Climate-vulnerable countries face a dual challenge of maintaining sustainable public debt while investing in climate resilience. Jamaica's experience with Hurricane Melissa reveals a self-reinforcing cycle where disasters force underprepared countries to take on additional debt, diverting resources away from future resilience measures.
A wirelessly powered implant uses electrocatalysis to remove excess glucose from the bloodstream, offering a drug-free approach to managing diabesity. In a proof-of-concept study, obese mice with type 2 diabetes experienced weight loss and improved blood glucose levels without adverse effects.
A new AI system, DxO, has been developed to guide diagnostic reasoning and improve diagnostic accuracy while reducing testing costs. The system achieved accuracies of 79.6% to 84.5% and average costs ranging from $1,303 to $8,945 per case, outperforming participating human doctors.
Research suggests combining artistic experiences with conservation science can deepen understanding of biodiversity and correct misconceptions about threatened species. Poetry can evoke empathy, wonder, grief, and a sense of responsibility, motivating people to care and take action in conservation efforts.
The 2026 survey ranked the top 20 biotech, biopharma, and pharma employers, with Ionis Pharmaceuticals receiving the top honor. The survey, conducted by The Brighton Consulting Group, analyzed responses from over 5,100 employees from North America, Europe, Asia, and other locations.
Female Anopheles mosquitoes employ a 5-step process to bite humans, combining chemical sensing and biomechanical coordination. They bite faster and hunt for blood vessels more quickly than yellow fever-carrying Aedes aegypti mosquitoes, resulting in potentially painful bites.
A new digital twin model suggests that two out of nine FDA-approved drugs have the potential to slow preterm labor. The model, called Simulated Immunome Modeling of Clinical Outcomes (SIMCO), evaluates the impact of eight drugs on immune cell activity in pregnant and non-pregnant individuals.
Research suggests that reduced brain beta wave activity may be a neural marker for schizophrenia, correlating with speech distortion and clinical severity. The study monitored brain activity in patients and controls, finding that beta-band dynamics may signal a potential for targeted interventions.
Researchers have developed a device called Scentronic, which can detect and transmit scents across distances using artificial intelligence and machine learning. The device has the potential to improve nutritional outcomes for patients with sensory challenges and enhance food quality for astronauts and warfighters.
A new analysis of clinical trial data highlights the delicate balance between preventing graft-versus-host disease and infections in stem cell transplant recipients. The study found that two immune-suppression treatments, cyclophosphamide and tacrolimus, have different effects on T cell immunity and the risk of complications. This rese...
Researchers have created a new antifungal drug, mandimycin M16, which selectively targets fungal ergosterol without disrupting human cholesterol. This breakthrough could lead to safer and more effective treatments for fungal infections, including multidrug-resistant strains.
A new imaging agent JAS239 enables pinpointed removal of lung cancer tumors with near-infrared fluorescent imaging. The agent selectively binds to lung cancer cells and successfully accumulates in excised human lung tumors.
Researchers have developed an optogenetic switch to control G protein signaling in excitable cells, providing a potential therapeutic tool to restore cellular excitability and alleviate symptoms of mood disorders and epilepsy. The system uses light-activated GPCRs to activate GIRK channels, suppressing cellular activity and offering ne...
A recent study suggests that brain blood vessels shape fine motor control in the cerebellum, a crucial structure for motor movements. Researchers found that a specific enzyme, PRMT5, in blood vessel cells regulates neural circuits in the cerebellum, which can impact motor coordination.
Tall ice cliffs in Antarctica and Greenland calve more quickly than thought, with the likelihood of catastrophic ice retreat being limited by gradual changes in ice thickness. Researchers found that cliffs in areas with rapidly flowing glaciers tend to be taller and more prone to calving.
Researchers analyzed 17 years of GPS and acceleration data from 850 animals to find that atmospheric conditions play a crucial role in reducing energy costs of flight, with soaring birds experiencing minimal energy expenditure. The study challenges traditional views on flight energetic costs, suggesting that atmospheric conditions shou...
