A team of Cornell scientists discovered that certain genes have their transcription regulatory factors already in place, but in a latent state. This 'poised' state allows these genes to rapidly respond to environmental changes, like the presence of bread sugars.
Researchers from Tokyo University of Science developed a flexible flow sensor that can measure shear stress and flow angle on curved surfaces. The sensor demonstrated effectiveness in measuring airflow speeds up to 170 m/s and has potential applications in industrial-scale fluid machinery.
An AI-based model has been developed to assist radiologists in detecting and identifying leadless implanted electronic devices (LLIEDs) on chest X-ray images. The model achieved high detection and classification accuracy, even with suboptimal image quality, and showed promise for real-world deployment.
Researchers identify CCIN mutation as cause of teratozoospermia and male infertility, revealing crucial role in sperm head shaping. The findings provide insights into the genetic basis of the condition and potential treatment options.
A new study reveals that mammal diversity declined over time, with faster evolutionary rates among social, aquatic, and herbivorous species. Using skull shapes of 322 living and extinct mammals, researchers found that the rate of change tapered off after a peak around the Cretaceous-Paleogene extinction.
Researchers from Australian National University confirmed the existence of a large core at Mars' center, measuring approximately 3,620 kilometers in diameter. This discovery sheds light on the Red Planet's magnetic field and its significance for sustaining life.
A new small-molecule compound regulates serotonergic neurons and has been shown to have a fast-acting antidepressant effect in mice. The findings provide a promising avenue for developing new therapeutics for MDD and other difficult-to-treat mood disorders.
The CABI-led study provides a comprehensive review of the devastating fall armyworm (Spodoptera frugiperda), highlighting its serious impact on maize and other cereal crops in Africa and parts of Asia and Australasia. The research offers recommendations for research to enhance sustainable management of FAW in invaded regions.
A 460km-long river under the Antarctic ice sheet affects the flow and melting of ice, potentially accelerating ice loss. The discovery reveals more active water flow than previously thought, which could make it more susceptible to changes in climate.
The Annenberg Science and Public Health Knowledge Monitor assesses public knowledge on climate, maternal health, vaccination, and more. The quarterly survey reports aim to highlight strengths and weaknesses in public knowledge and inform public health strategies.
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
Scientists discovered the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE). The study suggests a therapeutic strategy for the disease, which currently lacks treatment.
Researchers have successfully treated six children with relapsed and treatment-resistant B-ALL using CRISPR-edited T cells, achieving deep remission in four patients. The treatment has shown promise as a viable alternative to currently available treatments.
A collaborative effort aims to lower rates of obesity and diabetes by increasing access to locally produced fruits and vegetables in the Mississippi Delta. The $6.6 million NIH grant will fund community-based programs to expand local production and consumption of healthy foods, targeting high-risk areas with high rates of these diseases.
Researchers discovered a specific population of brainstem neurons controlling sickness behaviors in mice, including reduced eating and movement. Inhibiting these neurons blunted the effects of inflammation on behavior, highlighting the link between the immune system and neural pathways regulating behavior.
Enzymatic reactions induce phase separation and autoregulation of enzyme activity, creating dynamic environments for cellular processes. This novel mechanism provides an alternative to traditional understanding of cellular organelle function.
A new study from the University of Missouri School of Medicine found that short-term exposure to reduced physical activity and increased sugar consumption disrupts insulin response in blood vessels, with men more prone to vascular insulin resistance. In contrast, young women are protected against this condition.
A new study in Nature provides high-resolution structures showing how two key biochemical states of actin work jointly with bending forces to determine how actin can interact with other proteins. The research reveals a model of protein regulation that involves biochemical states and force working in concert.
A new exercise-testing approach detects asymptomatic cardiovascular abnormalities in pediatric cancer survivors, highlighting the need for routine monitoring before symptoms appear. The method assesses exercise data through a combination of peak and submaximal parameters simultaneously.
A team of researchers identified the precise mechanism of nuclear envelope repair, finding that lamin C, BAF, and cGAS work together to facilitate rapid repair. The study provides insights into rare genetic disorders such as laminopathies and has potential applications for understanding and treating related diseases.
