Dr. Charles N. Serhan received the ASIP 2018 Rous-Whipple Award for his work on molecular and cellular basis of inflammation and its resolution, recognizing his discovery of endogenous anti-inflammatory mediators that activate anti-microbial defense mechanisms.
A new emphasis on preparing for conception is needed to improve health in future generations. Research suggests that parental diet and lifestyle before conception can influence the risk of future chronic disease in children.
Combination therapy of pembrolizumab and chemotherapy significantly improves overall survival and reduces progression risk in patients with non-squamous non-small cell lung cancer. The study found a 51% reduced risk of death compared to chemotherapy alone.
A Kaiser Permanente study of over 15,000 girls and their mothers found that maternal overweight and hyperglycemia are associated with earlier onset of puberty. The study suggests that the in utero environment may affect pubertal development, increasing the risk of adverse health outcomes.
The American Association of Anatomists presented its 2018 Award Recipients to recognize outstanding achievements in human anatomy education, scientific research, and leadership. The recipients included Valerie D. O'Loughlin, Kurt Albertine, Jeffrey Laitman, and Jason Organ for their contributions to the field.
BNSF Railway has been awarded the 2018 INFORMS Prize for their pioneering integration of operations research and analytics programs. The O.R. program has driven better decision-making in various aspects of the company's rail network, resulting in annual savings of over $110 million.
Scientists have developed a new method to create more sophisticated brain-like organoid models by transplanting them into rodents, enabling longer survival and increased complexity. This breakthrough could lead to better therapies for neurological disorders, as well as the potential for human cell transplantation in the brain.
A new study found that individuals with tetraplegia and sleep apnea have distinct responses to airway narrowing, leading to increased risk of sleep disruption. This knowledge can inform targeted therapies for those affected by the condition.
A new liquid biopsy-based cancer model has revealed insights into the development of chemotherapy resistance in small-cell lung cancer. The study found that intratumoral heterogeneity, or differences in gene expression between tumor cells, contributes to rapid chemotherapy resistance.
A phase I clinical trial of BLU-667, a novel precision-targeted drug, reports significant durable disease control in patients with RET-driven cancers. The study reveals an overall response rate of 37% for RET-driven cancers, with responses of 45% for non-small cell lung cancer.
Researchers found that giving patients a single dose of anti-PD-1 therapy before surgery can predict tumor response and patient outcomes. The study also revealed that immune cells active against cancer were present in patients with longer recurrence-free survival.
A deficiency of TRIF, a key innate immune adaptor, significantly shortens the survival time of ALS mice by allowing the accumulation of toxic reactive oxygens. This study reveals a new role for innate immunity in ALS pathomechanism and provides a clue to develop a therapeutic approach for protecting motor neurons.
Australia is joining the Lancet Countdown, a global health and climate change initiative. The country will track its progress on 40 indicators across five categories, including adaptation planning, mitigation actions, and public engagement.
A study published in Frontiers in Psychology found that consuming raw fruit and vegetables is associated with lower levels of mental illness symptomology and improved psychological wellbeing. The top 10 raw foods related to better mental health include carrots, bananas, apples, and dark leafy greens.
The Pancreatic Cancer Collective, funded by the Lustgarten Foundation and Stand Up To Cancer, will accelerate research for pancreatic cancer patients. The initiative aims to improve diagnosis and treatments, as well as support the next generation of pancreatic cancer investigators.
Researchers found tumors with PTEN loss are less likely to generate an immune response, suggesting PTEN levels can predict treatment outcome. The study's findings may improve personalized medicine for BRCA-deficient ovarian cancer patients.
The SU2C Multiple Myeloma Dream Team aims to revolutionize the treatment of the incurable blood cancer by detecting precursor conditions such as MGUS or SMM. The team plans to analyze blood samples from approximately 50,000 people to identify biomarkers that can predict high-risk progression.
Research suggests that taking painkillers during pregnancy could reduce the number of cells in the testes and ovaries, which give rise to sperm and eggs. This could lead to an early menopause in females and affect the fertility of future generations.
Sebelipase alfa and two investigational RNAi therapeutics, givosiran and ARO-AAT, demonstrate positive findings in treating lysosomal acid lipase deficiency and acute intermittent porphyria. Long-term tolerability and improvements in liver injury markers are observed.
Researchers used Bio-Rad's Droplet Digital PCR technology to identify potential epigenetic biomarkers for lung cancer recurrence and detect HPV cfDNA in cervical cancer patients. The studies found associations between biomarker levels and treatment outcomes, indicating the clinical utility of ddPCR technology.
