Researchers discovered a molecular link between multicentric carpotarsal osteolysis (MCTO) and kidney disease, highlighting pathogenic MAFB accumulation and PI3K/AKT signaling. Treatment with imatinib suppressed AKT phosphorylation and attenuated glomerular injury in mice.
A national study found almost half of Australian men aged 30-59 exceed the recommended weekly alcohol intake, with factors such as smoking, illicit drug use, and psychological distress linked to risky drinking. The research highlights the need for targeted approaches to reduce alcohol-related harms among middle-aged men.
A new study proposes a model to analyze the dynamic cumulative effect (DCE) of ballast settlement on ballasted tracks. The results show that DCE exacerbates deterioration and affects dynamic performance, especially in ballasts with higher moisture content.
A new national clinical trial investigates whether fewer invasive bladder exams can safely reduce discomfort and improve quality of life for patients with bladder cancer. Led by Dartmouth Cancer Center, the study aims to show that fewer procedures are just as effective at keeping patients healthy.
The study uses DNA barcodes to track and compare dozens of gold nanoparticle designs in living tumour models, identifying those effective at reaching mitochondria. Two formulations emerged as standout performers, achieving high tumour regression when combined with RNA therapy and photothermal treatment.
Researchers discovered that KD025 restored neural connections and improved memory and visual recognition in mice with schizophrenia-associated gene variants. The drug also reduced ROCK2 overactivity without causing serious side effects common to current medications.
Researchers from The University of Osaka have discovered a two-factor system that controls stem cell differentiation, involving the stabilization of the CoREST corepressor complex at gene promoters. This process prevents stem cells from drifting towards differentiation and maintaining their pluripotency.
Researchers identify key mechanism behind age-related persistence of pulmonary fibrosis, revealing disabling collagen clearance due to loss of protein fPRDM16. Restoring fPRDM16 expression rejuvenates fibroblasts' healing function and resolves fibrosis.
Researchers analyzed centuries-old Swedish newspapers to reconstruct past porpoise distribution patterns in the Baltic Sea. The study found that harbour porpoises once occupied a wider area than they do today, with a loss of about one third of their historic range. Historical records provide valuable insights for conservation efforts.
A study by UCLA Health researchers linked low immune responses to higher mortality rates in patients, using tuberculosis screening tests as a tool. The results suggest that these tests can predict mortality in various patient groups, including those undergoing organ transplants and cancer patients on immunotherapy.
Researchers have identified potential mechanisms linked to reduced type 2 diabetes risk in chronic cannabis users. A team led by Nicholas V. DiPatrizio found that specific compounds within cannabis regulate metabolism, leading to significant weight loss and improved glucose regulation in obese mice.
Researchers developed a novel diagnostic support framework using visual question answering to generate interpretable findings from chest CT images. The system demonstrated strong agreement with reference descriptions and provided clinically meaningful outputs.
Researchers challenged thermodynamic-based framework for catalyst design and proposed new principle focusing on declining efficiency of solid-phase electron transport. They designed homonuclear cobalt-cobalt dual-atom catalyst DA-CoCo, significantly enhancing charge transport in solid intermediates, validating the new design principle.
The study demonstrates a significant improvement in red light emission from Eu-doped gallium nitride grown on a semipolar crystal plane. The approach selectively promotes the formation of highly efficient luminescent centers, resulting in brighter and more stable red LEDs for next-generation micro-LED displays.
Professor Eiichi Araki's pioneering research on insulin signaling has led to a deeper understanding of the molecular mechanisms of diabetes. His discoveries remain foundational for researchers striving to overcome insulin resistance and improve treatment options.
A new report by Nuffield Council on Bioethics warns of governance gaps in neural organoid research, threatening public trust and scientific progress. The organization calls for new approaches to regulating emerging biotechnologies and sector-wide best practice guidance.
A new review highlights the importance of using the right amount of biochar in different ecosystems, with recommended application ranges varying from 5 to 40 tonnes per hectare. Biochar can enhance ecological functions by increasing water-holding capacity, reducing greenhouse gas emissions, and supporting beneficial microbial activity.
