A new study by the University of Oslo found that brains with an older appearance are associated with lower birth weights and a genetic tendency towards smaller brain size. The researchers measured the pace of brain aging in 1,500 adults over 10 years and found no strong correlation between estimated brain age and future brain changes.
SourceUniversity of Oslo, Department of Psychology, Center for Lifespan Changes in Brain and Cognition·JournaleLife·TypeImaging analysis·DateNov 16, 2021
Researchers have designed a digital camera-based system that can accurately detect jaundice in newborns within one second, sending diagnoses to carers via SMS. The system uses image processing techniques to detect bilirubin levels, triggering blue LED phototherapy and treatment.
SourceUniversity of South Australia·JournalDesigns·TypeExperimental study·DateNov 16, 2021
Researchers have found two genetic risk variants that may exacerbate the severity of sepsis and COVID-19 in African Americans, who carry nearly 40% of these variants. The study identifies potential pathways to reduce health disparities driven by these gene mutations.
SourceUniversity of Pennsylvania School of Medicine·JournalImmunity·DateNov 16, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers discovered short bursts of activity in the brain, known as 'events,' which occur regardless of brain state or activity. These events are guided by the brain's structural network and may be tied to the physical structure of brain regions, offering a potential new avenue for understanding brain injuries and disorders.
SourceIndiana University·JournalProceedings of the National Academy of Sciences·DateNov 16, 2021
A systematic review of over 500,000 under 18s found that flavoured vapes are an important aspect of vaping enjoyed by young people, potentially encouraging them to switch from tobacco smoking to less harm vaping. However, the study warns that more needs to be done to prevent young non-smokers from being attracted to vaping.
SourceUniversity of East Anglia·JournalAddiction·TypeSystematic review·DateNov 16, 2021
Scientists harness higher-order protein catenation to create complexed proteins with potential as artificial antibodies. The new method enables the synthesis of protein [n]catenanes, which show improved binding affinity and prolonged serum half-life.
SourcePeking University·JournalJournal of the American Chemical Society·DateNov 16, 2021
A recent study published in Circulation found that patients receiving a combination of antiplatelet drugs for many months (up to 2.5 years) after stent procedures may not receive the full benefit of treatment. The researchers compared characteristics of 8,864 patients from an older trial to 568,540 contemporary patients and determined ...
SourceMassachusetts General Hospital·JournalCirculation·TypeObservational study·DateNov 16, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A team of researchers has developed a simple and efficient method of quantum encryption using single photons, which can detect any attempt to hack the message. The breakthrough brings us closer to securing our data against quantum computers' potential attacks.
SourceThe Hebrew University of Jerusalem·JournalACS Nano·TypeExperimental study·DateNov 16, 2021
A two-year follow-up of participants found that those who had both their mitral valve and tricuspid valve repaired at the same time experienced better outcomes, including less progression to moderate or severe leakage. This study provides high-level evidence for surgeons on how to perform tricuspid valve repair in these patients.
SourceJohns Hopkins Medicine·JournalNew England Journal of Medicine·DateNov 16, 2021
A new study warns that searching for signs of life on Mars could be fooled by fossil-like specimens created by non-biological processes. Researchers say it's crucial to distinguish these from evidence of ancient life on the Red Planet to aid future missions.
SourceUniversity of Edinburgh·JournalJournal of the Geological Society·TypeSystematic review·DateNov 16, 2021
Scientists at the University of Southampton have created nanoparticles that can target and kill deadly bacteria hiding in human cells. The breakthrough could lead to a new treatment method using injectable or inhalation-based antibiotic-laden capsules, potentially saving thousands of lives annually.
SourceUniversity of Southampton·JournalACS Nano·TypeExperimental study·DateNov 16, 2021
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A new review in the Journal of Dairy Science explores the relationship between serotonin and calcium metabolism in dairy cows, highlighting its importance in maintaining calcium balance. Research shows that mammary serotonin drives hormone production that modulates mammary calcium transport.
SourceElsevier·JournalJournal of Dairy Science·TypeLiterature review·DateNov 16, 2021
Researchers have developed a 3D cell culturing platform that allows study of lung fibroblasts and their microenvironment, enabling measurement of cell behaviors and microenvironment changes involved in IPF disease progression. The system's versatility enables personalized medicine and potential applications in studying other diseases.
SourceAmerican Institute of Physics·JournalAPL Bioengineering·DateNov 16, 2021
Researchers introduce silica into catalyst design to prevent phosphoric acid loss and improve stability, leading to enhanced oxygen reduction reaction efficiency. This results in improved power density at high temperatures.
SourceScience China Press·JournalScience China Chemistry·DateNov 16, 2021
Researchers at TU Wien discovered that a rhodium catalyst can be highly chemically active in some regions while completely inactive in others. The team found that the arrangement of atoms on the surface differs from grain to grain, leading to varying catalytic properties.
SourceVienna University of Technology·JournalNature Communications·TypeExperimental study·DateNov 16, 2021
A recent study suggests that the ancient Maya's agricultural strategies may have been more effective than previously believed. The research, which analyzed airborne lidar data, found that Maya settlements in Mexico and Guatemala were able to maintain a stable food supply despite environmental challenges.
SourceBrown University·JournalRemote Sensing·TypeImaging analysis·DateNov 16, 2021
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
The study, led by Universidad Complutense de Madrid, estimates that record temperatures are eight times higher than expected without global warming. At least one in four new record rainfalls is attributed to climate change.
SourceUniversidad Complutense de Madrid·Journalnpj Climate and Atmospheric Science·TypeObservational study·DateNov 16, 2021
A new study found that unique names increased in Japan between 2004 and 2018, with a greater rate of change for girls than boys. This suggests that parents increasingly valued their daughters' uniqueness and independence, highlighting sex differences in sociocultural changes.
