A randomized controlled trial found that filters, coupled with a digital health program, reduced urinary arsenic levels by 47% in households relying on well water. The study, conducted in American Indian communities, also showed significant increases in household use of filtered water for drinking and cooking.
A new study published in Microbiology Spectrum shows that an enzymatic cocktail can effectively kill a variety of mycobacterial species, including those causing tuberculosis. The research delivers the enzymes inside host macrophages where mycobacteria grow, increasing efficacy and reducing toxicities associated with current treatments.
A study published in PLOS ONE found that earlier puberty onset is associated with higher adult cardiometabolic risk and mediates the effects of childhood risk factors. The research suggests targeting puberty onset may improve health outcomes in at-risk girls.
Researchers at SLAC National Accelerator Laboratory propose detecting thermalized dark matter, which builds up on Earth's surface, using quantum sensors. The study suggests that superconducting quantum devices could be redesigned to detect low-energy galactic dark matter particles.
A new LbCas12a variant, ttLbCas12a Ultra, achieved high editing efficiency in Arabidopsis, generating homozygous or biallelic mutants in a single generation. The authors optimized this variant for improved performance.
Researchers at Massachusetts General Hospital successfully repurposed approved drugs to improve drug delivery to tuberculosis bacteria, promoting anti-bacterial host responses and improving health outcomes. The study found that combining bevacizumab and losartan enhanced TB drug delivery and reduced bacterial burden in rabbits with TB.
A large retrospective cohort study found that delirium in hospital patients aged 65+ is associated with a threefold increased risk of dementia. Delirium was linked to a higher risk of death and a tripled risk of dementia diagnosis compared to patients without delirium.
Researchers analyzed well-preserved microbiomes from 4,000-year-old teeth in Ireland, providing a snapshot of oral health in the past. The study found evidence of dysbiosis and an unusual abundance of S. mutans bacteria, suggesting that our ancestors' mouths differed significantly from ours.
A study of 280,783 adults in 55 LMICs found that only 20-30% take medications for hypertension and diabetes. The results highlight inadequate healthcare in these settings.
Researchers developed Umwelt software that allows blind and low-vision users to build customized data representations without an initial visual chart. The system incorporates three modalities: visualization, textual description, and sonification.
A study found open waste burning increases health risks to a remote Arctic community due to high levels of particulate matter (PM2.5) pollution. Continuous air quality monitoring is crucial for protecting public health, particularly in the Arctic region.
A study published in the Journal of the American Heart Association found that neighborhoods with more adversity have up to twice the increased risk of heart disease and stroke. The research highlights the complex interplay between social and environmental factors on health outcomes.
Scientists at Albert Einstein College of Medicine discovered that inflammation in certain neurons is necessary for forming long-lasting memories. The researchers found that DNA damage and repair within these neurons leads to stable memory assemblies, which are clusters of brain cells representing past experiences.
Children with developmental disabilities increased their moderate to vigorous physical activity by 17 minutes per day, while reducing sedentary time by nearly an hour per day through the 'Do As I Do' training intervention. The program also helped build responsibility, independence, and awareness of nonverbal cues.
Caterpillars of the Carolina sphinx moth have an extraordinary ability to instantly change their hemolymph's material properties, turning it into a viscoelastic fluid that helps stop bleeding. This discovery has potential applications for developing new drugs for humans to create fast-working thickeners of human blood.
A recent study by Rice University researchers found that undocumented immigrants and their families experienced significant mental health challenges during the COVID-19 pandemic. The four main stressors identified were anti-immigrant rhetoric, family stressors, economic changes, and limited access to healthcare, which had major negativ...
The report highlights key challenges and priorities in ensuring the NHS vision is realized, including improving workplace conditions, effective people management, and workforce planning. The authors emphasize the importance of operational management and new technologies to support the effective running of the NHS.
A comprehensive analysis of Triassic biostratigraphy, lithostratigraphy, and paleogeography of the Qinghai-Tibetan Plateau reveals a complex tectonic history. The study proposes a 'two continents and one basin' model, suggesting that the Indus-Yarlungzangbo Suture Zone served as a rift axis during Triassic time.
Researchers assessed the feasibility of dual PD-L1/CTLA-4 checkpoint inhibition in Stage II or III hormone receptor-positive, HER2-negative breast cancer. Eight patients received upfront durvalumab and tremelimumab prior to neoadjuvant chemotherapy, showing mixed responses and limited benefit.