A new study by Sage Madden reveals that barn swallow chicks' growth is stunted by cold spells within five days of hatching, smallest sibling status, and less food provided by parents. The research, published in PLOS One, provides insight into climate change's impact on chick development.
Researchers are exploring the use of sustainable carbon-based additives to replace toxic coatings and prevent corrosion on modern steel infrastructure. The proposed solutions aim to reduce environmental damage while protecting infrastructure worth over $2.5 trillion annually.
A new study by University College London researchers found that regularly taking part in arts activities slows the pace of biological ageing. Participants who engaged in arts and cultural activities more frequently appeared to have a slower pace of ageing, comparable to those who exercised at least once a week.
A team of researchers has developed a flexible neural sheet device that can record and stimulate neural activity across multiple sensory cortices in mice. The device, which is thinner than a human hair, is inserted into the epidural space to avoid brain penetration, allowing for wide-area coverage of the temporal and deep cortical areas.
A study found that distinct MYB proteins regulate pigment accumulation in brown cotton, with some promoting and others suppressing proanthocyanidin biosynthesis. The research identified key genes and transcription factors involved in pigment formation, providing new insight into naturally colored cotton production.
A large prospective study found that incorporating imaging and blood biomarker data into risk assessment improves prediction of adverse cardiac events in people with hypertrophic cardiomyopathy. The study used clinical history, cardiac MRI, and blood biomarkers to predict outcomes, providing fuller and more accurate predictions.
Korea University's College of Medicine has signed an MOU with Armed Forces Capital Hospital to develop public medical care and enhance medical training. The institutions plan to promote cooperation in joint research, personnel training, and customized educational curricula.
Researchers discovered that genes linked to neuronal communication are also altered in immune cells of patients with depression, reinforcing the systemic nature of the disease. This finding paves the way for developing blood tests to identify and diagnose depression, as well as new treatment approaches targeting inflammation.
A team of astronomers has produced the most detailed map of the cosmic web, tracing its network of galaxies back to one billion years old. The COSMOS-Web survey, conducted with the largest JWST survey, reveals a more informative large-scale structure than earlier maps.
Researchers develop tailored revascularization approach for moyamoya disease, improving circulation while minimizing complications. The technique, called STAPC, uses vessel diameter, blood-flow dynamics, and recipient brain arteries to guide surgical decisions.
A new Rice University study links climate variability to civil conflict and war risk, revealing nuanced relationships between climate patterns and local conflict risk. The research identifies regions susceptible to climate-driven political instability and provides evidence for a 'threat multiplier' effect.
The Health Sciences Building will serve as a nexus of learning, engagement, and research for UofL's four health sciences schools and the community. The building features extensive medical simulation facilities, dedicated spaces for learning, research, and work.
A study reveals NtMYC2a and NtMYC2b as upstream regulators of ABA-mediated seed germination in tobacco. The proteins form a heterodimer that activates NtABI5, enhancing ABA sensitivity. The findings provide new insights into MYC2 functions beyond jasmonate-related pathways.
Researchers investigate how positive emotions can be a source of dysfunction in particular contexts, particularly when not managed. The study aims to understand and develop treatments for positive mood disturbance in people with and without mood disorders.
A large multicenter retrospective study found that stable gestational glucose levels and minimal fluctuations increase the likelihood of low pre-eclampsia risk. The study's key findings suggest that blood glucose management is crucial for preventing pre-eclampsia, particularly in pregnant women with no pre-pregnancy chronic conditions.
The $12 million grant from the Four Pines Fund will help Henry Ford Health expand its proven Zero Suicide Model to Kaiser Permanente Colorado and HealthPartners in Minnesota. The model has been shown to reduce patient suicides by 25% or more.
Researchers used machine-learning-enhanced molecular simulations to show pristine graphene is intrinsically hydrophobic. Water molecules adopt configurations characteristic of hydrophobic surfaces near graphene, and thicker layers are even more strongly hydrophobic.
