Researchers found that mice genetically engineered to have dementia symptoms who received BCG vaccine showed reduced neurofibrillary tangles, sustained immune cell activation, and memory loss compared to untreated mice. BCG vaccination was also linked to reduced inflammation and improved cognitive function in the mice.
Researchers at Johns Hopkins Medicine report a 96% survival rate among children with severe aplastic anemia treated with half-matched bone marrow transplants from family donors. The approach expands access to potentially curative treatment, with patients experiencing strong engraftment and durable survival rates.
A Johns Hopkins Medicine-led team will build an artificial intelligence model to identify protein misfolding for earlier disease detection and treatment. The goal is to generate tools and resources for clinicians and researchers to diagnose and intervene at earlier stages of neurodegenerative conditions.
Johns Hopkins Medicine researchers have found a promising biological marker linked to treatment-resistant psychosis, a protein associated with blood pressure regulation. The study suggests that lower levels of angiotensin-converting enzyme (ACE) protein in the blood may reflect what is happening in the brain, potentially leading to mor...
A recent study from Johns Hopkins Medicine reveals that the liver and brain contribute to differing symptoms of the same rare inherited disorder. Researchers found that loss of ALDH7A1 in liver cells led to increased seizure susceptibility, while loss in astrocytes caused psychiatric symptoms. Sulforaphane reversed psychiatric symptoms...
Researchers developed a rapid urine test to detect invasive aspergillosis, with high sensitivity and specificity rates. The test was cleared by the FDA and has shown promise in identifying cases among patients with weakened immune systems.
Researchers at Johns Hopkins Medicine have identified a distinct type of prostate cell concentrated in the transition zone of the prostate, where benign prostatic hyperplasia (BPH) commonly develops. The WIF1-positive basal cells may contribute to prostate enlargement and establish the unique biological environment of the transition zone.
Chronic exposure to cigarette smoke reprograms lung stem cells, making them vulnerable to specific cancer-causing gene alterations. Researchers found that cigarette smoke altered both epigenetic programming and gene expression in lung stem cells, creating distinct precancerous cell states.
A decade-long study by Johns Hopkins Medicine researchers found that adults with sickle cell retinopathy who actively smoked were almost three times more likely to experience worsening of the eye condition. Smoking cessation is identified as a potential way to prevent vision loss.
Researchers at Johns Hopkins University School of Medicine identified a metabolic weak point in exhausted immune cells in head and neck cancer. The study found that blocking this weak point in laboratory experiments reactivates the cells, suggesting a potential target for future treatment.
Physicians from Johns Hopkins Medicine are using their network and foundation to bring aid to children in Nepal and Tibet affected by flooding. The relief fundraiser aims to provide medical supplies, blankets, and other essential items to families whose homes and schools were washed away.
A nationwide safety program significantly reduced hospital-onset MRSA infections by 65% in participating US hospitals. The program implemented evidence-based infection prevention strategies, including hand hygiene, environmental cleaning, and device-associated infection prevention, and engaged front-line workers across disciplines.
A 12-week study found that time-restricted eating resulted in modest weight loss (median 2.7%) and improved eating habits in adults with obesity and prediabetes. The study also showed no significant differences in inflammation markers and appetite hormones between the time-restricted eating and usual eating pattern groups.
Researchers at Johns Hopkins Medicine have developed a new approach to brain imaging that enables continuous monitoring of brain activity and disease progression for over 24 hours in freely moving mouse models. The cloud-based miniaturized microscope, CloudScope, allows scientists to access live imaging data remotely, providing a more ...
Researchers found no association between strength training and increased risks of ventricular arrhythmia for people with arrhythmogenic cardiomyopathy. A retrospective review of 355 participants showed that endurance exercise was associated with a higher risk of ventricular arrhythmia compared to strength training.
The study found that patients taking anifrolumab had lower rates of infections requiring hospitalization compared to those on conventional immunosuppressants. Anifrolumab also reduced the need for systemic antibiotics and increased the likelihood of viral infections, offering distinct benefits over conventional treatments.
