Scientists at Albert Einstein College of Medicine have developed a simple and accurate test to detect and quantify ricin, an extremely potent toxin. The assay detects small amounts of ricin more accurately and faster than ever before, paving the way for discovering drugs that could serve as antidotes.
Researchers suggest that autism symptoms may be reversible due to dysregulation of the locus coeruleus, a bundle of neurons processing sensory signals. The new theory proposes that fever can stimulate this system, potentially restoring its normal function.
A new process controlling cell fat storage has been discovered, which could lead to novel drugs for metabolic syndrome and fatty liver disease. The study found that autophagy regulates lipid metabolism, and disrupting this process can contribute to diseases such as obesity and type 2 diabetes.
A new test for metastasis could help doctors precisely identify which patients should receive aggressive therapy, sparing those at low risk from unnecessary treatment. The test detects the presence of a tumor microenvironment that predicts breast cancer spread.
Einstein College of Medicine has established a Specialized Cooperative Center Program in Reproduction and Infertility Research, focusing on menstrual disorders, endometriosis, and infertility. The center aims to translate breakthroughs in reproductive biology into clinical practice and address health disparities in the local community.
Researchers have created a new onsite method to quickly diagnose tuberculosis, reducing diagnosis time from weeks to days. The test uses bacteriophages with green fluorescence protein to detect the deadly drug-resistant strains that can mingle undetected with treatable TB strains.
A groundbreaking partnership between Einstein College of Medicine and the University of KwaZulu-Natal will focus on developing faster diagnostic tools and better chemotherapies for TB, MDR-TB, XDR-TB, and HIV. The institute aims to train a new generation of scientists in Africa and bridge the gap between bench and bedside research.
Researchers have identified genetic markers associated with aggressive head and neck cancer, specifically miR-205 and let-7d. These microRNA levels can predict poor survival outcomes and may lead to targeted treatment options.
The study developed three transition state analogs that disrupt quorum sensing in Vibrio cholerae and E. coli 0157:H7, reducing the risk of bacterial resistance. The compounds were tested on 26 successive generations and showed no signs of resistance development.
Researchers at Albert Einstein College of Medicine found that genetic differences in a gene called TAP can provide protection against high-grade Cervical Neoplasia, which is a premalignant condition caused by HPV.
The Empire State Stem Cell Board has awarded Albert Einstein College of Medicine $12.7 million to support promising medical advancements, including treatments for sickle cell anemia and obesity. The new grants will help create technologies for cancer, heart and liver disease, as well as age-related diseases.
A recent study published in the Journal of Clinical Endocrinology & Metabolism found that pre-diabetic adults with post-challenge hyperglycemia have a higher risk of cardiovascular disease due to increased glucose and insulin levels, triglycerides, inflammation, and impaired blood vessel function. Routine glucose screening and preventi...
The Einstein consortium will investigate two types of autophagy in liver and brain function under normal and stressful conditions. They aim to understand how impaired autophagy contributes to aging-related declines in organ function, immunity, and cognitive function.
Scientists have found a two-drug combination that inhibits the growth of susceptible laboratory strains and 13 XDR-TB strains, offering a new hope for treating this deadly form of tuberculosis. The drugs work together to target a bacterial enzyme, β-lactamase, which shields TB bacteria from antibiotics.
A new study found that women with a longer fertile lifespan, resulting in higher levels of naturally produced estrogen, had a lower risk of developing Parkinson's disease. However, hormone therapy did not offer protection against the disease, and may even have harmful neurological effects.
Scientists at Albert Einstein College of Medicine have developed radioimmunotherapy to target and destroy HIV-infected cells. The treatment, which uses antibodies attached to radioactive payloads, shows promise in laboratory and animal studies, and is currently being tested in pre-clinical trials.
Scientists at Albert Einstein College of Medicine have found that linker histone H1 is necessary for holding together pericentric heterochromatin, a region close to the center of chromosomes. H1 also regulates the expression of genes within this region. The study uses fruit fly larvae to examine H1's role in gene regulation.
