Researchers have identified a unique immune checkpoint receptor, KIR3DL3, found primarily in the intestine and lungs, suggesting its potential as a target for immunotherapies. This discovery could lead to new treatments for diseases such as lung and bowel cancer and autoimmune conditions like IBD.
A survey of over 1,200 benzodiazepine users found persistent symptoms months or years after discontinuation, including anxiety, insomnia, memory loss and suicidal thoughts. Long-term use was associated with negative life impacts such as job loss and increased medical costs.
A new study investigates the safety of discontinuing disease-modifying therapies for multiple sclerosis patients over 55, finding low risk of new clinical activity but unclear benefits. The study suggests that some older patients may consider a personal trial of discontinuation due to the low risk of recurrence.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a molecular mechanism contributing to congenital heart defects in infants with Down syndrome. The study found that an abnormal interferon response inhibits key molecular events required for heart development, leading to impaired cardiogenesis.
A team of University of Colorado School of Medicine researchers explores the impact of chatbot avatars on patient experience, trust, and compassion in healthcare. They found that chatbots may reinforce social stereotypes and biases, but also have potential to increase trust among underserved patient groups if designed with respect for ...
A new study published in Nature Genetics examines the relationship between gene expression and ancestry, revealing ancestry-specific patterns of genetic architecture. The research analyzed whole genome and RNA sequencing data from African American and Hispanic/Latino children, exploring ancestry-related differences in gene expression.
Scientists from the University of Colorado School of Medicine have made a significant discovery about the origin of paired appendages, a major evolutionary step that has been debated for over 100 years. The research team found that cells from the lateral plate mesoderm contribute to both heart development and limb formation.
Scientists at CU Anschutz Medical Campus developed a neuroprotective peptide that targets a key protein in the brain, providing significant benefits without lasting harm to memory and learning. The temporary inhibition of CaMKII showed no pre-formed memory erase and prevented brain cell damage even at low doses.
Researchers have found that craniospinal radiation can control metastasis in diffuse midline gliomas, leading to improved treatment options for patients. The study suggests that this approach may lead to long-term survival and potentially curative effects for these children.
A new phenopacket standard and tools enable health professionals to collect and share de-identified patient data across clinics, systems, and countries. This facilitates research into rare diseases, potentially leading to more discoveries and advancements in the medical field.
Researchers at CU Anschutz Medical Campus used metabolomics to study elite cyclists' metabolism during training and racing. The study identified healthy metabolomic signatures that can help detect dysregulations of key areas ahead of time, potentially leading to personalized exercise-as-medicine approaches for preventing chronic diseases.
Cancer caregivers from lower-income households are more likely to experience debt and work loss compared to non-cancer caregivers. This can lead to increased economic burden, stress, and a reduced ability to retire on time.
New research published in the journal SURGERY found that obesity is associated with increased risk of complications following surgery, including infection, blood clots, and kidney complications. Patients with overweight or obesity had higher risk-adjusted odds of developing these post-operative outcomes compared to those of normal weight.
Researchers analyzed outcomes for 144 Colorado patients who had lymph node sampling at the time of surgery for kidney tumors between 2005 and 2019. They found no statistically significant difference in clinically significant complications between patients who underwent more extensive lymph node sampling than those who didn’t.
Researchers at the University of Colorado Cancer Center have made a breakthrough in treating pancreatic cancer by combining radiation and immunotherapy. The treatment eradicates tumors while stopping the cancer from spreading, offering new hope for patients. Clinical trials are planned to further develop this therapy.
Researchers found that checkpoint inhibitors are not effective in treating relapsed aggressive lymphomas after CAR T therapy. The study involved 96 patients from 15 centers and showed only 19% response to checkpoint inhibitor therapy.
Burn-injured patients who use alcohol experience more severe complications, delayed recovery, and increased morbidity and mortality. Researchers found a correlation between inflammation markers and delirium during hospitalization, suggesting impaired cognitive function as a potential issue.
