Scientists at McGill University have discovered a new biological pathway involved in pain processing, which could lead to the use of existing cancer drugs as alternatives to opioids. The researchers found that EGFR blockers were as potent analgesics as morphine in mouse models of inflammatory and chronic pain.
Studies show that humans can learn new sounds while asleep, particularly during REM and N2 sleep phases. However, learned sounds are forgotten in deep sleep (N3) stage, suggesting a mechanism for unloading unnecessary memories. These findings reconcile two theories on sleep's role in memory consolidation.
The US Department of Energy's Wind Technologies Market Report reveals that wind power additions reached a record high in 2016, with 8,203 MW of new capacity. Bigger turbines are enhancing project performance, while low turbine pricing continues to push down installed project costs.
Researchers from University of California, Irvine estimate tens of millions of stellar-remnant black holes exist in the Milky Way galaxy. The number of black holes is expected to depend on the size of the galaxy.
Researchers stopped FUS protein clumping using phosphorylation, a natural cellular process that increases protein charge and repels aggregation. The findings could have positive implications for treating ALS and dementia.
Tropical Depression Noru is weakening over Japan due to warming cloud top temperatures. The storm's strongest sides are being identified using infrared light from the AIRS instrument on NASA's Aqua satellite.
A decade-long study in Antarctica's Dry Valleys reveals that an extreme melt season triggered changes in physical and biological characteristics, including increased soil species and population increases. The findings suggest that abrupt climate events can cause long-term alterations in polar ecosystems.
Research suggests including graphic content in serious stories can increase moral sensitivity and desire for intervention, contradicting prevailing wisdom on sensationalism. Editors should consider showing graphic video if the story is important and accurate representation of severe events is necessary.
The UH biotech program will expand to five colleges and universities nationwide, implementing its innovative approach to integrating classroom instruction and research. The program aims to demonstrate its effectiveness across various higher education institutions and has the potential to address real-world issues such as environmental ...
Researchers developed a novel macrocyclic host molecule with exchangeable caps, enabling control of ion uptake/release on an everyday time scale. The discovery enables practical applications like storage and transport of molecules or uptake/release of target molecules at will.
Environmental scientists at Virginia Tech have discovered that burning coal produces tiny titanium oxide nanoparticles, which can be toxic to humans. These nanoparticles were found in coal ash, city streets, and even wastewater treatment plants worldwide.
Researchers developed algorithms that pinpoint individuals most likely to influence peers to get tested for HIV status, resulting in a 70% reach compared to current methods. The AI-powered approach encouraged testing, with 37% of peers getting tested when selected by HEALER and 25% by DOSIM.
Distributed wind power has grown significantly in the US, with the nation's cumulative capacity reaching 1% of total wind power capacity. The 2016 report highlights the success of third-party financing and leasing options, which have made it more accessible for companies and individuals to install wind turbines on their properties.
Children worldwide can connect with astronauts aboard the space station via ARISS, inspiring youth to pursue STEM interests. The program has sparked powerful memories and lifelong passions among participants.
Researchers developed a new statistical method to calculate sea level rise, showing it's not only increasing but also accelerating. The study found the rate of sea level change on the East Coast is the highest in 2,000 years, with areas like New York City facing rapid increases.
A study found that immersive cycling workouts increase satisfaction and lower perceived exertion in novice exercisers. The immersive class created a high-intensity workout without feeling intense, resulting in higher heart rate zones without discomfort.
Researchers at MPFI uncovered the role of voltage-gated Ca2+ channels in determining neurotransmitter release and brain function. The team developed new methods to directly monitor channel impact, revealing a previously unknown region of the alpha subunit controlling channel positioning.
The NSF has awarded 19 projects to study neural and cognitive systems, advancing frontiers in cognitive science and neuroscience. The research focuses on four themes: education, engineering, computer science, and the impact of neural systems on these fields.
A James Cook University scientist has discovered an alcohol-free antiseptic solution that is safe and effective for minor surgical procedures. The study found a slightly lower infection rate with the new solution compared to traditional water-based antiseptics.
A new study reveals the dynamic assembly of the export gate complex in bacterial flagellum and injectisome. The research identifies FliO as a scaffold protein essential for assembly, providing candidate targets for experimental drugs.
A study found that older adults who visit emergency departments for falls are less likely to participate in fall prevention programs. Despite this, patients reported discussing their falls with healthcare providers and family members, suggesting room for improvement in the healthcare response.
An interdisciplinary team developed a novel method to scan the internal development of live insects using carbon dioxide-induced suspended animation. The technique allows for detailed, three-dimensional views of insect innards without harming them.
