint laboratory are working on designing next-generation materials for boosting green hydrogen production, combining the benefits of alkaline water electrolysis and polymer membrane technology. The goal is to produce ultra-pure gas with high yield while minimizing carbon footprint and pollutants.
The CNRS is one of six French actors to be honoured with Clarivate's prestigious Top 100 Global Innovators list for its role as a key global actor in innovation. The institute has demonstrated consistent excellence in patenting inventions, technology transfer, and international impact.
Researchers discovered 27 standardized bone tools over 1.5 million years old in Tanzania's Olduvai Gorge, pushing back known standardization by 500,000 years. The discovery suggests an early ability for planning and knowledge transmission among ancient populations.
The detection of a single muon from a cosmic neutrino interacting with the ARCA detector provides compelling evidence for the origin of the event. The ultra-high-energy neutrino has an estimated energy of 220 PeV, opening a new observational window on the Universe and expanding our understanding of high-energy phenomena.
Researchers discovered that diatoms possess phytochromes, which enable them to detect changes in the underwater light spectrum and sense their vertical position. This adaptation allows microalgae to adjust their biological activity in response to seasonal changes.
The researchers have revealed the precise positioning of RNA molecules and their interactions with the protective coat. This breakthrough enables the design of new drug molecules capable of binding to the protein coat, weakening viral RNA and inhibiting influenza virus replication.
The H.E.S.S. collaboration has detected the most energetic cosmic-ray electrons and positrons ever observed, with energies up to 40 TeV. This discovery provides new insights into the origin of these particles, suggesting they originate from a few sources in our solar system's vicinity.
The new QDlight laboratory aims to develop emitters and protocols for generating new quantum states of light, creating a fault-tolerant photonic quantum computer. The collaboration combines academic and technological expertise to overcome scientific obstacles in quantum photonics.
Scientists analyzed chlorine isotopes in salt extracted from the Mediterranean seabed to identify two phases of the Messinian Salinity Crisis. The event resulted in a massive loss of up to 70% of the sea's water volume over a short period, triggering volcanic eruptions and global climatic effects.
An international team has identified the sources of 70% of all known meteorite falls, revealing that 37% come from the Massalia family. The discovery was made possible by a telescopic survey and computer simulations of asteroid families' composition and evolution.
Researchers from CNRS and Paris Institute of Planetary Physics developed an innovative imaging method to probe volcano internal structure. The study revealed a large magma storage zone beneath La Soufriere volcano, providing greater anticipation for volcanic eruptions.
A recent study published in Science Advances found that the most threatened reef fishes receive less attention from scientists and the public due to commercial value vs. ecological importance. Small fish families like blennies and gobies are underrepresented despite their crucial role in trophodynamics.
Scientists have discovered a new defense mechanism in bacteria that uses cell-to-cell communication to 'warn' unaffected bacteria about potential threats, allowing them to shield themselves and spread the warning signal. This mechanism has been found to be effective against various antibiotics and toxins.
A research team led by a CNRS scientist has observed that gut cells play a role in the regeneration of intestine and other tissues like muscle and epidermis. The study found that gut cell plasticity varies according to their location, with those closer to the posterior end rebuilding more diverse cell types.
A study published in Ecology Letters found that humans have a greater impact on alien species diversity than geographic variables on most islands. Human factors such as colonisation pressure, habitat modification, and connectivity drive disparities in functional and phylogenetic diversity.
For the first time, a team of French scientists has observed brown dwarfs orbiting very close to bright stars using precise astronomical imaging. The findings provide new insights into the formation of these unusual celestial objects and massive exoplanets.
Researchers studied newborn baboon brain anatomy to predict future gestural communication handedness, finding that nearly 70% developed a right-hand preference. The study suggests a shared evolutionary heritage and potential clinical implications for brain surgery patients.
Researchers found that domestic horses were produced in large numbers around 4200 years ago, marking the start of a new era in human history. This led to unprecedented exchanges and interactions among diverse cultures across Eurasia.
A recent study by CNRS scientists analyzed the world's 100 largest MPAs and found that only a third of them offer real protection on a global scale. The study also reveals that unregulated and unmanaged areas account for a quarter of the surface area, with many MPAs allowing industrial activities incompatible with marine conservation.
Cell contraction, not adhesion, drives human embryo compaction, a crucial step in normal development. Defective contractility prevents implantation and ART success.
Researchers have found that genetic mutations are not essential for cancer onset, and instead, epigenetic dysregulation plays a crucial role. Epigenetic changes can cause gene expression to be altered, leading to tumour formation even after the signal has been restored.
A recent study suggests that the decline in genetic diversity of the Y chromosome between 3,000 and 5,000 years ago was caused by social change, rather than violent conflicts. The researchers analyzed anthropological field data and modeling scenarios to conclude that patrilineal organizations had a significant impact on the Y chromosome.
Researchers have achieved record speeds of up to 900 m/s by moving magnetic skyrmions using electrical currents. This breakthrough offers new prospects for developing higher-performance and less energy-intensive computing devices.
Researchers have identified TL1A, an alarmin molecule, as a key trigger for allergic reactions in respiratory diseases like asthma and rhinitis. The molecule cooperates with interleukin-33 to stimulate immune cells, leading to inflammation and treatment targets are being explored.
A recent study by CNRS scientists shows that zebrafish larvae without functional eyes still maintain synchronized circadian rhythms with light-dark cycles. This finding suggests alternative neural circuits may set the biological clock in some species.
Researchers developed a mathematical model to optimize World-class 400m and 1500m running performances by considering variability of motor control, oxygen consumption, and energy expenditure. The study found that improving aerobic metabolism and maintaining optimal velocity are crucial for achieving top performance.
A study of the Orion Nebula reveals that massive stars play a crucial role in shaping planetary systems. The intense ultraviolet radiation from these stars can either facilitate or hinder planet formation, depending on the mass of the star at the system's center.
Research finds seaports facilitate the spread of MtrBTN2, a rare contagious cancer in mussels, through biofouling. The disease is threatening coastal ecosystems and argues in favor of mitigation policies to stem its spread.