A study led by Albert Einstein College of Medicine found that children of centenarians live longer and have lower risks of cardiovascular disease and hypertension. The research, analyzing data from three geographically diverse studies, suggests that inherited biological factors beyond lifestyle contribute to exceptional healthy aging.
Researchers at Albert Einstein College of Medicine identified a biological process that sheds new light on how memory circuits mature during late adolescence. The study found that memories formed earlier in life become temporarily difficult to retrieve before resurfacing later with less precise detail.
BIO-VITAL brings together leading scientists in aging biology to support industry partners evaluating novel gerotherapeutics. The program combines Einstein's decades of leadership in aging research with specialized research cores, proprietary models, and translational capabilities.
Researchers have developed a new molecular imaging technology that illuminates proteins inside living cells and animals far more clearly than before. The system uses engineered fluorescent nanobodies to reduce background noise by as much as 100-fold, enabling sharper visualization of protein location and dynamics.
Dr. Ulrich Steidl, MD, Ph.D., has been appointed as the director of the prestigious Montefiore Einstein Comprehensive Cancer Center and vice president of cancer medicine at Montefiore Einstein. With extensive experience in blood cancer and stem cell research, Dr. Steidl aims to advance innovative science that improves lives worldwide.
Researchers at Albert Einstein College of Medicine have developed a new strategy to engineer immune cells that prolong their effectiveness, addressing a major limitation of current treatments. The new method generates longer-lasting immune cells that provide more sustained control of human blood cancers and suppression of HIV-infection.
A new study published in JAMA Internal Medicine found that adults with chronic pain who used medical cannabis had a 22% reduction in opioid use. The study, led by researchers at Albert Einstein College of Medicine, suggests that supervised use of medical cannabis can relieve chronic pain and reduce reliance on prescription opioids.
Researchers found that a decline in chaperone-mediated autophagy activity is linked to age-related muscle wasting and can be boosted by exercise and fasting. The study suggests that enhancing this process may be a promising therapeutic strategy for preventing or treating sarcopenia in aging populations.
The National Institutes of Health has awarded a five-year, $10.8 million grant to create the New York Regional Diabetes Research Center (NYR-DRC), a multi-institutional center that aims to discover scientific knowledge and translate it into improved care for people with diabetes and related metabolic diseases. The center will bring tog...
The project will develop prediction algorithms using AI and a novel cognitive assessment tool to identify individuals at high risk for crisis. The digital platform, available at no cost, will provide personalized models to predict clinical health outcomes, including symptom escalation, recovery time, and rehospitalization.
Researchers found that glioblastoma causes skull bone erosion, alters immune-cell balance in skull marrow, and interferes with the body's immune response. The cancer was found to be more aggressive when treated with drugs intended to inhibit skull-bone loss.
A study of 9/11 first responders found mutations in blood-forming cells may explain increased leukemia risk, suggesting a targeted intervention against environmental toxins. The research also identified IL1RAP as a protein culprit, which could be used to prevent or treat blood cancers in individuals exposed to similar disasters.
A large study found the HPV vaccine to be highly effective in protecting young women from infections caused by the virus, including those who didn't receive the vaccine. The research also showed clear evidence of herd immunity, suggesting that widespread vaccination can indirectly protect unvaccinated individuals.
Researchers discovered that LRP8, a low-density lipoprotein receptor, is the key protein TBEV uses to infect human cells. In experiments with mice, treatment with a decoy receptor prevented TBEV infection, highlighting the importance of LRP8 in neurological disease.
Dr. Amanda Raff has been appointed as the senior associate dean for medical education at Albert Einstein College of Medicine. She brings nearly 20 years of experience in medical education and has received numerous awards for her teaching.
Dr. Britta Will has been appointed as the permanent director of the Ruth L. and David S. Gottesman Institute, succeeding Ulrich Steidl. Her research focuses on restoring blood regeneration in older adults and those with cancer. She aims to advance fundamental research into stem cell function and tissue regeneration to combat chronic de...
