Researchers found that patients with stage III melanoma who received immunotherapy alone had better rates of distant metastasis-free survival compared to those who underwent completion lymph node dissection. The study suggests that de-escalation of unnecessary therapies, such as CLND, may improve patient outcomes and reduce complications.
Researchers found that Neem bark components target a wide range of viral proteins, suggesting its potential as an antiviral agent against emerging coronavirus variants. The study showed the bark extract was effective in reducing virus replication and spread in SARS-CoV-2 human lung cells.
A recent study by CU Anschutz researchers advances the understanding of the immune system during COVID-19, focusing on the interferon response. The findings provide a new model for staging COVID-19 pathology and have important therapeutic implications for treating severe cases.
Researchers found AI/AN adults with dementia face high hospital costs & chronic conditions, highlighting need for outpatient care & home services. Existing resources are often inadequate due to rurality & social determinants, leading to disparities in access.
In young adults, women are at a higher risk of ischemic strokes, with a 44% greater incidence compared to men. Researchers highlight the need for further research into the causes and non-traditional risk factors that contribute to this disparity.
A recent survey found that while most clinicians and patients agree that transparency is essential, providers are concerned about added stress for patients due to complex reports. Patients want providers to contact them within 24 hours of abnormal results, but clinicians struggle with managing time and navigating data.
Physicians in Colorado are more willing than expected to provide medical aid in dying, with 81% open to discussing the topic and 88% willing to make referrals. However, 46% were unwilling to serve as consultants, highlighting the need for better understanding of the challenges physicians face in this practice.
A study published in Aging and Cancer found that most cancer-free individuals over 60 carry at least 100 billion cells harboring oncogenic mutations. Researchers hope to understand how these mutations interact with the tissue environment to determine cancer risk, and how they differ between tissue types.
A new publication sheds light on how words used in relation to firearm injuries and deaths can impact prevention efforts. The authors emphasize the need for shared, informed, non-judgmental language to create trust and sustainable collaboration among clinicians, researchers, and the public.
Researchers found that higher lymphoma volume at diagnosis was associated with increased risk of recurrence. This could lead to improved patient outcomes by selecting the most appropriate treatment. The study also explored PET-based measures of initial disease burden, which may help predict patients' risk of recurrence.
Researchers have uncovered how a viral RNA changes shape to hijack host proteins, revealing the role of cryogenic electron microscopy in making this discovery possible. The study highlights the emerging power of cryo-EM to visualize multifunctional dynamic RNA structures.
A study found that lung cancer screening rates increased significantly among high-risk males who gained access to Medicare, with a 16% jump in screenings reported. The rise is attributed to the reduced out-of-pocket costs and greater access to care for these individuals, many of whom were previously uninsured.
Researchers discovered that retinal pigment epithelium cells release exosomes containing normal proteins and those associated with drusen, a key AMD manifestation. This finding may lead to early diagnosis through biomarker detection in blood, tears, or saliva, potentially treating millions of Americans before geographic atrophy onset.
Researchers at the University of Colorado School of Medicine have been awarded a four-year grant to study systemic biomarkers of inflammation that signal the progression of age-related macular degeneration. The team aims to develop risk profiles for patients with intermediate AMD to predict rapid vision deterioration.
Scientists at the University of Colorado School of Medicine have identified specific genetic biomarkers in blood samples that can indicate the severity of COVID-19. The study's findings suggest that these signals can be used to monitor SARS-CoV-2 status and predict clinical outcomes.
A rhythmic approach to music therapy is being tested to improve fine motor skills in Parkinson's patients. The therapy uses specific combinations of rhythm and movement to reprogram brain frequencies, with promising results so far.
A CU Cancer Center member is developing a decision aid for breast cancer patients, gathering data on well-being outcomes after surgery. The study found that women who underwent lumpectomies reported better psychosocial and sexual well-being than those who had mastectomies.
A recent study published in the journal Birth found that family physicians deliver babies in 67% of rural hospitals and are the only physicians who deliver babies in 27% of them. If they stopped, patients would have to drive an average of 86 miles round-trip to access maternal care.
A cross-sectional study found a correlation between rural geography and easy access to handguns, leading to higher risks of suicidality among Colorado teenagers. The findings can inform the allocation of educational firearm safety and suicide prevention resources in the state.
Pediatric oncologist Adam Green and his team have discovered genetic mutations that may predict the development of these secondary tumors, allowing for early detection and alternative treatments. They are also exploring FDA-approved chemotherapy drugs as potential treatments.
Researchers discovered that adrenal gland metastases are unresponsive to checkpoint inhibitors due to the secretion of corticosteroids. Surgical removal is the current best course of action for patients with these metastases. The study's authors hope to develop a nonsurgical treatment option in the future.
A new center will be established at CU Anschutz Medical Campus to investigate rheumatoid arthritis and spondyloarthritis, with the goal of identifying new treatments and preventing disease. The center will combine resources from over 40 researchers and provide funding for graduate students and postdoctoral fellows.
Researchers at the University of Colorado will test an online decision aid to improve firearm safety for caregivers of people with Alzheimer's disease and related dementias. The study aims to reduce firearm injuries and deaths while promoting older adult independence and autonomy.
Scientists discovered a protein, IL13Ra2, that promotes brain metastases in breast cancer patients. High levels of this protein are associated with poor survival rates. Researchers aim to develop targeted therapies for this specific population.
A team of researchers led by CU Cancer Center member Jean Mulcahy Levy examined tumor samples before and after treatment with a targeted medicine. They found additional mutations that can create resistance to the therapy, highlighting the need for new treatments or combination therapies.