A new study compares ancient and modern whole milk powders, revealing surprisingly similar compositions despite advancements in dairy production. The analysis of a 100-year-old Antarctic sample shows that key nutrients and protein structures remain largely unchanged.
Simulations reveal that social media's shadow banning technique can subtly influence user opinions, making its detection challenging. The study highlights the dangers of this tactic for opinion manipulation on social networks.
A new study finds that Europe's forgotten forests have the potential to support high species diversity and resilience to climate change. The Eurasian aspen, a keystone species, is well-suited to thrive in these environments due to its ability to regenerate quickly and colonize new areas.
A team of scientists from MIT's McGovern Institute found that a new brain imaging method, DIANA, generates misleading signals instead of detecting neurons' rapid impulses. The study reveals that the trigger for the stimulator is causing artificial signals, which can disappear with slight variations in the imaging process.
Researchers at Kyoto University have discovered a signal protein called ERK that plays an active role in causing growing lung tissue to curve. This finding reveals a previously unknown regulatory system governing the development of intricate branching patterns in mouse lungs.
Researchers found that neural networks use a similar path to chart their way from ignorance to truth when presented with images, despite varying network designs and training recipes. This commonality holds the potential for developing more efficient image classification algorithms, reducing the computational power required by AI systems.
Researchers have identified a protein, NPEPPS, that enables cisplatin-resistant cancer cells to become responsive to treatment. This discovery could increase patient eligibility and make platinum-based therapies more effective.
A new study from the University of Bath reveals that social media influencers can move away from producing free content by focusing on authenticity, relationality, and quantification. The research found that building meaningful connections with followers and using data to assess impact are crucial for commercial success.
A study found that emotional reactions to climate change influence policy preferences. Guilt and anger are linked to support for personally costly policies, while hope and sadness back proactive approaches. Fear is associated with support for regulatory policies across the board.
New research from Cedars-Sinai found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) used to treat diabetes and obesity increase the risk of aspiration pneumonia following endoscopy. The study recommends patients taking these medications stop their medication in advance of procedures to avoid complications.
Researchers tracked 50 pregnant Angus and Hereford beef cows fitted with GPS collars to understand individual grazing patterns. They found consistent and distinct patterns across the two years, even when water sources changed, suggesting that recognizing personality types can benefit both animal health and environmental conditions.
Scientists unveil strong and organized magnetic fields near Sagittarius A* black hole, strikingly similar to M87*, suggesting common traits among all black holes. The discovery hints at a hidden jet in Sgr A* and reveals the importance of magnetic fields in black hole interactions.
A study predicts that climate change will lead to a major species turnover in North American cities by the end of the century. Cities with cooler and wetter climates are expected to gain new species, while warmer cities may lose many species.
The completed sugarcane genome sequence offers new opportunities for breeding programs worldwide, addressing stagnant sugar yields. The high-quality genome data will improve understanding of complex traits like yield and disease resistance.
Researchers at McGill University have discovered a faster and safer method to test the movement of new drugs within the body. This approach accelerates the drug development process while reducing its risks.
Researchers found that parents with high chemical intolerance scores were 5.7 times more likely to report a child with autism, highlighting the potential preventive role of avoiding toxic exposures. The study also suggests that reducing exposure prior to and during pregnancy could help prevention.
Researchers have developed a new strategy to combat cancer by activating oncogenic signaling in cancer cells, leading to their exhaustion. The approach has shown promising results in animal studies, with minimal side effects.
Researchers from KIST have found that nitrate enhances the natural purification of groundwater through the formation of new iron oxides, increasing removal efficiency and duration. This breakthrough is expected to revolutionize water quality management strategies for ASR systems.
A new study led by Dr. Mareike Albert identified epiregulin as a growth factor involved in brain expansion in humans, but not in mice or other primates. The findings were made using 3D cell culture technology and brain organoids.
Australian researchers have helped develop new global anaemia guidelines that could change the diagnosis and treatment of the condition for millions of people. The revised guidelines provide a clear set of haemoglobin thresholds that can be uniformly used to diagnose and treat anaemia, reducing unnecessary costs and pain.
A new study found that people experiencing homelessness have a higher prevalence of dementia, especially in younger age groups. The researchers suggest that unhoused individuals should be screened for dementia at younger ages due to the complexity of diagnosing the condition in this population.
