Researchers at the University of Bath have created a novel bacterial system to mass-produce cyclic proteins and peptides, addressing a significant bottleneck in the development of new therapeutic treatments. By harnessing the natural cyclization process from the Oldenlandia flower, they improved heat and chemical stability, as well as ...
Researchers at MIT have developed an alternative method to study molecular signals in cells, allowing them to track up to seven different molecules simultaneously. The technique uses fluorescent proteins that flicker on and off at different rates, enabling the tracking of specific cellular functions over time.
Researchers at RCSI University of Medicine and Health Sciences have developed a material that can speed up bone healing while reducing the risk of infections. The implant combines antimicrobial treatment with gene therapies to repair bone and prevent infection.
A Binghamton University professor leads a research team to explore the stability of power grids with inverter-based resources, which have changed the grid's dynamics. The goal is to characterize the stability region without numerical simulation.
A two-year study found that participants who received personalized coaching experienced a modest boost in cognitive testing, measuring a 74% improvement over the non-intervention group. Additionally, improvements were noted between the two groups in measurements of risk factors and quality of life.
A study published in Med suggests that low-dose radiation therapy can improve heart function by reducing inflammatory immune cells and scar tissue in the heart. Researchers found improved pumping capacity and increased survival of mice with heart failure after receiving radiation therapy.
Researchers at Osaka Metropolitan University have successfully developed a novel pneumococcal vaccine that demonstrates efficacy in suppressing pneumococcal pneumonia in macaques. The vaccine's design combines proprietary mucosal vaccine technology with pneumococcal surface proteins to cover a wide range of serotypes.
A study in Belize found that Indigenous farmers' slash-and-burn techniques increased forest plant diversity when used in intermediate-sized farm patches. This contradicts the standard view of slash-and-burn as a cause of deforestation, and highlights the importance of Indigenous knowledge for sustainable agriculture.
A study by CHOP researchers found that seizure patterns and response to treatment can help determine epilepsy trajectories and developmental outcomes for patients with STXBP1-related disorders. The study identified key treatment windows and outcome measures that will inform the interpretation of clinical trial success.
The American Heart Association and Neurocritical Care Society emphasize the need for improved critical care management of patients after cardiac arrest. The consensus statement highlights gaps in knowledge, particularly in areas like neurological, cardiac, and gastrointestinal care.
A study by Peking University found that COVID-19 prevention measures exacerbated social phobia in Chinese college students, with risk factors including lower GPA, bullying experience, and mobile phone dependence. Protective factors included female gender, postgraduate status, and moderate trust in strangers.
A new study from the University of Eastern Finland found that individuals with higher wealth levels had greater hospital care and medication costs before diagnosis. However, after diagnosis, wealth was associated with lower healthcare costs due to differences in comorbidities among different wealth groups.
Researchers from the University of Helsinki found that asteroid Phaethon is composed of olivine, carbonates, iron sulfides, and oxide minerals, matching the spectra of rare CY carbonaceous chondrite meteorites. This discovery explains the formation of gas near the Sun and the subsequent release of dust and gravel into space.
Researchers discovered that impure ice is less sticky than pure ice due to its unique structure and quasi-liquid layer. The study found that slow freezing processes preserve contaminants within the ice, leading to weaker adhesion. This discovery could lead to the design of next-generation winterization techniques.
Researchers characterized nearly 600 microbial genomes, revealing two types of microbes: minimalists and maximalists. Minimalists share resources with friends, while maximalists can produce energy and transform biomolecules, offering insights into life in the Earth's crust and potential on Mars.
Researchers developed an accurate error prediction model and implemented soft-decision decoding to overcome limitations in hard-decision decoding, extending the upper limit of error correction to infinity.
Researchers have combined 14 studies on piglet gut bacteria to uncover common patterns in microbiome development over time. The analysis revealed predictable trajectories and important details at a fine time scale, with an accuracy of 70% in predicting animal age based on microbiomes.
Researchers at Salk Institute uncover a mechanism for repairing damaged nerves during peripheral neuropathy, with protein Mitf playing a key role. The findings have the potential to inspire novel therapeutics that bolster repair function and heal peripheral neuropathy.
Researchers at Nagoya University have discovered a unique healing mechanism in newts that could aid humans in recovering faster from tendon injuries. By understanding how newts regenerate damaged tendons without scar tissue, scientists hope to develop more effective treatments for human athletes.
A new study finds that nearly 1 in 5 US children have inadequate health insurance coverage, with commercially insured children showing higher rates of inadequacy. During the COVID-19 pandemic, there was a significant decrease in insurance gaps and out-of-pocket costs for commercially insured children.