A large study of postmenopausal women found no evidence that multivitamins reduce the risk of common cancers or cardiovascular disease. Researchers analyzed data from 161,808 women and found no association between multivitamin use and breast, colorectal, endometrial, kidney, bladder, stomach, ovary, or lung cancer.
Researchers at Albert Einstein College of Medicine have discovered that the protective capsule of Cryptococcus neoformans fungus grows by linking saccharides together, allowing it to evade the immune system. This finding could lead to new therapies or vaccines against fungal infections.
Research from Albert Einstein College of Medicine found that Ashkenazi Jewish men carrying specific gene mutations have a higher risk of developing aggressive prostate cancer. The study identified three particular mutations, including BRCA1-185delAG and the mutated BRCA2 gene, which increased the risk of high-grade tumors.
A study of third-graders found that daily recess improved classroom behavior, social development, and health. Children who received more recess behaved better and were likely to learn more.
New photoactivatable fluorescent proteins (PAFPs) and advanced fluorescent proteins (FPs) allow scientists to visualize individual cellular molecules in living cells. These tools are transforming biomedical research by enabling the study of cancer cells, protein-protein interactions, and cellular processes.
A study by researchers at Albert Einstein College of Medicine found a topical microbicide using RNA interference to protect against genital herpes infection for up to a week. The microbicide combines two siRNAs to offer both immediate and sustained protection, providing hope for a cost-effective therapy in developing countries.
Scientists at Albert Einstein College of Medicine identified a small intracellular protein, p115, that helps cells commit suicide and is required for the pro-apoptotic function of the Golgi protein. This discovery could lead to drugs for combating cancer and other diseases characterized by overproduction of cells.
Research by Drs. Bergman and Siegal explores evolutionary capacitance, a concept addressing stability of species under accumulated genetic variation. They found that most genes hold variation in reserve, releasing it when functionally compromised.
Research at Albert Einstein College of Medicine found that high insulin levels in postmenopausal women are associated with a higher risk of developing breast cancer. Women with the highest insulin levels were nearly 50% more likely to develop breast cancer compared to those with lower insulin levels.
Researchers at Albert Einstein College of Medicine developed a technique to make foreign pancreatic cells invisible to the immune system, dramatically protecting them from rejection. The new method could pave the way for routine use of cell transplants as a therapy for type 1 diabetes in humans.
Researchers at Albert Einstein College of Medicine found that a brain enzyme, p70 S6 Kinase 1, plays a key role in regulating feeding behavior and metabolism. Increasing the enzyme's activity reduces food intake and body weight, while lowering it has the opposite effect.
Researchers at Albert Einstein College of Medicine have identified a protein called Menainv, which is present in invasive cells within a breast tumor. This protein enables tumor cells to become invasive and metastasize to other parts of the body.
Researchers at Albert Einstein College of Medicine have developed a new technique to count individual mRNA molecules within single cells, revealing detailed insights into gene expression and regulation. The study found that housekeeping genes are not always expressed at a constant level, but rather exhibit restricted variability.
Four Americans, including US Senators Edward Kennedy and Mina Bissell, are being honored with the American Cancer Society's Medal of Honor for their outstanding contributions to cancer research and control. The recipients have made significant impact in funding, legislation, and awareness campaigns.
A recent study published in Psychology and Health suggests that attending religious services regularly can reduce the risk of death among post-menopausal women by approximately 20 percent. The researchers found that even after controlling for other factors such as social support and lifestyle choices, the improvements in mortality rate...
A study found that overusing medications containing barbiturates or narcotics can lead to more frequent migraine attacks. The use of these medications was associated with an increased risk of transformed migraine headaches, a form of migraine characterized by 15 or more days of headache per month.
