Macrophages produce excess inflammatory cytokine IL-1beta when damaged mitochondria release signals; p62 coats damaged mitochondria, ensuring removal. This prevents chronic inflammation and potentially age-related diseases.
Researchers at the University of Birmingham have identified key regulators of blood cell development using a 'big data' approach. By studying six consecutive stages of development, they discovered previous unknown regulators and explained how regulatory elements work together to drive gene expression and stage transitions.
A team of scientists collected over 70 fertile/flowering orchid specimens from the field during the 6-week Lengguru 2014 expedition. Four new orchid species were identified among them, all collected in high-altitude forests above 1000 meters above sea level.
According to Matthew Logan, PhD, a retired police officer and psychologist, a small percentage of violent incidents involving the police dominate headlines. The article argues for greater public airing of the police perspective to provide a more balanced understanding of violence.
A pregnant Brazilian woman infected with the Zika virus had a stillborn baby with severe tissue swelling and central nervous system defects. The case provides evidence that congenital Zika infection may be linked to hydrops fetalis, hydranencephaly, and fetal demise.
A study published in Journal of Applied Psychology found that players who display team-first behavior in college tend to be drafted earlier and earn higher salaries in the NFL. Researchers analyzed media reports of such behavior and found a significant impact on draft positions and first-year salaries.
Researchers found that failing cardiac tissue had increased levels of acetylated mitochondrial proteins, promoting metabolic defects in heart failure. In a mouse model, they detected elevated protein acetylation at the earliest stages of heart failure, supporting the role of hyperacetylation in disease progression.
The Geographical Management of Cancer Health Disparities Program (GMaP) grant supports region-specific cancer research, education, outreach, and training needs. Moffitt serves as the hub for GMaP Region 2, which includes partner institutions in Alabama, Arkansas, Florida, Georgia, Louisiana, Missouri, Mississippi, and Puerto Rico.
The US medical community will play a key role in determining the ethically acceptable path forward for clinical application of mitochondrial replacement techniques (MRTs). MRTs aim to prevent certain debilitating diseases related to mutated mitochondrial DNA by replacing a mother's mtDNA with that of another woman. The first use of MRT...
A new research essay in Cell journal suggests that the US can follow the UK's approach to regulate germline editing and mitochondrial replacement therapy. The authors argue that the UK's experience with MR therapy provides a well-drawn regulatory framework for evaluating the safety and ethics of germline editing.
Researchers found proofreading molecules apply physical tension to RNA, preventing splicing errors and enabling alternative splicing sites. This mechanism regulates splice site choice, shifting the perspective on the realm of possible activities for this class of enzymes.
Researchers at Massachusetts General Hospital found that inducing the hypoxia response, the body's reaction to low oxygen levels, may relieve symptoms of mitochondrial diseases. Activation of this response alleviated mitochondrial pathology and extended survival in animal models.
Researchers have developed a targeted substance that blocks the pathogenic function of an Alzheimer's enzyme in cells, reducing toxic β amyloid peptide production. This selective inhibition may lead to effective treatment without severe side effects, offering hope for Alzheimer's patients.
A Finnish study found that genetic variants associated with musical creativity are linked to specific brain regions, including chromosome 4 and chromosome 18. These findings suggest a biological basis for music composition and arrangement, highlighting the role of multiple genes in creative activities.
The use of residual disinfectants in drinking water has been compared between Western European countries, the U.S., and waterborne outbreak data. The Netherlands has the lowest risk of waterborne disease despite no residual disinfectant use due to newer pipe infrastructure.
The MIT Energy Initiative welcomes Exelon as a member to advance key enabling technologies crucial to addressing climate change. The partnership aims to accelerate deployment of clean energy technologies through collaborations with academia, government agencies, and industry stakeholders.
The newly discovered Rafflesia consueloae is the smallest of its kind, measuring only 9.73 cm in diameter, and has been named after Filipino conservationist Connie Lopez. The species was classified as Critically Endangered due to habitat loss and hunting, highlighting the need for continued protection.