SourceTokyo University of Science·JournalCurrent Research in Behavioral Sciences·TypeSurvey·DateNov 16, 2021
Researchers from HSE School of Linguistics and Centre for Language and Brain conducted an experiment to understand how language speakers perceive polysemous words. The proximity of figurative senses to the literal sense affects perception as semantically different.
SourceNational Research University Higher School of Economics·JournalFrontiers in Psychology·DateNov 16, 2021
Researchers have identified thousands of novel brain-expressed gene isoforms, revealing a complex web of protein production in the brain. The study suggests that genes expressed in the brain may produce far more proteins than previously thought, with potential implications for diseases such as Alzheimer's and schizophrenia.
SourceUniversity of Exeter·JournalCell Reports·TypeExperimental study·DateNov 16, 2021
A study found that vaccination rates among Indian children improved significantly between 1992 and 2016, with a 70% drop in child mortality from vaccine-preventable diseases. However, zero-dose children remained concentrated among disadvantaged groups, including low-income households and mothers with limited education.
SourceUniversity of Montreal·JournalThe Lancet·TypeData/statistical analysis·DateNov 16, 2021
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Scientists are using peptide nucleic acids to study SARS-CoV-2 RNA pseudoknots, a crucial mechanism for viral replication and translation. Understanding this process could lead to new methods to disrupt it, potentially leading to more effective treatments.
A study conducted at the University of São Paulo analyzed how dogs living inside the home exchange looks with their owners to obtain food or other desired objects. The researchers found that 95.7% of those living inside the home used gaze alternation at least once, while those living outside communicated less intensely.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalBehavioural Processes·DateNov 16, 2021
Researchers at Stanford University have developed a new method for rapidly prototyping complex geometries mirroring symmetries present in problems of interest. This technique uses a mixture of water and propylene glycol, along with a slippery surface, to create droplet lattices that can be manipulated and observed over time.
SourceStanford University·JournalProceedings of the National Academy of Sciences·DateNov 16, 2021
Microtubule structures play a crucial role in regulating insulin release from pancreatic beta cells, with dynamic turnover leading to increased insulin secretion. The findings have important implications for understanding diabetes and could lead to new treatments.
A researcher at MUSC's Hollings Cancer Center is developing 'living drugs' by precision-engineering CAR Tregs to treat autoimmune diseases. The CAR Tregs can delay or reduce damaging inflammation, offering a potential solution for conditions like Type 1 diabetes.
SourceMedical University of South Carolina·JournalFrontiers in Immunology·DateNov 16, 2021
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A study involving Drosophila found that a constant and precisely regulated energy supply is essential for nerve development, particularly during the degradation of nerve connections. Malnutrition was shown to intensify defects in this process.
SourceUniversity of Münster·JournalCell Reports·TypeExperimental study·DateNov 16, 2021
Researchers at the University of Basel have developed a new family of iron-based sensitizers for dye-sensitized solar cells, promising a low-cost supplement to traditional photovoltaic systems. The new materials achieve overall efficiency of 1 percent, but represent a milestone in further research and development.
SourceUniversity of Basel·JournalDalton Transactions·TypeExperimental study·DateNov 16, 2021
A URI researcher has published a series of articles in the journal Biological Invasions to address concerns about diversity, equity and inclusion. The study found that the editorial board was overwhelmingly American and white, with most papers published by Americans and Europeans.
SourceUniversity of Rhode Island·JournalBiological Invasions·TypeSurvey·DateNov 16, 2021
A new study by the University of Kent's School of Economics found that religious competition substantially increases the probability of conflict-related violence in Colombia. The presence of a new religion group makes potential contributors or soldiers more scared, leading to violent action from armed groups.
SourceUniversity of Kent·JournalJournal of Economic Behavior & Organization·TypeObservational study·DateNov 16, 2021
Climate scientists have identified abrupt transitions in ice core records using a new statistical method. The method analyzes the ratio of two oxygen isotopes to determine whether changes are due to noise or significant climactic shifts.
SourceAmerican Institute of Physics·JournalChaos An Interdisciplinary Journal of Nonlinear Science·DateNov 16, 2021
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Peng Li, an assistant professor at West Virginia University, has received the 2021 Young Investigator Award from Eli Lilly for his groundbreaking research on acoustic waves and microfluidic devices. His innovation, VSSI technology, offers improved performance, smaller size, and lower cost compared to commercial products.
Researchers developed a novel approach to study molecular fluctuations in one-dimensional shock waves, characterizing frequencies two orders of magnitude lower than those in boundary layer flow. The model correctly predicts fluctuations in high-speed vehicle shocks traveling at Mach 2-10.
SourceUniversity of Illinois Grainger College of Engineering·JournalPhysics of Fluids·DateNov 16, 2021
A team at Sandia National Laboratories tested specially designed stainless-steel containers for fire safety and found they did not split open even when heated to 2000 degrees Fahrenheit. The containers developed small pinholes instead, allowing superheated gas to escape without pressurizing the container.
Researchers have uncovered the first fossil evidence of a rare botanical condition known as precocious germination, where seeds sprout before leaving the fruit. A 40-million-year-old pine cone encased in Baltic amber shows embryonic stems emerging from the seeds, providing insight into plant biology and ecology.
SourceOregon State University·JournalHistorical Biology·TypeObservational study·DateNov 16, 2021
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers developed AI models to predict protein interactions, identifying over 100 probable complexes and 700 previously uncharacterized ones. This breakthrough could lead to new treatments for human disease.
SourceUT Southwestern Medical Center·JournalScience·DateNov 16, 2021
A study found that lung cancer screening rates increased significantly among high-risk males who gained access to Medicare, with a 16% jump in screenings reported. The rise is attributed to the reduced out-of-pocket costs and greater access to care for these individuals, many of whom were previously uninsured.