State crime researchers reveal Uzbek government helped solicit bribes from telecommunications firms owned by Western interests, with assets totaling over $850 million currently under US forfeiture proceedings. The report details how foreign corporations and banks were implicated in a racketeering scheme led by political heiress Gulnara...
Researchers at the University of Bradford have discovered a new drug candidate, HXR9, that targets HOX genes to prevent cancer cell growth and induce apoptosis. Combining HXR9 with another drug shows enhanced results in reducing cancer growth.
A new study presents the post-glacial history of Lake of the Woods, a 4000km lake complex in North America. The research team analyzed sediment cores from the lake and found dramatic hydrological changes over the past 12,000 years.
Researchers have developed a new microscope technique that allows for the first time to produce 3D images of live embryos in cattle, enabling the selection of healthy embryos before in vitro fertilization. This breakthrough could significantly improve IVF success rates and reduce costs.
A new study by Dr. Véronique Bohbot and Dr. Greg West found that playing action video games for 90 hours can lead to grey matter loss in the hippocampus, but playing 3D-platform games may be safer and more beneficial for brain spatial memory. This research highlights the importance of choosing the right type of game to play.
Scientists found that babies associate words with content between 6-8 months old during a midday nap, while awake they can't connect new objects to the corresponding name. This early word learning ability suggests that children hold real word meanings in their long-term memory much earlier than previously assumed.
A recent study from the University of Illinois sheds light on what may be happening in the brains of MS patients during upper respiratory infections. Researchers found an increase in glial activation and elevated levels of chemokine CXCL5, which could lead to a drug intervention to inhibit relapses.
A new report reveals a significant increase in colorectal cancer mortality rates among adults under 55, with the rise confined to white individuals. Despite declining CRC incidence rates in other age groups, the authors suggest that rising mortality may be due to true disease occurrence rather than earlier detection.
Researchers developed a noninvasive ICP monitoring device using advanced signal analysis algorithms. The study showed strong association between noninvasive and invasive methods, with good correlation between ICP values.
Researchers from UT Tyler and Sugar Research Australia used TACC supercomputers to analyze genetic data from affected and unaffected plants. They created a reference genome for sugarcane's transcriptome, allowing them to explore gene expression related to the disease.
A new study reveals that the British government's initial efforts to pay for World War One through loans from the public were a failure. The War Loan scheme raised less than a third of its £350 million target, with most funds coming from wealthy financiers and companies.
Researchers have developed a new technique to suppress scattering from material defects, improving the performance of sensors and communication systems. By inducing chirality in sound waves, they can reduce energy loss and increase data fidelity.
A new study published in Radiology found structural abnormalities in the brains of individuals with one of the most common genetic causes of autism. The abnormalities corresponded to cognitive and behavioral impairments, highlighting a potential future role for imaging in identifying those who need urgent intervention.
Edward O'Brien's research aims to understand how the speed of protein assembly affects its structure and function, a question that was once considered unresolved by scientists. His team is developing computer simulations to model protein translation and explore the origins and consequences of translation rate changes on protein behavior.
A four-year program led by the Johns Hopkins Center for Communication Programs (CCP) increased modern contraceptive method use by 10 percentage points and desire for fewer children in six Nigerian cities. The program's successes were attributed to its coordinated campaign to create demand for family planning services.
A new study from the Monell Center enables researchers to pinpoint the unique molecular components needed for each type of taste cell to function. This breakthrough provides a treasure trove of information on how taste cells respond to different compounds and can help devise ways to promote healthy eating.
A new gene therapy has been found to be safe and effective in treating patients with coronary artery disease, enhancing circulation in the heart muscle. The biological bypass method involves injecting a natural human growth factor into the heart muscle to promote vascular growth.
The study reveals that ancient China experienced four warm epochs, including the 20th century, with temperatures comparable to current levels. This challenges the idea that modern warming is unprecedented in recent history.
A clinical trial has demonstrated the safety and effectiveness of a new treatment using virus-specific cells to treat viral infections in patients who have received a hematopoietic stem cell transplant. The treatment resulted in an overall complete or partial response rate of 92% in patients with severe, drug-resistant viral infections.
Researchers at the University of Huddersfield found that Loyalist former-paramilitaries in Northern Ireland are working to demythologise the past and deter young people from violent activity. They argue that this approach can provide a valuable precedent for other conflict zones around the world.
