Research suggests a potential viral link between HCMV and intestinal cancer in mice, where infected cells develop tumors. Meanwhile, scientists identify a key protein regulating breathing in mice and explore survivin as an anticancer target.
A Phase IIb/III trial shows afatinib benefits patients with lung adenocarcinoma whose cancer progressed after chemotherapy and erlotinib or gefitinib. Patients receiving afatinib experienced delayed disease progression and greater tumor shrinkage, but no significant difference in overall survival.
Growing plants with red flowers or striped blooms can significantly increase the number of visits from bumblebees, according to a study by Norwich BioScience Institutes. The research found that stripes following the veins of flowers provide a visual guide for pollinators, directing them to nectar and pollen.
Researchers have found that Labidolemur kayi shares similarities in bone features with other mammals, indicating its living relatives are rodents, rabbits, flying lemurs, tree shrews and primates. The study provides valuable information for understanding the origin of primates.
A Phase II study of the new-generation lung cancer drug PF-299 has shown impressive results in preventing disease progression when administered as a first-line treatment in patients with advanced disease. The study found that 85% of patients with EGFR mutations remained progression-free for at least nine months.
Researchers at Woods Hole Oceanographic Institution found that ocean acidification would only affect whale hearing by a negligible 2 decibels by 2100. The impact on marine animals relies heavily on natural noise levels, not human-made noise from ships.
A recent study found that women with epilepsy are more likely to experience infertility compared to the general population, particularly those taking multiple epilepsy drugs. The study also revealed that older women and those with less than 10 years of education were more likely to experience infertility.
A recent study found that cancer patients taking targeted therapies have significantly decreased levels of sexual function and satisfaction. The researchers surveyed 51 patients and found that men's erectile function scores were just 53% of the maximum, while women's desire and arousal scores were also affected.
Scientists compare ocean microbe genomes to understand environmental adaptations and evolutionary changes. The study found significant differences in phosphorus-related genes between Atlantic and Pacific populations, revealing a strong selective force driving these adaptations.
Researchers found that mice exposed to dim light at night gained about 50% more body mass than those in a standard light-dark cycle. The study suggests that timing of eating is critical to weight gain and may be contributing to the obesity epidemic in Western countries.
A Phase-II trial investigating pazopanib for relapsed/refractory urothelial cancer has generated promising results, with four patients experiencing tumor shrinkage and twelve seeing their metastases die due to 'necrotic evolution'. Researchers are eager to translate this activity into a survival advantage.
The study found that stricter limitations on land development lead to higher rental and purchase prices, while people saving for a house in markets with limited land availability need larger down payments and buy houses later in life. The research also suggests that relaxing borrowing constraints increases home ownership rates
A new Ohio University-led study suggests that combining preventive medication and behavioral changes offers significant relief from frequent, disabling migraines. The research found that the combination of these interventions resulted in a 77% reduction in migraine frequency, days with migraine, and improved quality of life.
A nationwide clinical trial is underway to test the effectiveness of ranolazine in treating ventricular arrhythmias. The study aims to determine if ranolazine decreases death and cardiac arrhythmias, as well as hospitalizations from cardiac causes.
Researchers have discovered that specialized bacterial filaments, known as nanowires, can conduct electricity, allowing microbial colonies to thrive. The findings suggest a new way for bacteria to transfer electrons and support each other, potentially leading to breakthroughs in biofilm resistance and sustainable energy.
Researchers found that cancer patients across all stages exhibit a high burden of somatic symptoms, including fatigue, pain, and insomnia. These symptoms significantly impair daily functioning and overall well-being, highlighting the need for comprehensive symptom management strategies.
Scientists have developed a microchip technology that rapidly tests potential drugs on tiny worms, identifying promising chemicals for regenerating nerve cells. The technique has already found one class of neuronal regenerators and holds promise for treating Alzheimer's, Parkinson's, and ALS.
A new study found that a slowing of population growth could contribute to reducing greenhouse gas emissions, with slower growth paths by 2050 accounting for 16-29% of necessary emissions reductions. Urbanization and aging also play significant roles in shaping future emissions.
A study published in Archives of Internal Medicine found that hormone therapy after menopause increases the risk of developing kidney stones by approximately 20 percent. The research calls into question the long-held belief that estrogen protects women from the disease, and clinicians need to consider the risks and benefits of hormone ...
Research by Sergio Lira at Mount Sinai School of Medicine found that HCMV-infected mice develop intestinal tumors as they age, with increased tumor growth compared to normal mice. The study suggests a potential viral link to intestinal cancer in humans, although further work is needed to confirm the association.
Using large-scale computer simulations, researchers at Georgia Tech have identified hydrodynamic interactions as a dominant factor in intracellular diffusion, accounting for much of the reduction in molecular movement. This finding has significant implications for understanding disease states and developing therapeutic drugs.
A new study by the University of Bristol has found that dogs with separation-related behaviors tend to make more pessimistic judgments, suggesting a cognitive bias. The research provides insight into animal emotions and highlights the importance of addressing underlying negative emotional states in dogs.