SourceUniversity of Colorado Anschutz Medical Campus·JournalMedical Care·DateNov 16, 2021
A new coating developed by researchers at the University of Illinois Chicago uses thermoresponsive properties to create a hygroscopic slippery layer that prevents harmful substances from coming into contact with surfaces. This technology delays ice and frost formation, outperforming commercial products by up to ten times.
SourceAmerican Physical Society·JournalAdvanced Materials·DateNov 16, 2021
Researchers aim to reverse tissue damage and scar buildup in lungs affected by Idiopathic Pulmonary Fibrosis (IPF) using a protein domain. The team hopes to identify therapeutic agents that can be used to treat the disease, which affects 100,000 Americans annually.
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A study by Heinrich-Heine University Düsseldorf analyzed viral sequences from Gambia, Ghana, Nigeria, and Senegal, finding distinct patterns of SARS-CoV-2 variants. The researchers believe genetic drift mechanisms, such as the founder effect, may contribute to these variations.
SourceHeinrich-Heine University Duesseldorf·JournalScientific Reports·TypeCase study·DateNov 16, 2021
A major new study found that woodland and hedgerow creation can support higher numbers of pollinators, including bees, hoverflies, and butterflies. The survey, which covered hundreds of sites across Wales, revealed the importance of carefully managed habitats in land management incentive schemes.
SourceUK Centre for Ecology & Hydrology·JournalJournal of Applied Ecology·TypeObservational study·DateNov 16, 2021
A new study by MIT researchers finds that video clips have a modestly larger impact on political persuasion than the written word, but only by one-third. Participants were more likely to believe events occurred when shown in a video, but this advantage was limited to changing attitudes and behavior.
SourceMassachusetts Institute of Technology·JournalProceedings of the National Academy of Sciences·DateNov 16, 2021
Researchers use game theory and economics to steer evolution in a better direction, identifying conditions for improved outcomes through policy changes and coordination. The study provides a mathematical formula to determine when evolution managers will have sufficient incentive to steward biological resources.
SourcePLOS·JournalPLOS Biology·TypeComputational simulation/modeling·DateNov 16, 2021
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
George Mason University researchers will provide a professional development program to enhance Northern Virginia teachers' content-integrated instruction for culturally and linguistically diverse students. The ACE-STEM project aims to improve STEM literacy development and family literacy programs for English learners.
Researchers discover that finger snaps produce the highest rotational accelerations observed in humans, even faster than professional baseball pitchers. The study explores the role of friction and finds a 'Goldilocks zone' necessary for optimal energy storage.
SourceGeorgia Institute of Technology·JournalJournal of The Royal Society Interface·TypeObservational study·DateNov 16, 2021
The 74th APS Division of Fluid Dynamics Annual Meeting featured presentations on COVID-proofing daily life, kimchi physics, and extreme heat waves. Researchers also discussed advancements in fire-fighting trees and the science behind jellyfish engineers.
A new study by Montefiore Einstein Cancer Center investigators found that a COVID-19 booster shot helps most cancer patients with no immune response after two-dose vaccination, significantly increasing antibody levels. The study also shows that all cancer patients benefit from vaccination, particularly those with blood cancer.
SourceAlbert Einstein College of Medicine·JournalCancer Cell·TypeObservational study·DateNov 16, 2021
The new project aims to bridge the gap between complex rare category analysis and state-of-the-art techniques. It will focus on developing explainable methods for detecting defective silicon wafers and severe complications among diabetes patients.
SourceUniversity of Illinois School of Information Sciences·DateNov 16, 2021
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers from York University found that COVID-19 lockdowns in India had less impact on air pollution than initially thought. The study revealed that local sources of emissions, such as vehicles and fuels, had less influence on air pollutant levels than regional emissions sources.
SourceYork University·JournalEnvironmental Science Processes & Impacts·DateNov 16, 2021
The study found that grandmothers activate brain areas associated with emotional empathy when viewing photos of their grandchildren, indicating a strong emotional connection. In contrast, adult children elicit a stronger cognitive empathy response in grandmothers.
SourceEmory Health Sciences·JournalProceedings of the Royal Society B Biological Sciences·TypeImaging analysis·DateNov 16, 2021
A new study has identified the CCR2 gene as a key player in the progression of type 1 diabetes. The research found that lower blood levels of CCL-2, a ligand for CCR2, were associated with increased immune cell recruitment to the pancreas, leading to islet cell destruction.
SourceMedical College of Georgia at Augusta University·JournalJournal of Translational Autoimmunity·DateNov 16, 2021
Researchers at Tel Aviv University conducted a cross-adoption experiment with fruit bat pups to determine whether boldness is genetic or learned. The findings indicate that the pups behave like their adoptive mothers, not biological mothers, suggesting that boldness is an acquired trait passed on through mother's milk.
SourceTel-Aviv University·JournalBMC Biology·DateNov 16, 2021
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A recent study found that most vocal learners, such as dolphins and whales, sound higher than expected based on their body size, not lower. This challenges the idea that faking body size is linked to vocal learning and suggests a different evolutionary scenario for vocal communication in mammals.
SourceMax Planck Institute for Psycholinguistics·JournalPhilosophical Transactions of the Royal Society B Biological Sciences·TypeObservational study·DateNov 16, 2021
A new vaccine combines the part of the 'spike' protein with a combination adjuvant, inducing full protection in aged mice and potentially equivalent to current mRNA vaccines. The formulation is relatively easy to manufacture and may not require extreme cold storage, enabling its use in more settings.