Researchers at Adelaide University argue that climate risk assessments need evaluative governance to prioritize acceptable risks and promote long-term action. The study suggests introducing four sequential steps to shift thinking towards longer-term solutions.
Researchers develop heterocyclic-linked covalent organic frameworks (COFs) that utilize light to trigger specific redox reactions, reducing soluble uranium into insoluble forms. The materials have shown impressive photocatalytic uranium extraction efficiency and potential for environmental cleanup and nuclear fuel security.
The Faculty of Economics and Law, Piacenza-Cremona Campus, Università Cattolica del Sacro Cuore has earned AACSB accreditation for its commitment to teaching, research, and student learning. This achievement demonstrates the institution's ability to combine academic excellence with innovation and global perspective.
A new study provides direct geochemical evidence of phosphorus spikes in ancient oceans, which triggered environmental disruptions and led to two major mass extinctions. The research suggests that these influxes of phosphorus boosted biological productivity, leading to increased oxygen consumption and global cooling.
The University of Pennsylvania has been awarded a three-year, $650,000 Institutional Challenge Grant to support a research-practice partnership focused on addressing youth homelessness across the Commonwealth. The partnership aims to examine the effectiveness of state policies in reducing homelessness and create an evidence-based polic...
New research reveals that complex terrain is vital to brush-tailed rock-wallaby habitat choice, essential for conservation and reintroduction programs. The study suggests shelter from predators and environmental extremes is the key factor influencing den site selection.
A team of horticulture scientists has identified the single genetic region controlling primocane-fruiting in blackberries, a discovery expected to speed up breeding for improved varieties. The study validated the result through genetic linkage mapping and identified candidate genes involved in flowering regulation.
Researchers found a sustained reduction in colorectal cancer incidence and death associated with single flexible sigmoidoscopy screening, particularly in men. The study suggests that this screening method can provide long-lasting benefits beyond the usual 15-year screening age range.
AiiDAlab simplifies material research and simulations by automating workflow management, analysis, and visualization. Researchers can now focus on gaining new insights without requiring advanced computing skills.
Researchers developed a stevia-PVA hydrogel-based triboelectric nanogenerator that demonstrates improved mechanical strength, electrical output, and recyclability. The device achieves over 70% visible light transmittance and can be recycled via a water-assisted process, making it an eco-friendly material for wearable devices.
Recent advances in medications, devices, and care pathways are redefining heart failure (HF) treatment. Emerging therapies beyond traditional EF silos have demonstrated broad efficacy across LVEF categories.
The article discusses the ethics of describing gene-editing therapy for sickle cell disease. Despite FDA approval, it argues that framing these treatments as a 'cure' is misleading and may cause unrealistic expectations. The essay also highlights the need for structural drug policy reform to expand freedom.
A recent study from the University of Kansas found that a common mutation in the PTPN22 gene may provide a survival advantage against viral infections, including coronavirus. The mutation was previously associated with an increased risk of developing autoimmune diseases such as diabetes and lupus.
Researchers found a protein called RAB5c that helps white blood cells kill Aspergillus fumigatus, a common airborne fungus. Without this protein, immune cells are disarmed despite attacking at full force. The discovery could lead to new treatments for patients with weakened immune systems.
Researchers found amino acids are consistently more diverse and evenly distributed in biological samples than abiotic ones, while fatty acids show the opposite pattern. This fundamental principle of life may be detectable in data collected by space missions.
A novel noninvasive brain stimulation approach, TIs, significantly improved movement in patients with Parkinson's disease compared to a sham treatment. The technique targets the subthalamic nucleus and produced clinically meaningful improvements in bradykinesia and tremor.
Cells have a new fail-safe mechanism to handle misfolded proteins that accumulate in liver cells, explaining why only some patients with alpha1-antitrypsin deficiency develop liver disease. This discovery could help predict which patients are at highest risk of needing a liver transplant.