A new model shows that encampment sweeps, bans and move-along-orders contribute to 15-25% increase in deaths among people experiencing homelessness over a 10-year period. Involuntary displacement is linked to increased overdose deaths, hospitalizations, injection-related infections and hindered access to medications.
Scientists at the University of Colorado Anschutz Medical Campus identified protein FAM193A as a key component of a mechanism suppressing tumor growth. The discovery offers new potential for cancer therapies targeting p53, a frequently mutated gene in human cancers.
A study published in Frontiers in Surgery finds that patients with schizophrenia and schizoaffective disorder have lower postsurgical mortality than those with Parkinson's disease, suggesting DBS as an ethical option for treatment-refractory cases. Comprehensive consideration of factors is done on a case-by-case basis for successful DBS.
A new study reveals that only one affordable prenatal supplement meets nutritional guidelines, but its high cost and complex dosing regimen make it inaccessible to many. The study calls for improved nutritional care during pregnancy and more research on nutrient-dense foods.
A new research letter highlights how quickly Colorado's children and teenagers can access a loaded gun, increasing the risk of adolescent suicides and firearm injuries. Nearly one-third of middle and high school students report having access to a gun within 24 hours or under 10 minutes.
Researchers have developed a microfluidic squeezing technology that stimulates anti-tumor activity in a subtype of HPV16-positive head and neck, cervical, and anal cancers. The treatment uses peripheral blood mononuclear cells trained to recognize and attack cancer cells without genetic modifications.
A new dietary approach has been identified to treat eosinophilic esophagitis by eliminating only dairy products, showing similar effectiveness to the standard six-food elimination diet. This breakthrough study led by CU School of Medicine researchers offers a more patient-friendly treatment option with fewer drawbacks.
A study suggests that fructose metabolism in the brain may be driving the development of Alzheimer's disease, an evolutionary survival pathway gone awry. Researchers found that fructose reduces blood flow to areas involved in self-control and memory, leading to progressive brain atrophy and neuron loss.
Researchers at CU Cancer Center have discovered a way to activate the p53 tumor suppressor gene, which can kill cancer cells. By inhibiting two repressors of p53, the Integrated Stress Response is activated, leading to cancer cell death in multiple cancer types.
Researchers from the University of Colorado found that Paxlovid significantly reduced rates of hospitalization and death among non-hospitalized patients infected with recent Omicron subvariants. The study used real-world data from 28,000 patients and suggested a benefit for Paxlovid in preventing severe disease.
A recent gene expression study has discovered 45 novel genes associated with body mass index (BMI), shedding light on the biology of obesity and potential treatments. The research, conducted in a diverse multiethnic cohort, highlights the importance of genetic factors in obesity and opens doors to new biomarkers and therapeutic targets.
Researchers compared two methods of corneal transplant tissue preparation, finding the new DMEK EndoGlide technique to be safe and effective while providing a faster process. The study suggests this method may lead to better long-term outcomes for patients with Fuchs' dystrophy.
Researchers discovered a drug combination that targets immune evasion pathways in MYC amplified Medulloblastoma, a fatal childhood brain cancer. The treatment uses epigenetic drugs to unblock 'don't eat me' pathways and make tumors more appealing to macrophages.
Researchers at the University of Colorado School of Medicine have discovered a new mechanism for slowing scarring of heart tissue, a process known as cardiac fibrosis. The study's findings suggest that inhibiting the degradation of eicosanoids may be a promising approach to preventing or reversing cardiac fibrosis.
A new multidrug treatment combining pembrolizumab and all-trans retinoic acid has proven effective in treating stage IV melanoma, with an overall response rate of 71% and a one-year overall survival rate of 80%. The study's results are promising for patients who have failed traditional immunotherapy.
A new study suggests that olfactory viral inflammation may accelerate the onset of Alzheimer's disease by disrupting connections between the sense of smell and memory centers. Researchers found altered myelination in the olfactory tract, leading to inflammation in the hippocampus, which controls memory and learning.
