Researchers found that nearly 600,000 veterans with extra X or Y chromosomes had similar rates of occurrence to the general population, but white and Asian veterans were disproportionately affected. The study suggests that early identification of these conditions can prevent illnesses associated with Klinefelter and Jacobs syndromes.
Researchers have identified a protein, NPEPPS, that enables cisplatin-resistant cancer cells to become responsive to treatment. This discovery could increase patient eligibility and make platinum-based therapies more effective.
Researchers at the University of Colorado Anschutz Medical Campus have developed three types of drug inhibitors that can help investigate CaMKII's role in brain diseases such as Alzheimer's. These tools provide a detailed first assessment of the protein's functions in any given system, making it accessible to a wide range of scientists.
A new study from the University of Colorado Anschutz Medical Campus suggests that managing circadian rhythms through intense light and chronologically timed therapy can help prevent or treat various circulatory system conditions, including heart disease. The research found that intense light stabilizes the PER2 gene and increases level...
Researchers found that patients recovering from robotic lung surgery do not fully recover even after 90 days, despite common expectations. The study suggests a more thoughtful approach to pre-surgery communication with patients is needed to better understand their recovery experiences.
Researchers have identified how bacteria in the digestive system break down tryptophan into an inflammatory chemical that primes the immune system towards arthritis. A Mediterranean diet rich in plant-based fibers and lean meats may tip the balance towards anti-inflammatory pathways, while a Western diet may exacerbate inflammation.
A study published in the journal Med found that sensory nerves accelerate tumor growth by suppressing specific immune cells within the tumor microenvironment. Blocking nerve activity with FDA-approved drugs like botox or gabapentin can stop cancer progression for about six weeks, and may have synergistic effects with radiation treatment.
Scientists have discovered that inhibiting the Mdm2 protein can prevent the destruction of synapses and dendritic spines in Alzheimer's disease. This breakthrough could lead to a new approach for treating the disease, which may be more effective than current anti-amyloid therapies.
CU Anschutz researchers find specific brain cells in the hippocampus that respond to odors and facilitate rapid go, no-go decisions. The study reveals the involvement of time cells in associative learning and their potential role in memory encoding.
A recent poll found 88% of adults have robust confidence in childhood vaccines. Meanwhile, vaccination coverage for children remains high and stable, with 93% of kindergarten students receiving state-required vaccines. The authors argue that constant focus on vaccine hesitancy can distort reality and drive a false narrative.
Researchers identified kynurenine as a key biomarker affecting RBC storage quality and efficacy. High levels of kynurenine indicate fragile blood, prone to rupture, while lower levels suggest better storage stability.
A study published in ScienceDirect reviews the overlap between cannabis use and psychosis, highlighting the potential risks of cannabis on neurobiology. The study suggests that cannabis can exacerbate psychosis symptoms and impact motivation and attention, but also notes some potential benefits of cannabis use for social functioning.
Pediatric sepsis experts have released new diagnostic criteria that will be used worldwide to diagnose life-threatening infections in children. The updated criteria, known as the Phoenix Criteria, include measures of respiratory, cardiovascular, and coagulation dysfunction.
Researchers found that a team intervention provided by phone leads to persistent improvements in depression, anxiety, and quality of life for people managing chronic illnesses. The program demonstrated early, persistent, and clinically meaningful improvements in adults with COPD, HF, or ILD.
Mobile methadone units show significant impact in expanding opioid treatment access in rural areas, with a 13-point increase in Medication for Opioid Use Disorder (MOUD) treatment rates. Adding units exclusively to rural Louisiana provides nearly 20% of beneficiaries within 24 miles of a provider.
The Colorado Center for Personalized Medicine has hit a major milestone of returning clinical genetic results to over 30,000 patients, making it a leader in providing personalized patient care. The center is also studying pharmacogenomics and providing results to guide drug selection and dosing.
A new study found that older drivers with newly diagnosed migraines are three times more likely to experience a motor vehicle crash, while those with previous diagnoses are not at increased risk. Researchers also explored the relationship between migraine medications and driving habits, but found no significant impact.
Researchers found that less than two percent of patients in Medicaid and commercially insured plans received Z-codes to document Social Determinants of Health. The study highlights the need for improved tracking and documentation of SDOH in healthcare settings, with recommendations for policy changes and provider education.
A study by Sean O’Leary and colleagues found that COVID-19 vaccine hesitancy remained stable in Colorado, but parental trust vacillated during the pandemic. The researchers used a validated survey to track vaccine attitudes of parents, revealing trends indicating that misinformation has affected parental trust in childhood vaccines.
A nationwide study led by University of Colorado cardiologist Larry Allen will examine the effectiveness of electronic tools in improving heart-failure treatment. The five-year study will involve 2,000 patients and aim to address underutilization of treatments for this common chronic disease.
Researchers created a full-thickness, biodegradable patch from tissue-engineered materials that can withstand the intense cardiac environment. The patch has the potential to correct congenital heart defects in infants without requiring invasive surgeries.
Researchers Matthew Sikora and Benjamin Bitler aim to understand the genetic risk factor for ovarian cancer that varies greatly among ethnic communities. The five-year project will focus on a specific genetic variant, rs3820282, which has been linked to various gynecologic diseases.
Researchers at the University of Colorado Anschutz Medical Campus have developed an evidence-based interactive mapping tool to assist policymakers in regulating cannabis products. The tool includes 452 studies on high-concentration THC exposure and health outcomes, providing a public health resource for informed legislation.
Researchers have identified six distinct subgroups of rheumatoid arthritis based on their cellular composition, using a cell atlas encompassing over 300,000 cells. This breakthrough could lead to more effective and personalized treatment plans for patients with the disease.
