Research found that after three hours of exposure to pollution, heart rate variability declines, indicating increasing physiological stress on the heart. The study suggests that individuals with cardiovascular conditions or those spending long periods outdoors should take note of air quality alerts.
The University of Louisville is launching the Nutrition and Metabolic Health Center to tackle chronic diseases, with a focus on prevention and new treatments. Researchers will investigate the impact of nutrition and environmental factors on health, with the goal of improving prevention and treatment options.
The University of Louisville's MD-PhD program has received a federal designation and funding, enabling it to amplify its curriculum and increase the number of physician-researchers trained. The National Institutes of Health (NIH) has designated UofL's program as an elite Medical Scientist Training Program.
A new study published in JAMA found that customized treatment for babies born with opioid withdrawal can significantly reduce hospital stays and speed recovery. The approach, which combines symptom-based dosing with the Eat, Sleep, Console model of care, helped infants recover an average of 2.3 days sooner.
Scientists discovered a natural microbial compound that protects the gut and supports future treatments for inflammatory bowel disease. UroA activates a protective pathway in intestinal epithelial cells, triggering the release of molecules associated with maintaining normal intestinal function and repairing the gut lining.
The University of Louisville has opened an expanded Pediatric NeuroRecovery Center, featuring state-of-the-art facilities and increasing treatment capacity by 33%. The center provides life-changing therapies to children with spinal cord injuries, accelerating recovery and expanding access for those in need.
Researchers discover specific calcium signals in microglia that regulate anxiety and grooming behaviors, offering new opportunities for therapies and diagnosis. Mice lacking the Hoxb8 gene are susceptible to extreme anxiety and pathological overgrooming.
The Health Sciences Building will serve as a nexus of learning, engagement, and research for UofL's four health sciences schools and the community. The building features extensive medical simulation facilities, dedicated spaces for learning, research, and work.
UofL Health – Brown Cancer Center oncologists and researchers will continue developing novel therapies using patients' own immune system to defeat cancer. The center's faculty and research facilities support clinical trials that bring new treatments to patients.
A study from University of Louisville researchers found that perfluorooctane sulfonate (PFOS) can worsen liver damage when combined with alcohol consumption. The study showed that PFOS exposure can increase fat accumulation and markers of liver damage, disrupt the liver's ability to manage fats, and activate pathways that promote liver...
The Kosair for Kids Center for Pediatric NeuroRecovery is expanding its facilities to increase treatment capacity by 50%, allowing up to 24 children per day to receive life-changing therapies. The new 12,500-square-foot space will also enhance research collaboration and improve patient care.
The UofL Green Heart Louisville Project found that residents living in neighborhoods with more trees showed lower levels of general inflammation, a risk indicator for heart disease. The study showed a 13-20% reduction in inflammation, corresponding to a nearly 10-15% reduced risk of heart attacks and certain cancers.
Researchers aim to understand how arsenic exposure causes cancer and other health concerns. They believe zinc can help mitigate these effects by regulating gene expression. A zinc deficiency can increase the risk of similar health problems.
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
Researchers at the University of Louisville are studying Yersinia pestis bacteria to better understand its ability to evade the immune system. The team hopes to develop new ways to control infectious diseases, including plague and other lung infections.
A new UofL study shows that nicotine salts in pod-based e-cigarettes can increase the risk of irregular heartbeat and cardiac arrhythmias. The research found that these aerosols stimulate the same receptor that is inhibited by beta blockers, leading to increased sympathetic nervous system activity.
The UofL School of Nursing will develop an accelerated LPN-to-BSN pathway and increase nurse practitioner diversity to address Kentucky's healthcare shortage. The grants will support scholarships for up to 83 students and collaborate with health systems across the state.
The University of Louisville has been awarded $11.5 million from the National Institutes of Health to research and treat eating disorders. The project will investigate how eating disorders develop in childhood and adolescence, their contribution to suicidal behaviors, and the development of innovative personalized treatment.
A University of Louisville law professor is creating a generative AI toolkit to aid legal writing instruction, providing resources for professors to incorporate the technology into their curricula. The open-source materials will enable instructors to customize their use of genAI and align teaching objectives with student outcomes.
The University of Louisville is increasing training for medical students in rural communities and West Louisville to prepare them for primary care careers. The grant will enhance programs that attract and train physicians to practice in medically underserved regions.
The Resilience Justice Project at Brandeis School of Law will examine how eight US coastal cities ensure climate adaptation plans are fair and equitable. The team aims to produce a guidebook of best practices and webinars to help cities adapt planning for all neighborhoods.
University of Louisville researchers have received a five-year, $11.7 million National Institutes of Health grant to investigate the connection between microorganisms and disease. The study will focus on various chronic conditions, including Alzheimer's disease, heart disease, diabetes, periodontitis, and colorectal cancer.
Researchers will survey residents of two Louisville neighborhoods to identify features that promote health and well-being. The project aims to create a 'universal basic neighborhood' that has all necessary community assets to help residents thrive.
UofL researchers, led by Jun Yan, will investigate the causes of immune system overresponse in COVID-19 patients, leading to severe lung disease and death. They aim to develop methods to predict, prevent or control this response with potential treatments for other conditions.
A study by University of Louisville researchers found that exposure to e-cigarette aerosols can cause heart arrhythmias in animal models, promoting arrhythmias and cardiac electrical dysfunction. The study suggests that certain flavors or solvent vehicles in e-liquids may disrupt the heart's electrical conduction and provoke arrhythmias.
