Researchers at H. Lee Moffitt Cancer Center develop adaptive therapy to keep resistant cells in check, prolonging survival without disease progression in mouse models of triple-negative and ER+ breast cancer. The approach is being tested in a clinical trial for prostate cancer patients.
Researchers found that physical strength is a key attribute in judging leadership potential, with strong men perceived as better leaders and having higher status. This effect does not depend on physical attractiveness, and even manipulating body size and height had no impact on participants' ratings.
A new study by Stanford bioengineers and physicians finds that measuring the rigidity of an hour-old fertilized egg can predict its viability more accurately than current methods. The technique, published in Nature Communications, could improve the success rate of single-egg IVF and ultimately benefit both mothers and babies.
A new study by MIT economist Christopher Knittel suggests that technology-driven cost reductions in fossil fuels will lead to continued use of oil, gas, and coal unless governments pass new taxes on carbon emissions. Burning all available fossil fuels could raise global average temperatures by 10-15 degrees Fahrenheit by 2100.
A study by UTMB found that APPs prescribed short-acting inhalers and consulted with pulmonary specialists more often, leading to lower ER visits for COPD and higher follow-up rates. However, they had lower vaccination rates and less frequent clinic visits after hospitalization compared to physicians.
Researchers from eight European countries have mapped the abundance and diversity of earthworms across the continent, highlighting their crucial role in soil health. The study's findings emphasize the need for further data collection to validate the results and improve monitoring.
A recent study by the American Academy of Neurology has found that most Ebola survivors experienced brain symptoms six months after their initial infection. The study, which followed 82 Ebola survivors from Liberia, revealed common neurological problems such as weakness, headache, memory loss, and depressed mood.
Research identifies cellular stress-sensors proteins that favor viral lytic gene expression and cell cycle arrest. The study provides insight into the link between stress responses, cell cycle regulation and virus reactivation in oncogenic herpesviruses.
The Zika epidemic underscores the importance of prioritizing vaccine development for pregnant women, who face specific challenges in clinical trials and labeling guidelines. Researchers highlight the need for a pregnancy-specific ethical framework, standardized measurement of outcomes, and more baseline data to optimize vaccine safety ...
Coral reefs are already experiencing slower growth due to ocean acidification, which is causing coral calcification rates to decrease. The study found that increasing the pH of seawater can stimulate calcification rates.
Agriculture technology improvements can cut emissions by up to 50%, but reductions in beef consumption are necessary to meet EU climate targets. Cutting back on beef and increasing poultry and pork consumption can help achieve the targets.
Recent gene therapy developments focus on viral vectors like AAV for safe gene transfer, and new gene editing tools offer targeted gene inactivation or insertion. These approaches aim to treat multiple diseases with platform strategies.
A Chapman University study found that couples who engage in regular foreplay, set a romantic mood, and express love experience higher sexual satisfaction. The study of over 38,747 men and women aged 40-46 revealed that satisfied couples also reported more frequent sex, oral sex, and orgasms.
A study from Brigham and Women's Hospital found that monthly monitoring and support from pain specialists increased PCP confidence in prescribing opioids, improved patient compliance, and enhanced communication between practitioners. The research highlights the benefits of careful monitoring and pain management support within primary c...
A study published in the Journal of Industrial Ecology found that consumers are responsible for more than 60% of global greenhouse gas emissions and up to 80% of world water use. Changing consumption habits can significantly reduce environmental impact.
Researchers at MUSC have discovered a safe method for producing retinal pigment epithelial-like cells using human proteins, which can be transplanted to treat macular degeneration. The study also found an effective way to repair the damaged Bruch's membrane beneath these cells, rejuvenating the tissue.
A new study found that a computer-based attention bias modification treatment reduced negative attention biases and clinician-rated depressive symptoms in adolescents with major depression. After 12 months, participants in the active ABM group reported even greater reductions in self-reported depressive and anxious feelings.
