A global team of scientists, led by Albert Einstein College of Medicine researcher Robert Kaplan, has identified hundreds of gene variants that influence adult height. The study, which analyzed data from nearly 184,000 people worldwide, proves the effectiveness of genome-wide association studies in explaining observable traits.
Researchers at Albert Einstein College of Medicine have developed a microscope apparatus that achieves unprecedented resolution in living cells, allowing them to visualize the dynamic mechanism by which messenger RNA molecules pass through nuclear pores. This breakthrough could lead to treatments for disorders such as myotonic dystrophy.
A study by Albert Einstein College of Medicine researchers provides concrete evidence that children with autism spectrum disorders process sensory information differently than typically developing children. The findings support decades of clinical observations and could lead to objective measures for evaluating the effectiveness of aut...
A new study suggests that common hypertension medications can increase blood pressure in some patients. Researchers found that measuring renin levels through a blood test could help doctors choose the most suitable treatment for their patients, reducing the need for additional medication and improving blood pressure control.
A study by Dr. Paul Frenette reveals a unique 'partnership' between bone marrow stem cells, which could lead to advances in regenerative medicine. The partnership involves hematopoietic stem cells (HSCs) and mesenchymal stem cells, with the latter playing crucial roles in maintaining HSCs and facilitating regeneration.
Researchers aim to mitigate radiation-induced gastrointestinal syndrome using stem cell-based therapies. The new grant will support the development of bone marrow transplant techniques and identify chemical agents that accelerate repair and regeneration of irradiated stem cells.
A five-year, $4 million NIH grant will support a prospective study on antiretroviral therapy for people co-infected with MDR-TB and HIV in South Africa. The study aims to gather evidence for clinical practice and public health policy worldwide.
A panel of experts recommends translating laboratory findings into medicines that can benefit the aging population, with a focus on regenerative therapies and lifestyle improvements.
A study published in the Journal of Neurophysiology found that rejection by a romantic partner activates brain areas associated with motivation, reward, and addiction. This can lead to extreme behaviors like stalking, homicide, and suicide during break-ups.
A recent study has found that Jewish people from different regions share a common ancestry and distinct genetic traits. The research provides detailed genetic maps of major Jewish subpopulations, which can help understand genetic links to diseases like heart disease, cancer, and diabetes.
Researchers will investigate person-to-person transmission of XDR-TB using advanced epidemiologic techniques and social network analysis. The findings could alter public health approaches for controlling the XDR-TB epidemic in sub-Saharan Africa.
Einstein College of Medicine receives significant NIH funding to continue its Diabetes Research and Training Center, supporting research into central nervous system role in diabetes, epigenetics, and diabetic complications. The grant enables the development of new therapies for prevention or treatment of diabetes.
A multicenter team of researchers, including scientists at Albert Einstein College of Medicine, has received a NIH 'Glue Grant' to develop a strategy for discovering the structure and function of unknown enzymes. The research may result in new drug targets and lead to new enzymes for industrial reactions.
The study reveals the crystal structures of two key fluorescent proteins, blue and red, allowing for rational design of new proteins with specific colors. This breakthrough enables researchers to explore biological processes in normal cells versus cancer cells.
Einstein will increase research space and recruit new stem cell scientists with the new facility expansion, focusing on four broad themes: stem cell biology, genetics, cancer stem cells, and translational stem cell research. The renovation is expected to create 150 new jobs and drive scientific innovation for multiple diseases.
Researchers will examine the relationship between housing status and cardiovascular risk among nearly 1,000 Latino adults. The study aims to influence housing policy and reduce racial disparities in cardiovascular health.
A study by Einstein researchers suggests that a mutated protein accumulation may be key to understanding the disease. The defective huntingtin protein interferes with cellular autophagy, leading to toxicity and cell death.
A study of nearly 13,000 FDNY rescue workers found that those exposed to World Trade Center (WTC) dust suffered a persistent decline in lung function, with no meaningful recovery. The largest decline was observed among workers who arrived at the WTC site on 9/11.
Researchers create 10-minute audio CDs to encourage aerobic activity and promote positive lifestyle habits in inner-city children. The CHAM JAM program aims to increase physical activity levels, transform school-based health policies, and combat type 2 diabetes among children and adolescents.
Researchers at Albert Einstein College of Medicine have found two novel ways to kill TB bacteria, using an enzyme called GlgE and a second pathway that also synthesizes alpha glucans. This combination could lead to a potent therapy that prevents resistant TB strains from developing.
A new study found that migraine sufferers are at a doubled risk of heart attack compared to those without migraines. The research also reveals an increased likelihood of stroke and high cardiovascular risk factors, including diabetes, hypertension, and high cholesterol.
A new study shows that transferrin, a blood protein, can alleviate anemia and prevent fatal iron overload in humans. The research, conducted at Albert Einstein College of Medicine, suggests that treatment with transferrin could benefit people with thalassemia and other types of anemia.
Research from the Women's Health Initiative Memory Study finds elevated blood pressure increases white matter lesions, a known risk factor for dementia. Maintaining normal blood pressure may help prevent brain damage and associated cognitive decline.
Researchers found a 'longevity gene' associated with slower cognitive decline and reduced risk of dementia and Alzheimer's disease. The CETP gene variant alters protein function, leading to higher HDL cholesterol levels and increased protection against age-related illnesses.
Researchers at Albert Einstein College of Medicine developed a new approach to treat and heal skin abscesses caused by antibiotic-resistant staph bacteria using nitric oxide-releasing nanoparticles. The therapy was shown to clear up infections and promote healing in mice, offering a potential breakthrough in treating MRSA infections.