High-arched palate is under-researched, but researchers developed a reliable technique using a mouse model of Treacher Collins syndrome to study its genetic aspects. The study found that TCS mice exhibited high-arched palates and provided significant criteria for defining the condition.
Researchers have discovered that a new medication, pioglitazone, can reduce the risk of stroke and heart attack by nearly a quarter in patients who have previously suffered a stroke or mini-stroke. This breakthrough finding presents a promising new strategy for preventing cardiovascular disease.
Researchers found that each smaller group of herring varied out of sync with others, but their collective diversity helped stabilize the population. This 'local matters' perspective highlights the importance of protecting local diversity in ensuring overall sustainability of the resource.
A team of researchers at Penn State University and the University of Pittsburgh has developed a new way to use enzyme reactions to trigger self-powered mechanical movement. The enzyme pumps can precisely control flow rate without an external power source and turn on in response to specific chemicals in solution.
Research finds that lymphatic vessels play a critical role in obesity development, with chyle leakage triggering weight gain and insulin resistance. Restoring lymphatic function reverses obesity in Prox1-haploinsufficient mice.
Researchers at the Colorado School of Public Health have published a comprehensive review of ways to monitor physical activity and tools for occupational exposure scientists. The study highlights complex relationships between physical activity and common chronic diseases, such as heart disease and arthritis.
A new Penn study links moving more with decreased mortality, finding even small amounts of physical activity can have a significant impact. Adding just 10 minutes of light activity per day can reduce the risk of mortality, according to the research published in Medicine & Science in Sports & Exercise.
Research from the University of Kent shows that parental pressure is a key factor in young male athletes' positive attitudes towards doping. The study found that perfectionism and pressure from coaches were less influential on doping attitudes compared to parental influence.
Scientists have developed a new method to analyze the genetic tree of diseases like HIV to identify possible gaps in transmission chains. The study uses computational phylogenetic analysis to examine how strains of HIV are transmitted and can now evaluate the possibility of unsampled intermediaries or common sources.
Researchers have developed a cooling technique that protects the brain's speech centers during surgery and identifies specific areas responsible for word formation and speech timing. The study used focal cooling to map brain functions, including speech ability, and found distinct roles for specific brain regions in forming words.
A recent study published in the Journal of Pediatric Gastroenterology and Nutrition found that children with autism do not have a unique pattern of abnormal results on endoscopy or other tests for gastrointestinal disorders. The researchers analyzed the results of diagnostic tests in 61 children with autism being evaluated for GI sympt...
A team of researchers discovered that people with Down syndrome have altered white matter insulation in their brains, affecting nerve transmission. This finding may lead to new treatments for DS patients and has implications for other developmental disabilities like autism.
Researchers found that young leaves grow at the same time as older ones perish, causing a shift in tree canopy towards younger leaves with higher photosynthetic capacity. This internal dynamics of the rainforest drives seasonal changes in photosynthesis, which was not previously accounted for in climate models.
A team of Spanish researchers has accurately detected a structure in the innermost region of a quasar at a distance of over 5 billion light-years using the gravitational microlensing effect. This breakthrough will help us better understand how galaxies were born and evolve.
Researchers found that mitochondria in brain cells rapidly change shape and function in response to high blood sugar levels, affecting peripheral tissue functions. The study suggests that alterations in this mechanism may be crucial for type 2 diabetes development.
Researchers discover that mammalian egg cells acquire essential cellular components from their undifferentiated sister cells, called germ cells. This mechanism, previously only documented in lower animals, is believed to play a crucial role in the unique properties of eggs.
Researchers discovered a gene in snails that determines shell twist direction, which may offer insights into human body asymmetry. The study found that the same gene affects left-right symmetry in other animals, including frogs.
A new catalyst, made from palladium and tin, can efficiently produce hydrogen peroxide on demand, making it accessible to underdeveloped regions. This process overcomes the challenge of decomposing the product into water quickly after production.
A new University of Michigan study finds that voting restrictions are actually increasing voter turnout among Democrats, who become angrier about the laws' impact on minority voters. The study reveals that media frames about voter ID laws trigger powerful emotions in Democrats, leading to increased participation.