Researchers have identified a gene that enables malaria parasites to resist artemisinin treatment, leading to potential development of new drugs and control strategies.
Prof. Dov Shmotkin's research investigates how people's well-being is tied to their concept of time trajectory, which encompasses past, present, and future. The study found that a stable time trajectory is associated with higher well-being in older adults, particularly those who can contrast their present with past traumatic experiences.
The University of Illinois College of ACES will strengthen rural farmers' livelihoods by modernizing agricultural Extension systems in 20 poorest developing countries. The five-year project aims to transform these systems to increase farm incomes and improve rural poverty, using sustainable natural resource management practices.
Researchers develop test system to investigate histone modification function and its influence on gene expression and cellular division. The study reveals a complex interplay between histone modifications and the genetic code.
A recent study found that only 58% of young people with mental health problems successfully transitioned to adult care services, highlighting a significant gap in provision. The research team identified key factors contributing to the poor transition experience, including inadequate information transfer and inconsistent documentation.
Researchers at Emory University found that monarch butterfly females prefer milkweed plants with high levels of cardenolides to lay eggs on, reducing parasite infection in their offspring. This behavior is thought to be a form of self-medication, and the study's findings may have implications for human health.
Studies have found that patients with cancer who experience pain or depression also report a high rate of physical symptoms such as fatigue, dry mouth, and nausea. These somatic symptoms are associated with substantial functional impairment, disability, and healthcare use, even after controlling for medical and psychiatric comorbidity.
A study of 1,509 non-diabetic participants found that insulin resistance was associated with a 45% greater risk of any type of vascular event. Insulin resistance was also linked to an increased risk of ischemic stroke, particularly in men.
A study of over 1,000 children found that excessive screen time is related to higher psychological difficulty scores, regardless of physical activity. Children who spent more than two hours per day on screens had better psychological scores, while those with moderate physical activity fared better in certain areas but worse in others.
Postmenopausal women taking estrogen therapy are at a higher risk of developing kidney stones, according to a study. The research found a significant increase in kidney stone development, with a fivefold greater risk in women with a history of kidney stones.
Scientists have discovered that whales' feces pump up ocean productivity, increasing phytoplankton growth and secondary productivity. This boost has a significant impact on fisheries, resulting in bigger fisheries and higher fish abundances.
Researchers have identified a potential target for diabetes drugs by discovering how certain insulin gene mutations cause proinsulin proteins to misfold in pancreatic beta cells. The study found that misfolding of normal proinsulin proteins occurs when mutant protein is present, leading to insulin deficiency and diabetes.
A team of scientists has demonstrated the feasibility of Raman amplification, compressing long laser pulses to 1000 times shorter with intensities 300 times greater. This method could replace current expensive systems with smaller and more cost-effective ones, making technologies like x-ray development more accessible.
The IT industry is on pace to grow its carbon emissions at twice the rate of its contributions to gross domestic product. The study found that green innovation will be essential for ICT profitability in a carbon-constrained economy.
A recent study found that newer treatments for age-related macular degeneration, including intravitreous bevacizumab and ranibizumab, do not significantly increase the risk of cardiovascular complications or death. The study analyzed data from 146,942 Medicare beneficiaries treated for AMD in 2005 or 2006.
Studies examine resource use and costs in the last six months of life for Medicare beneficiaries with heart failure and Canadian patients who died of heart failure, revealing increased hospice use but high hospitalization rates. Increasing availability of alternative care venues may help reduce hospitalizations and contain costs.
Global research has identified new genes associated with body fat distribution and obesity, shedding light on biological processes involved. The studies found 13 new gene regions linked to waist-hip ratio and 18 genetic variations associated with increased susceptibility to obesity.
Researchers at PNNL have redesigned sodium-nickel chloride batteries to deliver 30% more power at lower temperatures, making them safer and cheaper to manufacture than lithium-ion batteries. The planar design enables compact stacking, improving the battery's performance for large-scale energy storage.
Researchers identified a compound called CIQ that selectively enhances NMDA receptor function, targeting specific subunits believed to contribute to schizophrenia symptoms. This approach aims to compensate for deficits in patients with the condition by manipulating receptor signaling.
A new study in Applied Cognitive Psychology found that college-aged men can accurately remember a woman's initial sexual interest based on visual cues. The study suggests that tracking and remembering a partner's emotions may play a role in the initiation and maintenance of serious romantic relationships.
Australian scientists have developed a measure to assess embryo health and likelihood of successful pregnancy in IVF treatment. The research found that embryos with higher glucose uptake are healthier and more likely to result in successful pregnancies, with women's embryos consuming more glucose than men's.
Distant galaxies in the early Universe are creating 1,000 new stars per year, exceeding our galaxy's star formation rate. These galaxies contain enormous amounts of raw material for new stars, suggesting a higher gas content than previously thought.
A scientist at Florida State University has developed innovative techniques to characterize proteins, enabling faster and more accurate prediction of their structure and dynamics. This breakthrough could lead to the development of new drugs targeting specific proteins and designing new molecular machines.
A recent study found nearly 50% of pharmacies in Zambia do not carry antiepileptic drugs, hindering efforts to treat the condition. The lack of affordable treatment options is attributed to cost, regulatory issues, and logistics challenges.