Scientists have discovered four new fruit fly species in the Himalaya region of India, revealing previously unknown information about their flower visitation habits. The study also revises the descriptions of all Lordiphosa genus representatives in India and highlights a unique sex comb adaptation in one of the newly described species.
A study found that a single injection of the longevity hormone klotho fragment improved spatial and working memory, strengthened neuron connections, and countered cognitive deficits in mice. The treatment lasted for several weeks and showed promise as a potential therapy for neurodegenerative diseases.
The Cherokee Nation has screened almost half of its population for hepatitis C and is on track to eliminate the virus. The tribe's progress towards elimination is attributed to the development of new antiviral drugs and collaboration with healthcare organizations.
Patients without coronary artery calcium had significantly lower risk of future heart attacks or strokes, even with diabetes, high blood pressure, or bad cholesterol levels. A CT scan may be worthwhile to discuss treatment options and add more information about the patient's 10-year risk.
Researchers identified synthetic lethal interactions that inhibit tumor growth in mesenchymal cells, a promising approach for treating alternative lengthening telomere (ALT) cancers. Simultaneous inhibition of BLM and FANCM genes could lead to more effective treatment with fewer side effects.
Researchers at Kansas State University are developing new treatments for E. coli by inhibiting the activity of NleB, a protein that contributes to bacterial virulence. The study resolves an ongoing debate about the protein's function in different strains of E. coli.
Researchers at MIT have developed a new terahertz laser design that boosts the power output of chip-mounted lasers by 80 percent, opening up new possibilities for medical and industrial imaging and chemical detection. The device has been selected by NASA for its Galactic/Extragalactic ULDB Spectroscopic Terahertz Observatory mission.
Researchers at MIT have found a way to precisely target the enzyme HDAC2, which blocks genes required for memory formation in Alzheimer's patients. By blocking its interaction with Sp3, they were able to reverse memory loss in mice, offering a potential new treatment approach.
A study found that bacteria's past adaptation to antibiotics influences their evolutionary dynamics of multi-drug resistance. The researchers used Pseudomonas aeruginosa and sequenced the bacteria's genomes to understand the genetic basis for resistance.
Researchers at Mayo Clinic and University of Iowa found a human gut microbe, Prevotella histicola, that effectively suppresses immune disease in a mouse model of MS. The study suggests that this microbe may play a role in treating MS, an autoimmune disease caused by the immune system's attack on the myelin sheath.
A randomized, controlled clinical trial found that an online team-based game improved glucose control in veteran patients with type 2 diabetes. Participants who played the game had significant reductions in hemoglobin A1c levels, with those having severe diabetes experiencing the greatest improvement.
Researchers at Uppsala University have developed a new method for rapidly determining bacterial resistance patterns in urinary tract infections, reducing the time from days to minutes.
Scientists have successfully grown a structure similar to an early stage of human development using pluripotent stem cells. The lab-grown amniotic sac embryoid, or PASE, exhibits key features such as two distinct halves and a hollow center, making it a potential tool for exploring infertility research.
A new meta-analysis reveals that Indigenous Peoples are significantly more likely to contract viral hepatitis due to factors like poverty, injection drug use, and lack of access to healthcare. The study shows disparities in prevalence rates across North America, South America, Australia, and New Zealand.
Researchers at University of Utah Health successfully rejuvenated the plasticity of adult mouse brains, specifically in the visual cortex, by triggering a shift with a single gene. This breakthrough suggests a potential target for new treatments that could recover brain youthful potential and reduce cognitive decline with aging.
Physicists at Johannes Gutenberg University Mainz introduce a new mechanism explaining dark matter's observed quantity, suggesting instability in its early universe phase. This alternative to the WIMP theory could be tested in future experiments on gravitational waves and CERN's LHC particle accelerator.
A large California study found that pregnant women with sleep disorders such as insomnia and sleep apnea are at a higher risk of delivering their babies before full term. The study also suggests that treating sleep disorders during pregnancy could be a way to reduce the preterm birth rate.
A new discovery in Dinosaur Provincial Park reveals the existence of two previously unknown species: Latenivenatrix mcmasterae and Stenonychosaurus inequalis. These findings challenge current understanding of the Troodontid family tree in North America.
A coalition of entomologists suggests working together in local communities to protect pollinators while managing mosquito and tick populations. The research emphasizes the importance of collaboration between vector-control professionals and pollinator experts.
Scientists have discovered a new method to track penguin migration patterns using forensics, analyzing tail feathers for geochemical signatures. This approach can be applied to other marine animals and will help better understand and conserve charismatic species.
