A new study by researchers at Albert Einstein College of Medicine found that women's brains are five times more extensive in damaged tissue after repeated soccer heading compared to male players. The study suggests sex-specific guidelines may be necessary for preventing soccer-related head injuries.
Researchers have discovered the secret to the RSAD2 gene's success: an enzyme that generates a compound called ddhCTP, which sabotages viral replication by disrupting CTP conversion. This finding could form the basis for potent new antiviral drugs with a favorable safety profile.
A study found that New York City firefighters exposed to the 9/11 World Trade Center disaster site are at an increased risk for developing myeloma precursor disease, which can lead to the blood cancer multiple myeloma. The prevalence of MGUS was nearly twice as high in firefighters compared to a non-exposed group.
Researchers at Albert Einstein College of Medicine found that intense exercise reduces appetite by activating temperature-sensitive receptors in the hypothalamus, a region of the brain that regulates metabolism and weight. The study provides evidence that body temperature can act as a biological signal that regulates feeding behavior.
Research at Albert Einstein College of Medicine found that frequent soccer ball heading is associated with poorer performance on psychomotor speed and attention tasks. Players who headed the ball more frequently showed subtle reductions in neuropsychological function, which may lead to microstructural changes in the brain.
A clinical trial is underway to test an experimental peptide drug, ALRN-6924, which has shown promise against acute myeloid leukemia (AML) by tripling the median survival rate in animal models. The drug targets p53 and MDMX/MDM2 proteins, blocking tumor growth in both mature and immature AML cells.
A new family of viruses, Autolykiviridae, has been discovered that kill more marine bacteria than previously known tailed viruses. These viruses may also be present in the human gut and could play a role in maintaining the ocean's ecology and influencing human health.
Researchers will evaluate a promising experimental assay and novel research into microRNAs to predict breast cancer risk. The study aims to develop personalized treatment and improve outcomes for tens of thousands of women annually.
Researchers at Albert Einstein College of Medicine are studying the genetic protections against Alzheimer's disease using two existing longitudinal studies on aging. The study aims to identify networks of genes in healthy centenarians that protect them against dementia, which could help identify new targets for drugs to treat Alzheimer's.
Researchers will study the effects of a multicultural healthy diet rich in anti-inflammatory foods on cognitive function and inflammation. The study aims to assess whether this diet can reduce cognitive decline and Alzheimer's disease risk in middle-aged and older participants.
Researchers investigate how gut bacteria metabolize chemotherapy drug irinotecan, finding that certain individuals are more likely to experience severe side effects. The study suggests analyzing patients' microbiomes before treatment could predict and prevent adverse reactions.
Dr. Juan Robles has received a $1 million grant to support Bronx students pursuing healthcare careers and create a more inclusive workforce. The program aims to bridge the cultural gap between doctors and their patients, which research shows enhances communication and trust with patients.
Researchers found that nerves stimulate the formation of new blood vessels that promote tumor growth in prostate cancer. They discovered an "angio-metabolic switch" triggered by norepinephrine binding to endothelial cells, which changes how cells metabolize glucose, favoring glycolysis.
Einstein researchers have been awarded a $9 million grant to study the genetic differences between healthy centenarians and people with no family history of extreme longevity. They aim to identify rare gene variants that contribute to longevity and develop drugs that mimic these effects, potentially leading to longer, healthier lifespans.
Scientists at Albert Einstein College of Medicine have discovered a compound that directly makes cancer cells commit suicide while sparing healthy cells. The new treatment approach, BTSA1, works by triggering apoptosis in cancer cells through the BAX protein, leaving healthy cells unscathed.
Researchers Kartik Chandran and Jonathan Lai will develop broadly active monoclonal antibody therapies for Ebola and extend the strategy to Marburg virus. They will also investigate how hantaviruses enter the human body.
Researchers at Albert Einstein College of Medicine and Montefiore Health System are conducting a five-year study to test whether medical marijuana reduces opioid use among adults with chronic pain. The study will enroll 250 HIV-positive and HIV-negative adults who use opioids and have received certification for medical marijuana use.