Researchers introduced RFdiffusion3, a generative AI system that designs proteins and nucleic acids at the atomic level, enabling precise control over molecular interactions. The tool outperforms previous approaches in designing protein structures and organizing catalytic sites, producing functional enzymes from scratch.
Emerging market dilution theory proposes AI-generated content could undermine entire markets for human-created works, but experts argue it oversimplifies human-AI creativity relationships. The authors suggest clarification through collaboration, data, and surveys to evaluate AI's impact on creative markets.
Researchers have discovered that brief physical contact between healthy and bleached corals can restore symbiotic algae, allowing for faster recovery times. This process occurs via tissue fusion and is successful only for corals from the same genetic background.
A comprehensive study of 18,476 Chinese participants reveals 'clocks' of human aging that can predict chronic disease and mortality. The research provides clinically relevant metrics for health monitoring and disease prevention, shedding light on aging's impact on metabolism.
Researchers developed an mRNA antibody therapy that can neutralize SARS-CoV-2 and evade its escape mechanisms. The therapy, which combines structural engineering and mRNA technology, shows promise in protecting against emerging variants, including the XBB.1.5 and JN.1 variants.
The fight against antimicrobial resistance is threatened by drug-resistant tuberculosis, highlighting the need for preventative frameworks and holistic control measures. New AI technologies and strategies are being developed to tackle the threat, including the use of genomic surveillance and streamlined clinical trial designs.
A new small molecule therapy targets the brain's microglia cells to protect neurons, reducing markers of neuronal damage and inflammatory signaling. The therapy, VG-3927, is well-tolerated and penetrates the central nervous system, reducing levels of a marker of TREM2 in patients with Alzheimer's disease.
A new study analyzing over 2,300 burials in ancient China finds that social-relational networks shaped inequality long before the rise of states. These networks controlled access to labor, resources, and symbolic capital, producing unequal social-relational networks that predated state formation.
Co-exposure to heatwaves and landscape fire smoke has increased globally, affecting 55.9% of the global population between 2000 and 2019. The top 5 countries with highest annual averages of co-exposure were the Democratic Republic of the Congo, Indonesia, Mexico, Brazil, and the Russian Federation.
The discovery at Shég' Xdaltth'i' provides evidence for a trans-Beringian cultural link between Alaska and other western sites, dating back 13,800 years. The site's tools and artifacts, including hafted-biface forms and pre-Clovis material, suggest a connection between Beringian and Paleoindian cultures.
Researchers found that breast milk antibodies can neutralize multiple respiratory viruses, including influenza, RSV, and adenovirus, in mouse models. The study suggests that these antibodies could be used to prevent seasonal influenza and pandemic responses.
A new study of nearly 900 dogs found that larger and male dogs undergo accelerated molecular aging, with pronounced DNA methylation on the X chromosome and at transposable elements. This accelerated aging is reflected in shorter lifespans, with smaller breeds living nearly twice as long as larger breeds.
A new study found that the gut microbiome, influenced by diet, plays a key role in shaping vaccine side effects, including fever and inflammation. The study suggests that targeting the microbiome could reduce vaccine-related inflammation without compromising immune protection.
Researchers developed AlphaProof Nexus, an AI framework that autonomously tackles select math problems, seeking proofs and verifying solutions. The system solved dozens of open problems across various fields, demonstrating AI's potential for automated mathematical discovery and research.
Restricting phone use in class improves academic performance, especially among lower-performing students, with minimal impact on higher-performing students. Removing phones also reduces disparities in GPA, indicating a potential way to close learning gaps.
Longevity products claiming to prevent or reverse aging face difficulties in establishing effectiveness and safety, with the FDA suggesting enforcement and rigorous evidence is needed. The public demands industry to welcome such enforcement, emphasizing the importance of robust testing and regulation.
New research detects rapid true polar wander (TPW) in ancient sea-level changes, challenging previous views of its significance. The study reveals four intervals with significant TPW signals, including the mid-Cretaceous and Late Jurassic–Early Cretaceous periods.
Researchers are closing the gaps in women's health by studying pain disorders, menopause, and immune system roles in pregnancy. Studies have highlighted the need for precision-medicine approaches to address persistent health disparities among women.