A novel synthetic energy system supports yeast cell growth and produces highly reduced chemicals, achieving high yields of biofuels. The system's reductive metabolism enables efficient energy production, overcoming stoichiometric constraints and outperforming natural metabolic processes.
A team of researchers at the University of Tokyo has discovered a new mechanism to stabilize lithium metal electrodes and electrolytes, leading to enhanced energy density. By introducing a compound called ferrocene into specific electrolyte systems, they achieved high Coulombic efficiency, a critical factor in battery cycle life.
Researchers found that 90% of surveyed individuals did not recognize six out of seven endangered species. Increasing public knowledge and recognition can boost conservation support for these vulnerable animals. The study highlights the need for targeted marketing initiatives to change people's perception of lesser-known species.
A global study found that high and moderate alcohol consumption is associated with increased odds of stroke, while low-level drinking has no link. The INTERSTROKE research involved almost 26,000 people worldwide and explored the role of alcohol intake in stroke risk, revealing complex associations with socioeconomic factors.
Advanced nanoparticles carrying a bacterially derived compound target the STING pathway, disrupting blood vessels and stimulating an immune response. This approach suppresses tumor growth and metastasis in several types of cancers.
Researchers at Chongqing University investigate the contribution of water molecules to the hydrogen evolution reaction (HER) mechanism. They found that water molecules act as both reactants and solvents, influencing the kinetics and dynamics of HER. Enriching and reorienting interfacial water can dramatically improve HER kinetics.
The US beef industry is found to be the least efficient at using virtual water, with a significant amount of blue water needed to produce just one ton of boneless beef. Researchers have developed a model to trace virtual water flows in beef supply chains, revealing major disconnects between consumption and production counties.
A new study from CU Anschutz Medical Campus reveals that shingles can increase the risk of stroke, especially in people under 40, due to prothrombotic and proinflammatory exosomes. The researchers suggest using antiviral agents and anti-inflammatory medications may help mitigate this risk.
A study found that seeing or hearing birds is associated with improved mental wellbeing in both healthy people and those with depression. The link between birdlife and mental health was not explained by environmental factors.
Researchers identified rare Earth elements produced by neutron star mergers for the first time, using kilonova spectra simulations and ATERUI II supercomputer. The discovery confirms previous hypotheses about element creation and advances our knowledge of the Universe.
Research shows that nationalist nostalgia is a key rhetorical tool for the radical right, emphasizing a superior past and linking it to issues like immigration and economic decline. This type of nostalgia can be exclusionary and polarizing, targeting migrants and oversimplifying complex social problems.
A Phase Ib clinical trial found that sequential administration of PARP inhibitor olaparib and WEE1 inhibitor adavosertib is safe and well-tolerated, with promising signs of anti-tumor activity in patients with advanced cancers driven by DNA damage response mutations. The combination showed durable responses in patients with resistant c...
A new type of pacemaker that uses precise targeting capabilities to bypass pain receptors and reduce patient discomfort is being developed. The device, which uses light and optogenetics, could improve the quality of life for millions of people affected by atrial fibrillation.
A research group at Kobe University has successfully synthesized α-amino acid N-Carboxyanhydrides (NCAs), a crucial precursor for artificial polypeptides, using the photo-on-demand phosgenation method. This new synthesis method eliminates the use of toxic phosgene and is considered safe, inexpensive, and simple.
Researchers discovered a novel metallic crystal, Kagome metal, with unusual electronic behavior on its surface. The material's unique atomic structure allows for the manipulation of electrons' spin chirality, which can be controlled by applying a local voltage.
Climate change is exacerbating health crises among migrant workers in the US agriculture sector, with extreme heat and chemical exposure posing significant risks. The Lancet report highlights the unequal burdens of climate change, particularly on vulnerable populations.
A new study found that college students experience an estimated 102 alcohol-related consequences, including blacking out and missing work, over their four years of study. Students who believe their parents disapprove of drinking have fewer negative consequences.
Researchers found that ancient viral DNA in the human genome can act as antivirals, protecting human cells against certain viruses. The study, published in Science, provides proof of principle for this effect and reveals a potential genome defense system.
Researchers analyze seismic surface waves to determine Martian crust density and structure. The data reveals a uniform crust beneath the impact sites, contradicting earlier findings at the InSight lander.