A new prediction tool developed by MIT engineers can detect rogue waves in calm waters, giving sailors a 2-3 minute warning. The algorithm analyzes wave groups and predicts the probability of a rogue wave developing based on their length and height.
A new study shows that large companies in developed countries prioritize social acceptance over profit maximization in their sustainability management activities. Legitimacy-oriented measures, such as improving employee motivation and reputation, are more important than profit-driven tools like eco-efficiency analyses.
Researchers create microrobots that mimic the movement of ciliates, beating filaments propelled by green light. The robots exhibit wave-like movements and can potentially be used for medical applications, such as detecting and curing diseases.
Researchers propose a novel framework to uncover hidden patterns of transmission and identify super spreaders in epidemics. Asymptomatic carriers can play a significant role in spreading diseases, and understanding their contribution is crucial for targeted interventions.
A recent study suggests that immunotherapy can improve cognitive ability in patients with schizophrenia by suppressing inflammation. The study found significant improvements in cognitive function after just two doses of an immune-suppressing drug, tocilizumab.
The research team aims to establish a link between nighttime wellness and daytime learning and behavior in children with developmental disabilities. They are developing bed-based sensors to track breathing and heart rates, as well as wearable sensors to monitor child behaviors.
Researchers at UMass Amherst and Oxford University describe a new law for predicting wrinkle wavelength on curved surfaces, enabling the use of wrinkles to sculpt surface topography. Experimental results support the validity of this local law, which incorporates mechanical and geometrical effects.
The Patient Empowered Precision Medicine Alliance (PEPMA) aims to rapidly match patients with the right drugs for their condition. The project leverages University-derived technologies to determine whether existing drugs can be repurposed to treat rare conditions.
A new study at McGill University reveals that complex interactions between neurotransmitter receptors and other proteins help explain the brain's ability to process information quickly. Researchers used multiple techniques to examine AMPA receptors, a major player in brain signaling.
A recent study published in Science confirms that the Aliso Canyon natural gas well blowout was the nation's largest methane release. The event released over 100,000 tons of methane into the air, doubling the rate of methane emissions from the entire Los Angeles Basin.
Researchers investigate the formation of a tiny volcanic island near Nishinoshima volcano, Ogasawara Islands, Japan. The island's unique lava flows and internal pathways provide valuable insights into the geological processes that shape our planet.
Dr. Marisa Orr receives a five-year CAREER grant to develop an online Academic Dashboard for empowering engineering students to make adaptive decisions and achieve academic success. The project aims to improve student outcomes by reducing time to graduation and increasing student satisfaction with their major and eventual career.
A recent study found that over half of elderly colorectal cancer patients receive ineffective treatments, leading to significant financial burdens. The study examined data from over 20,000 Medicare patients between 2000 and 2009, revealing a 32% increase in treatment costs and only a one-month increase in median survival.
Researchers at University of Sheffield developed an automated programming method for swarm robots, reducing human error and increasing reliability in complex tasks. The method uses supervisory control theory to ensure predictable behavior, making it suitable for safety-critical applications such as driverless cars.
Researchers from the Center for Nanoparticle Research design a novel therapeutic agent capable of impeding neuronal cell death associated with Alzheimer's disease. The treatment targets mitochondrial dysfunction and oxidative stress, offering new hope for treating this debilitating neurodegenerative disorder.
Researchers found that unmanaged forests remain productive despite surface ozone pollution, due to differential sensitivity among tree species. Ozone impacts are more pronounced in low-diversity systems like crops and managed forests.
A new study led by Alistair Evans of Monash University found that molars follow the inhibitory cascade rule, simplifying human tooth evolution. The team can now predict the size of missing fossil teeth using this rule.
A James Cook University study found adult females remain in coastal areas year-round, giving birth and raising young. The team tracked over 100 sharks for more than two years, discovering a mysterious attraction to a specific bay near Townsville.
A new heat wave formula developed by a University of Missouri researcher provides a uniform definition for extreme temperatures, enabling public health agencies to prepare for heat waves. The formula accounts for missing weather data and regional climates, improving the accuracy of heat wave warnings.
