A new study has identified Del-1, a bone marrow protein, as a potential regulator of hematopoiesis, the process by which blood cells are created. Targeting Del-1 may enhance immune cell production and improve stem cell transplants for both donors and recipients.
A team of seven University of Maryland undergraduates developed a portable electroencephalogram (EEG) device that uses audio tones to detect Alzheimer's disease before symptoms appear. The device exploits changes in brainwaves, allowing for early diagnosis and treatment, potentially saving billions in healthcare costs.
A study found that ibuprofen, a commonly prescribed NSAID, increases blood pressure and is associated with a higher incidence of hypertension in patients with osteoarthritis or rheumatoid arthritis. Celecoxib, on the other hand, showed a slight decrease in blood pressure, while naproxen had a relatively small increase.
New research suggests that corals build their hard, calcium carbonate skeletons faster and in bigger pieces than previously thought. This active construction method helps them grow much faster and with greater control.
Researchers found high-quality panda habitat is growing, but areas outside nature reserves are experiencing fragmentation due to human activities and natural events. The study highlights the need for continued conservation efforts to address these gaps.
Tropical Storm Pakhar made landfall in southeastern China, with NASA's Suomi NPP satellite capturing an image of the storm shortly after. The storm had maximum sustained winds near 63 mph and was centered about 54 miles southwest of Hong Kong.
Fossil analysis reveals morphological similarities between late Pleistocene Bahamian birds and their modern counterparts, indicating extinction due to sea level rise, warming, and wetting. The findings suggest that climate change played a significant role in the disappearance of these species.
A research team at GW University will study the body's natural defenses against HIV, focusing on killer T-cells that can kill infected cells. The goal is to boost these immune cells to eliminate viral reservoirs and provide guidance for further therapeutic strategy development.
A study by USC researchers found that white women with a genetic predisposition to Alzheimer's are more likely to develop the disease during a critical decade in their lives. The study, which included data from over 57,000 participants, contradicts long-held beliefs about who is at greatest risk for Alzheimer's.
An online experiment with over 9,000 participants reveals social biases in the sharing economy, favoring high-star rated profiles and decreasing trust with increasing risk aversion. The study supports the notion that reputation offsets trust judgments based on social biases.
A study by researchers at the University of Zurich found that chronic lack of sleep leads to increased risk-taking behavior in young adults. After sleeping only 5 hours a night for a week, participants displayed significantly riskier behavior, including taking greater financial risks.
Tiny plant cells in coral tissue produce osmolytes to regulate pressure, helping corals survive in salty waters. This finding has important implications for managing coral reefs under climate change.
Tropical Storm Harvey is expected to produce heavy rainfall accumulations of 15-25 inches over the upper Texas coast and into southwestern Louisiana. The storm's center is located near Port O'Connor, Texas, with maximum sustained winds near 40 mph and slight re-strengthening possible later today.
A new study published in CMAJ found that maternal suicide is a leading cause of death during pregnancy and the first year after giving birth. The study suggests that perinatal women who are suicidal may be at higher risk to complete suicide, and highlights the need for improved mental health supports.
A study found that sildenafil increased the risk of hospitalization and death in patients with valvular heart disease and residual pulmonary hypertension. The drug should be avoided in these cases.
Researchers discovered that epicatechin monomers in cocoa enhance beta cells' ability to secrete insulin, improving blood glucose control. The study suggests these compounds could potentially delay or prevent type 2 diabetes onset in patients.
A new study has identified four key strategies for preventing overcrowding in emergency rooms, including the involvement of executive leadership and a data-driven approach. High-performing hospitals use coordinated strategies, gather data to adjust operations in real-time, and hold staff accountable to reduce crowding.
New research suggests that anti-aldosterone-type drugs can significantly increase survival rates in STEMI heart attack patients when used alongside standard therapy. The study pooled data from two trials and found a 60% reduction in deaths among MRA-treated patients compared to controls.
A novel screening programme for vascular disease saves one life for every 169 men assessed. The combined screening for abdominal aortic aneurysm, peripheral artery disease, and hypertension gained more living years for lower costs than European cancer screening programmes.
A new study from Karolinska Institutet found that CABG reduces the risk of fatal heart disease and myocardial infarction in patients with type 1 diabetes by 45% and 47% respectively, compared to PCI.
Research shows that administering shingles vaccine several weeks prior to starting tofacitinib for rheumatoid arthritis results in robust immune responses. This is particularly beneficial for patients with rheumatoid arthritis who are at a higher risk of developing shingles.
Researchers have successfully grown single crystalline films of perovskite CH3NH3PbI3 on electron-collecting substrates, exhibiting excellent photovoltaic properties. The resulting devices achieve high efficiency rates, closing the gap with traditional silicon-based solar cells and offering a promising solution for renewable energy.