New research reveals a relationship between virus concentration and organic carbon in wastewater treatment plant effluents. The study found that viruses can affect the concentration of organic carbon, leading to potential negative impacts on aquatic ecosystems nearby.
A study found that nearly half of Medicaid beneficiaries who completed opioid rehab did not receive follow-up care or medication-assisted treatment within a month. Patients with prior prescriptions for opioid use disorder medications were 24% more likely to get follow-up care and medication.
A one-year lifestyle intervention with a digital app and group counselling improved diet quality, reduced abdominal obesity and insulin resistance among 2907 Finnish adults at risk of type 2 diabetes. The study suggests that commitment to lifestyle counselling supports positive changes.
Research from the University of Pittsburgh found that high COVID-19 stress in women is associated with changes in menstrual cycle length, period duration, and spotting. The study suggests that these changes can have economic and health consequences for women, including increased costs for feminine hygiene products.
Researchers at La Jolla Institute for Immunology discovered a direct link between TET protein loss of function and missing genes in embryonic stem cells, which can lead to cancer growth. The study found that TET proteins are crucial for maintaining genome stability, and their loss results in aneuploidies, a common feature of cancer cells.
A study found that the HASTER lncRNA promoter regulates the activity of the HNF1A gene, which causes diabetes. This discovery paves the way for new therapeutic strategies by manipulating this regulatory element.
A study published in BMJ Open found that quad bike injuries among children are significantly more severe and common than car injuries. The research highlights the need for public education campaigns to educate on ATV-related injuries, particularly in young riders.
Researchers used seismic data and orbital observations to refine knowledge of Mars' planetary interior. The studies provide new constraints that validate and refine models of the planet's internal structure and dynamics of major impacts.
Triboelectric nanogenerators can harness mechanical energy from the environment and deliver it efficiently. Researchers have designed a new type of nanogenerator with constant inherent capacitance, which stores approximately two times more charge than existing time-dependent designs.
A study published in JAMA Pediatrics found that developmental-behavioral pediatricians can diagnose most autism cases in young children without ADOS testing. In 90% of cases, the ADOS results did not change the original clinical diagnosis, suggesting that DBPs can accurately assess ASD symptoms.
Fruit flies have evolved to adjust their vision by moving the retinas inside their eyes, similar to human eye movements. This allows them to track moving objects and maintain visual resolution despite having fewer photoreceptors than humans.
A team from the University of Geneva has identified the structure of the SEA complex, a key regulator of cell growth, and how it controls the activity of the major regulator of cell growth, mTOR. The discovery provides new insights into how cells perceive nutrient levels to regulate their growth.
The Global Bioconvergence Center of Innovation aims to bridge academia, government, and industry by promoting interdisciplinary synergies in life sciences, biomedical research, marine sciences, AI, and complex systems. The center will accelerate the development of practical solutions for a 'One World, One Health' society.
A new experimental drug has shown promising results in treating liver cancer, with two patients experiencing a partial response to the treatment. The drug, NMS-01940153E, targets an enzyme that plays a critical role in cell division and growth, and its side effects are manageable.
Researchers found that individuals with high levels of fatty acids in their sebum are more attractive to mosquitoes. The study, published in Cell, used a round-robin tournament to test the attractiveness of human skin samples to Aedes aegypti mosquitoes.
A study from Washington University in St. Louis found that amines used in herbicide formulations volatilize, releasing toxic particles into the atmosphere and affecting climate chemistry. The research highlights the importance of understanding amines' role in atmospheric pollution.
Researchers found that actors' brain activity suppressed when hearing their own name during performance, indicating potential impact of theatre training on human brain. The study also investigated interpersonal coordination between actors and found specific brain systems involved in social interactions.
Researchers from Humboldt University of Berlin and Leibniz Institute for Zoo and Wildlife Research examined the facial motor nucleus of African and Asian elephants. They found more facial motor neurons than any other terrestrial mammal, with African savanna elephants having up to 63,000 neurons.
A recent study published in Nature suggests that Mars is still experiencing volcanic activity, with quakes originating from the Cerberus Fossae region indicating a warm source of molten lava. The seismic data also shows darker deposits of dust surrounding the area, suggesting geological evidence of more recent volcanic activity.
