Aging reprograms skin genetic activity by increasing inflammatory gene expression in the epidermis, leading to a loss of skin function. This mechanism is mediated by the collaboration of two proteins, BMAL1 and YAP, which normally maintain skin homeostasis.
A Drosophila study shows that macrophages detect nutritional stress caused by high-sugar diets and send a signal to the endocrine system to delay development. This delay helps buffer the impact of the diet on growth, allowing organisms to reach adulthood in better condition.
MD4SB integrates molecular dynamics tools into three European Research Infrastructures, enabling researchers to share and reuse data, and accelerate drug discovery. The project also involves pharmaceutical companies like Almirall and Sanofi.
A study by IRB Barcelona and BSC suggests that the origin of complex cells was a longer, more gradual process than previously thought. The researchers identified signals from bacterial groups and giant viruses that may have facilitated gene exchange, contributing to the complexity of eukaryotic cells.
Research in flies shows that tumor cells with chromosomal instability can become senescent and release signals altering neighboring tissue behavior. This process promotes tumor growth by inducing the death of nearby healthy cells.
Researchers at IRB Barcelona used AI to design new chemical entities that selectively target specific cell types, demonstrating superior activity compared to conventional screening strategies. The methodology, called phenotypic discovery, uses observable responses in cells rather than a specific molecular target.
Researchers discovered that degrading mutant KRAS protein leads to greater lung cancer regression and more durable antitumor responses than conventional inhibitors. The study also identifies resistance mechanisms distinct from those previously described, offering new insights into targeted protein degradation therapies.
The MAF Test predicts breast cancer prognosis and helps identify patients who may benefit from treatment. In South Korea, the test could improve survival rates for approximately 34,000 newly diagnosed breast cancer patients each year.
HelixAI develops AI-driven platform for researchers and clinicians to integrate complex biomedical data, improving diagnosis and prognosis. It also launches Helix for Longevity, a consumer-facing application estimating biological age and providing personalized recommendations for health promotion.
Scientists discover that tRNA gene mutations can alter the reading of the genetic code, leading to increased protein synthesis errors. This phenomenon is linked to aging and cellular decline, with potential implications for neurodegenerative diseases like Alzheimer's.
A study by IRB Barcelona researchers sheds light on the regulation of protein production in fatty liver cells, revealing a key role for CPEB4 in controlling gene expression. The findings provide new perspectives on the disease and its progression towards more severe forms.
The European project CGI-Clinics brings AI-powered Cancer Genome Interpreter (CGI) closer to clinical applications, enabling reliable and scalable tumour genome interpretation in precision oncology. The platform leverages machine learning to transform complex genomic data into actionable insights.
A study led by Dr. Marco Milán identified mitochondria as a key player in a rare disease causing microcephaly, a condition where the brain develops to a smaller size. The researchers found that mitochondria dysfunction leads to proteotoxic stress, causing cells to accumulate errors in chromosome distribution, resulting in microcephaly.
A study published in Science Advances reveals a mechanism to bind to intrinsically disordered proteins, providing a new approach for therapeutic design. The research, led by Dr. Xavier Salvatella, shows that these proteins adopt more organized conformations when clustering, allowing for selective binding by a drug.
A new study provides a long-sought structural explanation for how Vibrio cholerae colonizes the human gut and produces the cholera toxin. The research reveals that ToxR and TcpP stabilize a specific part of the RNA polymerase directly onto DNA, achieving virulence gene activation without reshaping the transcription machinery.
A study reveals how colorectal tumors use TGF-β to prevent immune cells from reaching and attacking the tumor. The researchers suggest strategies to improve immunotherapy efficacy by blocking this dual barrier and identifying new therapeutic targets.
Researchers found that smoking and biological sex shape how normal cells evolve in healthy bladder tissue, with certain mutations gaining an advantage to expand into clones. This study offers new insights into cancer risk and prevention by providing a way to understand tissue evolution and identify early warning signs.
IRB Barcelona researchers discovered a new strategy to combat obesity by activating brown fat, boosting energy expenditure and improving metabolic health. The approach, driven by Neuritin 1 protein, increased energy burning without affecting food intake or physical activity.
Researchers identified key factors behind a successful immunotherapy response in a young patient with rhabdoid tumour. The study highlights the potential of sequencing technologies to track immune cell profiles and develops personalized cell therapies.
A team at IRB Barcelona developed a tool to generate customized aneuploidies, precisely labeling cells carrying these abnormalities in living tissue. This allows for real-time observation of cell behavior, revealing the presence of haploinsufficient genes and their removal through cell competition.
DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy, pinpointing mutational escape routes that let cancers resist treatment. The framework reveals which genes may ignite resistance to anticancer drugs, suggesting a core circuitry boosting strategy.
A centralized and accessible database aims to integrate molecular simulation data, ensuring findability, accessibility, interoperability, and reusability. This will amplify the impact of these data and avoid duplication.
The conference gathered international researchers to discuss AI's role in drug discovery and development, including generative AI strategies for designing chemical compounds. The speakers emphasized the significance of personalized medicine, where therapies will be tailored to each patient's unique molecular profile.
Researchers discovered that Wingless triggers cellular reorganization and contraction of tissue to form constrictions in the fly intestine. This finding expands our understanding of Wingless signalling pathway and its role in morphogenesis and organ development.
A new study has identified two cell types with distinct biological properties that respond differently to treatment after acquiring the same mutation. Understanding these differences is crucial for developing personalized therapies and preventing aggressive forms of cancer.
