Researchers have found that levels of certain proteins in the blood are associated with a greatly reduced risk for developing Type 2 diabetes. High levels of IGFBP-1 and IGFBP-2 were linked to a significant reduction in diabetes risk, suggesting these proteins may help stratify people at risk for diabetes.
A large-scale study found that children with sleep-disordered breathing are more likely to develop behavioral difficulties such as hyperactivity and emotional symptoms. The study suggests that snoring, mouth breathing, and apnea can have serious consequences for children's behavior and social-emotional development.
Researchers found high triglyceride levels strongly predict ischemic stroke in postmenopausal women, exceeding the risk associated with cholesterol levels. The study analyzed data from over 900 women who experienced strokes, revealing a nearly two-fold increased risk for those in the highest triglyceride quartile.
Researchers have discovered a biomarker, miR-375, that can predict the life-threatening nature of head and neck cancer tumors. The study found that patients with lower levels of miR-375 are more likely to experience aggressive disease progression.
Researchers propose using personalized medicine to identify individuals at highest risk for developing type 2 diabetes, allowing for targeted prevention efforts. Current methods are inefficient, but new biomarkers and approaches hold promise for preventing and controlling the disease.
Scientists at Albert Einstein College of Medicine have discovered a mechanism that controls the survival of messenger RNA in cells, which could lead to new treatments for cancer. The study found that mRNAs made from specific genes are born with molecular self-destruct timers that ultimately destroy them.
Researchers at Albert Einstein College of Medicine have developed a novel antimalarial agent, BCX4945, which kills the deadliest malaria parasite by starving it of vital building blocks. The study shows promising results in non-human primates, paving the way for more potent therapies against this deadly disease.
The Einstein-Montefiore site is one of only 25 federally-funded centers in the country, facilitating Phase II clinical trials for rare neurological diseases. The center aims to streamline logistics and provide research expertise, reducing study initiation time from years to months.
A recent study found that elevated blood sugar levels are associated with an increased risk of colorectal cancer in postmenopausal women. Researchers observed nearly 5,000 women over 12 years and discovered that those with higher glucose levels were more likely to develop the disease.
Researchers found that frequent soccer heading can cause brain injury and cognitive impairment, particularly in areas responsible for attention, memory, and executive functioning. A threshold level of approximately 1,000 to 1,500 heads per year was identified, with higher frequencies associated with significant injury.
Researchers at Albert Einstein College of Medicine discovered that cancer cells use autophagy, a natural recycling process, to obtain energy. By blocking this process, the study found that tumor growth and metastasis can be stopped, providing potential new strategy for cancer treatments.
Einstein researchers discovered a mechanism governing cell specialization, where a pair of proteins act as super regulators of existing ones. This finding has implications for cancer, stem cell research, and regenerative medicine, as it suggests that specific proteins can be turned on or off to create specialized cells.
Researchers at Albert Einstein College of Medicine have demonstrated the brain's key role in regulating glucose metabolism in humans. The study found that drugs targeting the brain and central nervous system could be a novel approach to treating diabetes.
The National Cancer Institute has awarded Albert Einstein College of Medicine two grants totaling $8 million to study the microenvironments that drive the spread of cancer. The research aims to understand the complex process of metastasis, which is responsible for most cancer-related deaths.
A consortium led by Einstein researcher Nir Barzilai aims to sequence the complete genomes of 100 healthy centenarians in 30 days. This effort, backed by a $10 million 'X Prize,' seeks to uncover genetic advantages behind exceptional longevity and develop personalized medicine strategies.
The Eunice Kennedy Shriver National Institute has awarded Einstein College of Medicine a $5.7 million grant to fund IDDRC research, focusing on autism spectrum disorders, neurogenetic and seizure disorders, and more. The center aims to improve diagnosis, prevention, and treatment methods, leveraging advances in research and technologies.