A nationwide retrospective study showed that adjuvant chemotherapy after neo-adjuvant chemotherapy and surgery significantly improved overall survival in patients with pancreatic adenocarcinoma, regardless of lymph node status or resection margins. The study included nearly 900 patients and was published in JAMA Oncology.
A study published in PLOS ONE found that patients who used virtual reality (VR) during hand surgery required less sedation and had shorter recovery times compared to those who received monitored anesthesia care. VR use also improved patient comfort and reduced anxiety.
The University of Colorado Anschutz Medical Campus and the US Department of Defense have co-hosted a summit on firearm suicide prevention. The CU faculty lead report outlines 10 recommendations to improve evidence-based interventions, including repealing prohibitions on questioning service members about personal firearms and implementi...
A study from the University of Colorado Cancer Center highlights the need for more data on pregnancy and targeted therapy in women with oncogene-driven lung cancer. The authors share their experience with pregnancies and surrogacy, emphasizing the importance of informed decision-making.
Researchers at CU Anschutz Medical Campus have identified a less invasive way to treat HPV-unrelated head and neck squamous cell carcinomas by combining radiation with immunotherapy. The approach resulted in remarkable success rates, including 75% of patients experiencing major pathological responses or complete responses.
Researchers at CU Anschutz Medical Campus found that irradiating only select lymph nodes near a tumor can significantly decrease cancer recurrence and improve patient outcomes. This approach eliminates the source of immune cells for immunotherapy to work on, but preserving long-term systemic immune response.
A new study explores how older adults plan for future changes, such as stopping driving or using firearms. The research found that reducing access to potentially dangerous situations should be prompted by declining ability, not age alone. Trusted messengers like family and clinicians can lead conversations around limiting access, and s...
A University of Colorado study reveals aggressive behavior towards caregivers is a significant issue in Parkinson's disease, with factors including grief, loss of motor symptoms, and cognitive fluctuations identified as contributing to the problem. The research also highlights the impact on caregivers' mental health and relationships.
CU Anschutz researchers found changes in myelination during learning, altering neuronal communication speed. These changes could lead to better treatment for neurological injuries and disorders like multiple sclerosis.
Researchers at CU Anschutz Medical Campus found that administering midazolam increases the risk of myocardial injury in non-cardiac surgery performed at night. The timing of drug administration can affect its efficacy and increase the risk of heart damage, suggesting a need to reevaluate treatment strategies.
A new study from CU Anschutz Medical Campus reveals that shingles can increase the risk of stroke, especially in people under 40, due to prothrombotic and proinflammatory exosomes. The researchers suggest using antiviral agents and anti-inflammatory medications may help mitigate this risk.
A unique bacterium found in the gut microbiome may trigger an autoimmune response that leads to rheumatoid arthritis (RA) in individuals already at risk. The discovery opens up possibilities for targeted therapies and prevention strategies.
A study by CU Anschutz scientists found that overexpressing a gene tied to cell division boosts memory and learning in AD mice. Higher KIF11 levels also correlate with better cognitive performance in adults with amyloid pathology.
A new study in Cell Systems explores the benefits of using multiple data types in drug discovery. Gene expression and cell morphology provide complementary information for drug prioritization, advancing drug discovery, functional genomics, and precision medicine.
Researchers used big datasets to show that annual health care costs were significantly higher among children without allergist care for peanut allergy compared to those who received care. Care from an allergist resulted in lower total health care costs, saving $1,923 per child.
Research found that blood transfusions following solid tumor removal in pediatric oncology patients are associated with higher rates of post-surgery infectious complications, shorter disease-free intervals, and tumor recurrence. The study aims to inform thoughtful use of blood transfusion and encourage multi-center data collection.
The toolkit provides step-by-step guidance on finding and publicizing firearm storage locations, as well as sample storage agreements. Eight states already have partial maps available online, with Colorado and Washington leading the way.