The Phase III trial confirms that abiraterone acetate extends life by four months for patients with advanced prostate cancer, improving median overall survival to 14.8 months. This breakthrough treatment challenges the standard care for men with advanced disease.
A study published in Journal of Women's Health reveals a rapid increase in diabetes hospitalizations for young adults, particularly young women, which echoes the dramatic rise in obesity rates across the US. The number of hospitalizations among younger adults more than doubled from 1993 to 2006.
A Phase III study showed that everolimus improves progression-free survival by 5.1 months in patients with advanced neuroendocrine tumors. The drug has antitumor efficacy in addition to currently available agents, offering new treatment options for rare cancers.
A study of 25 cancer survivors found that fertility concerns were inadequately addressed by doctors, with many feeling guilty about their sexual function. Fertility was crucial to these patients' sense of identity and body image, highlighting the need for healthcare professionals to address these issues.
A randomized study found that adding topotecan to carboplatin and paclitaxel did not improve progression-free survival in patients with ovarian cancer, but increased toxicity. The standard regimen of carboplatin and paclitaxel remains the best care for epithelial ovarian cancer.
The CU-Boulder student-built dust counter on NASA's New Horizons mission has reached a distance of 1.67 billion miles from Earth, breaking the record for the most distant working space dust detector. The instrument collected data in agreement with earlier measurements made by NASA's Galileo and Ulysses missions to Jupiter.
A study published in Cancer found that racial disparities in breast cancer care persist, even after accounting for patients' insurance and socioeconomic status. Black and Hispanic women are less likely to receive recommended treatments compared to white women.
A large-scale study of 1,286,350 participants across various studies confirms that female and male math skills are substantially equal. The findings challenge long-held stereotypes and emphasize the importance of promoting confidence in girls' math abilities to encourage them to pursue careers in STEM fields.
A meta-analysis of eight clinical trials found that folic acid supplements did not reduce the risk of cardiovascular events, cancer, or death over a five-year period. The study showed a significant reduction in homocysteine levels with folic acid supplementation but no corresponding benefit for cardiovascular health.
Materials scientists from Jena University have created a cellulose implant that can trigger the regeneration of cartilage produced naturally in the body. The implant, which consists of a sponge-like structure with two different surfaces, is designed to adhere to bone and stimulate cartilage growth.
The AACR will honor two leading breast cancer researchers, Klaus Pantel and Alan Ashworth, for their groundbreaking work on detection and treatment of breast cancer. Pantel will receive the Outstanding Investigator Award for his pioneering research on minimal residual disease, while Ashworth will deliver the Distinguished Lectureship f...
The number of retinal procedures nearly doubled between 1997 and 2007, driven by new treatments for neovascular AMD. Vitrectomy, a surgical removal of the eye's gel, increased significantly, while injections of drugs into the eye also rose substantially.
A Rutgers-led research team has received a $3.3 million NIH grant to develop technology that combines advanced ultrasound and magnetic resonance images to pinpoint cancerous tissue during biopsies. This could lead to more accurate diagnoses and reduced false negatives.
Researchers found that targeting epidermal growth factor receptor (EGFR) provides substantial clinical benefit for women with hard-to-treat triple-negative breast cancer. Adding cetuximab to chemotherapy doubled response rate and time to progression compared to chemotherapy alone.
A study found that invasive bush honeysuckle substantially increases the risk of human disease by providing a habitat for deer to congregate, allowing ticks to spread diseases. The research suggests that this effect may be seen with other invasive plants as well.
A meta-analysis found that carotid artery stenting was associated with increased risks of short- and long-term adverse outcomes, including stroke, death, and restenosis. In contrast, carotid endarterectomy was linked to lower rates of these complications.
The GSA awarded its President's Medal to the founders of Keyhole, Inc., developers of Google Earth. The award recognizes their impact on advancing geosciences through a groundbreaking tool for education and entertainment.
A University of Wisconsin-Madison doctor has won a $2 million grant to develop video games that uncover and neutralize implicit biases against women, minorities, and people with disabilities. The project aims to change attitudes, beliefs, and behaviors in academic institutions, ultimately increasing diversity in STEM fields.
A study by University of Washington researchers found that study-abroad students double their alcohol consumption while abroad, up to eight drinks per week. Drinking behavior differs according to country and age, with younger students and those in Europe and Australia drinking more heavily.
A study published in Brain Stimulation found that transcranial magnetic stimulation (TMS) is an effective, long-term treatment for major depression. The therapy was shown to be durable in the majority of patients and prevented relapse when reintroduced as an adjunct to medication.
A 55-million-year-old extinct mammal, Labidolemur kayi, has been found to share a common ancestor with rodents and primates. The study reveals minute details in the skull, including bone structures smaller than one-tenth of a millimeter, which provide valuable information for understanding the origin of primates.
Researchers at Heidelberg University Hospital developed a therapy concept to treat high-risk patients with sensitized kidneys, achieving comparable transplant survival rates as non-immunized patients. After one year, 95% of transplanted kidneys were still functioning.