A groundbreaking study analyzed the behavior of atoms in COVID-19 proteins to understand its evolution and spread. The research found critical distinctions in mechanical stability among various virus strains, highlighting how these differences contribute to the virus's aggressiveness.
Researchers will incorporate advanced semiconductor technologies and AI into a millimeter-wave radio system to increase bandwidth while reducing energy consumption. The project aims to save tens to hundreds of terawatt-hours of energy per year, contributing to climate change mitigation.
Health experts argue that Health Canada's secrecy on pesticide data hinders constructive public debates and allows the agrochemical industry to influence policy. The Canadian Medical Association Journal calls for transparency in data about pesticides, citing a need to address potential health risks and ensure safe use of these products.
Researchers at UCSF and Kaiser Permanente Washington found that participants who received personalized coaching experienced a 74% improvement in cognitive testing compared to non-intervention participants. The study also showed improvements in risk factors and quality of life, with modest but significant increases in cognitive function.
Researchers at Kaunas University of Technology develop method to treat cigarette butts using pyrolysis, producing oil, char, and gas with real applications in fertilizers, wastewater treatment, energy storage, and biofuels. The process reduces biodiesel production costs by adding triacetin-rich oil as an additive.
Researchers developed a formula to predict properties of nuclei formed from charged clusters, essential for understanding element formation in stars. The approach simulates low-energy nuclear reactions using numerical lattices and Whittaker functions, enabling accurate calculations.
A team of researchers from Texas A&M University is developing a low-cost, safe, and controlled cancer treatment using programmable bacteria. The $20 million project aims to create an efficient bacterial therapeutic that can target cancer cells with high precision, reducing side effects and costs.
Researchers found that 1,8-cineole inhibits inflammatory pathways in the gut, while ginsenoside Rk2 alleviates liver inflammation and restores intestinal barrier function. Another compound, specnuezhenide, modifies gut microbiota and has potential to inhibit colorectal tumor growth.
A Hamburg collaboration between EMBL Hamburg and TUHH has yielded new insights into a lipid-degrading enzyme from an exotic microbe, which may contribute to the development of more sustainable industrial processes. The findings could help improve chemical processes in various branches of industry.
A Canadian study examines how rapid shift to virtual care during COVID-19 pandemic impacts primary care doctors' well-being. The researchers found that basic psychological need satisfaction at work was associated with higher well-being, while controlled motivation towards using virtual care predicted lower well-being.
A new framework for using AI in healthcare considers medical knowledge, practices, and procedures to improve patient care. The proposed framework provides practical guidance for designers, funders, and users on how to integrate AI systems with the greatest potential to help patients.
The ultra-high resolution NexGen 7T scanner allows neuroscientists to see functional MRI features 0.4 millimeters across, enabling the study of brain circuitry underlying different diseases with higher spatial resolution. This will help track signals propagating through the brain and reveal underlying causes of developmental disorders.
A multi-institutional team led by Columbia Engineering aims to develop AI systems that better communicate with people and react to unforeseen circumstances. They will integrate causal modeling techniques with traditional AI decision-making methods, focusing on real-world applications in public health and robotics.
A novel contamination-detection method enables faster and safer T-cell therapy production, reducing the risk for patients and speeding up treatment. The method uses cutting-edge technology to identify harmful microorganisms within 24 hours.
A recent study found that women-led studies have more female coauthors than men-led studies, closing the gender gap in ice core science. The research also shows that senior women play a crucial role in catalyzing women's participation in publishing.
Researchers found that cat and dog owners with lower mental wellbeing scores were more anxiously attached to their pets, while avoidantly attached owners were associated with poor care and impulsiveness in dogs. The study suggests that understanding the attachment bond between owners and pets can help promote wellbeing for both.
The University of Cincinnati is conducting a clinical trial to test the safety and effectiveness of lattice therapy, a method of delivering radiation that targets specific areas of tumors. The trial aims to enroll 37 adult patients and analyze the underlying biology of tumor and immune responses to lattice therapy radiation.
A new study finds that wind and solar projects can generate millions of dollars by leveraging bitcoin mining during the precommercial phase. The research suggests strategic placement of mining farms to maximize productivity, with Texas emerging as a top state for profitability. The authors recommend policy incentives to encourage envir...
A new study found that frequency and content of clinician-patient breast density discussions varied by women's race, ethnicity, and literacy levels. Women from different racial and ethnic groups reported varying experiences in discussing their breast density with clinicians.
A team of scientists developed a technique to rapidly detect genetic changes in malaria parasites using portable MinION sequencers. They demonstrated the first end-to-end, real-time pathogen monitoring from clinical blood samples in rural, resource-limited malaria hotspots.