Researchers at Albert Einstein College of Medicine found that adult neural stem cells in the hypothalamus govern how fast aging occurs in the body. By replenishing these stem cells or the molecules they produce, it's possible to slow and even reverse various aspects of aging throughout the body.
The NIH-funded Einstein-Rockefeller-CUNY Center for AIDS Research aims to prevent HIV transmission and develop a cure. The center will focus on behavioral science, clinical translation, biomarker discovery, and HIV vaccine development to improve population health outcomes.
Scientists have identified two natural human antibodies that can neutralize all five known ebolaviruses, offering a breakthrough in the fight against these deadly viruses. The antibodies work by interfering with the virus's ability to infect cells, preventing it from multiplying and causing disease.
A new study published in Neurology suggests that frequent soccer ball heading is a common and underrecognized cause of concussion symptoms. The study found that amateur soccer players who frequently head the ball are at an increased risk of experiencing classic concussion symptoms, even without an overt collision.
The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) project aims to identify biomarkers associated with epilepsy development and develop novel therapies. The research team will collaborate with patients and their families to improve treatment options.
Einstein secured over $160 million in NIH funding in 2016 to support major research projects in aging, intellectual and developmental disabilities, diabetes, cancer, and infectious diseases. The grants also enabled the establishment of new research centers and collaborations with Montefiore Medical Center.
The grant will support a new research program focused on 22q11.2 Deletion Syndrome, an incurable genetic disorder associated with delayed intellectual development and psychiatric conditions. Einstein's IDDRC will also provide critical support for dozens of ongoing studies in intellectual and developmental disabilities.
A new regional center for diabetes translation research has been established at Albert Einstein College of Medicine, supported by a $2.9-million NIH grant. The center aims to improve diabetes prevention and control in low-income communities and racial/ethnic groups disproportionately affected by the disease.
Researchers at Albert Einstein College of Medicine found that brain activity while walking and talking can predict the risk of falling. The study, published in Neurology, involved 166 healthy older adults who were asked to perform tasks such as walking and reciting letters. The researchers found that elevated brain activity during thes...
Researchers at Einstein College of Medicine and Penn State University will use smartphones to assess cognitive changes in seniors with Alzheimer's disease. The five-year study aims to develop personalized interventions to prevent dementia by analyzing risk factors such as stress, pain, and sleep.
Researchers at Einstein College of Medicine are studying the genetic basis of congenital heart disease, with a focus on rare syndrome 22q11.2 deletion syndrome. The goal is to discover why some individuals have severe disease while others have mild presentations.
Researchers at Albert Einstein College of Medicine have developed a novel immunotherapy strategy that targets specific types of cancer while minimizing side effects. They aim to create new and more effective immunotherapies by modulating T cells with a fusion protein.
Einstein researchers conclude that the maximum human lifespan has already been reached at 115 years, with a possible limit of 125 years. This finding suggests that further advances in medicine may not extend human lifespan beyond this point.
A new therapeutic strategy targeting a shared Achilles' heel of all Ebola viruses has shown promising results. Two monoclonal antibodies blocked the invasion of human cells by all five ebolaviruses, and one protected mice exposed to lethal doses of Ebola Zaire.
Researchers at Albert Einstein College of Medicine receive a $3.7 million NIH grant to identify biomarkers signaling Mtb activity in HIV-infected individuals. The goal is to develop tests that can predict active TB disease progression, optimizing preventive therapy timing and effectiveness.
The Einstein-Montefiore and CUNY research team will use the data for their own research projects, addressing scientific clinical and healthcare delivery questions that inform care in Central Africa and beyond. The ongoing study involves over 50,000 HIV-positive children and adults taking anti-retroviral therapy.