Researchers analyzed myeloid lineage immune cells in glioblastoma patients, revealing non-polarized cell state and potential therapeutic strategy. The study suggests stimulating these cells to adopt an anti-tumor identity may be effective.
Tropical cyclone Yalo formed near Tahiti on Feb. 25, with NASA's Aqua satellite capturing infrared and microwave data. The storm is forecast to intensify before running into adverse conditions, threatening French Polynesia and Austral Islands.
Researchers have discovered significant differences in cells derived from dura mater and skin samples across the lifespan, highlighting the importance of considering the cell's original location and donor age. These findings necessitate further exploration into epigenetic patterns in stem cells used for new tissue and organ generation.
Researchers from Rockefeller University have identified a hormone called amylin as a critical component of the system responsible for regulating food intake. Amylin acts in the brain to help control consumption, working in concert with another hormone leptin to control body weight.
A new study published in the Journal of Applied Psychology found that individuals with elitist world views tend to perceive white male researchers as more credible, while those with egalitarian beliefs view women or people of color as more credible. The research highlights the impact of ideology on evaluating academic credibility.
Research uncovers Amazon forest seasonality, revealing a dynamic pattern of leaf growth and death that explains variations in photosynthesis. The findings improve climate models and provide insights into the forest's ability to adapt to dry periods.
The new CVIA journal published its second issue with a special focus on Electrophysiology. Key findings include strategies for preventing stroke in high-risk atrial fibrillation patients, catheter ablation as a cornerstone in AF management, and the role of multimodality imaging in substrate characterization.
Researchers analyzed Instagram posts from over 3 million users in food deserts and non-food deserts, finding that foods high in fat, cholesterol, and sugars were more common in the former. Regional staples like steak and okra were also prevalent in their respective communities.
Researchers at the University of Massachusetts Amherst have identified a new molecular property that could lead to more efficient and cost-effective materials for cell phone and laptop displays. The property, directional intrinsic charge separation, was found in crystalline nanowires of an organic semiconductor molecule known as TAT.
Researchers used autonomous acoustic sensors to detect and record marbled murrelet calls, identifying over 19,000 potential calls and confirming 7,218 actual calls. This technology offers a viable alternative to traditional surveys, enabling broader, more cost-effective searches for these endangered seabirds.
Researchers discovered that Amazon forests' annual increase in photosynthesis is caused by synchronization of old leaf loss and new leaf growth, contradicting assumptions about constant canopy greenness. This finding will help improve predictions of forest responses to climate change.
A clinical trial found that paroxetine modestly improves decision-making and reaction time, and suppresses inflammation in people with HIV-associated cognitive impairment. This is the first time a SSRI has been shown to improve key measures of cognition in people with HIV in a controlled study.
A study published in Current Biology found that the gene responsible for twisted snails' shells is linked to internal asymmetry in frogs. This suggests that body asymmetry may be an evolutionarily ancient characteristic of animal development.
Heavy rainfall causes gullies to expand rapidly, with predicted climate change increasing rates up to three times faster. Researchers have developed a model to predict gully expansion and warn of devastating consequences for agriculture, water quality, and infrastructure.
A team of Cornell researchers has developed two-dimensional superstructures out of single-crystal building blocks, showcasing atomic coherence and superior electrical properties. The discovery has potential applications in energy absorption and light emission, but challenges remain to further improve the results.
A new Australian bush tomato species, Solanum watneyi, has been discovered and named after the botanist character in the book and film adaptation of The Martian. The plant was identified as a relative of the potato and its discovery has sparked recognition from the botanical community.
A recent study found that ocean acidification is already affecting coral reefs, causing them to grow slower than they did in preindustrial conditions. The research, published in Nature, manipulated seawater chemistry in a natural coral-reef community to determine the impact of excess carbon dioxide on coral reef growth.
A recent study published in Science reveals that the Aliso Canyon natural gas well blowout released over 100,000 tons of methane, doubling the rate of emissions from the entire Los Angeles basin. The disaster created the largest known human-caused point source of methane in the US.