Researchers at Einstein College of Medicine will study the genetic basis of conotruncal defects, also known as CTDs, which account for more than one-third of all heart defects. The study aims to identify novel therapies and preventive strategies for these defects.
A nationwide study found that people taking oral steroids are twice as likely as the general population to have severe vitamin D deficiency. This increased risk is particularly pronounced for steroid users under 18, who were 14 times more likely to have a severe vitamin D deficiency.
Scientists have identified a novel type of antibody that works against pneumococcal bacteria by causing them to clump together, leading to the expression of genes that could kill some of their siblings. This finding could improve vaccines against pneumonia and reduce hospitalizations and deaths from pneumococcal disease.
A study by researchers at Albert Einstein College of Medicine found that close supervision by rheumatologists and the use of immunosuppressant drugs can improve the survival of lupus patients with end-stage kidney disease. Patients who visited their rheumatologist regularly had significantly higher four-year survival rates compared to ...
The Einstein College of Medicine consortium aims to collect and analyze data on nearly 40,000 patients with antiretroviral therapy (ART) in Burundi, Cameroon, and Rwanda. The project will help improve the care and lives of residents by providing a robust database for researchers to examine the real-world practice and results of ART.
A new TB vaccine candidate has shown promising results in animal studies, inducing a robust T-cell response that could protect against the disease. The vaccine, developed using a closely related species of bacteria, proved both potent and safe, with vaccinated mice living up to 135 days versus 54 days for control mice.
A recent study published in The Lancet found that NYC firefighters exposed to the 9/11 World Trade Center disaster site were at least 19% more likely to develop cancer in the seven years following the disaster compared to non-exposed colleagues. The study evaluated the health of over 9,800 WTC-exposed and non-exposed firefighters.
Scientists at Albert Einstein College of Medicine have discovered a key cellular protein, Niemann-Pick C1, that is essential for the Ebola virus to infect cells. The finding suggests a possible strategy for blocking infection due to Ebola virus, which has killed up to 90% of those infected in some outbreaks.
Researchers at Albert Einstein College of Medicine have developed a new fluorescent protein, iRFP, that allows for the non-invasive visualization of internal organs in live animals. The protein absorbs and emits light in the near-infrared spectrum, enabling clear imaging without radiation exposure or contrast agents.
Researchers at Einstein College of Medicine identified a key player in breast cancer spread, CCL2, which recruits immune cells to facilitate tumor growth. By blocking CCL2 signaling, they found potential for halting or slowing metastatic disease.
The open-source software, GenPlay, is designed to help biologists visualize, analyze and transform raw genomic data. Biologists can now analyze their own data using a user-friendly tool that provides continuous visual feedback, making it easier to make sense of the avalanche of new data.
Drs. Arturo Casadevall and Ekaterina Dadachova have been awarded a $100,000 Grand Challenges Explorations grant to develop radioimmunotherapy for HIV/AIDS treatment. Their project aims to target and destroy infected cells using radioactive isotopes attached to antibodies.
The Einstein Aging Study will explore the relationship between cognitive and motor aging, as well as pain and stress, as novel risk factors for Alzheimer's. Researchers will assess biomarkers, genes, and neuro-imaging procedures to facilitate earlier diagnosis, prevention, and treatment of Alzheimer's disease.
Researchers at Albert Einstein College of Medicine have identified Aurora A as a critical target for therapies against rhabdoid tumors, a rare and aggressive childhood cancer. The study found that the loss of a tumor suppressor gene leads to increased expression of Aurora A, which is essential for tumor growth.
Researchers at Albert Einstein College of Medicine observed the activity of a single gene in living yeast cells, tracking mRNA production and transcription initiation. The study provides new insights into how genes are regulated in single-celled organisms like yeast, which can inform our understanding of similar processes in humans.
Researchers have found promising results in using liver-cell transplants to treat a genetic disorder affecting the liver and lungs. The treatment reversed fibrosis in diseased liver cells, providing a potential alternative to current expensive therapies.
