The Montefiore-Einstein Center for Cancer Care has received a $3.93 million grant from the National Cancer Institute to support clinical oncology research. Four new scholars have been selected, including Drs. Thomas Ow and Akiva Novetsky, who will focus on radiation therapy and gynecologic oncology surgeries.
A new study by Montefiore and Einstein researchers recommends referring pregnant women with severe headaches and elevated blood pressure immediately for neuroimaging and monitoring. The study found that high blood pressure is a major indicator of preeclampsia, which can lead to pregnancy complications.
Researchers identified a unique doorway in the blood vessel wall that allows breast cancer cells to spread to other parts of the body. The discovery could lead to new treatments and better predict whether breast cancer will spread.
A clinical trial found that telephone counseling led to significant A1c level reductions among participants with extremely elevated levels. The intervention resulted in an average decrease of 2.1 percentage points, compared to a 1.3 percentage point decrease for those receiving printed self-management materials only.
A new elective course helps medical students recognize and overcome biases related to health disparities. Through role-playing and skills training, students increase their knowledge and self-reported confidence in addressing these issues.
Researchers at Einstein College of Medicine presented multiple studies on risk factors and predictors of aMCI and dementia in older adults, including the impact of perceived stress, diet, and coping mechanisms. The findings suggest that early detection of cognitive decline is crucial for implementing effective preventive interventions.
The National Institutes of Health has awarded a $10.5 million grant to the Einstein-Mount Sinai Diabetes Research Center, which aims to expand ongoing diabetes research projects, initiate new studies, and improve service delivery in the New York metropolitan area.
A survey of over 1,000 U.S. adults found that miscarriages are common, affecting one in four pregnancies, yet many believe them to be rare. Participants also incorrectly perceived causes of miscarriage, including genetics, stress, and lifestyle choices, highlighting the need for better education about this topic.
Researchers at Albert Einstein College of Medicine developed a nanoparticle therapy that reduces fidgetin-like 2 enzyme levels to promote wound healing. The treatment accelerated healing in mice with skin excisions or burns by over twice as much as untreated controls, showing promise for faster recovery from various types of wounds.
Researchers have developed a new fluorescence microscopy technique that shows where and when proteins are produced in individual cells. The technique allows direct observation of messenger RNA molecules being translated into proteins, shedding light on protein synthesis irregularities contributing to human diseases.
Researchers at Albert Einstein College of Medicine have developed a new type of vaccine that prevents both active and latent infections caused by herpes simplex virus type 2 (HSV-2). The vaccine, dubbed "delta-gD-2," provides complete protection against subsequent infection in mice, suggesting it could be effective in humans.
Researchers found a possible link between maternal age and abnormal chromosome numbers, which can cause birth defects like Down syndrome. The study used genetic data from over 4,000 families and found that the shuffling process of parental chromosomes becomes less regulated with age.
Researchers at Albert Einstein College of Medicine have developed a novel yeast-based high-throughput assay to identify inhibitors of the Plasmodium falciparum transporter, which could lead to the development of new antimalarial drugs. The technique was used to screen over 64,000 compounds and identified 171 potential antimalarial drugs.
A new study from Albert Einstein College of Medicine found that children with short sleep duration and sleep-related breathing problems have a higher risk of becoming obese by age 15. The research aimed to track the combined effect of these two risk factors in children over time, filling a gap in previous studies. Children with severe ...
Researchers have found that specific cells are required for the spread of breast cancer, which could lead to new anti-cancer therapies and improve predictive tests. The study combined tumor cells from patients with breast cancer with laboratory models and found a correlation between high MenaINV levels and metastasis.
Six faculty members at Albert Einstein College of Medicine have been named 2014 AAAS Fellows, recognized for their contributions to various fields including virology, cell biology, and cancer research. The awardees include Aviv Bergman, Margaret Kielian, Richard Kitsis, U. Thomas Meier, Robert Singer, and Jan Vijg.