SourceBoston Children's Hospital·JournalScience Translational Medicine·DateNov 16, 2021
A nationwide study found that hospitalized COVID-19 patients taking immunosuppressive medications did not have a significantly increased risk of dying from COVID-19 or being put on a ventilator compared to non-immunosuppressed patients. However, patients taking rituximab were at a substantially increased risk of death.
SourceJohns Hopkins Bloomberg School of Public Health·JournalThe Lancet Rheumatology·DateNov 16, 2021
The discovery of fossilized leaves from Quercus section Heterobalanus in Lawula Formation pushes the origin of this species back by nearly 20 million years. The findings suggest that the group was already adapted to cool and dry conditions in some regions as early as the late Eocene.
SourceScience China Press·JournalScience China Earth Sciences·DateNov 16, 2021
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers found that candesartan reduces accumulation of extracellular matrix proteins and normalizes blood flow in mice with hereditary cerebral small vessel disease. The study suggests a potential new treatment avenue for age-related cerebral arteriopathy.
SourceNiigata University·JournalJournal of Clinical Investigation·DateNov 16, 2021
Researchers developed metrics to quantify information in animal responses to reward feedback, showing that animals exhibit undermatching behavior. The new metrics provide a way to predict this deviation from the matching law, offering insights into adaptive behavior and decision-making.
SourceDartmouth College·JournalNature Communications·TypeComputational simulation/modeling·DateNov 16, 2021
A UCalgary study found that the steroid dexamethasone alters immune cell function in a sex-dependent manner, benefiting male patients but providing little to no benefit for females. The researchers' findings suggest that current treatments may only be effective for half the population.
SourceUniversity of Calgary·JournalNature Medicine·TypeObservational study·DateNov 16, 2021
A new study from the University of Georgia found that vaccination results in a more robust immune response than natural infection. Even with waning antibodies, vaccinated individuals still have protective immunity against severe disease and hospitalization.
SourceUniversity of Georgia·JournalFrontiers in Immunology·DateNov 16, 2021
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Scientists at Washington University in St. Louis have created a biocompatible adhesive hydrogel that can stick to various surfaces underwater, with properties similar to natural mussel foot protein and spider silk. This breakthrough has potential applications in tissue repair, particularly for tendon-bone repair.
SourceWashington University in St. Louis·JournalACS Applied Materials & Interfaces·TypeExperimental study·DateNov 16, 2021
The study of 2.2 million primary care visits found similar rates of follow-up care for all three visit types, including emergency department visits and hospitalizations. Virtual visits were shown to be a convenient and safe way to address some primary care needs without generating many follow-up office visits.
SourceKaiser Permanente·JournalJAMA Network Open·DateNov 16, 2021
Researchers produce large quantities of powerful cancer-fighting iNKT cells using stem cell engineering and organoid technology, offering a potential solution for mass-producing an off-the-shelf immune cell therapy. The therapy, which uses hematopoietic stem cell-engineered iNKT cells, has been shown to be effective in killing multiple...
SourceUniversity of California - Los Angeles Health Sciences·JournalCell Reports Medicine·TypeExperimental study·DateNov 16, 2021
Researchers at Penn State created a nanocomputing agent that controls protein function involved in cell movement and cancer metastasis. The logic gate, embedded in the focal adhesion kinase (FAK) protein, demonstrates ability to control conditional operations, introducing possibilities for precision therapeutics.
SourcePenn State·JournalNature Communications·DateNov 16, 2021
Researchers discovered that ants pass proteins through mouth-to-mouth exchanges to share metabolic labor and adapt to colony needs. This discovery sheds light on how ants divide tasks between individuals and the colony's life cycle.
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers tracked methane emissions from the region's 10,000 oil and gas wells, finding that they fell by half between 2015 and 2020. Despite this decline, methane leaks remained high, accounting for about six to eight percent of produced natural gas.
SourceUniversity of Utah·JournalScientific Reports·TypeObservational study·DateNov 16, 2021
A recent UTSW study found that Hispanic ischemic stroke patients receive lower-quality thrombectomies than their white counterparts, with similar outcomes observed between Black and white patients. This disparity highlights the need for targeted interventions to improve access to high-quality stroke treatment for underserved populations.
SourceUT Southwestern Medical Center·JournalJournal of Stroke and Cerebrovascular Diseases·DateNov 16, 2021
A multidisciplinary team from UCI has published a new guide for statistical analysis in neuroscience research, providing an overview of mixed-effects models and clear instructions on their application. The guide aims to improve the validity and reproducibility of experimental findings in the field.
SourceUniversity of California - Irvine·JournalNeuron·TypeExperimental study·DateNov 16, 2021
A UCI-led team has developed a high-throughput screen methodology to identify compounds that affect the functional role of Rh, a key G protein-coupled receptor. The study reveals new allosteric modulators that can alter rod light response kinetics or reduce rod sensitivity, paving the way for next-generation therapeutics.
SourceUniversity of California - Irvine·JournalJournal of Biological Chemistry·TypeExperimental study·DateNov 16, 2021
Researchers at UCSF discovered a narrower blood pressure range during surgery that significantly improves neuromotor recovery in patients with spinal cord injuries. Patients whose mean arterial blood pressure was between 76 mmHg and 104-117 mmHg had maximal recovery, indicating a potential new treatment guideline.
SourceUniversity of California - San Francisco·JournaleLife·DateNov 16, 2021
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A fraction of patients with high dihydrolipoamide S-Succinyltransferase (DLST) expression in their tumor cells may benefit from CPI-613, a drug targeting the TCA cycle. DLST plays a crucial role in TNBC pathogenesis, and its expression could serve as a biomarker for targeted therapy.