Researchers at Penn State have created a two-dimensional heterostructure by combining a topological insulator with a monolayer superconductor, demonstrating topological superconductivity and Ising-type superconductivity. The hybrid structure could pave the way for more stable quantum computers and explore Majorana fermions.
A team of researchers at USC is launching a comprehensive study to investigate the connection between type 2 diabetes and dementia in adults with Hispanic ancestry. The five-year study will examine brain structure and activity, blood flow, blood glucose and insulin levels, and cognitive functioning in 200 participants.
A recent study found that companies' zero-deforestation supply chain commitments have reduced tree clearance in the Brazilian Amazon by only 1.6% between 2006 and 2015. Despite this, over 50% of soy-suitable forests in Brazil remain unprotected. Experts call for stronger regulations to effectively combat deforestation.
A team of scientists has developed a novel photonic neural network accelerator based on a non-volatile Opto-Resistive RAM Switch, achieving programmable nonlinear activation functions. The accelerator demonstrates superior performance in MNIST handwritten digit recognition tasks, with accuracy rates up to 91.6%, reduced power consumpti...
A Yale-designed 'Prime and Spike' nasal vaccine approach can help combat COVID-19 by bolstering immune responses in the respiratory system. The strategy, which involves a combination of a prime vaccination and a spike protein booster administered directly into the nostril, has been shown to reduce viral shedding and transmission.
A new study identifies a specific mechanism of faulty DNA repair in tumors as a key factor in determining patient outcomes with immunotherapy. Tumors with defective DNA repair proteins had significantly better responses to immunotherapy, whereas those with silenced production of DNA repair proteins did not.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
A new study using wearable devices found that moderate-to-vigorous physical activity significantly reduces cardiovascular disease risk, even when total physical activity volume is increased. Increasing the proportion of intense physical activity within overall activity levels has an additional substantial benefit.
The researchers developed a novel approach to infrared spectroscopy called Infrared Diffusion-Ordered Spectroscopy (IR-DOSY), which separates molecules with different sizes into distinct sets of IR peaks. This method has potential applications in fields such as proteins, polymers, pharmaceuticals, and biomedicine.
Researchers at HKU have developed a novel technique to measure the rotational and translational motion of cell markers with high precision. This breakthrough technology uses single nitrogen-vacancy centers in nanodiamonds to tackle the long-standing challenge in mechanobiology research.
Researchers developed investigational monoclonal antibodies targeting EBV's gH and gL proteins, blocking infection in human cells and providing nearly complete protection against EBV infection in mice. The findings highlight viable vaccine targets and potential treatment options for immunocompromised patients.
A new two-year project is being launched to reduce the spread of retracted research and improve confidence in scientific discovery. The goal is to create a system that can signal retraction status consistently to humans and machines.
The American Heart Association is launching a two-year initiative to expand and enhance post-acute stroke care across Montana, Nebraska, and North Dakota. The project aims to maximize recovery of function lost during a stroke, reduce risk of secondary effects, and extend high-quality guideline-directed care for all patients.
A recent BYU study found that socioeconomically disadvantaged children report higher levels of worry than advantaged peers, leading to lower math and reading scores. The study suggests that targeted support for disadvantaged children can enhance their academic outcomes and flourishing.
A new therapy combining Imagery Rehearsal Therapy with Targeted Memory Reactivation has been shown to significantly reduce nightmare frequency and increase positive dreams in patients. The treatment, which involves associating a major piano chord with positive scenarios, resulted in lasting benefits even three months after the experiment.
A University of Central Florida researcher is leading a $1.25 million project to map and manipulate materials at the nanoscale. The research aims to unlock new capabilities of materials at the nanoscale, potentially leading to new catalysts and compounds applicable in quantum science, renewable energy, life sciences and sustainability.
Researchers at the University of Kentucky have created a new class of gold(III) compounds that show promise in treating aggressive breast cancer. These chiral compounds possess a unique mechanism of action that causes cancer cells to dysfunction, depriving them of energy and inhibiting growth.
A new technology called RADARS allows scientists to detect and target specific cell types and states, opening up potential applications in diagnostics and therapeutics. The platform detects a particular RNA sequence in live cells and produces a protein of interest in response.