A team of scientists has uncovered the role of mitochondrial proteins in driving autophagy, a process crucial for maintaining cellular balance and energy production. By regulating this process, researchers hope to develop new strategies for treating metabolic diseases such as obesity and diabetes.
Researchers have discovered a key strategy through which persister cells evade the immune response and resist cancer treatments. Inhibiting an epigenetic mechanism could unlock inflammatory genes and compromise persister cell viability.
A study by IRB Barcelona has identified a molecular mechanism underlying idiopathic autism, linking the lack of a specific neuronal microexon to decreased gene expression crucial for neuronal development. The discovery reveals how CPEB4 condensates regulate gene expression and highlights potential therapeutic approaches.
Dr. Direna Alonso-Curbelo's ERC Consolidator Grant project, IGNITE, aims to unravel the complex interplay between genetic and non-genetic factors that ignite tumor development. The research focuses on understanding how inflammation drives pancreatic cancer initiation and progression.
The EMA's orphan designation for G2B-002 marks a significant milestone in the fight against pediatric brain tumors. The innovative product leverages Gate2Brain's proprietary technology to enhance drug delivery across the blood-brain barrier, promising enhanced effectiveness and safety for complex cancer treatments.
The conference explores molecular determinants of cancer therapy resistance, a major challenge in the fight against cancer. Researchers discuss new therapeutic approaches and address resistance mechanisms involving tumour cells and the tumour microenvironment.
Researchers have made a breakthrough in understanding how cells generate microtubules, the scaffold structures that help maintain cell shape and facilitate division. The study found that CDK5RAP2 activates the γ-tubulin ring complex, enabling efficient microtubule nucleation.
A team of scientists developed an advanced computational technique to predict gene architecture through nucleosome position, combining experimental approaches with machine learning techniques. The study demonstrates that nucleosomal architecture is greatly influenced by DNA sequence information and physical signals.
A study by IRB Barcelona researchers has identified five independent factors that determine patients' response and survival after receiving checkpoint inhibitors, a type of immunotherapy. These findings provide a framework for current and future biomarkers of immunotherapy response and could lead to more accurate patient classification.
Scientists at IRB Barcelona have discovered a link between gene copy number alterations and mutations in tumour suppressor genes, which could lead to new cancer treatments. The study found that both increases and decreases in the number of gene copies can drive cancer evolution.
Researchers have discovered that synchronization between the central circadian clock and peripheral clocks in muscle and skin is crucial for maintaining tissue function and preventing degenerative processes associated with aging. Time-restricted feeding can partially replace the central clock and enhance the autonomy of the muscle cloc...
A study reveals that increased levels of TP53INP2 correlate with greater muscular strength and healthier ageing in humans. Boosting this protein's presence improves muscle mass and function, suggesting a potential strategy to combat sarcopenia.
A recent study reveals the 3D structure of Asc1, a protein gate that controls amino acid transport in neurons. The findings provide crucial information to develop new drugs for neurological disorders such as schizophrenia, stroke, and ALS.
Researchers at IRB Barcelona have identified 'coldspots' in the cancer genome with lower mutation rates, linked to low DNA methylation. This discovery could facilitate targeted therapies and diagnostic tools to monitor specific genomic regions and prevent cancer development.
A study by IRB Barcelona and Sant Joan de Déu Hospital reveals three distinct patterns explaining the occurrence of second cancers in children, including a mutational footprint from chemotherapy. The research advances understanding of pediatric cancer and highlights the importance of clinical data sharing.
A recent study has identified a promising solution to combat resistance to protein degraders, which are a novel approach in drug discovery. The researchers found that the drug RBS-10 selectively removes resistant cells by targeting the enzyme NQO1, which is overexpressed in these cells.
Senescent tumour cells generated by chemotherapy can create an environment that helps tumour cells escape treatment. Eliminating these cells with immunotherapy boosts the effectiveness of chemotherapy.
Researchers identified hundreds of genes subject to recent selection in six Candida species, providing valuable knowledge for developing better treatments. The study also found a potential spread of resistance through mating between susceptible and resistant strains.
Researchers analyzed genome sequences from over 4,000 tumours to identify patterns of DNA mutations that vary between individuals. They found 13 distinct patterns, with 10 corresponding to different types of tissue, and discovered that the density of mutations in specific genes varies significantly between individuals.
Researchers at IRB Barcelona developed BioExcel-CV19, a repository of Molecular Dynamics simulations to understand SARS-CoV-2 infection. The database provides over 10,000 trajectories for key proteins and facilitates community-wide analysis.
A team of researchers has discovered a new inactive form of the p38a protein, which is regulated by the cellular redox state. This finding opens up new avenues for developing therapeutic compounds that modulate the activity of p38a more precisely.
Researchers at IRB Barcelona discover iron accumulation as a driver of pathological senescence and fibrosis, highlighting its role in various fibrotic disorders. The study identifies potential methods for non-invasive assessment and treatment of fibrotic diseases via MRI and chemical compounds.
Researchers have discovered a new approach to targeting transcription factors in prostate cancer by exploiting the formation of protein droplets. This process can be used to inhibit androgen receptor activity, which is essential for the growth and survival of cancer cells.
Researchers at IRB Barcelona found that vitamin B12 is essential for cellular reprogramming and tissue repair, improving reprogramming efficiency. The study also shows promise for treating ulcerative colitis by supplementing with vitamin B12.
Researchers at IRB Barcelona have identified the mechanism by which the MAF protein promotes breast cancer metastasis, revealing a key interaction with the estrogen receptor. This finding opens up new therapeutic options for patients with high MAF levels, who may benefit from treatments aimed at preventing metastases.