Researchers are developing a system that uses AI and robotics to track what's installed inside the growing ship and compare it to a digital twin of the intended structure. The system will create reports of mismatches that workers can use to make adjustments, potentially reducing delays in delivery.
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.
A new AI chip using spectral convolutional neural networks (SCNN) analyzes meibomian gland tissue for diagnosis of dry eye disease, outperforming traditional methods and capturing molecular information in a single measurement.
A randomized clinical trial found that testosterone treatment significantly improved sexual activity, sexual desire, and quality of life scores in men after prostate cancer surgery. The treatment also improved body composition and aerobic performance without increasing the risk of biochemical recurrence.
Researchers in Ecuador create biodegradable paper from brewer's spent grain, achieving mechanical properties similar to commercial papers. The process has economic viability at $3.28 per square meter, reducing reliance on virgin raw materials and closing material loops.
A Finnish study found that partners of women with gestational diabetes are more likely to have chronic diseases and mental health disorders. Lifestyle and socioeconomic factors also play a role in their increased risk, highlighting the importance of family-level preventive measures.
Lokmanoglu will investigate how images spread online during politically charged moments, their impact on polarization, and the effectiveness of media literacy prompts in identifying non-authentic images. Her research has implications for consumers of media and engaging with the world in an increasingly polarized society.
Reanalysis of 540-million-year-old microfossils from Brazil reveals they are not animal traces but rather communities of fossilized microscopic bacteria and algae. This finding suggests that invertebrates may not have existed or left marks during the Ediacaran period due to limited oxygen levels.
Researchers have developed a modular technology, LIDAPE, that can directly and precisely edit single amino acids in endogenous proteins without altering their genetic code. This innovation has the potential to create next-generation protein-editing therapeutics by transforming small molecules into precise chemical transformations.
Researchers developed a compact silicon photonic 'Vernier Caliper' spectrometer with near-uniform resonator responses across a broad wavelength range. The device resolves fine spectral peaks as little as 0.74 pm, outperforming commercial benchtop spectrometers in accuracy.
A global study published in Nature Human Behaviour analyzed data from over 8,000 participants to investigate the connection between physical activity and emotional well-being. The results showed that mood improves with everyday movement, and people are more physically active when they feel better.
A retrospective cohort study examining over 840,000 breast cancer patients found a potential link between GLP-1 RA use and improved outcomes among obese or diabetic patients. GLP-1 RAs were associated with lower risk of death and recurrence over a 10-year follow-up period.
Researchers at Leibniz Institute for Food Systems Biology found that bitter-tasting herbal extracts stimulate proton secretion in human gastric cells, with polyphenol-rich extracts showing the strongest effects. The study identified three human bitter taste receptor subtypes as key mediators of this response.
Elke Deuerling, a molecular biologist at the University of Konstanz, has been elected as a member of the Leopoldina, the German National Academy of Sciences. Her work on proteostasis, the regulation of cellular protein levels, has significantly contributed to the understanding of protein protection in delicate formation phases.
A global research team developed an 'All-Surface' 3D laser patterning technique to directly draw highly conductive carbon circuitry on transparent glass. This technology overcomes conventional 2D lithography limits, enabling the fabrication of complex 3D interconnected electrodes and redistribution layers.
A study links insulin resistance and leptin dysregulation to cognitive impairment in bipolar disorder, highlighting the potential of targeted clinical pathways. Metabolic alterations are associated with cognitive deficits and poorer performance in memory and attention.
Researchers have created a three-dimensional lattice that captures water from the air and stores it using ultraviolet light. The material can store up to 5% of its mass in water molecules, with potential for scalability to impact global water stress.
Researchers discovered that Akkermansia bacteria, which aid human digestion, also thrive in the ocean by breaking down seaweed sugar. This finding highlights the importance of these bacteria in both human health and marine ecosystems.
