A new study found that nearly half of patients discharged with take-home methadone successfully connected to treatment within 72 hours. The likelihood of successful follow-up increased if patients were already enrolled in an OTP or received higher methadone doses.
Researchers discovered a connection between sugar metabolism and alcohol addiction, identifying ketohexokinase (KHK) as a key enzyme involved in the process. Blocking KHK showed reduced alcohol consumption and liver damage in mice, suggesting a potential new treatment for both conditions.
Researchers at CU Anschutz discovered a genetic program within lymphatic endothelial cells that enables storage and archival of antigens, helping the immune system remember infections. This understanding could lead to improved vaccines and therapies by fine-tuning immune memory.
Researchers mapped physiological differences in individuals with Down syndrome across the lifespan, identifying unique effects of trisomy 21 on childhood, adolescence, and adulthood. The study highlights the need for personalized medicine tailored to different life stages.
A new clinical trial found that feeding blueberries to infants as their first solid food can reduce allergy symptoms and support long-term health. The study suggests early introduction of blueberries may improve infants' immune systems and gut health.
A new study found that caffeine can damage red blood cells during storage and reduce their effectiveness after transfusion, especially in individuals with certain genetic variations. The research suggests a personalized approach to blood transfusion based on lifestyle factors and genetic traits.
A study published in Annals of Translational Medicine found that intense light therapy can lower troponin levels and increase ANGPTL4 protein, protecting heart tissue. The treatment may reduce the risk of myocardial injuries after non-cardiac surgery, which affects 20% of patients and increases one-year mortality rates.
A new study from the University of Colorado Anschutz Medical Campus introduces a more individualized approach to restarting methadone treatment for people with opioid use disorder. The findings suggest that tailoring methadone doses to each patient's unique circumstances can improve care without compromising safety.
A nationwide study found that a smartphone-based digital therapy reduced repeated suicide attempts by 58.3% among patients with a prior history of attempting suicide. The app guided users through short lessons focused on managing emotions and building safety plans.
A new study found that most air cleaning technologies have not been tested on humans and their potential risks are not yet fully understood. Researchers recommend choosing technologies independently tested in real-world environments to reduce illness in homes, schools, or workplaces.
A study by the University of Colorado Anschutz Medical Campus found that older adults participate more in social activities after moving into long-term care facilities. However, gaps in access to these opportunities persist, affecting men, nursing home residents from minority groups, and those with lower participation rates before admi...
The EFFECT Trial aims to evaluate the effectiveness of early fibrinogen replacement in trauma patients, with a potential to redefine resuscitation practices and save lives. The trial is a major collaboration between CU Anschutz and Octapharma, enrolling 800 participants across top-tier trauma centers nationwide.
Researchers found that common respiratory infections like COVID-19 and influenza can awaken dormant breast cancer cells in the lungs, leading to a massive expansion of metastatic cells. The study suggests that individuals with a history of cancer may benefit from taking precautions against respiratory viruses.
A new study from the University of Colorado Anschutz Medical Campus shows that free, open-source AI tools can help doctors report medical scans just as well as more expensive commercial systems without compromising patient privacy. The research highlights a promising and cost-effective alternative to widely known tools like ChatGPT.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
Researchers at CU Anschutz Medical Campus have found a new source of patient-specific stem cells by collecting amniotic fluid from vaginal fluid after childbirth. This method allows for expanded and readily available access to these stem cells, which can be used to create functional heart tissue for treating congenital heart defects.
A recent study from the University of Colorado Anschutz Medical Campus has challenged decades-old neuroscience dogma by revealing that dopamine acts with extraordinary precision in the brain. This discovery offers fresh hope for millions living with dopamine-related disorders, highlighting the importance of targeted treatments.
A study published in Science Advances found that repurposing FDA-approved drugs can enhance the safety of nanomedicines by blocking complement activation and minimizing adverse effects. The research identified iptacopan, a drug approved for rare blood disorders, as a promising candidate for improving immune responses to nanoparticles.
A new study reveals that PCOS patients often face dismissal and misunderstanding from the healthcare system. The study found that patients reported feeling ignored or minimized when raising concerns about their symptoms, leading to delays in diagnosis and treatment.
A study by CU Anschutz researchers identifies a protein called granzyme used by the immune system to attack pathogens in early-stage rheumatoid arthritis. The study also detected remnants of Porphyromonas gingivalis, a bacteria that causes gum disease, in joint tissue samples.
A recent study has discovered a connection between brain damage and an increased likelihood of committing crimes. The research, led by Harvard Medical School and the University of Colorado Anschutz Medical Campus, found that damage to the right uncinate fasciculus was linked to criminal behavior.
A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can effectively introduce continuous glucose monitors (CGMs) into their practices. The study found that both self-guided and virtual CGM initiation services were successful, regardless of clinic size or diabetes expertise.
A new study reveals that college football players experience a higher rate of obstructed sleep apnea, often associated with cardiometabolic diseases. Researchers used wearable devices and questionnaires to determine OSA prevalence among 58 CSU football players, finding 35% had clinically defined mild to moderate OSA.
The University of Colorado Anschutz Medical Campus has received a historic $40 million gift to support research into treating and curing serious eye diseases like macular degeneration and glaucoma. The gift will also enable the development of new technologies and recruit top talent.
Researchers validate new at-home cervical cancer screening device, the Teal Wand, as a safe and effective alternative to traditional in-clinic screenings. The device detects precancer 96% of the time, detecting HPV-related cells that may develop into cancer.