A new study from Trinity College Dublin reveals that modifying ECT can minimize cognitive side effects while maintaining its effectiveness in treating severe depression. The 'unilateral' approach, involving unilateral electrode placement, shows promising results.
A reduced glycerin formulation of tenofovir gel was found safe when used daily and around the time of sex for HIV prevention. Participants were as likely to follow through using the gel with sex as they were taking daily oral PrEP, demonstrating its potential as a rectal microbicide for people at risk of HIV from anal sex.
Research led by UI Scientist Brian Dennis finds honeybees' decline rooted in hive size, which becomes unstable when cooperative functions are degraded. The study proposes regional pesticide management and conservation programs to help honeybees.
The USDA Forest Service's new interactive guide, Southern Forest Products - An Economic Engine, tells the story of forest products in the South over the last decades. Using FIA data loaded onto the Esri ArcGIS Online platform, the guide provides a constantly updated guide to southern timber product outputs and mills that process them.
A study published in PLOS ONE found that adult male gorillas call more frequently than females and juveniles during feeding, especially when consuming aquatic vegetation, flowers, and seeds. This food-associated calling may help express well-being and aid group coordination and social cohesion.
UT Southwestern Medical Center researchers have designed a powerful 3-D microscope capable of creating high-resolution images of living cancer cells in controlled microenvironments. The new approach enables detailed study of cell interactions with their environment, accelerating discovery in biology.
A new study in Behavioral Ecology suggests that young male western bluebirds may benefit from living with their parents as helpers for a year before starting a nest of their own. This cooperative breeding strategy can increase both the parents' and the helper's lifespans, as well as reproductive fitness.
Scientists struggle to study Zika due to low symptom visibility and lack of approved tests. Pharmaceutical companies are racing to develop vaccines, but a broader approach targeting multiple viruses could provide future protection
Scientists have found that tropical fires in Southeast Asia and Africa are responsible for high ozone concentrations in the air above the western Pacific Ocean. The ozone is a byproduct of burning organic material, which is transported thousands of miles away by winds.
Researchers found that CRP biomass yield can reach up to 6.4 metric tons per hectare, but economic analyses show that costs of fertilizer application may outweigh benefits. Implementing a system where land owners harvest one-third of their acreage per year could reduce government costs by $31 million annually.
The James Webb Space Telescope is being assembled over the next two years, with recent installations of primary mirror segments and upcoming tests at NASA Goddard and Johnson Space Center. The telescope will undergo end-to-end optical testing in a simulated cryo-temperature environment before final assembly and launch preparation.
Scientists at the University of Michigan have developed a novel method to observe insulin production in the pancreas of living animals. The technique allows researchers to see how much insulin is present and respond to sugar levels in real-time, revealing surprising insights into pancreatic function.
Climate change is forcing species of migrating fish to shift their range towards the poles, affecting people who depend on them. Wealthier communities with stronger resource management tend to benefit more from these changes, exacerbating global inequality.
Researchers optimize algae-based biorefineries to produce cleaner energy with reduced costs and carbon footprint. The study's model uses flue gases as a source of CO2, reducing expenses by almost 90%.
Researchers at NYU Langone Health found that non-native English speakers performed slower on sideline vision tests and had higher saccade rates compared to native English speakers. The study suggests that clinicians and trainers need to consider language when interpreting test results, which may impact concussion detection.
A recent study published in Neurology found that maintaining mental activity can slow the onset of Alzheimer's symptoms in people without a family history of the disease. For those with the APOE4 gene, continued learning and intellectual activity in middle age can lower amyloid plaque levels.
A new Yale-led study suggests that climate change reallocates global wealth in unpredictable ways, leading to a potential net loss in global wealth. The researchers argue that price impacts in resource-rich areas can significantly affect wealth reallocation.
A recent study published in the BMJ found that intensive blood pressure lowering treatment using antihypertensive drugs may increase the risk of cardiovascular death in people with diabetes and systolic blood pressure levels under 140 mm Hg. However, for those with high blood pressure, treatment is crucial to prevent complications.