The new Data Science Institute will support researchers in harnessing vast amounts of data to advance scientific discovery and patient care. With seed funding, the institute aims to foster interdisciplinary collaborations and provide cutting-edge tools and academic knowledge to extract valuable insights from massive datasets.
Dr. Ulrich Steidl, a leading expert in blood diseases, has been elected to the Association of American Physicians for his groundbreaking research on myelodysplastic syndromes and acute myeloid leukemia. His work seeks to understand the characteristics of pre-leukemic stem cells and develop drugs to interrupt their progression.
Dr. Adam Kohn has been appointed as the Chair of Neuroscience at Albert Einstein College of Medicine, succeeding an extensive national search. He will lead research focused on visual processing and neural coding.
Researchers found that two subtypes of bacterial vaginosis increase the risk of developing chlamydia infections. The study analyzed cervicovaginal microbiomes before, during, and after infection with chlamydia, identifying a link between specific bacteria types and increased risk.
Marina Konopleva joins the Eradicating MRD in AML TeamLab to develop new ways to detect and target Minimal Residual Disease. MECCC has developed multiple targeted agents that have become standard of care for older AML patients, and will partner with Break Through Cancer to deepen understanding of MRD drivers.
A new study found a 29% increase in risk for developing dyslipidemia due to COVID-19, with seniors and people with type 2 diabetes being most affected. The research suggests that tackling dyslipidemia can reduce the risk of cardiovascular disease in those who have had COVID.
Researchers at Montefiore Einstein Comprehensive Cancer Center have discovered a natural immune mechanism in mice that stops escaped cancer cells from developing into tumors elsewhere in the body. Alveolar macrophages recognize and interact with disseminated cancer cells, producing signals that keep them dormant.
The Einstein-led PROVIDENT consortium will conduct four projects to develop countermeasures against a wide range of emerging viruses, with a focus on three virus families: nairoviruses, hantaviruses, and paramyxoviruses. The grant aims to quickly respond to emerging viruses with existing research and tools.
Researchers at Albert Einstein College of Medicine discover a new way to improve HSC mobilization for clinical use. Trogocytosis, a mechanism where one cell type extracts membrane fractions from another, plays a role in regulating immune responses and cellular systems.
A new study found that an easy, five-minute assessment paired with recommendations in the electronic medical record system led to a three-fold improvement in diagnosis and treatment for patients with dementia. The '5-Cog paradigm' was developed to address cultural differences and testing disparities.
Researchers have developed a breakthrough therapy that can adapt CAR-T cell therapy to target solid tumors, potentially transforming cancer treatment. The therapy uses a novel antibody and costimulatory protein to activate T cells, overcoming the challenges of immune suppression in solid tumors.
Scientists at Albert Einstein College of Medicine discovered that inflammation in certain neurons is necessary for forming long-lasting memories. The researchers found that DNA damage and repair within these neurons leads to stable memory assemblies, which are clusters of brain cells representing past experiences.
A study published in Cell Stem Cell found that restricting iron levels in blood stem cells can reverse their decline and improve regenerative capacity. The researchers discovered that excess intracellular iron activates inflammation within HSCs, while restricted iron levels enable them to multiply and respond effectively.
The study aims to refine and validate a set of remote-testing methods called R-CARE Toolbox to assess older adults with dementia in diverse populations. Participants will undergo comprehensive assessments both in-person and remotely, followed by follow-up assessments at 18 and 36 months.
Researchers at Montefiore Einstein Comprehensive Cancer Center are conducting a phase 1 clinical trial of danvatirsen, a STAT3 inhibitor, to treat relapsed and treatment-resistant forms of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The trial aims to determine the safety and efficacy of the experimental treatment ...
Scientists at Montefiore Einstein Cancer Center have developed a novel HPV test that detects cervical adenocarcinoma and its precursor lesions with high sensitivity. The test assesses methylation levels in cervical tissue samples, offering a more accurate detection method for this common type of cancer.
Chikungunya virus has found a way to evade the immune system by hijacking host cells' cytoskeleton, allowing it to spread directly from cell to cell. This discovery could lead to the development of effective vaccines or treatments for this debilitating mosquito-borne disease.