Researchers found a significant reduction in emergency department visits and hospitalizations for heart failure exacerbation after bariatric surgery. Patients who underwent the procedure experienced a 40% decrease in these events, suggesting substantial weight loss can help prevent heart-failure-related adverse events.
A team of scientists, led by Bailong Xiao, has discovered the molecular mechanisms underlying mechanotransduction in Piezo proteins. They found that these proteins form a novel class of ion channels with distinct modules responsible for ion conduction and mechanical force sensing.
Archaeologists have uncovered an 11,000-year-old engraved shale pendant at the Early Mesolithic site of Star Carr in North Yorkshire. The subtriangular artifact contains series of lines that may represent a tree or tally marks, and is the earliest known Mesolithic art in Britain.
Researchers successfully generated functioning sperm-like cells from mouse embryonic stem cells and produced fertile offspring, providing a potential platform for treating male infertility. The breakthrough overcomes major obstacles to producing functional sperm and egg cells in a dish.
Research found that heme oxygenase-1 overexpression in mice protected against dilated cardiomyopathy, reduced mitochondrial fragmentation and promoted new mitochondria generation. This study demonstrates the importance of heme oxygenase-1 in controlling mitochondrial dynamics in the heart.
A recent US study of over 3,000 adolescent girls found that nearly a fifth of lesbian and four-fifths of bisexual teens had a male sex partner recently. The study highlights the importance of comprehensive sexual health education for all youth, including those who identify as lesbian or bisexual.
A study published in Nature Communications has discovered that genes can move from chlamydia strains in the eye to sexually transmitted strains, allowing them to infect the eye and cause Trachoma. This revelation challenges previous beliefs about Chlamydia evolution and highlights the potential for new variant Trachoma strains to emerge.
Researchers found that 70% of Ebola survivors reported musculoskeletal pain, while 48% experienced headaches and 14% had vision problems. The study highlights the need for further research into Post-Ebola Syndrome to understand its causes and consequences.
A study of US patients on dialysis from 2005 to 2012 found declining ESA use and hemoglobin concentrations, resulting in increased transfusions. However, rates of death and cardiovascular events decreased during this period, suggesting a possible beneficial effect of recent trends in anemia drug use.
Researchers from MIPT have experimentally demonstrated that copper nanophotonic components can operate successfully in photonic devices, outperforming gold-based components. The discovery enables the development of energy-efficient light sources, ultra-sensitive sensors, and high-performance optoelectronic processors.
A recent study published in PLOS Pathogens found that nitric oxide plays a protective role in the blood-brain barrier, reducing parasite invasion and inflammation. The researchers discovered that NO inhibits inflammatory molecules, such as TNF and MMP-9, which can lead to BBB damage.
NASA has visualized rainfall data to show the changes in US precipitation during El Niño, with areas like California and East Coast experiencing wet conditions. However, other parts of the country faced droughts and floods due to shifts in precipitation patterns.
Researchers discovered two potent Ebola antibodies that eliminate symptoms in just five days after infection. The monoclonal antibodies target different regions of the virus's glycoprotein and work by interfering with its entry into host cells.
A team of scientists tracked radio-tagged coconut rhinoceros beetles on Guam to locate hidden breeding sites. The study found that the beetles often congregated around damaged palm trees, suggesting thousands of new breeding sites may exist in the islands' jungles.
The BENEFIT trial suggests that treating Chagas disease earlier is crucial, as it did not show incremental benefits in cardiac outcome. The study found that 17-18% of patients died over a period of five years, with the number comparable to breast cancer mortality.
A new study from UMass Amherst found that older adults report feeling more serenity and having a richer concept of what it means to feel serene. They also exhibit fewer depressive symptoms and less shame associated with negative emotions compared to younger adults.
Scientists at Yerkes National Primate Research Center have successfully tested an immunotherapy agent that can push SIV out of its hideouts in infected monkeys. The treatment, which combines PD-1 blockade with antiretroviral therapy, resulted in more rapid viral suppression and active antiviral T cells.
A new study highlights the potential consequences of reintroducing genetically distinct subspecies into wild populations, particularly in endangered species. Researchers found that hybridization between non-native and local orangutan subspecies can lead to health problems and reduced reproductive success in offspring.