A study by Northwestern University found that out-of-state visitors to Colorado's marijuana dispensaries are increasingly visiting the emergency room, with a 109% increase in 2014 compared to 2012. Adverse side effects of cannabis use include anxiety, hallucinations, and cardiovascular issues.
A new study suggests that fetal alcohol exposure leads to long-lasting slow-wave sleep fragmentation, which is associated with learning problems and impaired cognitive function. The researchers found that mice exposed to binge amounts of ethanol displayed severe sleep fragmentation, memory impairment, and hyperactivity.
A recent study found that mental activity may help delay the onset of Alzheimer's symptoms, but it does not affect the underlying disease changes in the brain. For carriers of the APOE4 gene, continued lifetime learning was associated with lower levels of amyloid plaques.
A study by Dr. Fraser Scott and his team discovered a bacteria-killing protein called cathelicidin antimicrobial peptide (CAMP) that helps the pancreas regenerate and produce insulin. The research could lead to novel treatments for both type 1 and type 2 diabetes.
Using laser probe, neurosurgeons deliver chemotherapy drugs to patients with glioblastoma after opening the blood-brain barrier. The technology allows for longer treatment windows and potentially limits harmful effects of chemotherapy.
A Phase 2 trial found that maraviroc-containing regimens are as safe and well-tolerated as TDF and emtricitabine when used as PrEP to prevent HIV infection in high-risk men. Five participants became infected with HIV during the study, but their low drug levels suggested inconsistent use of PrEP.
A study published in JAMA Cardiology found significant variations in US hospital cardiac arrest care quality. Hospitals with better adherence to recommended guidelines have higher survival rates for patients treated for in-hospital cardiac arrest. The researchers estimate that an additional 22,990 to 24,200 lives could be saved annuall...
A comprehensive analysis of 526 NBA players reveals larger left ventricular cavity sizes, but not necessarily indicative of increased risk. Most athletes have normal left ventricular ejection fractions, with African American athletes showing increased wall thickness and mass compared to white athletes.
Scientists create a computer simulation that grows realistic forests down to individual trees to predict how climate-related changes will affect fire rates, plant growth, and forest recovery in Quebec hardwood forests. The 'LES' model can help identify necessary species for reestablishing forests after wildfires and other disturbances.
A new study published in the Journal of Clinical Psychiatry shows that genetic counseling is valuable for patients with schizophrenia, bipolar disorder, and similar conditions. Genetic counseling helps clarify misconceptions about the cause of psychiatric illnesses and reduces feelings of guilt and distress.
A study published in Annals of Emergency Medicine found ketamine to be an effective and safe sedation agent for patients with acute behavioral disturbances who do not respond to traditional methods. Only 10% of patients treated with ketamine required additional sedation or failed to achieve sedation within a set time frame.
The HPTN 073 Study found that a novel coordinated counseling and care approach resulted in high uptake of PrEP among BMSM, suggesting a lower rate of HIV infection. The study showed that 92% of participants completed the 12-month follow-up and 79% accepted PrEP.
Emerging genetic tools for mitochondrial DNA replacement offer the potential to prevent a multi-system genetic disease, but also raise questions about unintended risks to children and their descendants. The tools aim to prevent mother-to-child transmission of mitochondrial DNA disease.
Jacquet aims to identify expected winners and losers of closing the high seas to fishing and explore feasibility of changing fisheries policies. Her research focuses on large-scale cooperation dilemmas like climate change and wildlife exploitation.
Black adults have higher cardiovascular disease risk compared to non-Hispanic white adults. A study validated risk prediction models for CVD incidence in black adults, showing modest improvement over standard risk factors and biomarkers.
A new study found that a single embryonic rule regulates hominin tooth size, with variations in the expression of this rule accounting for differences in tooth size throughout human evolution. The researchers discovered that the inhibitory cascade pattern for adult molars is directly linked to the size of milk molars.