The Montefiore Einstein Cancer Center received a $2.9 million grant to train physicians and scientists to conduct clinical and translational oncology research, focusing on addressing health inequities in the Bronx. Scholars will engage in interdisciplinary research projects with community outreach and engagement.
A low-cost antibacterial regimen can prevent acute radiation dermatitis, a common skin problem affecting up to 95% of radiation therapy patients. The treatment involves using chlorhexidine and mupirocin nasal ointment twice daily, with no adverse effects or severe cases reported.
Researchers at Albert Einstein College of Medicine have found that long-term memories are formed through cycles of transcription and local translation of a short-lived protein. The study provides insights into the causes of neurological disorders such as autism spectrum disorder and Alzheimer's disease.
A $4.1 million NIH grant will help Montefiore Einstein researchers identify factors besides obesity that contribute to high rates of type 2 diabetes among children in the Bronx. The study aims to assess biological and social risk factors for youth-onset T2D, including food and housing insecurity.
The Albert Einstein College of Medicine and Montefiore Health System have received a seven-year, $30 million grant from the National Institutes of Health to continue supporting the Harold and Muriel Block Institute for Clinical and Translational Research. The grant will advance translational science and health equity by accelerating th...
A four-year study will track health outcomes among older Black and Hispanic residents in the Bronx to understand how neighborhood redevelopment affects cardiovascular disease. The research team will use medical records, interviews, and data modeling to measure the impact of both medical and nonmedical risk factors on CVD health.
Researchers will investigate the relationship between heart function and aorta stiffness to identify risk factors for heart failure in Hispanics/Latinos, who are disproportionately affected by this condition. The study aims to develop new methods for predicting and preventing heart failure in underrepresented populations.
Researchers aim to reduce disparities in dementia diagnosis and treatment with a 5-minute screening tool. The study will enroll 6,600 participants in urban and rural communities.
The National Institutes of Health has awarded Albert Einstein College of Medicine a five-year, $6.6 million grant to train young scientists in kidney, urology, and hematology research. The New York Consortium for Interdisciplinary Training in Kidney, Urological, and Hematological Research will bring together experts from four medical s...
Scientists at Albert Einstein College of Medicine describe findings that could bolster the effectiveness of immune-checkpoint therapy by using natural killer (NK) cells. The research team developed a monoclonal antibody targeting KIR2DL5, which allowed NK cells to vigorously attack and shrink human tumors.
Researchers at Albert Einstein College of Medicine are conducting a five-year study to assess the tradeoffs between soccer's aerobic brain benefits and the adverse effects from heading. The study will enroll 280 young men and women and investigate whether soccer's aerobic benefits counterbalance the damage sustained from heading.
A five-year, $4.2 million grant will test two strategies to improve PrEP access in the Bronx, aiming to reduce HIV infection rates. The strategies include assigning a sexual health navigator to contact patients and offering telehealth consultations with specialists.
The Montefiore Einstein Cancer Center has received a $10 million grant from the National Cancer Institute to study lung metastasis in breast cancer. The research aims to understand the mechanisms of tumor cells seeding tumors in the lungs, a key site for triple-negative breast cancer metastasis.
Researchers will examine if SARS-CoV-2 infection induces lasting changes in the brain and affects neurocognitive function using neuroimaging, cognitive, and immunological tests. The study aims to identify biomarkers for diagnosing long COVID and inform treatment approaches.
Researchers uncover distinct metabolic defect in malnutrition-related diabetes, differing from type 1 and 2 diabetes. The condition affects tens of millions, mostly thin and impoverished adolescents and young adults, with limited treatment options available.
Researchers at Albert Einstein College of Medicine are developing novel biomarkers to predict post-traumatic epilepsy risk and treatments. The team aims to establish a biomarker panel that can identify people at high risk for PTE and predict their response to treatment.
The Albert Einstein College of Medicine has received a $11.3 million NIH grant to expand its efforts in preventing, treating and curing HIV infection. The center will support research initiatives identifying more effective approaches to expand PrEP uptake and increase ART adherence among marginalized populations.