A new study suggests that adding mitral valve repair to coronary artery bypass grafting does not significantly improve patient outcomes. The trial found no differences in mortality, readmissions, or quality of life between the two groups at one year.
The study identified a genotype that can predict survival in people who live longer, as well as risk factors for cognitive decline and frailty. Hearing impairment is also linked to increased risk of frailty, according to the findings.
The grant will establish home health services for clients with intellectual and developmental disabilities, providing primary care, mental health, and specialty services. The project aims to extend care coordination and compassionate service integration across institutions.
The study found that mental health problems differ among various subgroups of Hispanics and Latinos, highlighting the need for tailored mental health services. Depression affected 27% of the population, while antidepressant use was relatively low, especially among uninsured individuals.
Researchers from Einstein-Montefiore will present their latest research on neonatal lung disease, reducing wrong-patient errors in the NICU through electronic medical record identification re-entry function. They also explore oral health initiatives and global health delivery science projects.
A comprehensive study found that medications are the leading cause of allergy-related sudden deaths in the US, particularly among older people and African-Americans. The study analyzed death certificates from 1999-2010 and identified antibiotics as the most common culprit drug.
Montefiore Einstein Center for Cancer Care and Albert Einstein Cancer Center have been awarded a $3.4 million grant from the National Cancer Institute to conduct multi-site cancer clinical trials and research focused on reducing healthcare disparities in cancer care. The award will help change the burden of cancer, which is disproporti...
A new study suggests that measuring how fast the brain responds to sights and sounds can help classify people on the autism spectrum and diagnose the condition earlier. The study found a strong correlation between the speed of processing auditory signals and the severity of autistic symptoms.
Researchers will examine the relationship between open clinical records and wrong patient errors to determine best CPOE system formats. The study aims to identify optimal record openness settings to prevent medical errors.
Researchers from Montefiore and Einstein present findings on radiation therapy duration, dosing recommendations, and predictive indicators for clinical outcomes in locally-advanced cancers. The studies focus on improving personalized cancer care and overcoming treatment barriers.
A new Ebola treatment has shown promise against the Sudan strain of the virus in mice, using synthetic antibodies designed to target a key molecule on the surface of the virus. The treatment is not effective against the Zaire ebolavirus, which is currently devastating West Africa.
The NIH grant funds four collaborative projects, including those led by Dr. Robert Callender and Dr. Vern Schramm, who are working to understand the physics of atomic motions in enzymes. By doing so, they aim to design new classes of pharmaceuticals that can alleviate disease by targeting specific enzyme-substrate interactions.
A study led by Drs. Nir Barzilai and Joe Verghese aims to identify gene variants that prevent frailty in older adults. By building on previous research, the team hopes to develop drugs that mimic these genes' effects. The grant will explore biological pathways leading to frailty and investigate the role of exceptional longevity genotypes.
Researchers at Albert Einstein College of Medicine found that certain bacteria produce metabolites that strengthen the intestinal epithelium's barrier function. These metabolites activate a protein called PXR, which suppresses inflammatory responses and increases junction strength between epithelial cells.
A new test diagnoses motoric cognitive risk syndrome (MCR), which combines gait speed measurement with cognitive questions. People who test positive for MCR are twice as likely to develop dementia within 12 years, emphasizing the importance of early diagnosis and potential underlying cause identification.
Researchers at Albert Einstein College of Medicine are developing a drug discovery project targeting Parkinson's disease using a newly identified target and chaperone-mediated autophagy. The goal is to develop a prototype drug that can treat the underlying cause of the disease.
Montefiore and Einstein researchers present data at the 2014 Alzheimer's Association International Conference, focusing on triggers for mild cognitive impairment and dementia. The research aims to identify potential strategies to preserve cognitive function and delay or prevent Alzheimer's disease onset.
Researchers at Albert Einstein College of Medicine will study how breast cancer cells move and spread in the body. They aim to develop a test that predicts which breast cancer tumors will metastasize, based on the presence of a trio of cells called a tumor microenvironment of metastasis.