A survey of 1400 endangered species found 78 vulnerable to nitrogen-induced harms. Nitrogen's impacts on biodiversity are diverse, including direct toxicity, depleted oxygen, and invasive species that outcompete native populations.
A Phase 2 study found that patients treated with MultiStem therapy experienced a complete or near full recovery from their stroke after one year, with 23.1% achieving this outcome compared to 8.2% of placebo patients. The therapy appears to reduce local inflammatory response and protect neurons in the brain.
A new study suggests that the available budget for carbon dioxide emissions is on the low end of previous estimates, lending urgency to addressing climate change. The researchers propose a limit of 590-1240 billion tons CO2 from 2015 onwards to keep global warming below 2°C.
A Concordia researcher collaborated with individuals with intellectual disabilities to create personal video testimonials using iPads, showcasing their capabilities and successes. The study highlights the empowering potential of mobile technologies in promoting autonomy and inclusion.
Researchers at Arizona State University have developed a simpler method to produce antibodies against a range of infectious agents using DNA-based genetic immunization. The technique successfully expressed membrane proteins in mice and induced the animals to produce critical antibodies to bacterial and viral targets.
A team of scientists led by UH professor Liming Li analyze Cassini spacecraft data to understand the seasonal changes on Saturn. They also examine the energy budget for Jupiter and Saturn to better comprehend planetary climate evolution.
Researchers found that carbon nanomaterials, like C60 molecules, can enter immune cell membranes without triggering a response. This passive entry allows the materials to escape and evade the cell's disposal mechanisms.
A new climate model developed by the University of Wisconsin-Madison can better predict changes to the ocean-carbon sink, a crucial factor in understanding future climate change. The improved predictive capacity allows scientists to distinguish human-induced effects from natural variability.
A new species of blue-tailed monitor lizard unique to Mussau Island has been described, with distinct features including a pale yellow tongue and turquoise pigmentation. The lizard plays a crucial ecological role in the island ecosystem as a top-predator and scavenger.
A new study from the University of Southampton found that inland freshwater fisheries with higher biodiversity have higher-yielding and more stable fisheries. The research suggests that maintaining healthy freshwater systems is critical for food security and livelihoods, particularly in developing countries.
The European Union's complex and unpredictable decision process is hindering the introduction of genetically modified trees to the market. The current procedure involves extensive risk analyses, which are costly and time-consuming, making it difficult for scientists to predict the long-term consequences of GM tree use.
Conservatives tend to use nouns instead of adjectives to describe things, preferring clarity and predictability. This linguistic preference is linked to the values associated with conservatism, such as stability and tradition.
A new device, IS2B, developed by Arizona State University researchers accurately measures chemical contamination in water and sediment. The tool assesses the bioavailability of hazardous chemicals, which is essential for understanding health risks from pollution.
A Rice University study explores how opposition from target countries influences the expansion of state-owned enterprises. The authors identified five geopolitical factors that shape the level of welcome, including geographic distance, similarity of religious beliefs, government types, resource complementarity, and nationalist politics.
The VA has robustly implemented antibiotic stewardship practices across its facilities, with over 80% having an Infectious Disease specialist on staff. Formal policies and staffing patterns promoting appropriate antibiotic use were also widespread.
A study led by Dr Alistair Evans from Monash University has simplified the understanding of human tooth evolution, allowing for predictions on missing teeth. The 'inhibitory cascade' rule reveals a pattern in tooth size that was previously thought to be more complex.
A recent study by researchers at the University of California, Davis, found that gamers using thin avatars showed increased physical activity compared to those using obese avatars. The study replicated previous findings on both male and female participants.
Researchers have adapted the Trombe wall design to heat and cool buildings, reducing carbon emissions and fossil fuel use. The new system uses wind and solar energy to provide a comfortable indoor temperature all year round.
Researchers develop adaptive therapy that adjusts drug dose based on tumor response, controlling growth and allowing 60-80% of mice to be weaned off the drug. The treatment approach stabilizes tumors by maintaining a small population of drug-sensitive cells to suppress resistant cell growth.