Colleen Scott's patented research develops a shortwave infrared dye to visualize cancer cells, enabling safe and high-resolution deep tissue visualization. Her technology selectively targets cancer cells, allowing clinicians to identify tumor boundaries with greater precision.
A new study found that obesity-related changes in body fat send harmful signals to the brain, disrupting brain immune function and worsening Alzheimer's pathology. Restoring balance in phosphatidylethanolamines reduced lipid dysregulation, improved brain function and cognitive performance in Alzheimer's disease models.
Bionema Group Ltd, a Swansea University spin-out, has received the second King's Award for Enterprise: Sustainable Development. The company develops biological pest control and sustainable agriculture technologies, providing environmentally sustainable alternatives to synthetic pesticides.
Researchers developed genESOM, a generative AI that can expand dataset volume and simulate larger animal numbers while maintaining reliability. This allows for 30-50% reduction in animal experiments without compromising results.
Two studies by Rutgers University professor Colleen Berryessa explore how expressions of remorse are interpreted in the legal system, finding that it can lead to serious inequities in legal outcomes. The research highlights the need for greater awareness and education within the legal system to better understand how remorse is assessed.
Researchers at McGill University identify molecular switch that activates energy-burning pathway in brown fat cells, leading to potential breakthroughs in bone health. The discovery sheds light on the futile creatine cycle and its role in mineralization process.
A seven-year study found that nearly half of patients with benign paroxysmal positional vertigo (BPPV) experienced recurrence, while over a third reported persistent residual dizziness. The study highlights the need for ongoing care and patient education to mitigate long-term consequences.
A recent study analyzed 138 Indian cities using satellite data and explainable AI methods to show why urban greening needs to be tailored to humidity, canopy structure, and airflow. The findings highlight the importance of considering moisture management and ventilation in urban planning to effectively mitigate heat-related stress.
A new study reveals that four specific genes are crucial for the Atlantic herring's adaptation to low salinity in the Baltic Sea. The genes, expressed in sperm, eggs, and early embryos, enable the fish to reproduce successfully in brackish water.
A more integrated European energy system could significantly boost the continent's transition to clean energy, easing supply and price shocks. Greater integration will also enable efficient management of intermittent renewable electricity sources.
A new editorial by IOF members highlights the alarming high post-fracture mortality in Africa and emphasizes the need for a targeted, Africa-driven strategy. The authors propose five strategic priorities to build bone health into national health systems, education, and policy.
A study published in Aging Cell found that reducing dietary fat or animal-based protein can reduce 'biological age' in older adults. After just four weeks, participants showed significant reductions in biomarker profiles indicative of improved health and aging outcomes.
A simple 30-second sit-to-stand test can estimate muscle power and identify individuals at higher risk of hospitalization and mortality. The test revealed a strong association between low muscle power and increased risks of falls, fractures, hospitalizations, and mortality in older adults.
Researchers developed a mechanical prototype to demonstrate their bio-inspired sensor's ability to enhance vibration signals without amplification circuits or signal processing. The design aims to benefit acoustic and vibration sensors that need to detect very weak signals, such as microphones or biomedical sensors.
The Applied Immunological Research Symposium (AIRS) brought together renowned scientists to share groundbreaking findings on T cell exhaustion and its connection to vaccine interception. Keynote speaker Rafi Ahmed presented data showing how blocking PD-1 reawakens a core population of 'stem-like' T cells, unleashing them to fight disease.
A new study by Kyota Yasuda found a strong correlation between RBP diversity and neuronal count in six model organisms, suggesting that post-transcriptional regulation is a key factor in nervous system complexity. RBP diversity increased from 397 families in nematode worms to 469 in humans, correlating with enhanced neural complexity.
Researchers found that caregivers play a significant role in helping infants learn complex vocalizations, similar to how zebra finches use social feedback to teach their young. The study suggests that both humans and zebra finches rely on social environment to guide low-level temporal foundations of their vocal communication.
Researchers found that powdery mildew disease caused by different fungi infects strawberries in North America and Europe differently, indicating the pathogens jumped hosts over millions of years. This discovery can aid understanding of plant diseases and their spread.