SourceBoston University School of Medicine·JournalCommunications Biology·DateNov 16, 2021
Researchers discovered chemerin, a multifunctional protein, has antitumoral properties in mouse models of cancer. Bioactive chemerin overexpression inhibits neoangiogenesis, a process distinct from normal tissue vasculature. This effect may provide a therapeutic application for targeting solid tumors.
SourceImpact Journals LLC·JournalOncotarget·DateNov 16, 2021
Researchers, led by UC Santa Barbara professor Björn Birnir and the University of Oslo's Luiza Angheluta, have published a complete description of boundary layer turbulence. The theory unites empirical observations with the Navier-Stokes equation into a mathematical formula.
SourceUniversity of California - Santa Barbara·JournalPhysical Review Research·DateNov 16, 2021
A study using machine learning techniques found that maintaining an optimal range of blood pressure control during surgical repair of spinal injuries improves patient outcomes. The results suggest that precise upper and lower blood pressure targets, between 76-117mmHg, may help patients recover motor function after a spinal cord injury.
Researchers found that dysregulation of enzymes in the glucuronidation pathway is associated with castration-resistant prostate cancer. The study suggests that reducing UGDH expression and/or activity can reverse castration resistance, potentially preventing or delaying therapeutic resistance.
SourceImpact Journals LLC·JournalOncotarget·DateNov 16, 2021
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new study used machine learning to predict the zoonotic capacity of 5,400 mammal species, identifying those at high risk of transmitting SARS-CoV-2. The model, which combined data on biological traits with ACE2 receptor information, predicted 72% accuracy and identified numerous additional species with potential to transmit the virus.
SourceCary Institute of Ecosystem Studies·JournalProceedings of the Royal Society B Biological Sciences·TypeComputational simulation/modeling·DateNov 16, 2021
Researchers used NASA's Hubble Space Telescope to focus on a post-starburst galaxy nearly 500 million light years away. They discovered two periods of intense starburst before the galaxy stopped forming stars, shedding new light on its history and evolution.
SourceUniversity of Toledo·JournalThe Astrophysical Journal·TypeObservational study·DateNov 16, 2021
A large study comparing the brains of left-handers and right-handers found significant differences in brain asymmetry across ten regions. The research also discovered a link between genetic influences on handedness and brain asymmetries in language-related regions.
SourceMax Planck Institute for Psycholinguistics·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 16, 2021
A team of researchers at the University of Cambridge found that an air filtration machine removed almost all traces of airborne SARS-CoV-2 in COVID-19 wards. The study suggests that setting standards for cleaner air could reduce the risk of airborne transmission of infections.
SourceUniversity of Cambridge·JournalClinical Infectious Diseases·TypeExperimental study·DateNov 16, 2021
The Covestro Circular Economy Program aims to create opportunities for research, education, and innovation in circular economy principles. The program will prepare students with circular economy training to address the challenge of global waste and material use.
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
This study reveals cellular composition changes in colon organoids exposed to smoking and red/processed meat carcinogens, suggesting an overlap between inherited and environmental CRC risk. The findings provide novel insights into CRC etiology and reveal potential avenues for future research.
SourceImpact Journals LLC·JournalOncotarget·DateNov 16, 2021
The research team aims to increase organ-transplant access for underserved minority patients by developing an integrated dynamic stochastic simulation-optimization model. This model will help patients decide whether to accept a less compatible kidney or wait for a more compatible one.
A new genetic analysis reveals that freshwater mussel larvae's mimicry of fish attracts host fish, allowing the mussels to coexist and drive species diversity. The study found that specialized host-infection behaviors evolved over time, leading to adaptive radiation among the mussel species.
Physicists from Exeter and Zaragoza develop a theory to engineer non-reciprocal flows of quantum light and matter, paving the way for novel devices with directional character. This breakthrough may lead to the creation of quantum technologies requiring efficient, directional energy transfer.
SourceUniversity of Exeter·JournalProceedings of the Royal Society A Mathematical Physical and Engineering Sciences·DateNov 16, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A large study of UK patients found a significant association between SARS-CoV-2 infection and subsequent psychiatric illness, fatigue, and sleep problems. The research used health records of over 12 million patients to examine the relationship between COVID-19 and mental health issues.
SourceJAMA Network·JournalJAMA Network Open·DateNov 16, 2021
A new study by University of Pittsburgh researchers links econometric models with production profitability to predict the impact of demand shocks on carbon intensity. Small shocks are predicted to displace heavy crudes with higher carbon intensity, but the relation may be counterintuitive.
SourceUniversity of Pittsburgh·JournalNature·DateNov 16, 2021
Researchers at Universidad Complutense de Madrid have discovered alterations caused by ALS in the retina, which can be used as biomarkers for diagnosis and treatment monitoring. The study found changes in microglial cells and ganglion cell loss, with modifications evolving over the course of the disease.
SourceUniversidad Complutense de Madrid·JournalNeural Regeneration Research·TypeExperimental study·DateNov 16, 2021
A team of Boston College researchers has discovered a dramatic re-arrangement of magnetic domains with thermal cycling in a Mott insulator. They used spin-polarized scanning tunneling microscopy to map the local strength of antiferromagnetic ordering on nanometer length scales.
SourceBoston College·JournalScience Advances·TypeExperimental study·DateNov 16, 2021
A study by the University of Queensland found that COVID-19 pandemic responses must include actions safeguarding biodiversity and ecosystems. The research team advocates for a One Health approach to holistically address outbreaks before they happen.
SourceUniversity of Queensland·JournalThe Lancet Planetary Health·DateNov 16, 2021
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research in mice shows how diet affects immunity through a specific gut microbe. The study reveals that dietary amino acids trigger the release of metabolic byproducts from gut bacteria, modulating immune function and leading to inflammation.