The University of Louisville is launching a new campus to focus on health as a shared community resource, incorporating environmental and cultural factors. Researchers will engage with the community to discover how natural environments impact health.
Dr. John Pierce Wise leads a team to investigate chromosome instability in lungs caused by metal exposure, with hopes of preventing and reversing lung cancer in people. The research aims to understand why humans are more susceptible to metals-induced lung cancer than whales.
Researchers at the University of Louisville School of Dentistry found that oral bacteria like Porphyromonas gingivalis can suppress the production and effectiveness of proteins that protect humans from viral infection. This suppression increases vulnerability to infection, allowing viruses to enter the body more easily.
UofL researchers advocate for greater diversity in immunogenomics studies to better understand disease susceptibility and develop tailored treatments. The team aims to include a broader range of populations in their research to improve patient care and address health disparities.
The University of Louisville Hepatobiology and Toxicology Center has received $11.3 million in NIH funding to support its research into liver-related illness. The center aims to reduce the impact of liver illnesses through prevention and therapy development.
A clinical trial conducted at the University of Louisville showed that cell therapy using cells derived from a patient's own bone marrow and heart improved quality of life and reduced major adverse cardiac events. The treatment resulted in a significant reduction in hospitalizations and improved outcomes for patients with heart failure.
Researchers at UofL's Christina Lee Brown Envirome Institute aim to estimate how many people in a neighborhood are infected with COVID-19 by analyzing wastewater samples.
Researchers have found a way to make cell cultures respond more closely to normal cells, allowing drugs to be screened for toxicity earlier in the research timeline. By changing two components of the media used to culture the cells, they can make liver cancer cells behave more like normal liver cells.
UofL and Medtronic will develop a closed-loop system to monitor and adjust stimulator settings for multiple functions, including locomotion and bladder control. The project aims to improve the lives of people with spinal cord injury by reducing manual interaction and increasing positive outcomes.
Research found that warmer temperatures lead to decreased COVID-19 case rates, while cooler temperatures increase the rate of new cases. The study analyzed daily low temperatures and infection rates from Jan 22 to April 6, 2020, in 50 countries and showed a significant correlation between temperature and transmission.
The University of Louisville is developing a nasal spray to prevent SARS-CoV-2 infection using the Q-Griffithsin compound, which has shown promise against multiple coronaviruses and other viruses. The project aims to deliver the antiviral agent directly to the upper respiratory tract.
Researchers discovered stone tools dated to the earlier time period in a cave in Portugal, supporting a rapid westward dispersal of modern humans. The finding documents the presence of modern humans in westernmost Europe concurrent with Neanderthals.
The University of Louisville will establish a Center for Cancer Immunology and Immunotherapy to develop and improve cancer treatments that utilize the immune system. Researchers will focus on advancing strategies to use the immune response to fight cancer, with the goal of saving lives through immunotherapies.
Fatty acid binding proteins (FABPs) are chaperones that coordinate fatty acid transport between cells. Research by University of Louisville immunologist Bing Li reveals their role in lipid metabolism, obesity, and disease development.
The discovery of Adalatherium, a bizarre mammal from Madagascar, sheds light on the evolution of mammals during the time of dinosaurs. Its unique characteristics and preserved 3D structure offer valuable insights into the geography and fauna of the region.
Researchers describe a possible mechanism linking obesity and breast cancer, proposing that fatty acid binding protein (FABP4) drives tumor growth. Elevated FABP4 levels in obese individuals promote breast cancer development through direct interaction with cancer cells.
Researchers at the University of Louisville are using the computing power of thousands of computers in classrooms across Kentucky to identify drugs to treat COVID-19. The DataseamGrid, a network of computers housed in classrooms, is being used to test over 11,000 drugs and compounds for potential effectiveness against SARS-CoV-2.
Retinitis pigmentosa (RP) is caused by the starvation of photoreceptors due to disrupted glucose transport. Research led by UofL's Douglas C. Dean and Wei Wang found similar metabolic changes in lung cancer.
Researchers at the University of Louisville have developed a new method to keep human heart slices alive for up to 6 days, enabling more extensive preclinical testing of heart drugs and therapies. This innovation will facilitate improved testing of efficacy and toxicity, saving time and costs in clinical trials.
The Kentucky Biomedical Research Infrastructure Network (KBRIN) has received a $18.2 million grant from the National Institutes of Health to enhance biomedical research in Kentucky. The network provides access to equipment, collaborative networks, and funding for early-stage researchers.
Researchers are conducting a six-year study to investigate the factors contributing to poor health in rural communities. The study will recruit 4,000 participants from 10 rural counties and collect data on lifestyle, behavioral factors, medical history, and environmental elements.
A research team at the University of Louisville discovered that SA-4-1BBL boosts CD8+ and CD4+ T cells to target tumors for destruction. The molecule protects healthy mice from various cancer types when exposed to tumor cells, showing promise in cancer immunoprevention.
Researchers identified Porphyromonas gingivalis as a bacterial pathogen driving Alzheimer's disease pathology in the brains of patients. The study found that Pg infection led to increased production of amyloid beta and neuroinflammation.
A microbial metabolite from pomegranates, Urolithin A, has been shown to reduce inflammatory bowel disease by increasing proteins that tighten epithelial cell junctions in the gut. The researchers also found that a synthetic version of UroA, UAS03, shows therapeutic and protective effects against colitis.
Four participants with motor complete spinal cord injury regained walking ability and trunk stability using epidural stimulation paired with daily locomotor training. The study, published in New England Journal of Medicine, suggests that some brain-to-spine connectivity may be restored years after injury.