A new study found that dogs, like humans, rely more on consonants than vowels when parsing speech. This bias emerges in dogs with both early and later exposure to human speech, suggesting that statistical learning and not domestication is key. Dogs can detect changes in individual sounds and extract words from continuous human speech, ...
The American Association for the Advancement of Science (AAAS) has partnered with Consensus to index and run AI analysis across its six Science family journals. This partnership aims to make high-quality scientific research more visible and useful to researchers while preserving a clear path to the original source.
The Virtual Biotech multi-agent AI platform retrieves and analyzes diverse biomedical and clinical evidence to support early-stage drug development decisions. This platform has shown promising results in increasing the success rate of drug candidates, with 48% more likely to reach the market and 32% fewer adverse events.
A new study found that a rare inherited genetic mutation, EGFR T790M, significantly increases lung cancer risk among non-smokers, 62 times higher than average. The mutation is most common in the Southern Appalachian region of the US, where it arrived with British and Irish settlers during the colonial era.
A new study reveals that North Korea's underground nuclear tests at Mt. Mantap have triggered persistent and organized seismic activity via fault reactivation. The explosions have the potential to reactivate seismically quiet faults and produce earthquakes that may be difficult to distinguish from naturally occurring tectonic activity.
A new AI model called RADAR demonstrates substantial performance in abdominal CT diagnosis, outperforming existing systems across various diseases and clinical settings. The model achieves high accuracy in diverse patient cohorts, clinical settings, and imaging protocols, showcasing its potential for an expert-level generalist system i...
Researchers call for stronger implementation science in global education to close the gap between research discoveries and real-world practice. A four-stage framework is proposed to turn educational research into effective, equitable practice at scale, emphasizing testing across diverse populations and settings.
Researchers found that chemotherapy drugs like cisplatin and carboplatin can leave characteristic mutations in healthy liver tissue of children, potentially increasing the risk of future cancers. The study used advanced sequencing technology to detect mutations in non-cancerous tissues from pediatric cancer patients.
Ancient DNA analysis reveals genetic diversity in woolly rhinoceros fossils from mid-latitude Eurasia, contradicting the traditional Siberian origins theory. The study shows that the species' greatest genetic diversity arose in East Asia, while the Altai region served as a refugium and dispersal hub.
Rivers worldwide deliver nearly 263,000 tons of microplastics to the ocean annually, with 96% coming from the Global South. Heavy rainfall events can increase microplastic transport, particularly in regions with high plastic use and poor waste management, posing a climate-sensitive pollution threat.
Researchers found that psilocybin durably prevented chemotherapy-induced peripheral neuropathy in mice, preserving nerve function and tumor-killing effects. The study's findings have potential disease-modifying approaches to chronic pain and may reframe CIPN as a failure of resilience that can be addressed with early intervention.
Climate warming causes mountain plants to shift their ranges, leading to increased local extinctions among specialized high-elevation species. Declines in plant abundance often precede local extinctions, suggesting shrinking plant cover as an early warning sign.
An eight-year study of 335 women reveals individual molecular trajectories of aging diverge from population-wide patterns, influenced by genetics and environmental exposures. The study found over 5,000 genes and 181 metabolites changed over time, including those associated with age-related diseases.
A climate coalition adopting carbon pricing for heavy industries could reduce global greenhouse-gas emissions by 1.5% while generating $200 billion in annual revenue. The approach also limits carbon leakage and builds on existing policies, offering a practical pathway to overcome international climate-policy coordination problems.
The 2026 vehicle emissions standard rollback is founded on faulty assumptions, according to a recent study. The analysis hinges on incorrect valuation of fuel savings, which results in billions of dollars in benefits being removed from vehicle emissions standards. A new framework for translating consumer behavior into cost-benefit anal...
Researchers found that 92% of magnitude-3-or-greater injection-induced earthquakes were preceded by detectable foreshocks. Foreshock productivity and patterns reflect the interplay between fluid injection, seismogenic index, and fault stress state.