Curtin researchers have discovered two massive meteorite impact craters on Mars, with one containing ice at the lowest altitude ever observed. The findings provide valuable insights into Mars' subsurface structure and water ice reservoir, shedding light on the planet's formation and evolution.
Researchers have discovered a way to create ductile ceramics that can exhibit ultimate strength of up to 11 GPa, potentially leading to improved energy efficiency and reduced material usage. However, further studies are needed to scale up the process and apply it to larger materials.
A new study published in NEJM Evidence found that crossword puzzle training significantly improved cognitive function and daily activities, reducing brain shrinkage in individuals with mild cognitive impairment. The findings suggest that engaging with familiar activities like crossword puzzles may be more effective than computerized co...
Researchers at Nagoya University identified the pheromone PGE2 involved in puffer fish spawning behavior, which is synchronized with the lunar cycle. The study found that applying PGE2 to puffer fish triggers their characteristic writhing motion during spawning.
Scientists from Ural Federal University have proposed a new material for transporting electrons in perovskite solar cells, achieving an efficiency of 12%. The new material is twice as cheap, easier to produce, and has technological advantages over current electron-transport materials.
A study by international researchers found that descendants of transmigrants dominate and become influential actors in host community knowledge networks. This has led to the marginalization of native communities, who are now positioned at the margins of their local knowledge system.
Researchers at the University of Copenhagen develop a low-fat, more sustainable whipped cream alternative using lactic acid bacteria as building blocks. The bacteria-based foam can be whipped, peaks up, and retains liquid, making it a potential game-changer in the food industry.
Scientists have created a new type of battery that stores sodium ions in combination with their solvate shell, enabling reversible co-intercalation. This innovation could improve efficiency and performance at low temperatures, making it suitable for alternative cell concepts.
A new study warns that a lack of support for children's non-attendance from teachers and local authorities can lead to parents losing faith in the education system. Experts call for policies to be reformed to take account of underlying causes, rather than adopting a punitive approach.
Researchers will map developing brains, identifying cell types, activities, and locations as they differentiate during development and change throughout childhood and adolescence. The project aims to learn more about normal, healthy brain development and better understand how diseases like autism, schizophrenia, and Parkinson's emerge.
Johns Hopkins Medicine researchers have developed a novel genetic engineering approach to deliver gene therapy by utilizing a cell's natural process to
Researchers found high-end hotels inflate their ratings on platforms like Tripadvisor and Expedia when facing greater competition from Airbnb. The study, published in MIS Quarterly, suggests that hotels use fake positive reviews to counter negative reviews from rival hotels., Low-end hotels remain unaffected by Airbnb's presence.
Researchers found that playing a sound associated with a positive daytime experience during sleep can reduce nightmare frequency and increase emotional positivity in dreams. The study's findings support the development of new therapies for treating nightmares, which affect up to 4% of adults.
Researchers have discovered new routes to create strong metal-support interactions, enabling the stabilization of nanoparticles for industrially important reactions. These novel methods outperform traditional SMSI approaches in modulating geometric/electronic structures.
Researchers designed nanoscale ion-channel MXene electrodes with enhanced ion accessibility and high mechanical strength for high-capacity zinc-ion energy storage. The electrodes showed excellent anti-self-discharge properties and self-healing capabilities, making them suitable for flexible electronics.
Researchers have found conclusive evidence of a 3.5-billion-year-old shoreline with substantial sedimentary accumulation on Mars' northern hemisphere. The discovery provides key insights into the planet's ancient climate and its evolution, as well as the potential for life.
Research suggests that climate change can increase trust among Vietnamese rural households, particularly during periods of poor rice yields. As temperatures rise, communities come together to help each other, leading to increased social cohesion and trust.
Researchers have discovered that two seismic events detected by NASA's InSight lander were caused by meteor impacts, sending surface waves across the planet. These collisions provide valuable information about Mars' interior structure, with one study finding a denser crust than previously inferred.
A study published in Animal Behaviour found that bumble bees engage in playful behavior by rolling wooden balls repeatedly. The research showed that younger and male bees rolled the balls more than older and female bees, respectively.
The annual report shows a continued decline in overall cancer death rates among men, women, children, and adolescents. Additionally, there are modest improvements in survival for pancreatic cancer, with declines seen in lung cancer and melanoma.