Tropical Storm Franklin generated heavy rain when observed by NASA's GPM satellite, with rainfall rates exceeding 1.6 inches per hour around the center and south of its circulation. The storm is expected to bring life-threatening flash floods and mudslides to Mexico's Yucatan Peninsula.
Researchers found exposure to temperature extremes can negatively impact birth outcomes for pregnant women, including changes in gestation length and birth weight. The study highlights the need for further research on climate change's effects on maternal health and neonatal outcomes.
Researchers at McMaster University have discovered two new genes, SPOCK1 and TWIST2, that regulate brain metastases in lung cancer patients. These genes are present in the primary lung cancer of all patients with brain metastases but not in those without them.
Scientists have successfully generated dopaminergic neurons in a non-human primate model using induced pluripotent stem cells (iPSCs) derived from adult marmoset monkeys. This breakthrough advances the use of marmosets as a model for Parkinson's disease, enabling the development of regenerative medicine approaches.
Researchers identified a 'killer peptide' released by therapy-sensitive cancer cells, which can kill therapy-resistant cells and inhibit metastasis. The peptide enters only cancer cells, preserving healthy tissue.
A comprehensive taxonomic summary of all recognized species of crayfish worldwide has been created. The updated classification includes five families and 38 genera, and will impact various fields such as physiology, ecology, neurobiology, conservation, and evolution.
Researchers at FAU successfully manipulated the properties of hybrid systems made from carbon nanostructures and a dye. The team discovered that light stimulation could transfer electrons between the dye and carbon structures, a crucial requirement for dye-sensitised solar cells.
Scientists at Johannes Gutenberg University Mainz isolate and analyze gold in the rare +II oxidation state for the first time. The stabilization of this labile ion is achieved by a porphyrin macrocycle, allowing researchers to investigate its unique properties and behavior.
Researchers have identified a care plan for colon and rectal surgical procedures, presenting 12 components to improve preoperative and postoperative care. The clinical pathway aims to lower costs, improve safety, and speed recovery while increasing patient satisfaction.
Research confirms that video game design influences brain plasticity, with action games reducing hippocampus grey matter. Players using spatial strategies perform better, while those relying on response strategies are more affected.
Researchers from Stockholm University have established the SeaBOS initiative to engage global seafood companies in ocean conservation. The collaboration aims to address unsustainable fishing practices and promote marine ecosystem protection.
A University of Maryland study found that individuals who regularly consumed highly caffeinated energy drinks over five years were more likely to use cocaine and non-medically use prescription stimulants. The research suggests a potential link between energy drink consumption and increased risk for substance use among young adults.
The Regenstrief Institute is developing a novel, real-world automated patient identification system to tackle the challenge of matching patients with their medical records. The system aims to address the issue of inaccurate or incomplete patient data, which can lead to preventable medical errors and poor health outcomes.
A BYU research team has developed a machine learning approach to analyze grain boundaries in metals, enabling the prediction of material strength and corrosion resistance. By analyzing massive data sets, their algorithm provides insight into physical structures associated with specific mechanisms and properties.
Researchers have discovered the oldest Asian fossil of a hesperornithiform, a group of diving birds that adapted to ocean life. The specimen, named Chupkaornis keraorum, provides new insights into the early evolution of these birds and their adaptation to marine environments.
A new study by scientists at Portland State University and the National Snow and Ice Data Center found that the effects of climate change on glaciers in the western Ross Sea coast of Antarctica have not yet been observed. The research team examined glacier activity along over 700 kilometers of coastline using historic maps and satellit...
PIPER aims to detect primordial gravitational waves and study their effects on the cosmic microwave background, providing insight into the early universe's expansion. The mission will fly immersed in liquid helium at nearly absolute zero temperature.
Researchers have released high-resolution maps of Antarctica's McMurdo Dry Valleys, allowing scientists to compare present-day conditions with lower-resolution surveys conducted 13 years ago. The data provide detailed topography and insights into landscape changes, including rapid erosion along streams.
Researchers at Johns Hopkins Medicine discovered a biochemical process that gives prostate cancer cells the ability to change shape and invade other tissues. The study found that a gene called AIM1 is deleted in approximately 20-30% of prostate cancers confined to the gland and 40% of metastatic prostate cancers.
The LSU Health New Orleans School of Public Health will receive a $15 million grant over five years to support its cancer education, early detection, and control programs. The funding will help improve cancer screening rates and reduce disparities in cancer care across the state.
A study by UC San Francisco scientists found that administering klotho to young, aging or impaired mice rapidly improves their cognitive and physical performance. The treatment also showed benefits for aged mice and those with Parkinson's disease-like symptoms, suggesting a potential therapeutic application.