A study of over 136,000 postmenopausal women found a 45% higher risk of stroke and a 32% higher risk of death among those taking antidepressants compared to non-users. The researchers note that while the overall risk is small, it can have significant implications for large patient populations.
Dr. Matthew Levy has received $700,000 in Stand Up To Cancer funding to develop self-guiding drugs that target only cancer cells, reducing serious side effects of current therapies.
Researchers at Albert Einstein College of Medicine discovered a link between longevity and genes that maintain telomere length. The study found that individuals with long telomeres were more likely to have inherited genes that enabled effective telomerase production, potentially protecting against age-related diseases.
A study found that sustained modest weight loss can prevent or lower the incidence of type 2 diabetes in people at high risk, delaying diagnosis by about four years. Lifestyle changes also improved cardiovascular risk factors and were particularly beneficial among older adults.
The study found that mammals are protected from the majority of fungal pathogens due to their elevated body temperature, which is too high for most fungi to survive. This theory could help explain why mammals rose to dominance after the dinosaur extinction event.
Researchers aim to create a microbicide-releasing vaginal ring that protects women for weeks, targeting HIV infection at two different steps in its life cycle.
The Department of Health and Human Services has awarded Albert Einstein College of Medicine a three-year, $2.1 million grant to expand its Hispanic Center of Excellence. The center provides leadership and training in research to Hispanic students and faculty, with a focus on addressing health disparities in the Hispanic community.
A new drug-delivery system using nanoparticles encapsulating nitric oxide or prescription drugs could significantly lessen side effects associated with oral erectile dysfunction medications. The treatment showed improved erectile function in rats and held promise for safer and more effective ED therapy for millions of men.
The NIH awards Albert Einstein College of Medicine two grants totaling $3.5 million to study epigenetic changes and their contribution to diseases such as tumor development, aging, and abnormal growth. Researchers will focus on epigenetic modifications related to abnormal fetal growth and chronic kidney disease.
Einstein scientists have identified two small protein fragments that could be developed into an anthrax vaccine, potentially causing fewer side effects than the current vaccine. The research focuses on the protein toxin used in the current vaccine, looking for peptides that can trigger protective antibodies when injected into animals.
A research project led by Jan Vijg aims to unravel the mechanisms behind DNA damage and its role in aging, with potential treatments based on antioxidants and other interventions. The study involves four main areas of investigation and has the potential to lead to new strategies for delaying or curing age-related diseases.
Researchers at Albert Einstein College of Medicine found a strong link between concussions and brain tissue injury, using diffusion tensor imaging (DTI) to detect subtle changes in the brain. The study suggests that DTI scanning could help diagnose concussions and predict lasting loss of executive function.
Researchers at Albert Einstein College of Medicine have identified a distinct population of macrophages that may promote metastatic cancer growth. The study suggests that targeting these cells could inhibit tumor growth and potentially reduce cancer mortality.
A study of over 6,000 US children found that 9% had vitamin D deficiency and 61% were insufficient in the essential nutrient. Low vitamin D levels were associated with higher blood pressure, lower HDL cholesterol, and other risk factors for heart disease.
A study by researchers at Albert Einstein College of Medicine has identified a peptide called humanin that improves insulin action and lowers blood glucose levels in diabetic rodents. Humanin also protects nerve cells from death associated with Alzheimer's and other brain diseases.
Researchers at Albert Einstein College of Medicine found a strong association between elevated insulin levels and increased breast cancer risk in postmenopausal women. Women with higher insulin levels were more than twice as likely to develop breast cancer compared to those with lower insulin levels, especially among lean women.
Researchers developed a lab test to predict HIV microbicide safety, identifying why some 'safe' microbicides increased HIV transmission. The test detects disruptions in the vaginal epithelial barrier, which can facilitate HIV infection.
A new gene variant linked to increased risk of obesity has been discovered, affecting the central nervous system and leading to a 10-15% higher likelihood of being obese. The study examined data from eight studies involving genes and body weight, analyzing over two million genome regions.
Scientists have identified a method to predict which HIV-positive individuals are most susceptible to deadly fungal meningitis. The study found that people with low levels of IgM memory B cells are more likely to develop the disease, suggesting a genetic predisposition.
The Einstein Proteomics Research Center aims to identify brain proteins responsible for neurological complications in people infected with HIV, particularly those who are also addicted to drugs. The center will investigate the mechanism of HIV infection and develop biomarkers to detect neurological disease.
Researchers found that the gene ZBP1 is silenced in metastasizing breast cancer cells due to a methyl group attachment, leading to increased cell migration and proliferation. The study suggests potential drug targets for preventing metastasis and may help predict breast tumor outcomes by identifying signs of ZBP1 silencing.
A new study by Albert Einstein College of Medicine found that camphor-containing products can cause seizures in children, particularly those from Hispanic communities. The cases highlight the importance of proper labeling and education about the hazards of camphor usage.
Scientists have developed nanoparticles that release nitric oxide to combat drug-resistant Staphylococcus aureus skin infections, improving wound healing and reducing bacterial counts. The therapy has shown promise in treating MRSA and other infections, with plans for clinical trials.
Researchers at Albert Einstein College of Medicine found that an HDAC inhibitor, LBH589, is effective in killing head and neck cancer cells grown in the laboratory. The study identified a set of genes whose expression levels change in response to the drug, which may help doctors identify patients most likely to respond.
A new combination of chemotherapy drugs, topotecan and docetaxel, has produced clinical benefit for patients with recurrent gynecologic cancers. The treatment showed an unusually high proportion of women experiencing clinical benefit, with a median survival time of 18.5 months.