Breast cancer cells closer to blood vessels are more aggressive and directed in their invasiveness, according to a new study. The research provides detail on how cancer cells invade surrounding tissue and reach blood vessels, offering insights into early stages of metastasis.
Dr. Xingxing Zang receives Type 1 Diabetes Pathfinder Award for his innovative research on B7x protein, which may prevent T lymphocytes from destroying pancreatic cells. The award supports his five-year study to explore the role of B7x in diabetes prevention and treatment.
Researchers at Einstein and Montefiore will focus on developing new therapies for Alzheimer's, diabetes, Parkinson's, ALS, and other conditions. They aim to create unique stem cells derived from patients with blood diseases like sickle cell anemia and hemophilia.
Researchers found that intra-individual variability in cognitive function improves dementia prediction beyond individual test scores. The Einstein Aging Study evaluated 897 individuals, identifying 61 cases of dementia, and showed that within-person variability across multiple tests predicts future dementia.
Researchers at Albert Einstein College of Medicine found that a component of intestinal bacteria helps HIV penetrate the blood-brain barrier, increasing the risk of cognitive disorders. The discovery could lead to new strategies for preventing HIV from entering the brain and causing serious complications.
Researchers at Albert Einstein College of Medicine have prevented age-related decline in liver function and shown that maintaining efficient protein clearance can help stave off functional losses. The study suggests therapies to boost protein clearance might help maintain healthy lives well into old age.
The National Institutes of Health has awarded Albert Einstein College of Medicine and Montefiore Medical Center a five-year, $22 million grant to establish the Einstein-Montefiore Institute for Clinical and Translational Research. The institute aims to expedite the transfer of research discoveries from academia to patient care.
The Einstein-Montefiore Center for AIDS Research has received a $8.5 million grant renewal from the NIH, supporting its growth of AIDS research programs and international collaborations. The center's contributions to HIV/AIDS research and treatment include identifying key areas of study and developing innovative therapies.
Dr. Michael Brownlee, a renowned expert in diabetes research, has been awarded the prestigious David Rumbough Award by JDRF for his outstanding contributions to understanding diabetic complications. His innovative work on hyperglycemia-induced damage and the discovery of novel molecular pathways have significantly advanced the field.
Researchers analyzed data from a US national survey and found that lower sodium diets were associated with a significantly increased risk of cardiovascular disease. The study casts doubt on long-held assumptions about the risks of high-salt diets.
Researchers found that higher vitamin D levels were associated with a lower prevalence of PAD. Individuals with the lowest vitamin D levels had a 64% higher risk of PAD compared to those with the highest levels.
Researchers at Albert Einstein College of Medicine found that aberrant Notch signaling plays a role in diabetic nephropathy and focal segmental glomerulosclerosis, two major causes of end-stage renal disease. They discovered that gamma secretase inhibitors can protect against kidney disease, sparking hope for new treatment options.
Scientists at Albert Einstein College of Medicine genetically engineered immune cells to target and kill HIV-infected cells. This approach, using genes from elite controllers' immune systems, could lead to a new strategy for combating AIDS. The study shows promise in both test tubes and animal models.
Scientists at Albert Einstein College of Medicine identify genetic variations influencing human longevity. The study found that female children of centenarians had higher IGF-I plasma levels, suggesting a possible compensation mechanism for impaired growth.
Researchers at Einstein College of Medicine successfully cured hemophilia A in an animal model by transplanting healthy liver endothelial cells from donor mice. The study overturned conventional wisdom regarding the source of factor VIII, a crucial clotting protein lacking in people with type A hemophilia.
Researchers at Einstein College of Medicine argue that federal dietary guidelines may have a negative impact on health, including the current obesity epidemic. They recommend that guideline writers be guided by explicit standards of evidence to ensure public safety.
A study by Einstein researchers suggests that impaired autophagy may contribute to the development of Parkinson's disease. The team found that dopamine-altered alpha-synuclein molecules interfere with lysosomal digestion, leading to toxic compound accumulation and cell death.