Researchers found a high-risk subgroup of patients with the 'lemon-on-sticks' phenotype, characterized by low BMI and high WHR, who had poor outcomes and higher all-cause mortality rates compared to other phenotypes. This study highlights the need for personalized therapy in heart failure.
The European Centre for Medium-range Weather Forecasts (ECMWF) is upgrading its key forecasting systems, the Integrated Forecast System (IFS) and the Artificial Intelligence/Integrated Forecasting System (AIFS), to improve weather forecast accuracy. The upgrades include enhancements to ocean- sea ice interactions, wave forecasts, and s...
Researchers developed a core-shell Pd@CeO2/γ-Al2O3 three-way catalyst for stoichiometric NGV exhaust treatment, achieving high conversion rates and low temperature activity. The core-shell design strengthens metal-support interactions, increases oxygen vacancies, and optimizes the Pd-CeO2 interface as a primary active site.
A pilot study suggests that physical exercise can support stem cell donation by releasing specific types of blood stem cells into the bloodstream. The exercise stimulus increases stem cell numbers only moderately, but may offer a more targeted approach than medication.
Researchers found that individuals with stronger brain responses to negative information were more resilient in their thoughts and feelings. They accepted more offers with mixed consequences, indicating a lower value on negative outcomes. This study suggests that controlling negative thoughts may enable people to build mental resilience.
The university has established two new centers: the Center for Quality of All Lives and the Entrepreneurship Center. The former focuses on improving animal welfare and developing innovative veterinary-related devices, while the latter promotes entrepreneurial thinking and supports startup development.
A new AI framework, Hi4GS, revolutionizes wheat yield prediction by improving accuracy and identifying key genetic markers. The framework streamlines high-dimensional genotypic data, uncovering the actual genes influencing yield.
A Brown University study found that expanded Medicaid coverage significantly improves one-year mortality rates for young adults with kidney failure. The researchers discovered improvements in pre-dialysis care, increased use of dialysis, and longer dialysis sessions, all leading to better long-term health outcomes.
At ASCO 2026, City of Hope experts will present research on innovative treatments for various types of cancer. Their findings include the efficacy and safety of immunotherapy combinations, as well as the potential use of CBM588 to enhance immune checkpoint blockade in metastatic renal cell carcinoma.
A new study reveals that even gradual environmental change can push populations past a tipping point, beyond which they may suddenly collapse. The ability of species to adapt depends on three measurable factors: rate of change, environmental variation, and genetic drift.
Scientists analyzed a TiS2|Li3YCl6 half-cell in operando at BESSY II and discovered that intrinsic oxygen causes rapid capacity loss. Oxygen-containing species migrate to the cathode current collector, forming an amorphous layer rich in titanium oxides.
A new study found that telemedicine has not led to increased visits and medical spending across all payer types, easing concerns about ballooning costs. However, it also found that rural areas and commercially insured patients had higher spending, but these changes were not statistically significant.
A nationwide study found no significant association between telemedicine adoption and changes in US ambulatory visits or total medical spending. The expansion of telemedicine has eased concerns about increased utilization and spending, as the growth did not lead to large increases in these areas.
Researchers at Johannes Gutenberg University Mainz have made new constraints on dark matter particles using precision measurements of barium monofluoride molecules. The study found bounds on hypothetical Z' bosons that mediate electron-nucleus interactions, potentially shedding light on dark matter.
A new thermal barrier coating system features a dense eutectic core-shell structure that enhances CMAS resistance via dynamic sealing and self-removal. The coating combines a mechanically robust, deformable Zr-Ta-O top layer with a traditional YSZ underlayer.
Researchers developed a novel ultra-high-temperature, highly insulating, and corrosion-resistant TBC material using first-principles calculations. The material exhibits excellent mechanical and thermophysical properties, including low thermal conductivity, high coefficient of thermal expansion, and excellent toughness.