A Brazilian woman infected with Zika virus had a stillborn baby with severe tissue swelling and central nervous system defects, suggesting the virus may cause damage outside the CNS. The case raises concerns about the risk of stillbirths and other adverse outcomes in pregnant women exposed to the virus.
A study from the University of Eastern Finland found that balloon angioplasty can successfully treat acute mesenteric ischemia (AMI), a condition often misdiagnosed in older patients. The procedure led to a significant improvement in mortality rates compared to earlier treatments.
Researchers from Swiss and German institutions analyzed truffle samples for radioactivity 30 years after Chernobyl. The study found negligible amounts of radioactive caesium in Burgundy truffles, making them safe for consumption. The results suggest that the unique nutrient uptake mechanism of Tuber aestivum may be responsible for this...
Researchers are collecting measurements of plant mass, tree distribution and diversity of species from Gabon's rainforest, wetlands and savanna. The data will help prepare for upcoming spaceborne missions to better gauge the role of forests in Earth's carbon cycle.
A research team at the University of Tokyo has identified an enzyme called Trimmer, which trims the tails of small RNAs called piRNAs. This process helps regulate jumping genes, or transposons, that can disrupt host genes and contribute to diseases like cancer.
Researchers detect cryptochrome 1 in photoreceptors of dog-like carnivores and primates, hinting at a magnetic sense linked to the visual system. The molecule's presence suggests that these animals may use it to perceive the Earth's magnetic field.
Research identifies distinct geographical patterns of fatal unintentional firearm injuries in seven Appalachian states with lax child access laws. Five Western coastal states show high rates of 'legal intervention' deaths due to police actions or officer fatalities.
Rutgers University students Jason Kim and Professor Howon Lee created 3D Braille maps for the Joseph Kohn Training Center using a high-tech 3D printer. The goal is to help blind and visually impaired individuals navigate their surroundings with ease.
Sub-tropical Storm Winston was weakening in the South Pacific when NASA-NOAA's Suomi NPP satellite passed over it on Feb. 25. The Joint Typhoon Warning Center issued its final bulletin, stating that Winston was threatening Norfolk Island with tropical-storm-force winds.
Vanderbilt University Medical Center (VUMC) will lead the Direct Volunteers Pilot Studies under the first grant awarded in the federal Precision Medicine Initiative Cohort Program. The program aims to engage 1 million or more U.S. volunteers, providing a platform for expanding precision medicine approaches.
Researchers have discovered graphene's exceptional lubricity, which could drastically reduce energy loss in machines when used as a coating. The material's ability to slide smoothly across gold surfaces has significant implications for improving energy efficiency and extending equipment lifespan.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified ARGK-1 as a protein that can extend the natural lifespan of C. elegans by increasing energy regulation within cells. This finding may lead to new avenues for delaying human age-related diseases such as cancer and neurodegenerative disorders.
A single monoclonal antibody isolated from a human Ebola survivor has been shown to completely protect monkeys from lethal infection with the virus. The antibody, known as mAb114, was effective even when given five days after exposure, suggesting it could be used as a potential treatment for human cases.
Researchers studied brain activity in patients with severe epilepsy while navigating virtual landscapes on a computer screen. The results show that brain oscillations are driven entirely by internal processes, carrying information about speed and distance travelled during teleportation.
Researchers found bacteria can recognize and disrupt viruses using a novel RNA-based defense mechanism. This discovery could lead to improved ways to prevent crop diseases and dairy industry infections, and may inspire new gene-editing techniques.
Researchers used advanced calcium imaging to monitor neural activity in zebrafish brains, showing the tectum responds to multiple stimuli like sight, sound, and water flow. This discovery suggests a unified sensory view for both humans and fish, improving understanding of human sensory perception.
Researchers at University of Notre Dame develop new triple combination formulation to deliver HDACi across blood-brain barrier, improving brain function and prolonging mouse survival. The finding suggests potential therapy for NPC and other neurological diseases.
Researchers compared human male- and female-line genealogies with those of our closest animal relatives. Human 'Adam' is about 200,000 years old, while chimpanzee 'Adam' is over 1 million years old.