The number of people receiving HCV cure is increasing with new, highly effective treatments available; simplification of treatment delivery can accelerate global scale-up. Cure leads to reductions in liver-related deaths and cancer risk, as well as improvements in comorbidities.
A single treatment of fecal microbiota transplantation produces sustained clinical and cognitive improvements in patients with liver cirrhosis and hepatic encephalopathy. The study showed significant reductions in HE episodes and hospitalizations, as well as improvements in cognitive function over 1 year.
Researchers used an experimental therapy to block fibronectin protein, reducing scarred muscle tissue and saving mouse models from heart failure. The treatment restored function in damaged heart cells and reduced fibrosis.
A study published in the International Journal of Cancer found that regularly eating red meat increases the risk of distal colon cancer in women, with those on a red meat-free diet experiencing lower rates. The research suggests that a diet free from red meat significantly reduces the risk of this type of colon cancer.
A new study found that losing one night of sleep led to an increase in beta-amyloid, a protein linked to Alzheimer's disease. The study also showed that participants with larger increases in beta-amyloid reported worse mood after sleep deprivation.
NGM282, an engineered analogue of FGF19, inhibits bile acid synthesis and decreases markers of hepatic inflammation in patients with primary sclerosing cholangitis. Significant reductions in serum levels of ALT and AST were observed in the NGM282 3 mg/day treatment group.
The study confirms that long-term OCA treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with primary biliary cholangitis (PBC) who have had an incomplete response to ursodeoxycholic acid (UDCA). The majority of patients improved or maintained their histological stage, while two patients deteriorated.
Researchers at the University of Huddersfield have found that tungsten, a favored metal in nuclear fusion reactors, becomes brittle due to radiation damage. This discovery hinders the use of tungsten as a structural material, prompting the development of new alloys that can prevent embrittlement.
A national survey by Kessler Foundation reveals that 69% of people with disabilities are striving to work, overcoming barriers through job preparation and negotiation. The study also finds that many employees report experiencing and successfully addressing obstacles such as negative attitudes and pay disparity.
A new study found that extreme cold increases mortality and morbidity risks for people with cardiovascular and respiratory diseases, while extreme heat is risky for those with renal diseases. The research aims to develop tailored public service risk communication strategies.
Professor William Lee's research uses mathematical modeling to investigate topics such as Guinness bubbles and filter coffee machines. His work has led to the development of a mathematical model for coffee brewing that can aid machine design, and he is now exploring the link between strength and flavor in espresso.
A new study reveals increased risks for Alzheimer's disease and suicidal tendencies among children and young adults living in polluted cities. Researchers detected abnormal proteins indicative of the disease as early as infancy, highlighting the need for preventative measures.
Research by the University of Exeter and the British Trust for Ornithology found that people in crowded urban areas see fewer songbirds but more nuisance birds. In contrast, green and leafy suburbs have up to three and a half times more songbirds and woodpeckers, associated with positive human wellbeing.
Researchers Gary Lewin and Norbert Hübner are investigating the molecular mechanisms underlying neurological and heart diseases. They hope to identify ion channel anchors and characterize them at the molecular level, laying the groundwork for therapies that address tactile disorders and heart failure.
Researchers at UCR have isolated three new bacterial species from wild bees that may inhibit fungi growth in pollen provisions. These Lactobacillus strains could help preserve nectar and pollen for larvae, promoting bee health.
Researchers found that over one-third of patients denying a self-inflicted gunshot wound were likely trying to kill themselves. Hospitalized patients who denied a suicide attempt were nearly 11 times more likely to be discharged without inpatient psychiatric care. Brief psychological interventions can improve treatment outcomes.
A new study has reported a good correlation between an automated image analysis system and an expert reviewer for the identification of key markers of NASH disease activity in a pre-clinical model. The study used deep-learning algorithms applied to open-source pathology software (QuPath1) to accurately identify cell histology patterns ...
Two nationwide hepatitis C elimination programs in Georgia and Iceland have reported high levels of engagement, initiation of direct-acting antiviral agents, and cure among patients chronically infected with HCV. In Georgia, over 90% of diagnosed individuals were cured, while in Iceland, the prevalence of active HCV infection among peo...
Researchers at the University of Pittsburgh have developed a novel 'Tic-tac-toe' RF coil system for high-resolution brain imaging, addressing technical difficulties associated with ultrahigh field human MRI. The technology enables better understanding of neurological diseases such as depression, Alzheimer's disease, and schizophrenia.