The study provides information that can be incorporated into clinical assessments for the prevention of cardiac emergencies in basketball players. The analysis reveals that left ventricular cavity sizes in NBA players are larger than in normal adults, but proportional to body size.
Researchers develop new material to collect condensed water droplets using bio-inspired approach combining multiple natural systems. The material harnesses the power of desert beetles' bumps, cactus spines and slippery surfaces to facilitate condensation, promising applications in thermal power plants.
A study published in Scientific Reports found that birds migrating greater distances have more new neurons in brain regions responsible for navigation and spatial orientation. The research team discovered a trend of increasing new neurons in line with migration distance, with different brain regions affected in two species.
A new study reveals that pancreatic cancer is composed of four distinct subtypes, each with its own unique genetic profile and treatment possibilities. These findings have significant implications for diagnosis and treatment, potentially allowing for more accurate prognoses and targeted therapies.
A new study by Simon Fraser University researchers found that differences in working memory capacity correlate with the brain's ability to actively ignore distraction. Individuals with low memory capacity are unable to suppress distractors, leading to attentional deficits.
A UT Dallas study found that student-athletes with lowest GPAs reported viewing themselves as athletes over students, thinking about sports more than academics. Coaches may play a strong role in academic performance, and universities must ensure proper guidance for success.
Researchers found that omega-3 supplementation reduced breast density in postmenopausal women with a body mass index above 29, bordering on obesity. The study suggests that DHA alone may be preferentially protective in these individuals, offering an example of personalized approach to breast cancer prevention.
Scientists have found that ocean acidification is already slowing coral reef growth, with the potential for widespread devastation if left unchecked. Researchers manipulated seawater chemistry in a natural ecosystem to determine the impact of excess CO2 on coral reefs.
The International Terrestrial Reference Frame (ITRF) has been updated by NASA, enabling more detailed studies of global changes in Earth's ocean, ice sheets, land, and atmosphere. Four measurement techniques, including Satellite Laser Ranging and GNSS, contribute to the reference frame.
Researchers at CNIO have developed a gene therapy to repair telomeres, delaying ageing and potentially treating aplastic anaemia. The treatment uses virus-delivered telomerase enzyme to extend telomeres, increasing blood cell production.
Researchers at Ohio State University have engineered new calcium receptors to enhance or preserve heart function in mice without harmful effects. The study shows improved cardiovascular performance and reduced mortality compared to control groups.
Researchers at Dana-Farber Cancer Institute propose securitized consumer healthcare loans to spread the cost of therapies over many years, making them more accessible to patients. This approach aims to generate attractive returns to investors while providing affordable access to life-saving drugs and cures.
A new report from the American Brain Tumor Association reveals that malignant brain tumors are the most common cause of cancer-related deaths in adolescents and young adults aged 15-39. The study, which analyzed data from 2008-2012, also found a shift towards high-grade tumors with increasing age.
A new study demonstrates that pediatric patients with asthma who received their medications in hospital are more likely to avoid emergency department visits. The 'Meds-in-Hand' program, which provides on-site pharmacy delivery, significantly reduced ED visits and improved patient outcomes for discharged children with asthma.
Researchers at the University of Bath created a new laser capable of pulsed and continuous mid-infrared emission between 3.1-3.2 microns, overcoming a major challenge in laser development. The achievement uses silica hollow-core fibers to confine light and gas, enabling efficient interaction and mid-IR emission.
Research found that wastewater treatment plants are a significant source of microplastics in rivers, with particles traveling up to 2 kilometers downstream. The microplastics were home to potentially harmful bacterial communities, highlighting the need for improved filters and treatment processes.
Researchers found that Humboldt penguins' unique feather structure is anti-adhesive and hydrophobic, preventing ice from accumulating. The discovery led to the creation of a nanofiber membrane with similar properties, which could be used in applications like electrical insulation.
A new study found that differences in gene expression patterns in youth can predict longevity. Genes involved in energy production are less active, leading to longer lifespan. Researchers also discovered a potential link between mitochondrial function and longevity.