Research by University of Colorado geriatrician Kenneth Lam found that the average person moving into a nursing home is already severely disabled and receiving 27 hours of care per week. Assisted living residents are less likely to be severely disabled but still receive significant support.
Researchers at CU Anschutz Medical Campus and Johns Hopkins University found that hundreds of ketamine clinics make false or misleading statements about their treatments. The study highlights the need for accurate and balanced information about potential risks and benefits of these therapies, especially given the high financial costs i...
Researchers found that adolescence is characterized by a universal trade-off in energy demands, which leads to reduced physical activity. Energy boosts are needed for growth and sexual maturity, affecting adolescents more significantly than adults.
Researchers identified high levels of silica nanoparticles in kidney tissue of patients with chronic kidney disease. Exposure to sugarcane ash and rice paddies' burning is linked to the disease, suggesting a toxicant released by agricultural activities.
A new electronic health record documentation tool has been shown to improve the accuracy and completeness of clinical documentation for patients undergoing treatment for epilepsy. This tool enables medical providers to identify patients who are failing treatments earlier, allowing for rapid optimization of positive outcomes.
A new study led by Richard Johnson, MD, suggests that fructose is the key driver of obesity, bringing together long-incompatible theories on dietary causes. Fructose lowers active energy in the body, triggering hunger and food intake, and fatty foods become the major source of calories driving weight gain.
Researchers developed a promising strategy to reduce adverse reactions to nanoparticles by using complement inhibitors. The study showed that regulators being studied effectively inhibited complement activation by nanoparticles in human serum in vitro and animal models.
A coaching program created at CU Anschutz has shown significant improvements in burnout outcomes among female medical residents on a national level. The web-based program uses multi-modal interactions to help participants manage professional distress and improve well-being.
A CU School of Medicine research team has identified histone deacetylase 11 (HDAC11) as a potential target for treating obesity and metabolic disease. Inhibiting HDAC11 stimulates the expression of uncoupling protein 1, inducing fat cells to expend energy and potentially overcoming catecholamine resistance.
A new study published in JAMA Network Open suggests that reattribution of pain to mind or brain processes can lead to significant reductions in chronic back pain intensity. Participants who received pain reprocessing therapy reported being pain-free or nearly so after treatment, compared to those receiving placebo controls.
Research found ginger consumption makes neutrophils more resistant to NETosis, a process that contributes to inflammation and autoimmune diseases. Ginger supplementation also boosted chemical levels in neutrophils, inhibiting NETosis in response to disease-relevant stimuli.
The University of Colorado Anschutz Medical Campus has received a $54 million grant from the National Institutes of Health to advance clinical and translational science. The grant will enable the Colorado Clinical and Translational Sciences Institute (CCTSI) to translate discoveries into better health and patient care across the state.
Scientists at CU Anschutz Medical Campus discover that long-term potentiation requires structural functions of CaMKII, not enzymatic actions. This breakthrough opens the door to therapeutic use of inhibitors targeting only CaMKII activity.
Researchers developed a digital biomarker that detects early signs of Alzheimer's disease using EEG headbands, identifying abnormal levels of proteins in sleep patterns. The study found measurable problems with memory reactivation in 205 aging adults, paving the way for affordable devices to monitor brain health.
Researchers found that both dietary weight loss strategies improved the diversity of the gut microbiome. The study suggests that individuals can choose a strategy that works for them, regardless of its impact on their microbiome. Changes in the microbiome may also affect other body functions.
A large study found that fully vaccinated individuals have lower concentrations of inflammatory markers than unvaccinated participants after symptomatic COVID-19 infection. This suggests that vaccination significantly reduces morbidity and mortality by reducing elevated levels of cytokines and chemokines.
A new drug formulation designed for treating children with HIV has shown safety, tolerability, and effectiveness in a study published in The Lancet HIV. The formulation contains three medications and was found to suppress HIV levels below 200 copies/mL in 98% of participants.
Researchers have discovered two major mechanisms that contribute to the high risk of complications from lung infections in individuals with Down syndrome: poor ciliary function, which impairs the respiratory tract's ability to clear mucus and viral particles, and immune hyper-reactivity, which leads to an overactive immune response. Th...
Researchers at CU Anschutz Medical Campus identify fructose as a central conduit to obesity and diseases. Fructose works differently than other nutrients by lowering active energy, stimulating food intake and leading to weight gain.
Researchers analyzed data from 2014-2022 to calculate cumulative incidence rates of mass shooting event types. The study found that social-related mass shootings account for 27% of incidents, while domestic violence-related shootings are underreported, highlighting the need for awareness and support.
Researchers at CU Anschutz Medical Campus discovered a brain protein link to cognitive decline. Altering this CaMKII protein in mice mimicked aging effects on memory and learning.
A large international database analysis found nearly a quarter of esophageal adenocarcinoma patients had normal endoscopies but were still diagnosed within a year. The study suggests using high-quality equipment, rigorous sampling protocols, and future research on biomarker panels to improve screening effectiveness.
Research reveals chronic immune dysregulation in Down syndrome, with high interferon activity linked to autoinflammation and metabolic changes. Repurposing JAK inhibitors shows therapeutic benefits in reducing inflammation without suppressing the immune system.
A CU Anschutz study found that oral consumption of high doses of CBD during pregnancy impaired problem-solving skills in female mice. Fetal exposure to CBD also reduced the excitability of the pre-frontal cortex, a key area for learning.
Researchers have found that PD-L1 triggers signaling that intrinsically alters cancer cell phenotype, impacting immune milieu. The study's findings suggest a new approach to treating patients with limited response to immunotherapy.
Researchers at CU Anschutz Medical Campus have found that vaping nicotine during pregnancy can be detrimental to the baby, disrupting bone and lung development. The study suggests that nicotine in e-cigarettes is just as harmful as that in traditional cigarettes.