The Hubble Space Telescope has imaged a massive galaxy cluster, revealing its intricate structure and the presence of dark matter. The cluster is comprised of thousands of galaxies held together by gravity, with most of its mass existing in non-luminous dark matter.
Researchers have successfully entangled 20 calcium atoms in an ion trap experiment, demonstrating controlled multi-particle entanglement between neighboring groups of particles. The achievement holds significant promise for practical applications such as quantum simulations and information processing.
Researchers at Friedrich Schiller University Jena have successfully created tailored surface structures on curved carbon fibers using laser technology, enabling new applications in composite materials and optical devices. The method allows for precise control over the structure's size and shape, opening up possibilities for improving m...
A study published in Malaria Journal found that ambient temperature impacts the toxicity of commonly used insecticides against malaria vectors. The researchers explored the effect of temperature on pyrethroid and carbamate insecticides, revealing that temperature affects their efficacy differently for resistant and susceptible strains.
Researchers used the world's most powerful X-ray source to study fuel injection and combustion in a gas turbine engine. The data gathered will help advance gas turbine engine designs for higher power density and efficiency.
Researchers at NIST have developed a nanoscale coating for solar cells that absorbs up to 20% more sunlight, increasing efficiency and reducing costs.
A real-world study found that patients with chronic hepatitis C virus infection who achieve a sustained virological response (SVR) after direct-acting antiviral agent (DAA) treatment have lower all-cause mortality. Achieving SVR reduced mortality from both liver-related and unrelated causes at all stages of disease.
Researchers at MIT and Brigham and Women's Hospital have developed biocompatible gels for drug delivery using caffeine as a catalyst, eliminating the need for hazardous metal catalysts.
Researchers shed light on functional mechanism of ABC exporters, which transport a wide range of molecules out of cells. This understanding could lead to new therapeutic approaches by specifically influencing or inhibiting these processes.
Researchers at NUST MISIS developed a theory explaining how latent state formation occurs in layered tantalum disulfide, leading to ultra-fast memory capabilities. The material's nano-structural mosaics and charged vacancies contribute to its switching and memory effects.
Rice University scientists introduce a new technique to fine-tune two-component biological sensors, enabling tailor-made biosensors for diagnostic gut bacteria and environmental pollutant detection. The approach uses phosphatase activity to alter the sensitivity of these pathways, promising a major breakthrough in synthetic biology.
A nationwide US study confirms a significant decrease in liver transplant probabilities for HCC patients between 2005-2007 and 2014-2016. Patients with Medicaid insurance were less likely to receive transplants than those with private/commercial insurance.
Researchers are working to identify biomarkers for food allergies, aiming to improve understanding of how children's immune systems react to certain foods. Current blood tests are only 30-55% specific, leaving room for further innovation in diagnostics and treatments.
A well-controlled trial found that omega-3 fatty acid supplements taken orally proved no better than placebo at relieving symptoms or signs of dry eye. Despite insufficient evidence establishing the effectiveness of omega-3s, clinicians and patients have been inclined to try the supplements for various conditions, including dry eye.
Researchers developed a powerful mouse model using CRISPR-Cas9 and RCAS/TVA system to mimic glioma genetic alterations. The model enables the study of gene fusions and mutations in cancer progression and treatment response.
The study, funded by the National Eye Institute, tested oral omega-3 supplementation on patients with dry eye disease. Despite finding some improvement in symptoms and signs, researchers concluded that omega-3 supplements did not show a beneficial effect relative to placebo.
A study found that budesonide add-on therapy improves biochemical markers of disease activity but fails to improve liver histology in high-risk patients with primary biliary cholangitis. Budesonide was shown to produce clinically meaningful improvements in serum alkaline phosphatase levels.
A recent study published in the American Journal of Preventive Medicine found that racial minority adolescents have a high prevalence of substance use and are at a higher risk for suicidal thoughts and behaviors. The research team analyzed data from over 20 years of national surveys and found that Pacific Islander, multiracial, and Ame...
A new study reveals that extreme climate variability over the last century has synchronized ecosystem behavior on the West Coast, increasing risks of extinction for marine and terrestrial organisms. This synchrony is linked to changes in winter climate patterns, such as the North Pacific High, which have become more variable over time.
The percentage of liver transplants performed due to HCV infection has more than halved since the introduction of direct-acting antiviral drugs. Post-transplant survival rates among those with HCV infection are now similar to those with HBV infection, reaching an all-time high.
The OU mathematics department will use a $3 million NSF grant to study active learning methods for improving STEM student success. The project aims to develop models that work at any institution, with a focus on helping underrepresented minority students succeed in introductory math courses.