A new study from Montefiore Einstein Cancer Center found that CAR-T therapy was effective in Black and Hispanic patients, with outcomes comparable to those of white and Asian patients. The study showed no statistical differences in clinical outcomes or side effects among racial and ethnic backgrounds.
Researchers at Albert Einstein College of Medicine are awarded a $4.2 million NIH grant to detect behavioral markers for Alzheimer's disease that appear early in the course of the disease. The study aims to identify people at risk and develop new preventive strategies.
Researchers at Einstein Aging Study are investigating how social forces contribute to inequalities in cognitive health, particularly among Black and Hispanic Americans. The new grant will enable the tracking of over 700 Bronx adults with mobile technology to measure cognition directly as they engage in everyday activities.
A recent study led by scientists at Albert Einstein College of Medicine suggests that some smokers have robust mechanisms to limit mutations, protecting them from lung cancer. The findings could help identify those with an increased risk for the disease and warrant close monitoring.
Researchers at Albert Einstein College of Medicine found that increasing chaperone-mediated autophagy activity can prevent atherosclerosis by protecting macrophages and smooth muscle cells from damage. The study suggests that boosting CMA could be an effective strategy for curbing atherosclerosis and halting its progression, particular...
Scientists at Albert Einstein College of Medicine have developed a novel therapeutic strategy that uses bacteria to deliver tetanus toxin into pancreatic tumor cells, inducing an immune response and killing the cancer. The treatment has shown promise in reducing cancer metastases by 87% and increasing mouse lifespan by 40%.
A research team has devised a novel strategy to overcome chemotherapy resistance in cancer by boosting the pro-apoptotic BAX protein and targeting its inhibitor, BCL-XL. The two-drug combination achieved significant success against apoptosis-resistant human tumor cell lines and xenograft models, with minimal side effects.
Researchers aim to reduce SARS-CoV-2 transmission among people recently released from incarceration through on-site testing and education. A randomized trial will assess the effectiveness of rapid PCR tests, community health worker counseling, and smartphone-based surveys in preventing COVID-19 spread.
The grant will fund a new curriculum focused on diagnosing and treating people with opioid use disorder (OUD), including guidance on medications for addiction treatment (MAT). The program aims to train hundreds of medical students and residents to diagnose, treat, and care for individuals with substance use disorders.
The IMPOWR-ME research center will focus on developing evidence-based treatments for people with both conditions. The center aims to provide integrated care access, test novel treatments, and engage the community in advancing health equity.
Researchers will investigate brain circuitry, neurochemicals and immune system interactions to understand why people living with HIV are more vulnerable to depression. They aim to identify specific biomarkers of depression and develop better treatments.
A new study by Montefiore Einstein Cancer Center investigators found that a COVID-19 booster shot helps most cancer patients with no immune response after two-dose vaccination, significantly increasing antibody levels. The study also shows that all cancer patients benefit from vaccination, particularly those with blood cancer.
Ulrich Steidl, a leading cancer researcher, has received an NCI grant to study the molecular mechanisms of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The goal is to develop new treatments and cures for these fatal disorders.
Scientists at Einstein College of Medicine have successfully suppressed HIV infections in mice using a novel treatment strategy that boosts the immune system's CD8+ T cells. The therapy, known as synTac, selectively targets HIV-infected T cells, eliminating them from the body and offering a potential path to a functional cure for HIV.
The NY-CDTR promotes collaboration and research on effective strategies for improving diabetes prevention, care, and self-management, with a focus on health equity. The center will expand its efforts to address diabetes health disparities experienced by Latinx individuals through community partnerships and national initiatives.
A new community-based approach to managing asthma symptoms will be implemented in up to 40 public schools across the Bronx, enrolling 416 students aged 4-12. The study aims to reduce asthma symptoms among high-risk urban school children through a cluster-randomized controlled trial.
The university will support research on normal and abnormal brain development, including rare diseases that cause intellectual disabilities. Researchers aim to improve care and treatment for children with IDDs.
A campaign is being launched to encourage COVID-19 vaccination among people with intellectual and developmental disabilities (IDD) in New York State. The Einstein-Montefiore team has received grants from the state and federal governments to create tailored messages and content to counter vaccine misinformation and promote vaccination.
Researchers at Albert Einstein College of Medicine and City University of New York Graduate School of Public Health and Health Policy have been awarded a five-year, $14.5 million grant from the National Institutes of Health to continue leading and expand their research on HIV treatment and care in five Central African nations. The effo...
A researcher at Albert Einstein College of Medicine has received an NIH director's award to use genetic epidemiology tools to prevent HIV infection among people who inject drugs. The study aims to identify key players in hepatitis C transmission networks, which can also help curb the spread of HIV.
Researchers developed a novel drug that increases LAMP2A receptors, revitalizing chaperone-mediated autophagy and removing toxic protein aggregates. In mouse models of Alzheimer's, the drug reversed key symptoms, suggesting potential for human treatment.
Researchers at Einstein College of Medicine developed a topical drug that regenerates and restores function of erectile nerves damaged by radical prostatectomy. The siRNA gel enhanced nerve regeneration and restored nerve function in rat models, restoring erectile function.
A new study found that most people with cancer produce antibodies at a rate comparable to the general population, suggesting they should respond well to COVID-19 vaccines. However, patients with blood cancers had a lower seroconversion rate due to immunosuppressive treatments.
A study published in Neurology found that COVID-19 patients with neurological problems, including stroke and confusion, had a significantly higher mortality rate compared to those without these conditions. Individuals with stroke were twice as likely to die, while those with confusion had a 40% mortality rate.
The grant aims to establish a research center to investigate HIV- and human papillomavirus (HPV)-related cancers in Africa. The center will build on existing efforts that have improved research, clinical, and laboratory capacity in Rwanda.