The Centre of Excellence in Modelling and Simulation for Next Generation Ports (C4NGP) at NUS College of Design and Engineering aims to design the port of the future. The C4NGP focuses on creating sustainable ports with reduced environmental impact.
A new model for predicting outcomes in hypertrophic cardiomyopathy has been developed by incorporating prospective data, including clinical history, imaging, and blood biomarker tests. This study found that integrating these methods into risk assessment can improve the prediction of fatal and nonfatal cardiac events.
A new study by Yale University finds that garlic's diallyl disulfide compound blocks mating in mosquitoes and flies, including species that spread diseases. The finding could lead to environmentally friendly and inexpensive pest control methods.
Research suggests that exposure to environmental pollutants in early life can negatively affect bone development. A study of 88 healthy infants found associations between certain endocrine-disrupting chemicals and lower bone mineral density, emphasizing the importance of protecting vulnerable windows during pregnancy and after birth.
Researchers have developed a new computational workflow combining generative AI with atomistic simulations to identify promising platinum alloy catalyst structures for hydrogen fuel cells. The method produces high-performing candidates from several material combinations, addressing a longstanding challenge in catalyst design.
Researchers at Columbia University's Zuckerman Institute have developed a brain-controlled hearing system that can help people focus on one conversation among many. The system, which leverages the brain's natural ability to filter through background noise, dynamically isolates specific conversations in real-time.
A cohort study found a potential association between GLP-1 RA use and improved survival rates among obese breast cancer patients with related metabolic conditions. Further evaluation of GLP-1 RA therapy in randomized clinical trials is warranted based on these findings.
Researchers found ancient Chinese water buffalo feather decorations contained multiple bird species, including hoopoe, black-headed grosbeak, and yellow-bellied whistler. They also identified the adhesive as water buffalo glue, providing insights into cultural connections and species origins.
The Bioinspired123D system uses a 3-billion-parameter language model to generate reliable 3D design behavior from small models. The system achieves near fourfold performance improvement over larger state-of-the-art language models and demonstrates direct compatibility with standard additive manufacturing workflows.
Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.
The 2026 Carbon Future Young Investigator Award honors 10 recipients for their exceptional research potential and innovative capabilities in carbon-related science and technology fields. The award also acknowledges 30 Honorable Mention Award recipients, who have demonstrated significant contributions to their respective research areas.
The CRISPR/Cas13d system effectively targets and degrades hepatitis E virus RNA, reducing viral replication and infectious virus production. A limited combination of short guide RNAs can cover most viral variants, providing a promising approach to combatting the rapid adaptability of viruses.
A new editorial provides guidance on writing constructive peer reviews, emphasizing key takeaways such as 'picking battles' and maintaining professional courtesy. The guidance aims to elevate scientific data quality while mitigating impacts on authors' reputation and mental wellbeing.
The study found substantial state-level variation in HPV vaccine uptake, with Northeastern states exhibiting higher rates and Southern states showing lower rates. Several sociodemographic factors were not significant predictors of vaccination rates, highlighting the need for targeted interventions to improve vaccine uptake.
Researchers at KAIST demonstrated a chip-scale photonic approach for generating ultralow-noise and highly stable microwave and millimeter-wave signals based on optical frequency combs. The study enabled direct transfer of optical-reference stability to the microcomb, achieving record-breaking performance in low-offset frequencies.
Researchers analyzed a large dataset of Japanese Instagram ads to identify linguistic patterns linked to click-through rates. The study found that word choices for supplement and cosmetic ads differed significantly, with risk-related words boosting CTR in supplement ads, while motion-related language increased CTR in cosmetic ads.
The study utilizes high-sensitivity LC-MS to quantify TCA cycle intermediates in mouse ocular tissues, revealing dual differences in metabolic characteristics based on spatial distribution and biological sex. Key findings include tissue-specific metabolic phenotypes and sexual dimorphism of metabolic profiles.