A new study suggests a simple urine test could improve kidney transplant decisions by using donor urinary biomarkers, increasing accuracy and availability of transplanted kidneys. The study found that combining these biomarkers with the widely used Kidney Donor Profile Index significantly improves prediction of transplant success.
Researchers develop technology to capture 3D molecular snapshots of hair follicles and reconstruct time to visualize organ formation. By analyzing hair follicle development, scientists may gain insights into congenital conditions and develop new treatments for hair loss.
Scientists from Johns Hopkins Medicine report that an experimental mRNA platform, N4-acetylcytidine (ac4C), causes cells to produce more therapeutic proteins to fight disease than the industry standard mRNA platform. This may eventually lead to more efficient drugs that require smaller doses.
Researchers found that adding a metabolite of vitamin B2 to bacteria in lung tumors increases the expression of a protein on immune cells, activating them to attack cancer. This discovery opens a new field of immunotherapy, targeting a previously underutilized immune cell type.
A new study published in JAMA Network Open suggests that decision support guidelines can safely reduce unnecessary endotracheal aspirate culture testing for children with respiratory complications. The study, funded by the NIH and AHRQ, found a 16% decline in EAC culture testing among patients without signs of respiratory tract infection.
A new treatment framework for hepatocellular carcinoma (HCC) has been developed by a team of Johns Hopkins liver cancer experts, which provides guidance on best treatments based on tumor burden and biology. The BEACON-HCC framework incorporates emerging therapies such as external beam radiation therapy and novel combination therapies.
Researchers at Johns Hopkins Medicine have discovered that inhibiting sensory neurons with a nerve blocker can reduce abnormal bone growth in cartilage after childhood bone injuries, potentially improving recovery. The study found that the treatment reduced unwanted bone growth by up to 60% in mice.
A blood test that detects circulating tumor DNA can predict whether patients with advanced non-small cell lung cancer are benefiting from immunotherapy. The test was found to be accurate in predicting therapy response and can provide clinically meaningful information weeks before conventional imaging.
Researchers validated an AI-powered blood test that detected liver cancer in people from Guatemala and Romania with high accuracy, revealing new biological signals. The study builds on earlier research using a liquid biopsy platform and demonstrates the approach's effectiveness across different patient populations.
An observational study found that early remdesivir treatment reduced the risk of all-cause graft loss and cardiovascular events in adult kidney transplant recipients with COVID-19. The study included 432 participants, with 177 receiving at least three days of remdesivir therapy.
Researchers have identified a genetic driver of primary idiopathic hyperhidrosis, a chronic condition causing excessive sweating. The discovery suggests that the disorder can originate in the nervous system and may be treatable with targeted therapies.
A large retrospective study found that semaglutide and other GLP-1 drugs did not increase or decrease the risk of developing a blinding eye condition in adults with type 2 diabetes. The study analyzed data from over 200,000 patients and found no significant difference in the risk of neovascular age-related macular degeneration.
Researchers developed a KRAS-targeted vaccine and found it generated significant immune responses in participants with a hereditary predisposition to pancreatic cancer. The vaccine was safe and produced memory T cells that persisted over time.
A Johns Hopkins Medicine team created a computational model to forecast which patients with hepatocellular carcinoma (HCC) will benefit from combination treatment using immunotherapy and targeted therapy. The spatial QSP modeling platform accurately predicted response rates for virtual patients, demonstrating its potential to inform pe...
Researchers at Johns Hopkins Medicine have found a potential therapeutic target that can improve the potency of decitabine, a chemotherapy commonly used to treat bone marrow disorders and acute myeloid leukemia. By blocking DCTPP1's function with newly identified inhibitors, cancer cells become more susceptible to decitabine's ability ...
A new machine learning version of the Martin-Hopkins equation accurately assesses LDL cholesterol risk with minimal difference to the original, making it accessible to all laboratories. The simplified code enables clinicians and patients to make better decisions about starting treatments that prevent heart attacks and strokes.
A multicenter study has provided new evidence on the effectiveness of combined exercise and nutrition interventions in critically ill patients. Researchers found that such interventions did not improve outcomes compared to usual ICU care, but generated valuable insights for refining future rehabilitation and nutrition strategies.
