Scientists at Einstein College of Medicine identified two genes crucial for packaging fat into lipid droplets. Overexpressing these genes led to a significant increase in lipid droplet formation, while suppressing one of the genes resulted in a drastic reduction. This discovery could lead to new strategies for treating obesity and rela...
Researchers at Albert Einstein College of Medicine have found that perchlorate, an industrial pollutant linked to thyroid ailments, is concentrated in breast milk. High levels of perchlorate may deprive infants' thyroid glands of iodide, leading to mental impairment.
Researchers found that consuming vegetables rich in nitrite can reduce heart-muscle damage by 48% and provide protection from heart-attacks. Boosting nitrite levels in the diet could help prevent lasting heart damage or death, particularly for those at increased risk.
A study published in Medical Care found that people infected with HIV continue to die and suffer from AIDS complications due to delayed diagnosis and treatment. Researchers discovered that patients who had received medical care for other illnesses were often not diagnosed with HIV infections earlier, leading to severe complications.
Researchers at Albert Einstein College of Medicine successfully treated cancers by targeting viruses that cause them, slowing tumor growth and even causing tumors to regress. The approach holds promise for preventing cancer by destroying virus-infected cells before they become cancerous.
Three Einstein researchers have received $700,000 in grants from the Breast Cancer Research Foundation to study gene expression profiling, epigenetic changes, and metastasizing tumor cells. The studies aim to predict clinical outcomes, identify drug-resistant breast cancer cells, and develop new treatments.
A study by Albert Einstein College of Medicine found that people with higher education levels lose their memory faster after a dementia diagnosis. The accelerated decline in memory was observed to be 4 percent faster for each additional year of education.
Dr. John Greally and his team will develop high-throughput assays using high-throughput sequencing to analyze the human epigenome. They aim to identify patterns of epigenetic regulators and gain insights into how these mechanisms control genes.
The NIH grant will support research on biological mechanisms of healthy aging, aiming to identify genes contributing to exceptional longevity and prevent age-related diseases. Dr. Nir Barzilai's team will collaborate with experts in gerontology, neurology, genetics, epidemiology, and statistical genetics.
Scientists at Einstein College of Medicine have discovered the secret behind people living to 100 or more: favorable “longevity” genes that protect against disease-causing genes. The novel method used by researchers could lead to new drugs to protect against age-related diseases, including cardiovascular disease and diabetes.
Researchers at Albert Einstein College of Medicine measure transcription stages in real-time, revealing inefficient first two stages with only 1% polymerases remaining. Elongation phase takes 517 seconds, while pausing and rapid synthesis may regulate gene expression.
The new vaccine uses a virulent M. tuberculosis strain with genes knocked out to prevent apoptosis of mammalian cells, eliciting a strong and long-lasting T-cell response. This approach demonstrates superior protection compared to the standard BCG vaccine in animal models.
Adolescents from low-income families are at higher risk of developing migraines due to stress, poor diet, and limited access to medical care. In contrast, teenagers from affluent households have a lower prevalence of migraines, with only 2.9% experiencing symptoms annually.
Researchers at Albert Einstein College of Medicine found fungi can harness ionizing radiation to produce food and spur growth, recalculating Earth's energy balance. This discovery could provide a sustainable food source for long-duration space missions or planetary colonization.
Researchers at Albert Einstein College of Medicine have discovered a genetic signature that identifies cases of lymphoma susceptible to new molecular targeted therapy. The study found that tumors with this signature are killed by the new therapy, while those without it are resistant.
A study by Einstein researchers found that bioterrorism alerts can measurably raise anxiety levels, which could lead to adverse health effects. The team used volunteers to compare the impact of potent and neutral messages on anxiety levels.
A gene variant linked to exceptional longevity also helps maintain clear thinking and memory in centenarians, according to a new study published in Neurology. Researchers found that individuals with the CETP VV gene were twice as likely to have good brain function compared to those without it.
A clinical trial of gene transfer therapy for erectile dysfunction found significant and sustained improvements in patients who received a transfer gene called hMaxi-K. The therapy works by creating additional potassium channels in smooth muscle cells, relaxing the muscle and allowing blood flow required for an erection.
Researchers at Albert Einstein College of Medicine have found the mechanism by which folates in the diet are absorbed by the intestinal tract, solving a longstanding mystery. A genetic test can now detect hereditary folate malabsorption, a rare but potentially fatal disorder, allowing for early treatment and supplementation.
Researchers at Einstein and U. Albany will create a microchip to detect metastatic cells in human tumors, enabling more aggressive cancer therapy. The project aims to improve understanding of tumor microenvironments and cancer spread.
Researchers at Albert Einstein College of Medicine successfully targeted and destroyed HIV-infected cells in mice using radioimmunotherapy. The treatment aims to eliminate the virus-infected cells that make infections chronic, potentially leading to a cure for HIV-infected patients.
Researchers found highly resistant strains of TB in a rural area of South Africa, associated with high death rates in HIV-infected patients. The study highlights the need for action to tackle the problem of resistant strains that could jeopardize tuberculosis control and mortality prevention.