Researchers at Newcastle University have identified a significant decrease in mitochondrial complex II activity with age in human skin cells, offering a new pathway for anti-aging treatments. The discovery may also lead to a greater understanding of other organs' aging processes and potential drug developments for age-related diseases.
The ORFeome Collaboration has created a comprehensive library of open-reading frames, comprising 17,154 clones that code for full-length proteins. This resource allows researchers to express virtually any cell protein, enabling large-scale mapping of protein-protein interactions and functional screening.
A new study estimates methane leak rates from a 2015 California well blowout, which temporarily doubled Los Angeles' combined emissions. The research used airborne and surface measurements to quantify gas releases, highlighting the impact of single infrastructure vulnerabilities on climate policies.
A recent study by Hiroshima University has identified a key protein responsible for burning excess energy in the body, UCP1, found in brown fat cells. Increasing UCP1 levels can lead to a higher metabolism and less weight gain.
Pittsburgh researchers utilize enzymes to trigger mechanical movement in fluidic devices, showcasing a novel approach for self-powered systems. The studies reveal complex, time-dependent flows driven by simple enzymatic reactions.
Researchers used X-ray micro-computed tomography to study the microstructure of fried potato disks and observed how oil content and pathway networks change with frying time. The findings can be applied to other fried foods, revealing a correlation between pore size and oil uptake.
Researchers at Johns Hopkins University found that giving people time to learn what's possible to ignore improves visual search performance. Participants who were told to ignore distracting colors on a computer screen found the target letters faster and more efficiently over time.
ESTEVE has developed two new investigational gene therapies, EGT-201 and EGT-301, to treat Sanfilippo B syndrome and Hunter syndrome. The treatments join a promising gene therapy platform aimed at restoring enzyme function in patients with severe and debilitating rare diseases.
A Penn study found that using machine learning forecasts at arraignments can dramatically reduce subsequent domestic violence arrests. Machine learning analyzes data points like age, gender, and prior warrants to determine risk, offering extra information to courts.
A study by Penn State and Columbia University found that individuals who experience more negative emotions and perceive stressful events as more stressful have lower heart rate variability, a risk factor for cardiovascular disease. This suggests that reaction to stress is more important than its frequency in determining health risks.
Researchers develop new method to visualize intrathecal drug delivery using SPECT-CT imaging, revealing dynamics of cerebrospinal fluid movement and injection location. This technique may help optimize therapeutic options for neurological disorders.
Researchers at EPFL have developed a technology that accelerates scarring and prevents bacterial growth, aiming to reduce the death rate among victims of serious burns. The new bandage combines biological bandages with dendrimers to destroy microbes and prevent infections.
A recent study identified transthyretin (TTR) as an antigen that stimulates B and T cell immune responses in patients with juvenile idiopathic arthritis (JIA). Elevated levels of TTR in synovial joint fluid were found in some patients, leading to increased TTR autoantibodies.
A new study suggests that individual differences in brain structure and function affect both anatomical and cognitive factors, such as intelligence and memory. The researchers identified four unique traits that explained most of the differences in brain anatomy, with the remaining differences accounting for individual differences in in...
Researchers recommend reducing water usage for agriculture, using less road salt, and routing urban salt discharges to minimize freshwater damage. High salt levels can be toxic to aquatic organisms and kill fish and other food sources.
The University of Kentucky researcher has helped draft a comprehensive position paper on nutrition and athletic performance, synthesizing over eight years of research to provide evidence-based recommendations for athletes. The paper emphasizes the need for individualized nutrition plans that account for various factors affecting athlet...
Researchers at Einstein College of Medicine have identified a human protein called transthyretin (TTR) that causes an autoimmune reaction in the joints of Juvenile Idiopathic Arthritis (JIA) patients. Tafamidis, a drug targeting TTR, may be a potential treatment for JIA.
Researchers used 3D microscopic imaging to reconstruct the diets of medieval children, discovering differences in poor and wealthy families. The technique, dental microwear texture analysis, measures changes in tooth surface topography, offering a new way to access dietary information.