SourceHarvard Medical School·JournalNature·TypeExperimental study·DateNov 16, 2021
Researchers developed an automated method to detect and date abrupt climate events in paleoclimatic data, facilitating the study of climate tipping points in the past. The new tool can help establish chronology of close events and eliminate uncertainties during comparisons of different paleo records.
SourceUniversity of Copenhagen - Faculty of Science·JournalChaos An Interdisciplinary Journal of Nonlinear Science·TypeData/statistical analysis·DateNov 16, 2021
The European Society of Cardiology has published guidance for diagnosing and managing cardiovascular disease in patients with COVID-19. The two-part document provides practical information and advice to help clinicians care for patients affected by the pandemic.
SourceEuropean Society of Cardiology·JournalEuropean Heart Journal·DateNov 16, 2021
A new Rutgers study found young sexual minority Black men in NYC experience higher rates of stop-and-frisk encounters than their Hispanic and white counterparts. The researchers emphasize the need for community-based solutions to address these stressful interactions and promote mental health and wellbeing.
SourceRutgers University·JournalPLOS ONE·TypeData/statistical analysis·DateNov 16, 2021
A new research study reveals the emotional responses and coping strategies employed by family members of former athletes living with neurodegenerative disease. The study sheds light on the challenges faced by these families, who are often under immense strain, and calls for further support and care.
SourceOxford Brookes University·JournalThe Qualitative Report·DateNov 16, 2021
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Rice University computer scientists have discovered an inexpensive way to implement rigorous personal data privacy in large databases for machine learning. Using locality sensitive hashing, their RACE method creates small summaries of enormous databases while scaling for high-dimensional data.
SourceRice University·TypeExperimental study·DateNov 16, 2021
A new study by the Regenstrief Institute found that lack of protocols or standard operating procedures in the recovery room is a significant barrier to administering post-operative chemotherapy to reduce bladder cancer recurrence. The researchers identified 58 Michigan urologists who reported this as a major obstacle, emphasizing the n...
SourceRegenstrief Institute·JournalThe Journal of Urology·DateNov 16, 2021
A University of Adelaide study reveals that over 35% of fish caught off southern Australia contain microplastics, with the problem being most acute in South Australia. Simple actions like replacing plastic fishing equipment and using biodegradable bags can quickly reduce plastic pollution in the ocean.
SourceUniversity of Adelaide·JournalMarine Policy·TypeMeta-analysis·DateNov 16, 2021
Researchers at the University at Buffalo have created model protein-RNA droplets with properties similar to those of viscoelastic Maxwell fluid and Silly Putty. These droplets exhibit dual behavior, acting like both elastic solids and viscous liquids, depending on the timescale.
SourceUniversity at Buffalo·JournalNature Communications·DateNov 16, 2021
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers have developed a new approach to studying prostate cancer, allowing them to track the behavior of individual cancer cells from birth to organ spread. The technique uses whole-organ imaging and artificial intelligence to create a 3D reconstruction of the organ at single-cell resolution.
SourceCold Spring Harbor Laboratory·JournalCell Reports·DateNov 16, 2021
Researchers at GIST have made a breakthrough in creating a perovskite material with easily tunable electrical properties. The study used ambient pressure X-ray photoelectron spectroscopy and low energy electron diffraction to investigate the effects of fabrication conditions on the material's surface.
SourceGIST (Gwangju Institute of Science and Technology)·JournalJournal of Materials Chemistry C·TypeExperimental study·DateNov 16, 2021
A new study found that only 47% of women had a dental visit during pregnancy, highlighting barriers to care among Medicaid-enrolled women. Medicaid Pregnancy Dental coverage was often unaware or underutilized by reproductive-aged women, posing significant oral health risks.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalJournal of Women s Health·TypeCase study·DateNov 16, 2021
A recent study published in JAMA Open Network evaluates the performance of the EyeArt AI system, detecting diabetic retinopathy with high sensitivity and specificity. The results demonstrate the ability to accurately detect vision-threatening diabetic retinopathy without physician oversight, facilitating efficient diabetic eye exams.
SourceThe Lundquist Institute·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateNov 16, 2021
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Researchers from Genethon and Université de Paris have developed an AAV-based gene therapy that corrects skeletal damage caused by XLH in mouse models. The treatment targets liver hepatocytes to express therapeutic proteins, potentially offering a lifelong solution for this rare disease.
Researchers from Okayama University developed an AI-powered image classifier to simplify and speed up the task of image analysis in cell biology. The system achieved high detection accuracy for mitotic cells in plant species, demonstrating its potential for non-experts to use.
SourceOkayama University·JournalChromosome Research·TypeImaging analysis·DateNov 16, 2021
Researchers at Baylor College of Medicine identified over 300 genes with altered expression in advanced cancers due to genomic structural variations. The study found associations between tumor genomic rearrangements and altered metabolism-associated gene expression, suggesting potential mechanisms for therapy resistance. These findings...
SourceBaylor College of Medicine·JournalCell Reports·TypeData/statistical analysis·DateNov 16, 2021
Scientists discovered that low-frequency energy from earthquakes travels in a four-leaf clover pattern near the fault, while higher frequency waves travel in all directions. This finding could improve building designs and mitigate earthquake damage by prioritizing vulnerable areas within the pattern.
SourceUniversity of Texas at Austin·JournalGeophysical Research Letters·TypeObservational study·DateNov 16, 2021
Scientists identified multiple enzymes involved in C-glycoside metabolism, revealing a common reaction mechanism in both intestinal and soil bacteria. This discovery could provide insight into how the body breaks down these molecules and potentially lead to new treatments for diseases.
SourceUniversity of Tsukuba·JournalNature Communications·DateNov 16, 2021
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers developed an algorithm that combines product popularity and variety to increase customer appeal, resulting in a 30% increase in customer engagement. The study, conducted with Wayfair, also found the algorithm was efficient and required minimal customer data.