A new clinical trial has reported improved survival rates for babies born with a life-threatening fetal disorder called anhydramnios. The treatment involved repeated injections of amniotic fluid into the womb, followed by kidney replacement therapy after birth. Results show that some infants have survived and thrived into toddlerhood.
A new division at the James Buchanan Brady Urological Institute will support research, education, and care for urological conditions. The gift will accelerate advancements in surgical training, imaging, and technology to improve patient outcomes.
A machine learning model called plasmaCHORD filters out biological noise in liquid biopsy samples, enabling clinicians to better match therapies to their patients' tumors. The model has been shown to improve the ability to distinguish tumor from white blood cell mutations in approximately 83% of cases.
A new study from Johns Hopkins Medicine found that an AI-assisted diagnostic tool increased referrals for African American patients with diabetes, resulting in more people receiving necessary eye exams. The study suggests that integrating such tools could help address healthcare disparities in underserved populations.
A study found that most persistent viral detection despite effective therapy is due to defective, non-infectious virus copies. The 5'-leader region of the virus is responsible for producing infectious particles, but defects in this area prevent the generation of functional viruses.
A multicenter clinical trial found that adding aglatimagene besadenovec to standard radiation therapy improved disease-free survival for intermediate- and high-risk localized prostate cancer patients. The treatment reduced the risk of recurrence by 27% compared to the placebo group.
Researchers used magnetic particle imaging to track cell therapy injections in mice, finding that it can visualize therapeutic cells as they inject them. The technique shows promise for developing more effective treatments for certain cancers, autoimmune diseases like MS, and neurological conditions.
Researchers found that hydroxychloroquine use was associated with better cardiovascular and cardiometabolic health outcomes in patients with discoid lupus erythematosus. The study also found a lower risk of hypertension, hyperlipidemia, type 2 diabetes, stroke, and coronary artery disease among hydroxychloroquine users.
A new federally funded study using mice reveals that some epigenetic marks can be inherited in ways that break the rules of inheritance explored by Gregor Mendel's work. The study also found new examples of inheritance patterns that defy Mendel's law, including a naturally occurring paramutation.
Researchers found that mice fed high-fat diets during pregnancy developed more severe symptoms of necrotizing enterocolitis and had poorly developed intestines. The study suggests a link between maternal obesity and diabetes, as well as maternal diet, to the development of this deadly condition in preterm babies.
Researchers at Johns Hopkins Kimmel Cancer Center identified the missing link in how a common gut bacterium, B. fragilis, triggers colon cancer. The team found that BFT toxin binds to host receptor claudin-4 before causing damage, revealing a potential strategy for preventing colon damage and cancer.
Researchers identify genetic syndrome where unusually long telomeres predispose individuals to lymphoma and other cancers. Inherited loss-of-function mutations in the POT1 gene disrupt normal aging of lymphocytes, allowing cancer-associated changes to accumulate over time.
Researchers at Johns Hopkins Kimmel Cancer Center have achieved a 95% cure rate for sickle cell disease using a reduced-intensity bone marrow transplant regimen, preserving fertility in most patients. The study reports low rejection rates and durable engraftment with minimal immunosuppression.
A new study published in JAMA Network Open found that combining cannabis edibles and alcohol worsens driving impairment compared to consuming either substance alone. The research highlights the urgent need for wider public education about augmented effects from co-use and improved roadside detection methods.
Researchers found that blocking energy production pathways can slow tumor growth in group 3 medulloblastoma, an often-fatal form of pediatric brain cancer. An experimental therapy targeting energy metabolism has shown promise in reducing tumor growth in mice.
Johns Hopkins researchers have identified a club cell-specific role for the protein RhoA in asthma airway inflammation. The study demonstrates how RhoA can be selectively targeted to prevent asthma-related complications, and offers new details on a potential cell-specific therapeutic target.
Researchers at Johns Hopkins Medicine have made progress in transplanting retinal ganglion cells to restore vision in people with optic nerve damage. By disrupting the internal limiting membrane, a thin layer of tissue that blocks the growth and survival of transplanted nerve cells, scientists have seen improved transplantation surviva...