Researchers at Albert Einstein College of Medicine have developed a home-based intervention to improve oral hygiene and feeding practices among South Asian mothers in the Bronx. The program aims to reduce childhood obesity and cavities by targeting common risk factors such as bottle-feeding and extended use of sippy cups.
A study of nearly 3,000 centenarians and near-centenarians found that those who live exceptionally long lives have a delayed onset of major age-related disease. This suggests that discoveries made in one group of centenarians can be generalized to diverse populations.
Researchers used advanced MRI to predict which concussion patients would fully recover and identify brain areas involved in the repair process. The study found that high FA white-matter areas correlated with better outcomes, while low FA areas showed axon damage and cognitive impairment.
A nationwide study found that obese young adults are at risk for chronic kidney disease due to undetected albuminuria, with Mexican Americans and blacks showing higher rates. The study suggests that healthcare providers should test for kidney damage in obese young adults, emphasizing the importance of prevention through lifestyle changes.
Researchers have developed a technology allowing them to visualize single molecules of messenger RNA as they are translated into proteins in living mammalian cells. Initial findings suggest that this may shed light on neurological diseases such as Fragile X Syndrome and Alzheimer's, as well as cancer.
The grant aims to study APP processing and its role in synaptic transmission, potentially shedding light on Alzheimer's pathogenesis and revealing treatment targets.
Researchers at Einstein College of Medicine have identified a human protein called transthyretin (TTR) that causes an autoimmune reaction in the joints of Juvenile Idiopathic Arthritis (JIA) patients. Tafamidis, a drug targeting TTR, may be a potential treatment for JIA.
A new study found that benzodiazepine overdose deaths increased more than four-fold from 0.58 deaths per 100,000 adults in 1996 to 3.14 deaths per 100,000 adults in 2013. The rate of overdose deaths leveled off since 2010, but for certain groups, such as those aged 65 and over and blacks and Hispanics, the rate continued to rise.
Researchers discovered a strong link between HPV-16 presence in the mouth and increased risk of oropharyngeal cancer. Detecting oral HPVs may help predict people's risk for developing head and neck cancers.
Researchers have engineered antibodies that can potently neutralize Zaire and Sudan Ebola virus strains, providing high levels of protection for mice exposed to lethal doses. The findings are a significant step toward developing an all-inclusive treatment for Ebola virus that causes human disease.
Researchers discovered a molecular 'arms race' between Ebola virus and African straw-colored fruit bats that may have started over 25 million years ago. The study sheds light on the biological factors determining which bat species harbor the virus, with potential applications for preventing future outbreaks.
The Montefiore Einstein Center for Cancer Care has received a $1.18 million NIH grant to train surgical residents as researcher-surgeons, focusing on tumor microenvironment and novel targets. The program aims to equip future surgeon-scientists with the skills needed to succeed in cancer research.
Researchers from Montefiore-Einstein Center for Cancer Care presented findings on genetic risk factors, preleukemic states, and novel treatments for acute myeloid leukemia. They identified a genetic risk factor for avascular necrosis associated with treatment of ALL in children and demonstrated that moderate PU.1 inhibition can drive m...
Researchers at Einstein and Berkeley will develop new instruments to image genes and proteins in living cells, enabling visualization of gene regulation processes. The grant aims to create powerful microscopes and fluorescent probes to reveal mechanisms controlling gene expression.
Researchers at Montefiore Health System and Albert Einstein College of Medicine are exploring the impact of cognitive training on mobility among sedentary seniors. The study aims to develop effective interventions to improve cognitive functions and enhance mobility, with a focus on preventing disability in older Americans.
Researchers at Einstein College of Medicine will partner with Head Start to promote healthy sleep among preschoolers, aiming to improve social, emotional, cognitive, and physical development. The study's goal is to embed 'sleep health literacy' into early childhood education policy.
Research found that depleting the microbiome with antibiotics can reduce neutrophil activity in sickle cell disease, preventing acute crises and reducing organ damage. The study also suggests antibiotics may help treat septic shock by eliminating pro-inflammatory neutrophils.