Researchers found that honeybees' cluster behavior is a survival strategy against cold temperatures, not insulation. The study suggests that beekeepers should reconsider their hives' design and materials to reduce heat loss.
A team of researchers has introduced a unique method that uses voice data to assist in revealing the covered parts of faces, overcoming challenges to facial recognition systems. Their approach demonstrates significant improvements in recreating critical facial areas like the mouth, nose, and overall face shape.
Researchers created a full-thickness, biodegradable patch from tissue-engineered materials that can withstand the intense cardiac environment. The patch has the potential to correct congenital heart defects in infants without requiring invasive surgeries.
Scientists found that oceanic deoxygenation played a significant role in the Triassic–Jurassic mass extinction, leading to widespread ecosystem disruption and species extinctions. The global extent of deoxygenation was surprisingly similar to today's levels.
A new study from the University of Exeter emphasizes the importance of shared community spaces in addressing gentrification and its effects on rural communities. Dr. Joanie Willett's research found that these spaces can foster relationships, knowledge-sharing, and community action to adapt to changing futures.
Researchers found that a higher ratio of quadriceps to hamstring muscle volume was significantly associated with lower odds of total knee replacement. Training programs that strengthen the quadriceps in relation to the hamstrings may be beneficial for preventing knee replacement surgery.
Researchers at La Jolla Institute for Immunology and Massachusetts General Hospital mapped the genome to understand how IKAROS controls healthy B cell development. They found that IKAROS solves a big problem in B cell development by bringing together far-away genes through looping, leading to proper expression and antibody production.
Researchers assessed Veterans Affairs participants' coping strategies over three timepoints, finding that stable coping styles are associated with lower levels of anxiety and depression. The majority of the sample (71%) changed their coping style at least once during the study period.
Researchers from China University of Petroleum apply terahertz spectroscopy to characterize oil shale's anisotropy, organic distribution, and fingerprint spectrum. The method enables simultaneous characterization of main oil generation zones and natural gas zones.
A study published in the Canadian Medical Association Journal found that about 1 in 10 prescription drugs has a manufacturer-sponsored patient support program. These programs offer financial, nursing, and educational supports to patients, primarily for expensive and rare disease drugs.
Researchers at Duke University have developed a new computational model called Adaptive Physics Refinement (APR) that can simulate the movement of individual cancer cells across long distances within the entire human body. This approach captures detailed cellular interactions and their effects on cellular trajectory, providing valuable...
Amyloids have been found to selectively bind with codon-sized RNA, a crucial step in the emergence of life. These interactions may represent a universal genetic code that unites all living beings, increasing stability and order in an otherwise dilute system.
Dr. Ning Zhang's AntiFake tool uses adversarial techniques to make it difficult for AI tools to read voice recordings, preventing synthesis of deceptive speech. The tool has achieved over 95% protection rate against state-of-the-art speech synthesizers and is accessible to diverse populations.
A study published in Annals of Internal Medicine reveals a stagnation in cardiovascular health trends among middle-aged adults, with low-income individuals facing higher rates of hypertension and other risk factors. The research highlights the need to address social determinants of health contributing to these disparities.
Researchers predict that vampire bats will expand their locations in search of more stable climates, potentially linked to a spillover of rabies. The team's work aims to identify and track the bats by traveling to Colombia to contain the spread.
New research at Aston University found that extra practice in blending printed letter sounds can significantly help struggling beginner readers. The study, led by Dr Laura Shapiro, showed that training on both sounding out letters and blending sounds is most beneficial for phonological awareness.
Mount Sinai researchers have found that testosterone treatment is safer than previously reported, with a smaller degree of change in hematocrit levels. The study, involving over 6,670 transmasculine patients, suggests that providers can feel more comfortable prescribing testosterone as part of gender-affirming hormone therapy.
Biomedical engineers at Duke University created a new 'digital twins' framework using smartwatch data to capture personalized arterial forces over 700,000 heartbeats. This approach reduces the computational load by simulating tasks in parallel, enabling real-time tracking of cardiovascular disease progression and risk assessment.
Research published in BMC Medicine found that greater adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations is associated with a lower risk of all cancers combined and some individual cancers. Adhering to moderate levels of recommendation adherence scores was linked to significan...
A new study published in Gut found that higher HDL-C levels are associated with a reduced risk of gallstone formation, while lower LDL-C levels also show an inverse association. The study suggests that these findings could inform personalized risk assessment strategies and potential therapeutic interventions for cholelithiasis prevention.