Researchers aim to identify electrical activity in brain consolidation and test targeted brain stimulation to strengthen memories. The study could advance understanding of neural mechanisms involved in memory formation, potentially benefiting people with Alzheimer's disease.
Research published in European Heart Journal found that accumulating short bouts of vigorous activity across the week can help live longer. The study also showed that increasing intensity was associated with a reduced likelihood of cardiovascular disease.
The University of Minnesota has released four years of high-resolution imagery data to create the most detailed polar region terrain maps ever created. These maps will provide new insights into the effects of climate change over time, revealing glacier change, erosion, landslides, and flooding in incredible detail.
Researchers propose innovative solution to identify physical items uniquely and securely. Cholesteric spherical reflectors (CSRs) are used to create 'fingerprints' on surfaces, making them detectable by robots and AR devices but invisible to humans.
Researchers at Oregon Health & Science University have counted more than 10,000 nerve fibers in the human clitoris, exceeding previous estimates of 8,000. This discovery could lead to better outcomes for phalloplasty surgery and improved sensation for transmasculine patients.
Researchers have controlled a one-dimensional electron fluid to an unprecedented degree, discovering new properties of Tomonaga-Luttinger liquids in two-dimensional materials. The team's findings could pave the way for more robust quantum computers with enhanced fault-tolerance.
Researchers analyzed data from bike share stations in NYC, Chicago, and Philadelphia to understand disparities in bike share use. Key findings include concerns about traffic safety and personal safety among lower-income and people of color residents.
The study infers the dimensionality of complex networks using hyperbolic geometry, which captures relational structures in real-world domains. It reveals extremely low dimensions for molecular networks and higher dimensions for social networks and the Internet, with implications for network characterization and predictive capability.
A team of Rutgers physicians successfully treated a 5-year-old girl with anti-NMDAR encephalitis, a rare brain disorder, using blood plasma exchanges. The treatment, which involved nearly a dozen exchanges, led to the child's full recovery, highlighting the potential for late-stage treatment.
Researchers developed a new method to represent cell communication using graph neural networks, which uncovers the effects of tissue niche composition on gene expression. The node-centric expression models (NCEMs) identify cell-cell dependencies and molecular processes underlying cell communication.
A new study reveals that gut microbiota from patients with inflammatory bowel disease produce genotoxic metabolites called indolimines, which may contribute to the development of colorectal cancer. The study identified a previously unknown family of DNA-damaging compounds produced by the CRC-associated gut microbe Morganella morganii.
A new study in PNAS suggests that the spread of COVID-19 in US counties followed a hybrid lognormal-Pareto distribution, with 99% of counts conforming to Taylor's Law and the top 1% matching the Pareto distribution with infinite variance.
Researchers review emerging field of 2D ferroelectric materials with layered van-der-Waals crystal structures, offering new properties and functionalities not found in conventional materials. These materials show easily stackable nature, making them attractive as building blocks for post-Moore's law electronics.
Researchers found that immune checkpoint blockade therapy may be beneficial for certain cases of severe COVID-19. In pre-clinical trials, treatment with a PD-1 inhibitor restored T cell functionality and reduced inflammation in mice infected by MHV-A59, another betacoronavirus.
Scientists have detected seismic surface waves on Mars for the first time, providing new insights into the planet's crust and structure. The study estimates the average properties of the Martian crust between 3 to 18.6 miles below the surface, revealing faster seismic velocities that suggest compositional differences or reduced porosity.
Researchers identified a new clinical syndrome, Neuro-Ocular DAGLA-related Syndrome (NODRS), in children with termination variants in the diacylglycerol lipase alpha (DAGLA) gene. The study found that enzymatic activity was preserved despite mis-localization of the truncated protein.
Research from Portland State University suggests that taking music courses in higher- or mid-income schools leads to better math scores. The study found a positive relationship between arts course-taking and math achievement, but only among socio-economically privileged students.
Researchers at Kyoto University have developed a prodrug form of curcumin called TBP1901, which has shown anti-tumor effects without causing harm. The study found that TBP1901's conversion to active curcumin is dependent on the enzyme GUSB, suggesting its potential therapeutic targets.