Researchers will develop medical treatments to counteract lung injuries caused by chlorine gas exposure. The proposed treatments target impaired lung function and pulmonary edema with rolipram, and prevent inflammation with triptolide.
University of Louisville bioengineering researchers will use a $3.33 million award from the Wallace H. Coulter Foundation to help commercialize promising academic innovations into medical solutions. The five-year program aims to save, extend and improve patients' lives with a focus on translational research.
Patients in another clinical trial have reached the two-year mark following infusion of processed adult stem cells, while a new $12.8 million NIH grant renewal aims to perfect cardiac stem cell therapy for heart regeneration after a heart attack.
Ruth Carrico, an associate professor at the University of Louisville, has been named one of 21 RWJF Executive Nurse Fellows. The program aims to enhance nurse leaders' effectiveness in improving the US healthcare system, with a focus on addressing health care-associated infections.
Steven McCabe, MD, assistant professor at UofL School of Public Health and Information Sciences, will teach scientific research methodology to graduate students in Italy as part of the Fulbright Program. He aims to expand his decision analysis research and discuss research related to carpal tunnel syndrome.
Valerie McCarthy, RN, PhD, assistant professor at UofL School of Nursing, is building on her research theory of successful aging, which emphasizes the importance of adaptation and transcendence. Her goal is to develop interventions to promote well-being and positive aging experiences among older adults.
Researchers have successfully performed a new surgical procedure that uses a patient's own stem cells to line man-made bypass grafts, aiming to improve the long-term results of peripheral artery disease treatment. The first three patients enrolled in the clinical trial are doing well and report relief from symptoms almost immediately.
Researchers at UofL removed microRNA 21 from mice and found reduced skin tumor formation compared to control groups. The study suggests that miR-21 plays a role in cancer growth and that its removal increases the body's own tumor-suppressing ability.
Researchers at University of Louisville identified a protein sorting mechanism used by the salivary gland, which could lead to advanced therapies for patients with damaged or non-functioning salivary glands. The study found that a specific lipid molecule, PtdIns(3,4)P2, plays a crucial role in sorting proteins into vesicles for secretion.
Researchers replicated inflammatory gene changes of human kidney progression from mild to severe diabetic nephropathy using a mouse model. The study could lead to new understanding and potential treatments for diabetic nephropathy, the leading cause of kidney failure.
Researchers at the University of Louisville have achieved significant breakthroughs in treating paraplegia through epidural spinal cord stimulation and extensive locomotor training. The study's results, published in The Lancet, show that a paralyzed man can stand, step, and move his legs voluntarily with assistance.
The University of Louisville School of Nursing has established a Kentucky Racing Health Services Center (KRHSC) to provide comprehensive health care services to track workers. KRHSC, led by Whitney Nash, serves about 2,500 patients annually, offering acute and chronic care as well as preventive services.
A University of Louisville professor is developing a statistical model that can help determine what prolongs cancer-free survival. The new multi-state model analyzes how diseases progress from one stage to another, allowing for broad inspection of patient patterns and data collection.
A UofL-led consortium has been awarded $9.56 million to form the first-ever multicenter cardiovascular research network, studying cardioprotective therapies at the preclinical level. The four-center project aims to identify effective therapies and advance them to clinical trial stage.
Researchers at the University of Louisville developed an exercise program that improved leg strength and functional ability in patients with severe knee arthritis before knee replacement surgery. The study found significant gains in strength, but not in walking speed or other functional tasks.
Research highlights the importance of symptom management in improving quality of life for patients with stage IIIb or IV lung cancer. A study found that symptom distress was the strongest determinant of quality of life, followed by symptom severity and frequency.
Cardiovascular Innovation Institute researchers have received a $2.027 million grant from the National Institutes of Health to further develop an implantable pump for patients with single ventricle heart disease. The device has the potential to revolutionize treatment by reducing surgeries and improving survival rates.
A University of Louisville researcher has received a three-year grant to explore how the nervous system grows and develops. The study aims to identify genes involved in dendritic growth using animal models.
The University of Louisville has received a $1.5 million NIH grant to develop an interdisciplinary oncology palliative care education program. The program will integrate the services of physicians, nurses, chaplains, and social workers to provide comprehensive care to cancer patients.
Researchers at the University of Louisville have developed a new technology that prevents scar tissue from forming around implanted devices, allowing them to function longer. The technology uses tiny blood vessel fragments suspended in collagen gel to create an environment that resists scarring.
Lisa Carter-Harris has received the Johnson & Johnson Campaign for Nursing's Future -- American Association of Colleges of Nursing Minority Nursing Faculty Scholarship. The scholarship provides financial support to graduate nursing students from minority backgrounds who agree to teach in a school of nursing after graduation.
The University of Louisville has received a $3.15 million grant from the Helmsley Charitable Trust to support its cancer research program in Owensboro. The funding will be used to create new faculty positions and expand the research program, with a focus on developing plant-based pharmaceuticals.
A University of Louisville Public Health doctoral student is developing a model to simulate the travel of mercury from an emission source to humans, aiming to inform environmental policy decisions. The research will focus on Kentucky waterways, with the goal of reducing risk to subsistence fishers, anglers, and women of child-bearing age.
A study led by researchers at the University of Louisville found that individuals with a male first-degree relative with breast cancer perceive themselves as being at higher risk than those with a female relative. However, many lack awareness and discussion about genetic testing.
The study found that smaller hospitals in Kentucky and Indiana adopted quality improvement measures quickly and implemented the expanded surgical time-out checklist with high rates of adherence. Surgical specialists committed to accepting safety parameters, and clinicians provided an extremely high standard of care to patients.
A five-year study found significantly lower death rates from all causes and cancer in Paducah Gaseous Diffusion Plant workers compared to the US population. However, death from lymphatic and bone marrow cancers was slightly above national rates. Security workers had higher overall death rates than other employees.
Dr. Qingxian Lu has received a $60,000 grant from the Research to Prevent Blindness organization to investigate the role of MerTK in retinitis pigmentosa, a group of genetic disorders causing night blindness and vision loss.
Dr. Hui Shao has received a grant from the Research to Prevent Blindness organization to study Sjogren's syndrome, a chronic autoimmune disease affecting millions of Americans. Her team has discovered a protein called Klk22, which may play a role in the development of the disease.
A report from the University of Louisville's Institute for Bioethics, Health Policy and Law highlights the importance of effective communication in successful SARS quarantines, with key findings including the need for a single spokesperson and regular channels to boost compliance.
Attitudes toward pharmacogenomics vary by education level, race, income, and age, but most people are willing to participate in genetic research. Respondents trusted medical institutions over government or pharmaceutical companies to perform the research.
The University of Louisville has been designated as a CDC biodefense center, equipped with resources and expertise to research and prepare for bioterrorism attacks. The center will conduct epidemiological and communications research to ensure quick responses to potential epidemics.
Research by Dugatkin and colleagues shows that observing fights in swordtail fish affects their likelihood of winning. Psychological factors play a significant role in animal societies, predicting the outcome of interactions between group members. These findings have implications for understanding human social dynamics.
Researchers at the University of Louisville found a link between sleep apnea and high blood pressure through protein changes in laboratory rats. The study suggests that the connection plays a significant role in developing high blood pressure during bouts of sleep apnea.
Chemical engineers have developed a novel process to grow crops of nanowires, which could lead to improved design of advanced military and space gear, fuel cells, sensors and solar devices. The process uses pools or thin films of low-melting metals like gallium to create the nanowires.