A novel coordinated care program helped black men who have sex with men adhere to pre-exposure prophylaxis (PrEP), a medication regimen that prevents HIV infection. Nearly 80% of participants agreed to take PrEP, and 70% had protective levels in their plasma at the midpoint.
Adherence to guideline-recommended care following in-hospital cardiac arrests (IHCA) varies significantly among US hospitals, affecting patient survival. Top-performing hospitals have higher survival rates due to timely and high-quality care.
A study published in JAMA Cardiology found that cardiovascular disease risk prediction models developed with predominantly white populations are effective in black adults. The models were validated using data from the Jackson Heart Study and compared to existing algorithms.
A new study suggests that traditional assessment methods overestimate the vulnerability of salt marshes to sea-level rise. Salt marshes can generally survive higher rates of sea-level rise than predicted by current models, thanks to their ability to grow vertically and migrate landward.
A team of geneticists found that the R2d2 gene distorts cell division, leading to fewer offspring and violating Darwin's principle of natural selection. The discovery has implications for fields like basic biology, agriculture, and human health.
Tropical Cyclone Winston has weakened significantly due to strong vertical wind shear, with strongest storms pushed south of the center. The storm is expected to move south-southwest and weaken further, becoming sub-tropical south of New Caledonia.
Researchers from the University of Exeter are leading a European Commission-funded project to develop strategies for meeting climate change challenges on water, food and energy provision. The SIM4NEXUS project will investigate how policy makers can create sustainable integrated management systems.
Researchers have observed that three years after its explosion, the brightness of a type Ia supernova continues to shine brighter than expected. This finding suggests that the powerful explosions produce an abundance of heavy cobalt, which provides an extra energy boost.
An Ibero-American team has sequenced the Mesoamerican common bean genome, which will aid in improving production and conserving genetic varieties. The discovery has significant implications for agriculture, as it will help identify genes involved in disease resistance, drought tolerance, and seed quality.
Researchers have found that laser ablation creates a temporary opening in the blood-brain barrier, allowing chemotherapy drugs to pass into the brain. This breakthrough raises hopes for longer treatment options and improved patient outcomes.
A new cloud software tool called EucaTool estimates eucalyptus production in Galicia. It allows users to calculate growth and future production by measuring four stand variables.
A team of scientists has confirmed that a 'fast radio burst' originates in the distant universe, using CSIRO radio telescopes and the National Astronomical Observatory's Subaru telescope. The breakthrough allows researchers to weigh the normal matter in the universe, confirming the presence of missing ordinary matter.
Researchers turned skin cells into cancer-hunting stem cells that destroy brain tumors known as glioblastoma, a breakthrough discovery in medical science. The technique increases survival time by 160-220% and has the potential to offer a new and more effective treatment for the disease.
Mathematicians Gino Biondini and Dionyssios Mantzavinos develop a new mathematical model describing wave patterns with small irregularities. Their research shows that many disturbances evolve into single-class wave forms, answering a question scientists have been trying to answer for 50 years.
Researchers found a wild potato with almost seven times as much calcium as usual varieties. Breeding programs can now use molecular markers to identify high-calcium traits, speeding up the breeding process. This discovery aims to improve crop quality and reduce cosmetic issues in potatoes.
Researchers from PLOS ONE discovered three skeletons buried in medieval graves in France that may have belonged to Muslims, with DNA analysis revealing paternal lineage from North Africa. The burials follow Islamic rites and radiocarbon dating suggests the skeletons are from the 7th-9th centuries.
A new study from BSMS shows that computers can detect boredom by monitoring non-instrumental movements. The research has the potential to develop more engaging online tutoring programs and companion robots. By tracking subtle changes in body language, computers can adapt to a user's level of interest.
A high-salt diet has been found to contribute to liver damage in adult mice and embryonic chicks, with excessive sodium leading to cell death and decreased cell proliferation. Vitamin C treatment may partially counteract the negative effects of excess salt.