SourceUniversity of Toronto, Rotman School of Management·JournalManagement Science·TypeExperimental study·DateNov 16, 2021
A University of Sydney study found that diet has a stronger impact on ageing and metabolic health than three common diabetes drugs. The research suggests changing one's diet can be more effective in improving metabolic health than taking medications.
SourceUniversity of Sydney·JournalCell Metabolism·TypeExperimental study·DateNov 16, 2021
The Department of Modern and Classical Languages at George Mason University has received a grant of $398,227 to support the Global Exchange Office's Project GO. The program aims to help future global officers gain fluency in critical languages while learning intercultural communication tools.
Researchers developed a new membrane-based separation technology using MOF nanoparticles, which consumes up to 90% less energy than traditional methods. The technology overcomes interfacial adhesion problems by fabricating compatible MOF fillers, improving membrane performance.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalJournal of Materials Chemistry A·TypeExperimental study·DateNov 16, 2021
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new nasal vaccine, Protollin, is being tested in humans for the first time to prevent and slow Alzheimer's disease progression. The trial aims to determine safety and tolerability, as well as its effects on the immune system.
A Mount Sinai study reveals that young adult cancer patients exhibit distinct genetic hallmarks and immune system responses compared to their older counterparts. These findings suggest personalized treatment approaches for young adults with various types of cancers.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalCell Reports·TypeData/statistical analysis·DateNov 16, 2021
A new study of family doctors' views and experiences reveals that a software tool meant to reduce emergency hospital admissions is of limited use and benefit. The researchers found mixed views and experiences among GPs and practice managers about the tool, which was used in Wales as part of an earlier trial.
SourceSwansea University·JournalBritish Journal of General Practice·DateNov 16, 2021
A Mediterranean region study predicts increased crop water demands due to worsening climate conditions, affecting staple crops like maize and wheat. The findings highlight the need for precision agriculture and water management strategies to balance economic growth and environmental sustainability.
SourceCMCC Foundation - Euro-Mediterranean Center on Climate Change·JournalAgricultural Water Management·DateNov 16, 2021
Researchers found a specific plant extract activates a potassium channel that soothes pain, while having the opposite effect on another related channel, which can prevent diarrhea. The discovery could lead to new medicines for pain and gastrointestinal issues.
SourceUniversity of California - Irvine·JournalFrontiers in Physiology·TypeExperimental study·DateNov 16, 2021
The discovery of mineralized sponge fossils in Fontanarejo, Spain, has provided new insights into the evolution of living beings. The fossils, dated to around 530 million years ago, offer a unique window into the early Cambrian period.
SourceUniversidad Complutense de Madrid·JournalGeological Magazine·TypeExperimental study·DateNov 16, 2021
Researchers tracked vampire bats' gut microbes over four months, finding that those with closer social interactions shared more similar microbiomes. The study controlled for diet and environment, providing insight into the impact of social behavior on microbiome development.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalBiology Letters·TypeExperimental study·DateNov 16, 2021
Researchers at the Ragon Institute of MGH, MIT and Harvard have developed a new anti-malarial antibody that provides significant protection against malaria, outperforming existing best-in-class antibodies. The breakthrough could lead to improved distribution of monoclonal antibodies in endemic countries.
SourceMassachusetts General Hospital·JournalImmunity·TypeExperimental study·DateNov 16, 2021
A new process has been identified to accelerate the use of low-cost materials, transforming the energy sector with potential to replace silicone-based solar panels. The dynamic dimeric copper complexes offer a novel combination of fast charge transport and efficient redox mechanisms.
SourceNewcastle University·JournalChem·TypeExperimental study·DateNov 16, 2021
The discovery proposes replacing carbon-hydrogen bonds with nitrogen rings, enabling faster and more efficient production of drug candidates. This breakthrough could lead to rapid creation of potent and effective medication libraries.
The study assessed meadow ecosystem biomass to understand its contribution to carbon sequestration. It used species composition and functional groups to predict biomass values, finding a reliable method for assessing productivity without collecting data.
SourceKazan Federal University·JournalContemporary Problems of Ecology·TypeExperimental study·DateNov 16, 2021
A new study from UMass Amherst suggests that changing land-use patterns in the greater Narragansett watershed can help mitigate the effects of climate change. The research found that expanding forest cover and investing in green infrastructure, such as rain gardens and living roofs, can reduce surface runoff and nutrient loading.
SourceUniversity of Massachusetts Amherst·JournalScience of The Total Environment·DateNov 16, 2021
A recent study analyzed commercially insured patients and found that inpatient stays for eating disorders, including anorexia nervosa and bulimia nervosa, rose during the COVID-19 pandemic. The study included over 3.2 million people and highlighted the need for continued support and treatment for individuals affected by these conditions.
SourceJAMA Network·JournalJAMA Network Open·DateNov 16, 2021
Researchers found that CD4+ T lymphocytes — immune system cells — produced by people who received COVID-19 vaccines persisted at high levels six months after vaccination, with a significant response against the delta variant. The study also showed that vaccine-elicited fighters recognize and help attack coronavirus delta variant.
SourceJohns Hopkins Medicine·JournalClinical Infectious Diseases·DateNov 16, 2021
A new study suggests that the brain uses a mechanism called 'repulsion' to differentiate between similar environments. Researchers found that when participants were asked about stores shared between two cities, their brains showed surprisingly different patterns of activity, indicating that they were treating these familiar locations a...
SourceUniversity of Arizona·JournalNature Communications·TypeObservational study·DateNov 16, 2021
A team of researchers at Georgia State University has created a lightning-fast computer software that can process over 200,000 novel virus genomes in under two hours. The software provides valuable information for countries making early decisions about lockdowns, quarantines, and testing during infectious disease outbreaks.
