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Science News for August 10, 2009


Life and death in the living brain

Scientists have demonstrated a direct link between the death of old neurons and their replacement by newly born ones in a living vertebrate. The study found that introducing a chemical inhibitor to slow apoptosis resulted in fewer new neurons being formed, providing insights into age-related diseases.

Missing link of cloud formation

A team of researchers from Caltech and University of Copenhagen have discovered a new chemical compound in the atmosphere that may help explain how clouds form over forests. The compound, dihydroxyepoxide, is formed when tree-released hydrocarbons interact with atmospheric compounds, providing a missing link in cloud formation.

SourceUniversity of Copenhagen·JournalScience·DateAug 10, 2009

Scientists make multiple types of white blood cells directly from embryonic and adult stem cells

Researchers have successfully created various types of mature white blood cells from embryonic and adult stem cells, opening up new possibilities for studying disease development and treatment. The technique could produce cells tailored to specific infections or tumors, making it a potential tool for safety screening of new drugs.

SourceUniversity of Wisconsin-Madison·JournalJournal of Clinical Investigation·DateAug 10, 2009

Substance abuse, schizophrenia and risk of violence

A systematic review of 20 studies found that individuals with schizophrenia are at increased risk of violence, but this risk is greatly outweighed by the effect of substance abuse. Substance abuse significantly increases the risk of violence for those with a psychotic illness, similar to those without a psychotic illness.

SourcePLOS·JournalPLOS Medicine·DateAug 10, 2009

Found: A gene that may play a role in type 1 diabetes

Scientists at Stanford University have identified a gene variant that may play a role in the development of type 1 diabetes. The study found that cells in the pancreatic lymph nodes produce two forms of the Deaf1 gene, one functional and one nonfunctional. Increased levels of the nonfunctional variant were found in people with type 1 d...

Tumors feel the deadly sting of nanobees

Nanobees, nano-sized spheres carrying the toxic melittin from bee venom, successfully delivered and killed tumor cells in mice. By targeting cancerous tissue with precision, nanobees showed promise in treating established and early-stage cancers.

SourceWashU Medicine·JournalJournal of Clinical Investigation·DateAug 10, 2009

Mars, methane and mysteries

Recent methane discoveries on Mars suggest either biological or geological activity, with scientists investigating its disappearance after initial detection in 2003. The source of the methane remains unknown, but theories include surface trapping and chemical reactions.

SourceEuropean Space Agency·JournalNature·DateAug 10, 2009

New genes at work in patients with hereditary lung disease

Researchers at University of Florida have safely given new genes to patients with alpha-1 antitrypsin deficiency, enabling them to produce trace amounts of the protective protein for up to one year. This potential step toward a gene therapy could benefit approximately 100,000 Americans with the condition.

SourceUniversity of Florida·JournalProceedings of the National Academy of Sciences·DateAug 10, 2009

Biologists ID molecular basis of high-altitude adaptation in mice

Researchers have identified the molecular basis of high-altitude adaptation in deer mice, discovering specific mutations in hemoglobin genes that enable them to tolerate chronic hypoxia. These mutations increase oxygen-binding affinity, allowing animals to survive in low-oxygen environments such as the top of Mount Evans.

SourceUniversity of Nebraska-Lincoln·JournalProceedings of the National Academy of Sciences·DateAug 10, 2009

Bipedal humans came down from the trees, not up from the ground

Research suggests humans and African apes have distinct wrist bone features that indicate independent evolution of knuckle-walking behavior in two separate lineages. A study examining juvenile and adult wrist bones found key features associated with knuckle walking present in 96% of chimpanzees, but only 6% of gorillas.

SourceDuke University·JournalProceedings of the National Academy of Sciences·DateAug 10, 2009

NYU researchers explore how power influences interpretation

A recent study published in Personality and Social Psychology Bulletin reveals that individuals in positions of power tend to interpret crisis events, such as the 9/11 attacks, in a more abstract manner. The researchers analyzed public comments from September 2001 and found that those with power overestimated their ability to achieve o...

SourceNew York University·JournalPersonality and Social Psychology Bulletin·DateAug 10, 2009

JCI online early table of contents: Aug. 10, 2009

Researchers have identified a new gene, PTRF, which causes mutations leading to muscle weakness and lipodystrophy. The study found that these individuals had deficient caveolin-3 protein in their muscles, despite no mutations in the caveolin-3 gene.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 10, 2009

Urine samples could be used to predict responses to drugs, say researchers

Researchers from Imperial College London and Pfizer Research and Development found that urine samples can be used to predict how individuals will respond to certain drugs. The study looked at acetaminophen levels in urine before and after consumption and found that compounds like para-cresol sulphate were indicators of drug metabolism.

SourceImperial College London·JournalProceedings of the National Academy of Sciences·DateAug 10, 2009

How mice and humans differ immunologically

Researchers identified TLR9 expression patterns as a key factor in determining molecule toxicity between mice and humans. In mice, other immune cells expressing TLR9 were responsible for TNF-alpha production, leading to severe lung inflammation and toxicity.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 10, 2009

First black holes born starving

Recent simulations by astrophysicists reveal that the first black holes in the universe grew slowly and were deprived of gas, contradicting popular theories. The simulations suggest that these early black holes may have played a more complex role in the formation of supermassive black holes observed today.

SourceDOE/SLAC National Accelerator Laboratory·JournalThe Astrophysical Journal Letters·DateAug 10, 2009

New gene linked to muscular dystrophy

Mutations in the PTRF gene have been found to cause a form of muscular dystrophy with generalized lipodystrophy. The disease is characterized by progressive skeletal muscle weakness and deficiency of caveolin-3 protein.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateAug 10, 2009

Nanoelectronic transistor combined with biological machine could lead to better electronics

Lawrence Livermore National Laboratory researchers have devised a versatile hybrid platform that uses lipid-coated nanowires to build prototype bionanoelectronic devices. The platform enhances biosensing and diagnostic tools, advances neural prosthetics such as cochlear implants, and could increase the efficiency of future computers.

SourceDOE/Lawrence Livermore National Laboratory·JournalProceedings of the National Academy of Sciences·DateAug 10, 2009