Scientists aim to understand how the moon got its 'tattoos' with a novel mission concept involving two connected CubeSats. The Bi-sat Observations of the Lunar Atmosphere above Swirls (BOLAS) mission could provide data on lunar hydrogen cycles and mechanisms for hydrogen implantation, shedding light on the formation of lunar swirls.
A new study finds that smoking during pregnancy is disproportionately common among women with depression, affecting nearly one-third of this group. The study suggests that depression is a significant barrier to quitting smoking, and addressing it may be crucial for helping women quit during pregnancy.
Researchers have discovered a protein called cardiotrophin 1 (CT1) that can trick the heart into growing in a healthy way and pumping more blood. CT1 also repairs heart damage and improves blood flow in animal models of heart failure.
Researchers have successfully created a multi-nutrient rice variety that produces iron, zinc, and beta-carotene, addressing micronutrient deficiencies. The new rice lines could provide a solution to hidden hunger in Asia and Africa if they are widely adopted.
Researchers at Osaka University developed a non-invasive imaging technique to detect kidney damage and predict chronic kidney disease in diabetic patients. The method uses diffusion tensor MRI (DTI) to identify specific regions of the kidney with abnormal fluid dynamics, offering a promising approach to prevent kidney disease progression.
The NIH is awarding $18.9 million to accelerate the use of genome sequencing in clinical care, focusing on diverse and underserved populations. The Clinical Sequencing Evidence-Generating Research (CSER2) Consortium will develop innovative approaches and best practices to integrate genomic medicine into healthcare settings.
Researchers at Albert Einstein College of Medicine and Montefiore Health System are conducting a five-year study to test whether medical marijuana reduces opioid use among adults with chronic pain. The study will enroll 250 HIV-positive and HIV-negative adults who use opioids and have received certification for medical marijuana use.
The Pacific Northwest Research Institute (PNRI) is partnering with Merck to develop a comprehensive plan to bring a promising antifungal agent from the laboratory to clinical practice. The compound has potential to reduce the burden of opportunistic infections in people living with HIV in developing countries.
A recent study published in JAMA found that improvisational music therapy did not improve symptoms in children with autism spectrum disorder. The study, which lasted five months, showed small improvements and no significant difference between the groups.
A study published in Scientific Reports shows that high-frequency alternating magnetic fields can be used to destroy bacteria encased in a slimy 'biofilm' growing on artificial joints. The treatment increased the effectiveness of antibiotic treatment, reducing the need for multiple surgeries and weeks of IV antibiotics.
Researchers predict potential for rapid colonization of UK by Asian hornet, threatening honey bee and beneficial insect populations. Beekeepers and public advised to be vigilant in identifying nests and reporting sightings to halt destruction of bee populations.
Researchers at UTA are working on developing algorithms to minimize risks for unmanned aerial systems operating in populated areas. The goal is to increase public acceptance and benefit commercial use of UAS technology, ultimately contributing to safer operation in various risk conditions.
A study found that high-quality early intervention for children with autism can lead to significant cost savings. After just two years, the costs associated with the Early Start Denver Model were fully offset due to reductions in other services. The model uses a developmental curriculum and teaching procedures delivered by therapy team...
A study from the University of Waterloo found that George W. Bush and Barack Obama's military interventions between 2001-2016 set a precedent for Donald Trump to go to war unilaterally, expanding executive authority
Research suggests that psychedelic experiences can lead to transformative outcomes, including reduced anxiety and depression. Ego dissolution allows for expanded awareness and a shift in perspective, potentially beneficial for individuals struggling with addiction and psychiatric disorders.
A study published in JAMA found that colorectal cancer mortality rates declined in black individuals but rose in white individuals between 1970 and 2014. The disparity was particularly pronounced among younger adults, with increased mortality rates observed in white men and women since the mid-1990s.
Researchers at Tokyo Medical and Dental University identified a protein called MELK essential for correct HIV-1 coat removal. Depleting MELK reduced virus infectivity, while restoring it restored normal infection processes.
Researchers at Binghamton University developed a paper-based bacteria-powered battery activated by spit, which can generate reliable power from one drop of saliva. The battery has competitive advantages over conventional solutions due to the availability of biological fluid and long-term storage capabilities.
A study by Queen Mary University of London finds that children learn to balance work and family life from their parents' examples. Women who had stay-at-home mothers often struggle with balancing work and parenting, feeling torn between their fathers' strong work ethic and their own desire to parent like their mothers.