A study of over 14,000 children found Midwestern kids have the highest body mass index (BMI) levels, while Western kids have the lowest. The research suggests regional influences may play a role in childhood obesity, with factors such as environmental exposures and mother's education also contributing to BMI.
Researchers offer standards for machine learning studies in life sciences to promote reproducibility and advance knowledge. The bronze standard requires data, code, and models to be publicly available, while the silver and gold standards add more information to facilitate duplication of training processes.
Researchers found that nurse home visits for low-income mothers resulted in significant reductions in maternal and child mortality, including external causes of death and preventable causes. The study's findings support the benefits of Nurse-Family Partnership programs in improving pregnancy outcomes and child health.
A new study showcases the COVIDome Explorer, a public online portal for real-time COVID-19 data analysis, visualization and sharing. The platform enables rapid hypotheses testing, hypothesis generation and discoveries by experts and non-experts.
Lobular breast cancer patients often experience recurrence or metastasis despite hormonal therapies. CU Cancer Center researcher Matthew Sikora is studying the role of MDC1 in this subtype, finding it linked to estrogen receptor activity and potentially a novel target for treatment.
Researchers found a steady decline in blood glucose control over 15 years, with certain participants developing multiple complications. Minority groups and those with high blood pressure and dyslipidemia were at higher risk for developing complications.
A study led by D. Ross Camidge found that MET amplification drives a rare subtype of non-small cell lung cancer, which responded to crizotinib therapy. The research also highlights the importance of MET amplification testing and therapies for this unique patient population.
Researchers studied the mechanism of liposome accumulation in tumors using fluorescent microscopy and imaging. They found that different lipids have varying abilities to accumulate in tumors, with one lipid type showing remarkable extravasation and reaching immune and tumor cells.
A survey of 56 residents and 57 faculty members revealed differences in opioid prescribing habits, with faculty preferring more opioids for some procedures. The study aims to improve surgical recovery by developing new protocols and a dashboard to track opioid prescribing practices.
A study by CU researchers found that choline deficiency in Black pregnant women is linked to increased risk of developmental and behavioral issues in their children's later lives. The research also highlights healthcare disparities in caring for Black mothers and their children in the US.
A new study published in Emerging Infectious Diseases found that mathematical models informed early statewide policies in Colorado, avoiding 97% of potential hospitalizations. The modeling team developed a SEIR model calibrated to Colorado COVID-19 data and provided real-time estimates to policymakers.
The University of Colorado Anschutz Medical Campus is highlighted for its record of turning discoveries into commercially viable products. The campus has developed vaccines and collaborated with industry partners to distribute them globally, improving patient care and public health.
Two studies by CU Cancer Center researchers found that chronic inflammation can serve as a key factor in the development of leukemia. Chronic inflammation reduces the fitness of normal cells, hindering their ability to reproduce and creating space for cancer-causing mutations to proliferate. The findings support the theory of adaptive ...
A pilot study found children with acute lymphocytic leukemia were four times more likely to live near oil and gas sites than other cancer patients. The new study aims to determine if there's a potential link between benzene emissions from oil and gas production and childhood ALL.
A new treatment sequence for esophageal cancer may improve patient outcomes by treating microscopic disease first. The approach adds chemotherapy for two to three months before radiation and surgery, potentially reducing mortality rates.
The CU Cancer Center has received a $2 million annual grant for five years to focus on head and neck cancers. The grant will support research projects, including immunotherapy mechanisms and dual inhibition of key pathways combined with radiation therapy.
Researchers discovered innate immune markers increased in frequency in modern people from a region that experienced the plague, suggesting these markers might have evolved to resist the disease. The study also found changes in allele distribution for immune-related genes, which could be evidence of past Yersinia pestis exposure.
Researchers developed a new basis for comparing tuberculosis treatments using an rRNA synthesis ratio, enabling more intelligent drug design and acceleration of treatments. This tool has crucial implications for combatting the global TB epidemic by providing a durable cure.
The COVID-19 pandemic significantly impacted graduate nursing students, causing increased stress due to juggling clinical work and studies. A total of 222 graduate nursing students completed a survey, revealing that overall stress increased during the pandemic, with 18.2% of students changing their graduate school plans.
Scientists at the University of Colorado Anschutz Medical Campus discovered that intense light can enhance the expression of the ANGPTL4 gene, which regulates fatty lipids in plasma. This could lead to a new tool for safely blocking the gene and reducing cardiovascular risk.
A new study published in Medical Care Research and Review found that Medicaid expansion provided a financial boost to hospitals, with uncompensated care costs declining by 28% in states that expanded Medicaid relative to 2013 levels. The study analyzed critical data at state and national levels using IRS and CMS data sources.
Researchers found that regulatory T cells are silencing T cells in cold tumors, leading to reduced immune response. Using medication to deactivate Tregs and radiation treatment can help boost immune response.
Researchers discovered that up to 60% of observed enhancers have coordinated binding events, indicating transcription factors work together to regulate gene expression. This cooperation may enable cancer cells to exploit existing enhancer systems, leading to changes in cellular identity.
Researchers at CU Cancer Center have discovered that tumor-suppressing genes MAP3K7 and CHD1 deletion increases androgen receptor signaling, making patients less responsive to anti-androgen therapy. This knowledge could lead to personalized treatment approaches for men with aggressive prostate cancer.
Researchers at the University of Colorado Cancer Center have discovered an NLRP3 inhibitor that can reduce inflammation in melanoma cells, potentially leading to reduced tumor growth and progression. The study's findings suggest that inhibiting NLRP3 could improve patient care for those resistant to checkpoint inhibitors.