SourceGeorgia State University·JournalJournal of Computational Biology·TypeComputational simulation/modeling·DateNov 16, 2021
The WOCN Society and medical organizations outline key principles for stoma site selection and marking. A properly placed stoma site can improve quality of life and reduce complications, while individualized consideration is necessary for optimal results.
SourceWolters Kluwer Health·JournalJournal of Wound Ostomy and Continence Nursing·DateNov 16, 2021
A study of healthy individuals aged 50-74 found that coffee and tea consumption was associated with reduced rates of stroke and dementia. People who drank 2-3 cups of coffee and 2-3 cups of tea daily had a 32% lower risk of stroke and a 28% lower risk of dementia compared to those who consumed none.
SourcePLOS·JournalPLOS Medicine·TypeObservational study·DateNov 16, 2021
A Québec research team studied the expression of three families of genes in the placenta and found associations with febrile seizure characteristics. The study, led by Professor Sarah Lippé, may help understand the underlying mechanisms of febrile seizures and their impact on children's cognitive development.
SourceInstitut national de la recherche scientifique - INRS·JournalJournal of Neuroendocrinology·DateNov 16, 2021
Researchers identified brain cells called angular head velocity (AHV) cells that track head motion speed, which improves estimation of own head angular speed when visual cues are available. This study sheds light on the neural mechanisms underlying navigation and self-motion guidance in the brain.
SourceSainsbury Wellcome Centre·JournalNeuron·TypeExperimental study·DateNov 16, 2021
Researchers created a portable electronic nose that can detect the stink of wastewater treatment plants with near-human accuracy. The device is combined with a drone to measure air quality and predict odor intensity, producing real-time maps for management.
SourceCell Press·JournaliScience·TypeExperimental study·DateNov 16, 2021
Scientists sequenced Plasmodium falciparum genomes to understand malaria parasite populations and track drug resistance biomarkers. The study identified population-specific SNPs that can be used to determine transmission routes and monitor drug resistance.
SourceOsaka City University·JournalScientific Reports·TypeMeta-analysis·DateNov 16, 2021
Researchers used a new X-ray technique to identify substances quietly eating away at the Mary Rose's timbers, contributing to its decay. The technique, developed by Kirsten Marie Ørnsbjerg Jensen, allows for better preservation of cultural artefacts and archaeological relics.
SourceUniversity of Copenhagen - Faculty of Science·JournalMatter·TypeImaging analysis·DateNov 16, 2021
Researchers at the University of California, Irvine developed a new 'body area network' fabric that enables battery-free communication between clothing and nearby devices. This innovation allows wearers to digitally interact with electronic devices and make secure payments using a simple high-five or handshake.
SourceUniversity of California - Irvine·JournalNature Electronics·DateNov 16, 2021
The University of Sydney's project searches for Earth-like planets around Alpha Centauri to determine if life could survive there. The team is using advanced telescope technology to analyze the stars' atmospheres and detect signs of life.
Researchers at Tokyo Medical and Dental University discovered a genetic variant associated with a poorer prognosis of chronic hypersensitivity pneumonitis. The variant, rs5743899, was linked to increased immune activation and fibrosis, leading to reduced lung function in patients.
SourceTokyo Medical and Dental University·JournalCHEST Journal·DateNov 16, 2021
Scientists designed a precursor compound with a single conjugated polymer chain and then formed a second rail through a zipper reaction to create a molecular ladder. The ladder has two tracks of conjugated polymers, allowing energy to move along the molecule in space.
SourceUniversity of Bonn·JournalNature Communications·DateNov 16, 2021
A recent study published in JNCCN found that only 31% of hospitals have immediate availability of all-trans retinoic acid (ATRA), a crucial blood cancer medication. This medication is essential for treating acute promyelocytic leukemia, which has a better prognosis when treated appropriately. The lack of ATRA availability poses a signi...
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·TypeSurvey·DateNov 16, 2021
A new AI application called DeepMReye uses MRI signals to read eye movements and infer thoughts, memories, and goals. It can also diagnose brain diseases by analyzing characteristic eye movement patterns.
SourceNorwegian University of Science and Technology·JournalNature Neuroscience·TypeImaging analysis·DateNov 16, 2021
Researchers suppressed cortical excitability to resolve self-interest vs. prosocial motivations in favor of cooperation, particularly in dictator games. In generosity games, no effect was observed. The study suggests the dorsolateral prefrontal cortex plays a key role in resolving conflicts between self-interest and prosociality.
SourceNational Research University Higher School of Economics·JournalScientific Reports·DateNov 16, 2021
A new study published in The BMJ has found that women with kidney failure experience significantly reduced life expectancy compared to men, with an average loss of 3.6 years of life. Women under 15 also experienced the most significant loss in life expectancy, with a 33-year loss for females.
SourceUniversity of Sydney·JournalThe BMJ·TypeMeta-analysis·DateNov 16, 2021
International researchers used machine learning to forecast marsh establishment under various environmental conditions, revealing that controllable local factors are more important than global climate change. The study suggests smart management of tidal flats can counteract threats and strengthen wetlands.
SourceRoyal Netherlands Institute for Sea Research·JournalGeophysical Research Letters·TypeData/statistical analysis·DateNov 16, 2021
A rapid same-day test has been developed to identify secondary infections in COVID-19 patients on intensive care, allowing for targeted antibiotic treatment and reduced risk of antimicrobial resistance. The test uses nanopore sequencing technology to analyze bacterial and fungal pathogens present in patient samples.
SourceNIHR Biomedical Research Centre at Guy’s and St Thomas’ and King’s College London·JournalGenome Medicine·TypeRandomized controlled/clinical trial·DateNov 16, 2021