The Einstein College of Medicine has been selected to conduct a landmark study on the health status of 4,000 people of Hispanic/Latino origin in the Bronx. The six-year study will investigate various diseases and disorders affecting the Hispanic population, including heart disease, diabetes, and cognitive impairment.
Dr. E. Richard Stanley has been recognized with the 2006 E. Donnall Thomas Prize for his groundbreaking research on CSF-1, which plays a crucial role in regulating cell proliferation, differentiation, and function in various diseases. His studies have also shed light on the roles of CSF-1 and its receptor in development and cancer.
Researchers at Albert Einstein College of Medicine have developed a novel technique to insert genes into the P. falciparum genome, providing valuable information about its virulence and resistance to antimalarial drugs. This breakthrough should significantly speed up research efforts to bring malaria under control.
Dr. Brownlee, a leading researcher in type 1 diabetes, has been awarded the prestigious JDRF Scholar Award to pursue innovative research directions. He aims to develop strategies to reduce susceptibility to diabetic complications through his studies on hyperglycemic memory and free radical production.
The study suggests a novel approach for duplicating leptin's actions when the body no longer responds to the hormone. STAT3 production is essential for leptin's best-known action: acutely reducing food intake. Activating STAT3 may allow normalizing appetite and producing health benefits for obesity, diabetes and infertility.
The GeriEd Program aims to improve physicians' skills in medicine and navigating the healthcare system to better care for elderly patients. The program will target 157 practicing physicians and residents, as well as 750 medical students annually.
Researchers at Einstein College of Medicine have observed a phenomenon where a gene plays a major role in organism development, displaying pulses of transcription that turn on and off at irregular intervals. This discovery could enable precise regulation of development by allowing genes to be turned on and off as needed, similar to a t...
Dr. Horwitz's research on paclitaxel's mechanism of action led to its development and approval for treating various tumor types. She now focuses on overcoming drug resistance, a major challenge in cancer treatment.
The study identified a specific genetic profile linked to longevity and favorable lipoprotein profiles in centenarians. The Apolipoprotein C3 (APOC3) SNP was associated with healthier triglyceride and cholesterol levels, lower hypertension rates, and improved cardiovascular health.
Researchers at Einstein College of Medicine have discovered two new compounds, 2-HA and 2-OA, that are more potent than isoniazid in killing bacteria. These compounds inhibit multiple biochemical pathways essential for bacterial survival, offering a promising alternative to current treatments.
Researchers discovered that gene-dependent loss of precision in Purkinje cells causes hereditary movement disorder ataxia type-2. A drug called EBIO improved motor coordination in ataxic mice by activating calcium-activated potassium channels.
A recent study published in Diabetes reveals that diabetes rates in the US have increased dramatically over the past decade, leading to a sharp rise in hospitalizations and deaths from coronary heart disease. As a result, progress made in reducing illnesses and deaths from this condition may be put at risk.
A study led by scientists at Einstein and Beth Israel found a significant link between the G2019S LRRK2 gene mutation and Parkinson's disease in Ashkenazi Jewish patients. The mutation was detected in 18.3% of patients, highlighting the importance of genetic counseling for early detection and diagnosis.
Researchers at Albert Einstein College of Medicine discovered that chronic suppression of malonyl CoA levels in the brain impairs nutrient-sensing mechanism, leading to increased food intake and obesity. The study suggests a potential new approach to treat obesity by re-adjusting malonyl-CoA levels in the human hypothalamus.
ZBP1 guides actin messenger RNA to cell periphery and regulates translation into protein. The enzyme Src adds a phosphate group to ZBP1, unlocking the mRNA for translation into actin protein. This discovery could lead to new cancer therapies by targeting ZBP1 expression.
Researchers have discovered a new strategy used by TB bacteria to resist fluoroquinolone antibiotics, which are often ineffective against multi-drug-resistant TB. The discovery also reveals that other disease-causing bacteria, such as Shigella and E. coli, have developed similar resistance mechanisms.
Researchers discovered a promising drug, benfotiamine, that completely blocked three biochemical pathways damaging blood vessels in diabetic rats. The study found that benfotiamine successfully normalized retinal tissue and prevented diabetic retinopathy in the animals.
Researchers at Albert Einstein College of Medicine found that Id2 gene is implicated in neuroblastoma development and underlies tumor growth. The study suggests developing drugs to counteract the Id2 gene may provide targeted treatment for neuroblastoma and other cancers.
Scientists have visualized individual mRNA transcripts for the first time, revealing a cyclical transcription process that hits its peak in 30 minutes. The technique also shows that genes are transcribed at a limited rate by the number of polymerase/mRNA units at a gene's stopping point.
MSH6 mutations have been found in human families with hereditary non-polyposis colon cancer, confirming the gene's role in cancer predisposition. Knockout mice studies show that MSH6 is crucial for preventing tumor development, highlighting a new path for research in cancer diagnosis and development.
A new study in Saccharomyces cerevisiae, also known as Brewer's yeast, indicates that mRNA localization regulates differential gene expression in the organism. The localization of a protein called ASH1 to the tip of budding daughter cells controls its expression.