Researchers at Albert Einstein College of Medicine and Montefiore Health System are searching for biomarkers to predict the duration and severity of depression in adolescents. The goal is to identify teens who need more significant help with their depression, potentially leading to new treatments.
Researchers aim to develop treatments that can prevent or treat Alzheimer's disease with two large-scale studies on pre-dementia conditions MCR and brain stimulation techniques.
A five-year grant from the National Cancer Institute will support research on cancer prevention and treatment in people living with HIV. The grant will focus on high-risk populations and aim to complete the ANCHOR Study, which investigates anal cancer prevention.
A study found that children's immune responses are better equipped to fight COVID-19 than adults. Children possess higher levels of certain cytokines associated with the innate immune response, which helps protect them from developing severe disease.
Researchers aim to determine how autophagy, a cellular recycling process, is related to Alzheimer's disease and dementia. They will examine the effect of compromised autophagy on peripheral tissues and explore potential interventions to reverse decline.
A new study aims to investigate how chemotherapy affects children's brain development and cognitive function, particularly sensory processing, memory, and attention. The researchers hope to develop protective interventions to prevent permanent harm from 'chemo brain'.
Researchers found that the gut microbiome plays a key role in triggering painful vessel-clogging episodes, or VOE, in people with sickle-cell disease. Stress triggers increased gut permeability, allowing beneficial bacteria to stimulate pro-inflammatory molecules, which promote inflammation and damage internal organs.
Dr. Britta Will, an assistant professor at Albert Einstein College of Medicine, has won the prestigious Pershing Square Sohn Prize for her innovative cancer research. Her studies focus on understanding mechanisms that create and sustain cancer stem cells in acute myeloid leukemia and myelodysplastic syndrome.
The Einstein-Mount Sinai Diabetes Research Center has received a $9.5 million grant from the NIH to support research in type 1 and type 2 diabetes, obesity, and metabolic disorders. The center will utilize a new shared Immuno-Technology Core (ITC) to pursue innovative projects, including immunotherapeutics and intermittent fasting diets.
Researchers have found that steroid therapy can be life-saving for COVID-19 patients with high inflammation levels, but risks for those without significant inflammation. The study used a common blood test to identify the best candidates for treatment.
Researchers are testing a combination of remdesivir and baricitinib to treat severe COVID-19 cases. The trial aims to reduce inflammation caused by the virus and prevent fatal complications.
Children with COVID-19 often require hospitalization and intensive care due to inflammation and respiratory issues. Researchers found that obesity and asthma were not associated with increased risk of enhanced care, but over half of the children had no known contact with a positive person.
A large study of cancer patients with COVID-19 reveals a dramatically high case-fatality rate of 28%, significantly higher than the overall US mortality rate. The study emphasizes the importance of preventing cancer patients from contracting COVID-19 and closely monitoring for dangerous symptoms.
The institution secured a record-breaking $178 million in federal fiscal year 2019, marking the largest annual total in its history. This funding supports major grants in Ebola and HIV studies, neuroscience, genetics, and improving health among minority groups.
A new study found that NYC firefighters' exposure to 9/11 World Trade Center dust is associated with a significantly increased long-term risk of cardiovascular disease. Those who arrived first at the site have a 44% higher risk of experiencing primary and secondary CVD events compared to those who arrived later.
Rimegepant, a novel gepant therapy, demonstrates significant relief from acute migraine pain and associated symptoms in a large-scale clinical trial. The study found that rimegepant effectively blocks the CGRP pathway, providing a new option for people with migraine not helped by existing medications.
The study reveals substantial differences between male and female roundworms, with sex-specific behaviors linked to distinct synapse strengths. The findings mark a major milestone in connectomics, the effort to map neural connections, and may provide insights into neurological disorders such as schizophrenia and autism.
The new MACS/WIHS Combined Cohort Study will investigate chronic conditions affecting people living with HIV, such as cardiovascular and lung disease, diabetes, and cancer. Researchers will also examine the impact of age, race, ethnicity, and health disparities on HIV-related comorbidities.
Researchers developed a new testing method using single-cell RNA sequencing to analyze individual cells in diseased organs, revealing genetic glitches that may allow for more effective treatment. The study found promising results in lupus patients and could potentially improve biopsy accuracy for other diseases.
The Prometheus Center for Excellence in Translational Research aims to develop antibody-based therapies against four highly lethal viruses with no approved vaccines or treatments. The project will leverage existing research on ebolavirus and apply it to other emerging viruses, focusing on virus transmission from animals to humans.
A new study by Albert Einstein College of Medicine found that 38% of children diagnosed with ASD no longer meet diagnostic criteria, but many continue to struggle with language and learning disabilities, emotional and behavioral problems. Only 3% recovered from ASD with no other issues.
The study found that the cerebellum influences reward processing and social behaviors, which could lead to new treatments for addiction. The researchers used optogenetics to activate cerebellar neurons connected to the ventral tegmental area (VTA), triggering pleasurable behaviors in mice.
Researchers identified protocadherin-1 as a key receptor facilitating hantavirus lung cell entry. Deleting this receptor made lab animals resistant to infection, offering potential therapeutic strategy against hantavirus pulmonary syndrome.
Researchers developed a gene-suppressing drug that, when combined with an over-the-counter gel, accelerated wound healing in mice. The treatment, tested on mice with skin excisions or burns, showed significant improvements in healing outcomes, including regeneration of hair follicles and collagen networks.
A new AI tool is being developed to help doctors diagnose and treat acute respiratory distress syndrome (ARDS), a deadly lung failure that affects approximately 200,000 people in the US. The tool will screen patients throughout Montefiore Health System and provide guidance on best practices for treating ARDS.