A new study by Technische Universität Berlin reveals that teaching Large Language Models to mimic human intuition and reasoning improves their ability to provide accurate medical care-seeking advice. The 'human reasoning blueprint' approach increased overall accuracy across all models, with significant gains in self-care advice.
Photoacoustic imaging uses lasers to reveal hidden blood vessels and nerve bundles, guiding surgeons for fewer complications. The technique enables real-time augmented reality video feeds during laparoscopic surgeries.
A postdoctoral program will be conducted by NYU researchers on quantum algorithms and applications, sponsored by IBM, with a focus on chemistry, computer science, materials science, physics, and optimization. The collaboration aims to advance quantum computing for large-scale, fault-tolerant quantum computers.
Researchers propose that ibasho, community-led spaces of belonging and social purpose, support long-term recovery and resilience. By restoring routines, roles, and neighborhood connections, ibasho helps individuals regain stability, dignity, and a sense of purpose after disasters.
Researchers from Columbia University have developed a theory explaining how carbon dioxide cools the stratosphere, even as it warms Earth's surface and lower atmosphere. The study reveals that CO2 molecules interact with infrared light in a specific 'Goldilocks zone' that expands with increasing atmospheric CO2 levels.
A recent study by Rockefeller University researchers provides the most comprehensive view to date of how HIV-1 escapes broadly neutralizing antibodies. The study identified over 100 mutations that enable viral strains to resist these antibodies, with some requiring only a single amino acid change.
Researchers have identified a hidden mechanism explaining why breast cancer can return years after successful treatment. Slow-growing breast cancer cells can form microscopic tumours that silently tick away in distant organs, evading detection for decades.
Protein language models have immense potential but lack explainability, leading to concerns over reliability and safety. Researchers propose four key places to understand a model's decision-making process and outline the need for more transparent and trustworthy AI in biotechnology.
A new study found that a fluid surrounding many ovarian tumors, known as ascites, helps cancer cells survive and spread. Researchers discovered that a decades-old cholesterol drug, bezafibrate, can disrupt this protection by altering fat storage and iron control, making cancer cells more vulnerable to existing treatments.
Researchers caution that weakening core safeguards in carbon markets risk worsening climate impacts and increasing net carbon emissions. Indigenous land stewardship is vital for maintaining intact ecosystems and vital carbon sinks, but alternative support mechanisms are needed to preserve the integrity of climate action.
A feasibility study assesses the integration of PeroCycle's patented carbon recycling technology into Jindal Steel's operations, aiming to reduce CO2 emissions and lower reliance on fossil-based agents. The partnership could set a new global benchmark for low-emission steel production in the Middle East.
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
The new certification framework covers the full IEC therapy process, including patient selection, clinical care, and post-infusion monitoring. It emphasizes critical aspects unique to IEC therapies, such as chain-of-identity and recognition of therapy-specific toxicities.
Preprints.org announces a new award to recognize widely read and shared preprints from the past decade. The platform, which hosts over 126,000 preprints, aims to increase early research dissemination across the scholarly community and the wider public.
A study found that cefiderocol and levofloxacin improved survival rates and reduced bacterial burdens in mice with severe hemorrhagic pneumonia. However, instances of hemorrhage differed between the two treatments. The results suggest that levofloxacin may be more effective against this infection.
Researchers developed a method to separate and quantify proton transport at individual interfaces in ultrathin ionomer films, enabling the evaluation of interfacial transport properties. The study revealed that proton transport at different interfaces is of a similar order of magnitude.
Research suggests that jellyfish bycatch can provide high-quality collagen without compromising quality. This circular bioeconomy solution offers new economic opportunities for small-scale fisheries while reducing waste. The collaboration with fishers revealed a willingness to participate in recycling jellyfish bycatch, but also highli...
Research in Canadian Medical Association Journal found that babies born to mothers with endometriosis are at a higher risk of congenital anomalies. The study included over 1.4 million births and found an increased risk of cardiovascular, gastrointestinal, genital, and musculoskeletal anomalies as well as neoplasms and tumours.