Researchers from Albert Einstein College of Medicine and Montefiore Medical Center will present their latest research on various topics including medication adherence in adolescents, the impact of resveratrol and vitamin D on insulin resistance, epigenetic and genetic triggers for diabetes, and the role of glucagon in metabolic homeost...
Researchers developed a new test that assesses metastatic risk by identifying specific cell types in tumor microenvironments. The test was more accurate than existing methods in predicting distant tumor spread and showed promise in tailoring therapy for breast cancer patients.
Researchers at Albert Einstein College of Medicine found that environmental influences, not gene mutations, contribute to autism spectrum disorder (ASD) in some cases. The study, published in PLOS Genetics, suggests that older mothers face a similar risk to older fathers and may be linked to epigenetic alterations in cheek cells.
A new fluorescent protein biosensor reveals the activation of Rac1 inside cancer cells during invadopodia formation, showing its role in controlling the invasion and spread of cancer cells. The study provides insights into the signaling mechanism that regulates cancer cell invasion and offers potential targets for developing treatments.
A seven-year study of nearly 900 middle-aged overweight women found that physical activity reduced the risk of developing heart disease. Low-to-moderate physical activity was the only lifestyle factor that protected these women from becoming at-risk for heart disease.
Leading scientists from the U.S., Canada, and Belgium discussed cancer stem cells, highlighting their challenges in targeted cancer treatments. The symposium aimed to spark productive dialogues among researchers attending, according to Paul Frenette, director and chair of Einstein's Stem Cell Institute.
Researchers at Albert Einstein College of Medicine will study how aging and poor nutrition interact to cause colon cancer mutations. They will use novel techniques, including single-cell whole-genome sequencing, to understand the development of tumors and identify new approaches for preventing and detecting colon cancer.
Researchers at Montefiore Headache Center and Albert Einstein College of Medicine found that relaxation following heightened stress triggers more migraine attacks. The study suggests that stress management and healthy lifestyle habits are crucial for people with migraines.
Researchers at Einstein College of Medicine made notable advances in understanding and treating cancer, including new discoveries about nerve cells, cancer-causing genes and epigenetics. They will present their work at the AACR Annual Meeting.
Researchers at Einstein will focus on discovering new immunotherapeutic candidates against Ebola and Marburg viruses, while another group will assess how well each antibody works. The project aims to advance treatments for hemorrhagic fever viruses, which cause severe diseases with high mortality rates.
Researchers have developed a new DNA test that can identify chromosomal variants and abnormalities in nearly 50% of miscarriage samples. The rescue karyotyping technique allows physicians to obtain genetic information from archived tissue, providing valuable insights into the causes of miscarriage.
The study, published in Science in June 2012 to May 2013, mapped the wiring diagram for the nervous system controlling mating behavior in male roundworms. The research provided a comprehensive map of neural connections and contributed significantly to understanding how animals control complex behaviors.
The Price Family Foundation has awarded a $3 million grant to Albert Einstein College of Medicine and the University of Oklahoma to investigate the structural biology of anaerobic microorganisms, with a focus on combating C. difficile infections. The joint project aims to find better treatments for these life-threatening infections.
A study by Einstein researchers identified a chemical 'signature' in blood-forming stem cells that predicts which AML patients will respond to chemotherapy. The findings, based on nearly 700 patient data, could help physicians identify patients who would benefit from standard treatment and spare them debilitating side effects.
Researchers at Albert Einstein College of Medicine developed a mouse model with fluorescently tagged beta-actin mRNA, allowing them to observe the molecular processes that culminate in memories. The study revealed a novel mechanism by which brain neurons control the synthesis of beta-actin protein.
A new study reveals that hepatitis C infection rates vary significantly among Hispanic groups in the US, with Puerto Rican individuals facing the highest risk. The study, which analyzed data from over 11,000 individuals, found that infection rates range from less than 1% to 11.6% among different ethnic groups.