A CU Anschutz study identifies a genetic variation in the GLP-1R gene that may explain why some children exposed to gestational diabetes become obese, while others don't. The study found that children with this variation gained weight faster and had higher BMI compared to those without.
The COLD-TUG test measures the time required for prosthetic donning and mobility in lower-limb amputation patients. Researchers found that patients with bone-anchored prostheses can don their prosthesis significantly faster, saving up to 61 seconds per session.
A new study published in Blood Cancer Discovery found that certain gene mutations and the maturity of leukemia cells affect how patients respond to venetoclax and hypomethylating agents. Researchers identified a subtype of acute myeloid leukemia with worse outcomes, particularly those without the NPM1 mutation.
A study found that blood cancer survivors are more likely to face financial hardship and take fewer medications due to high-cost immunotherapy treatments. Financial strain affects both Medicare-insured and uninsured patients, highlighting the need for better financial support and policy strategies.
Researchers found that B cells guide CD8 T cells to mount lasting defenses after vaccination, but their absence weakens immunity. The discovery could lead to new strategies to enhance vaccine effectiveness for those with compromised immune systems.
A retrospective study found that using pilocarpine eye drops post-goniotomy surgery improves surgical success and reduces the need for future medications. The study analyzed 532 procedures and showed significant improvements in clinical outcomes for patients who used pilocarpine drops.
A study found that psilocybin use increased nationwide since 2019, particularly among young adults and older adults with conditions like depression and anxiety. The researchers urge better education, tracking, and health system preparedness as poison center calls rise.
A recent US study found that nearly one in five adults have used multiple drugs in the past year, revealing new patterns in substance use. The study identified four distinct patterns of drug use among prescription, recreational, and illegal users, highlighting the need for tailored prevention and treatment strategies.
A recent study published by CU Center for COMBAT Research investigators found that targeting slightly lower levels of oxygen saturation, from 90-96%, had similar outcomes for adult trauma patients. This approach resulted in fewer days spent on supplemental oxygen and reduced hospital stays.
CU Cancer Center researchers discovered that H3K36 methylation regulates plasticity and regeneration in intestinal cells. The process, identified as a key 'switch', allows intestinal cells to regenerate after injury. This finding may lead to better treatments for colorectal cancer and other intestinal conditions.
A new study from the University of Colorado Anschutz Medical Campus identified significant mitochondrial dysfunction in lymphoblast cell lines from children with Dravet syndrome, a severe form of epilepsy. The findings suggest that mitochondrial defects play a role in the metabolic dysfunction observed in Dravet syndrome.
Fan Zhang's lab uses computational machine learning to analyze large-scale clinical and preclinical single-cell datasets, identifying new markers for prediction. Her team aims to pinpoint changes in the immune system associated with progression from preclinical RA arthritis to symptoms.
Experts propose evidence-based work design to mitigate administrative harms and improve patient safety, quality of care, and workforce well-being. The new framework aims to integrate short-term financial metrics with long-term outcomes, sparking a transformation in organizational decision-making.
Researchers have developed a new method to deliver antibiotics directly into the bladder tissue, eliminating over 90% of bacteria from the bladder. The nanogel-based drug delivery system shows promise in treating UTIs and could potentially lead to an eventual cure.
Researchers have developed a next-generation CAR-T cell therapy called ALA-CART that can enhance the effectiveness and longevity of cancer cells against harder-to-treat cancers. The treatment has shown promising results in fighting acute lymphocytic leukemias resistant to traditional CAR-T cells.
Incarcerated individuals face heightened health risks from wildfires due to poor ventilation, inadequate infrastructure, and pre-existing medical conditions. Climate change is intensifying wildfire conditions worldwide, posing immediate and long-term health impacts on this vulnerable population.
A new study reveals that when macrophages eat bacteria, they don't store them in compartments but convert them into critical nutrients for protein synthesis and energy production. The researchers also found that dead bacteria contain a molecule that signals immune cells to adjust their metabolism and control inflammation.
A new study found that interventions before, during, and after abdominal surgery did not reduce the severity of lung complications in patients compared to usual care. Lung function can make recovery more difficult and increase the risk of serious complications.
Researchers at the University of Colorado Anschutz Medical Campus found that primary care providers trained on advanced insulin technology or through telehealth can deliver similar positive results to specialists. The study focuses on Type 1 diabetes and highlights the potential for broader access to cutting-edge care.
A new study analyzing Long COVID healthcare utilization in Colorado reveals a significant shift from acute care to outpatient services following diagnosis. After diagnosis, hospitalizations decreased by 6.1 percentage points and emergency department visits dropped by 7.7 compared to matched controls.
A recent study published in JAMA Network Open found that heavy cannabis users exhibited reduced brain activity during working memory tasks, associated with worse performance. Abstaining from cannabis before cognitive tasks may help improve performance.
A new study found that Colorado's parental notification law imposes emotional, physical hurdles on adolescents seeking abortion care, delaying access and increasing stress. The law disproportionately affects vulnerable populations, including those with unstable family relationships or histories of trauma.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a promising drug candidate that accelerates the brain's natural repair mechanisms and improves vision-related brain functions. The treatment, LL-341070, enhances myelin repair, which is crucial for preventing vision loss in diseases like MS.
A breakthrough study reveals a critical pathway linking synaptic activity to gene expression changes necessary for learning and memory. Researchers identified the activation of receptors and ion channels generating calcium signals that rapidly communicate from synapses to the nucleus.
Researchers have identified a cognitive profile that can differentiate Dementia with Lewy bodies from Alzheimer's disease at the pre-dementia stage. This allows for more targeted care and symptom management, reducing the risk of misdiagnosis.