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Science News for August 24, 2009


JCI table of contents: Aug. 24, 2009

Researchers found that Six1 protein is central to tumor development in breast cancer, linked to EMT, stem/progenitor cells, and poor prognosis. Overexpression of Six1 also enhanced ability to metastasize, indicating its role as a key player in aggressive breast cancer.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 24, 2009

Comments with the Lancet South Africa series

The Lancet South Africa series proposes three strategies to address public sector workforce needs, affordable national health insurance, and competent leadership. The authors also discuss the decline in clinical research activity and capacity, as well as health inequities in South Africa, highlighting the need for jobs and cooperation ...

SourceThe Lancet_DELETED·JournalThe Lancet·DateAug 24, 2009

JNCI news brief: Surgeon training found effective in breast cancer sentinel lymph node trial

A new study published in JNCI finds that training methods for surgeons performing breast cancer sentinel lymph node resection are highly effective. The study evaluated three training methods and found a statistically significant positive association between procedural errors and false-negative rates.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateAug 24, 2009

USC study finds changes in DNA patterns are linked to prenatal smoke exposure

A new USC study reveals that prenatal tobacco smoke exposure is associated with detectable changes in DNA methylation patterns, which may impact childhood asthma and cardiovascular disease. Researchers found that children exposed to maternal smoke had lower global methylation levels and higher methylation in certain genes.

SourceUniversity of Southern California·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateAug 24, 2009

Aurora B answers an XIST-ential question

Researchers found that Aurora B kinase helps regulate XIST's chromatin binding by phosphorylating chromatin proteins during mitosis. This study provides insight into X chromosome silencing and may lead to a better understanding of noncoding RNAs and their role in regulating heterochromatin.

SourceRockefeller University Press·JournalJournal of Cell Biology·DateAug 24, 2009

Trust in a teardrop

A Tel Aviv University researcher suggests that tears signal vulnerability and attachment, making interpersonal relationships stronger. Crying is not just a symptom of pain or stress, but an evolution-based mechanism to bring people closer together.

SourceAmerican Friends of Tel Aviv University·JournalEvolutionary Psychology·DateAug 24, 2009

Link between erectile dysfunction and obesity explored in obesity and weight management

A new study published in Obesity and Weight Management explores the link between obesity and erectile dysfunction, finding that excess weight increases the risk of ED due to atherosclerosis-related hypertension and hormonal changes. Research shows that weight loss and increased physical activity can improve symptoms.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalObesity and Weight Management·DateAug 24, 2009

New research: Consumption of sugar substitutes assists in long-term weight control

A new study found that consuming sugar-free beverages with low-calorie sweeteners leads to greater dietary restraint, a key factor in successful weight maintenance. Researchers concluded that artificially sweetened beverages may be an important weight control strategy among individuals who have achieved or maintained weight loss.

SourceKellen Communications·JournalInternational Journal of Obesity·DateAug 24, 2009

Scientists discover new species of crustacean on Lanzarote

A team of scientists has discovered a previously unknown species of crustacean, Speleonectes atlantida, in the Tunnel de la Atlantida lava tube on Lanzarote. The new species is morphologically similar to another remipede found in the same cave system and is believed to be an ancient relic isolated from the main Caribbean group.

SourceSpringer·JournalMarine Biodiversity·DateAug 24, 2009

New technique can help diagnose mesothelioma

A new technique measuring pleural fluid mesothelin levels shows great promise in diagnosing mesothelioma. The study found that patients with mesothelioma had significantly higher levels of mesothelin than those with other conditions, allowing for a more accurate diagnosis.

SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateAug 24, 2009

US crop yields could wilt in heat

A study predicts that US crop yields could decrease by 30-46% over the next century under slow global warming scenarios and by 63-82% under rapid scenarios. Crop yields are most vulnerable to temperatures above 29-32 degrees Celsius, depending on the crop.

SourceNorth Carolina State University·JournalProceedings of the National Academy of Sciences·DateAug 24, 2009

Study finds promise in combined transplant/vaccine therapy for high-risk leukemia

Researchers found that patients with aggressive leukemia had few complications and mounted a strong immune system attack after receiving a cancer vaccine shortly after a stem cell transplant. The study suggests that the approach may be more effective than traditional transplant alone, with higher survival rates.

SourceDana-Farber Cancer Institute·JournalProceedings of the National Academy of Sciences·DateAug 24, 2009

Smoking increases risk of developing active TB

A recent study found that smoking is a significant risk factor for active tuberculosis (TB), with current smokers twice as likely to develop active TB as never-smokers. The study analyzed data from nearly 17,000 individuals in Taiwan and found that younger smokers were more likely to develop active TB.

SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateAug 24, 2009

Low-carb diets linked to atherosclerosis and impaired blood vessel growth

A study led by Beth Israel Deaconess Medical Center found that mice on low-carb diets developed significantly more atherosclerosis and had impaired ability to form new blood vessels compared to those on Western or standard diets. Standard markers of cardiovascular risk, including cholesterol, were not affected.

SourceBeth Israel Deaconess Medical Center·JournalProceedings of the National Academy of Sciences·DateAug 24, 2009

Still holding their breath: Mortality on lung transplant wait list remains high for some

New research finds that mortality among patients with idiopathic pulmonary arterial hypertension (IPAH) awaiting lung transplant has not decreased, despite implementation of a new allocation system. The study suggests that key prognostic indicators in IPAH are not adequately captured by the current LAS algorithm.

SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateAug 24, 2009

Researchers find saying 'I'm sorry' influences jurors

Researchers found that apologizing or using a first-person justification can result in lower frequencies of negligence verdicts against auditors. Apologies reduce the need for jurors to assign blame, while justifications influence their perception of the auditor's actions as reasonable and in accordance with professional standards.

SourceGeorge Mason University·JournalContemporary Accounting Research·DateAug 24, 2009