Researchers at Albert Einstein College of Medicine found a link between a brain molecule, TXNIP, and the development of obesity and type 2 diabetes. Elevated levels of TXNIP in nerve cells contribute to energy imbalance, decreased physical activity, and impaired glucose tolerance.
The National Institutes of Health has funded a study to develop an inhaled lung cancer treatment using the drug 5-azacytidine. Researchers at Albert Einstein College of Medicine aim to target premalignant lung cancer by reactivating genes that suppress tumors.
Researchers at Albert Einstein College of Medicine have identified two molecules that help cancer cells spread inside the body. The study found that these molecules regulate RhoC activity, which is positively correlated with increased invasion and motility of tumor cells.
A study by Albert Einstein College of Medicine researchers found that an enzyme family, katanin, regulates cell motility. Treating this enzyme can encourage cells to migrate in a particular direction to heal wounds. This discovery could lead to new therapeutic agents for conditions like diabetic ulcers and metastatic cancer.
Researchers will recruit 450 people age 70 and older for a five-year study to identify cognitive factors that influence mobility. The study aims to reveal specific abilities and brain structures that correlate with mobility problems, with the goal of preventing mobility decline and disability.
A study found that primary care physicians rarely monitor patients on prescription opioids, even those at high risk of misuse. Only a small minority of patients underwent urine drug testing, and few were seen regularly in the office.
A study of over 3,000 children found a correlation between low vitamin D levels and an increased likelihood of developing allergies, including food and environmental allergens. Children with vitamin D deficiency were 2.4 times more likely to have a peanut allergy.
Researchers developed a vaccine that triggers a protective immune response while preventing fatal inflammation. The experimental vaccine, using a synthetic gene, has shown promising results in animal models, protecting mice from a lethal challenge and reducing inflammation.
Researchers at Albert Einstein College of Medicine have developed nanoparticles containing nitric oxide that improve survival after life-threatening blood loss in hamsters. The therapy maintains blood circulation and protects vital organs by increasing levels of NO gas, which relaxes blood vessels and regulates blood pressure.
Scientists at Albert Einstein College of Medicine successfully visualized single molecules of naturally-occurring messenger RNA (mRNA) transcribed in living mammalian cells. This breakthrough technique has important consequences for human disease like cancer, as mRNA localization within tumor cells correlates with metastasis.
A new genetic blood test predicts IVF success by identifying the FMR1 gene subtype, with different subtypes associated with varying pregnancy rates. The test also suggests a link between autoimmunity and infertility, potentially informing fertility planning.
A national survey of US family physicians found that many have gaps in knowledge about IUDs, are uncomfortable discussing them with patients, and believe their patients would not be receptive. In contrast, those who insert IUDs in their practice tend to be more knowledgeable and confident in discussing the devices with their patients.
The study will explore the compound's effects on post-meal blood glucose metabolism in individuals with impaired glucose tolerance. Results could provide critical information for planning and conducting more definitive studies of resveratrol in diabetes prevention and treatment.
Scientists at Einstein College of Medicine discovered that genes involved in building protein complexes are activated randomly, not coordinately. This unexpected finding may change the way scientists think about cellular processes and synchronization.
Scientists have discovered a way to eliminate debilitating diarrhea caused by CPT-11, a chemotherapy drug used for treating colon cancer. By inhibiting an enzyme in bacteria of the digestive tract, patients may be able to receive higher doses of the drug without severe side effects.
The updated Strategic Research Plan identifies seven high-priority initiatives, including automated technologies for stem cell research and clinical research enterprise enhancements. These initiatives aim to strengthen existing research areas while exploring new ones.
Global research has identified new genes associated with body fat distribution and obesity, shedding light on biological processes involved. The studies found 13 new gene regions linked to waist-hip ratio and 18 genetic variations associated with increased susceptibility to obesity.
The Einstein research aims to understand the role of proteins in normal biological processes and disease pathways. The project will focus on determining the structures of thousands of biomedically important proteins.