Research published in Injury Prevention found that paid family leave in California is associated with a lower rate of children's admission for head injury, including cases of deliberate inflicted trauma. The study suggests that this policy may have positive effects on reducing childhood abuse admissions.
A new NASA visualization reveals an unusual 2015 El Niño pattern, with warmer sea surface temperatures across the Pacific and Atlantic. This differs from the stronger Eastern Pacific pattern seen in the 1997-1998 event.
Research suggests that long-term high-intensity exercise may lead to permanent structural changes in the heart, increasing the risk of arrhythmias. A review by sports cardiologist André La Gerche argues that large prospective studies are needed to fully understand the effects of intense exercise on heart health.
Researchers at Cardiff University have developed a new group of catalysts that can produce hydrogen peroxide on-demand in a simple one-step process, opening up possibilities for manufacturing the chemical in remote areas. The production of hydrogen peroxide is essential for water purification and could significantly reduce costs.
A recent study has discovered an intermediate gut microbiome from the Central African Republic's Bantu community, which incorporates some westernized lifestyle practices. The discovery sheds light on what factors may drive our microbiome differences, linked to metabolic disorders in Western populations.
A single monoclonal antibody isolated from an Ebola survivor protected non-human primates even after lethal infection, offering hope for a potential treatment. The findings suggest a novel site of vulnerability on the Ebola virus and may lead to effective therapy.
Scientists have discovered a way to specifically target and inhibit the most harmful behavior of the amyloid precursor protein in Alzheimer's disease. This new therapeutic strategy could potentially treat AD without causing major side effects.
Researchers at St. Jude Children's Research Hospital and the German Cancer Research Center have identified four new subtypes of a rare childhood brain tumor using molecular techniques. This discovery is expected to improve diagnosis accuracy and treatment options for these hard-to-treat cancers.
A study reveals a deep indigenous genetic history tracing back to the initial settlement of Australia 50 thousand years ago, challenging previous theories about an influx of people from India. The findings show a long and independent genetic history in Australia.
Researchers developed a new screening protocol to detect human polyomaviruses in tumor samples, but found no association with various types of cancer. The technique will aid in studying diseases linked to polyomaviruses, such as Merkel cell carcinoma caused by Merkel cell polyomavirus.
Researchers at Columbia University are reengineering and simplifying music to make it more enjoyable for listeners with cochlear implants. By analyzing which parts of music are most important for listener enjoyment, they aim to develop software that can take original pieces and reconfigure them or allow users to engineer their own music.
Researchers from Colorado State University have discovered a potential diagnostic tool for dengue fever by analyzing metabolomic profiles in patient serum. The study found that distinct metabolic clusters were associated with different disease outcomes, including the progression to hemorrhagic fever/dengue shock syndrome.
Researchers discovered that saposin B binds to the anti-malarial drug chloroquine, potentially leading to toxicity due to prolonged binding instead of removing damaged lipids. This finding opens up new avenues for investigating saposin B's role in other conditions, such as lysosomal storage diseases.
Research breakthrough reveals pancreatic tumours often lose miR-137 expression, triggering uncontrolled cell growth and cancer. Restoring normal miR-137 levels induces senescence and stops cells from spreading.
Kyoto University engineers have developed genetically modified E. coli that produce thebaine, a morphine precursor, 300 times more efficiently than yeast. This breakthrough could lead to the production of painkillers from microbes with low regulatory risk.
Researchers used fluorescent false neurotransmitter 200 to observe synaptic activity in mice, revealing that only a small number of synapses may be active at any given time. This discovery could help understand how brain signals are transmitted and potentially shed light on brain disorders such as Parkinson's disease.
A new study reveals that leaf quality, rather than leaf abundance, plays a crucial role in forest carbon cycles. The research finds that varying leaf quality can explain twice as much seasonal variation in ecosystem productivity as leaf quantity alone.
Researchers found that flowers with imperfect iridescence are easier for bees to spot than those with perfect iridescence, which can confuse bees' color recognition. This subtle signal allows flowers to communicate with bees without interfering with their ability to distinguish between colors.