A new study reveals the Antarctic Circumpolar Current's speedup is linked to Earth's temperature, slowing down during cold times and speeding up in warm ones. This suggests that today's speedup will continue as human-induced warming proceeds, potentially leading to ice loss and sea-level rise.
Research finds that watersheds in arid zones are more sensitive to underlying characteristics and less sensitive to climate variation, leading to a decline in water yield stability. This study provides insights for sustainable water resources development under climate change.
Scientists have uncovered a crucial step in the wound healing process that is disabled in diseases like diabetes and ageing, promoting tissue repair and regeneration. The discovery highlights the importance of sensory neurons in orchestrating the repair and regeneration of tissues.
The Antarctic Circumpolar Current's flow speed has fluctuated significantly over the past 5.3 million years, with slower speeds during glacial periods and faster speeds during interglacials. This study provides valuable insights into the current's response to climate fluctuations and its impact on Antarctica's ice sheets.
The grey seal population is facing new challenges due to climate change and a shortage of prey fish. Hunting quotas of up to 3,000 animals per year may threaten the species' survival if not reduced.
A new study aims to understand how family dogs influence children's physical activity levels, with researchers exploring ways to promote healthy habits in young people. The study found that about 20% of daily physical activity comes from time spent with the dog.
A French study found prolonged use of certain progestogen hormone drugs is associated with an increased risk of developing intracranial meningioma. Medrogestone and medroxyprogesterone acetate were linked to a significant increase in risk, particularly among women using these medications for extended periods.
Researchers developed an app to detect mild cognitive impairment, a potential indicator of Alzheimer's disease. The study used data from 199 older adults and found that the app detected MCI with high accuracy, comparable to in-clinic assessments.
Researchers developed a method using lipid nanoparticles to activate T cells and deliver genetic instructions in one step, simplifying the CAR T cell manufacturing process. This new approach reduces production time from 48 hours to 24 hours and increases accessibility to patients worldwide.
Researchers reconstructed spatiotemporal variations of rainy season precipitation on the Tibetan Plateau, identifying four distinct patterns and linking them to Westerly winds and monsoons. The study provides natural background support for understanding the coupling between these factors.
New research reveals that naked mole-rats have genetic adaptations allowing them to survive in low-oxygen environments and avoid heart damage. Their distinct cardiometabolic profile helps prevent cardiovascular events.
Researchers have discovered that high-latitude long-period oscillations play a crucial role in limiting the Sun's pole-to-equator differential rotation. The temperature difference between the poles and equator is found to be less than seven degrees, controlling the angular momentum balance in the Sun.
Exosomes have emerged as potential treatments for liver fibrosis by targeting specific non-parenchymal cells involved in the disease process. They can deliver therapeutic cargo directly to these cells, inhibiting inflammation and scar formation.
Researchers identified Slc43a2+ T cell subsets that expanded in both spleen and brain after virus infection, suggesting a homologous origin. Single-cell transcriptomic analysis revealed these cells matured and migrated from the spleen to trigger an immune response in the brain.
Researchers have recovered ancient microbiomes from 4,000-year-old teeth in Ireland, revealing major changes in oral microenvironments. The study identified bacteria linked to gum disease and provided the first high-quality ancient genome of Streptococcus mutans, a major culprit behind tooth decay.
Researchers at Stockholm University discovered that sleep affects how old one feels, with insufficient sleep adding 0.23 years to age perception. A study found that restricting sleep for two nights increased participants' perceived age by an average of 4.4 years, highlighting the importance of safeguarding sleep for a youthful feeling.
Researchers created a model to predict extinction likelihood based on human hunting and environmental pressures. The model accounted for interactions between humans, animals, and their environment, considering factors like climate change and life history traits.
Researchers analyze data from another series of observations to study Sgr A*, finding that strong and ordered magnetic fields are critical to how black holes interact with gas and matter around them. The discovery enhances theoretical models and simulations, refining our understanding of black hole dynamics near the event horizon.
Researchers have developed a visible-light mode-locked femtosecond fiber oscillator and amplifier, emitting red light at 635 nm. The device achieves a pulse duration of 199 fs and an average output power over 1 W.
Researchers have developed two innovative methods for mass-producing metalenses, reducing production costs by up to 1,000 times. The team achieved successful creation of large-scale infrared metalenses with high resolution and exceptional light-collecting capabilities.