The article presents a series of grid-based computational technologies for in silico virtual screening and molecular design of new drugs. The technologies use original CoMIn software to analyze molecular structure in terms of intermolecular interactions potentials and quantum functions.
A study in São Paulo City found that switching from bio to fossil fuels in flex-fuel cars results in a 30% increase in ultrafine particulate matter. The rise in ethanol prices led to a decrease in its consumption, causing an increase in nanoparticles pollution.
Scientists from Helmholtz Zentrum München have found that retrotransposons, particularly LINE1 elements, regulate global chromatin accessibility in the early mouse embryo. This study identifies a novel role for retrotransposons in shaping the chromatin landscape necessary for correct developmental programming.
A new study predicts that global warming will extend the range of the southern pine beetle, a tree-killing insect, through much of the northern US and southern Canada. The beetle's spread is threatened by rising winter temperatures, which could lead to loss of biodiversity, iconic forests, and damage to tourism and forestry industries.
Researchers have discovered a way to activate the proteasome in CD8+ T cells, generating more long-lived memory cells that can provide lifelong protection. This approach could be used as an adjuvant therapy to enhance vaccine and immunotherapy effectiveness.
PPPL physicists lead crucial experiments on Wendelstein 7-X, a magnetic confinement fusion experiment in Germany. The facility aims to create steady state plasmas and model a future power plant for limitless clean energy.
Nonagenarian patients undergoing TAVI had worse short-term outcomes but similar one-year clinical outcomes as younger patients. The study suggests that TAVI is safe and effective in elderly patients with aortic stenosis.
A large clinical trial found that oxygen therapy did not reduce mortality rates in patients with suspected myocardial infarction. The study enrolled over 6,200 patients and showed no significant difference in mortality rates between those who received oxygen and those who did not.
The IMPACT-AF trial found that education and feedback improved anticoagulation therapy adherence in atrial fibrillation patients. This resulted in a 9% absolute increase in anticoagulation use, with a 48% proportion of non-treated patients on medication in the intervention group.
A 3-year follow-up study shows that a short course of dual antiplatelet therapy is as beneficial as a longer course for patients who received a drug-eluting stent. The study found no significant differences in rates of cardiac events and major bleeding between those treated for 6 versus 18 months.
A minimally invasive catheter-based procedure lowered office and ambulatory blood pressure in uncontrolled hypertensive patients not taking medication. Renal denervation was effective in reducing blood pressure, even with small reductions correlating to significant cardiovascular risk reductions.
Researchers developed models to predict oil droplet size and gas bubble movement, finding dispersant use reduced toxic compounds and protected emergency workers. The study provides first answers to controversial policy questions about deep-sea petroleum releases.
A recent study found that the clinical benefit of LDL cholesterol lowering therapies depends on how it is lowered, with apoB particles playing a key role. The study used genetically randomized participants and found that reducing apoB levels had a greater impact on cardiovascular risk than reducing LDL cholesterol.
Astronomers observe magnetic field of a galaxy 5 billion light-years away, finding a similar strength and configuration to the Milky Way's. This suggests galactic magnetic fields form early in a galaxy's life and remain relatively stable.
A new study published by the European Society of Cardiology found that bag-mask ventilation does not improve survival rates compared to endotracheal intubation in out-of-hospital cardiac arrest patients. The trial included 2,043 patients and showed a higher incidence of failed ventilation with bag-mask ventilation.
NASA's Aqua satellite captured infrared data on Potential Tropical Cyclone 10, revealing cloud top temperatures colder than minus 63 degrees Fahrenheit. This suggests the storm has the potential to generate heavy rain and become a tropical cyclone over the next two days.
New research shows that injured mouse eyes can regenerate neurons, integrating them into the eye's circuitry. The study uses a zebrafish clue to discover cues that reprogram Müller glia into retinal neurons, opening new approaches for treating eye trauma and retinal disease.
A new study led by a University of Kansas sociologist reveals that 'marrying up' has become easier for men and improves their economic well-being. The researchers found that women are more likely to marry less-educated men, leading to a decrease in the overall net advantage of being female in terms of family-standard-of-living.
A study found that transdermal estrogen therapy improved sexual function in early postmenopausal women, but oral conjugated equine estrogens did not show the same benefits. The treatment also reduced pain and increased lubrication compared to placebo.
A recent study on the protein CLAMP in fruit flies identifies two essential roles: coordinating gene expression on X and Y chromosomes. This research offers a promising model for understanding how proteins function differently in specific contexts, crucial for developing targeted therapies with minimal side effects.
A breakthrough discovery in cardiovascular fibrosis research has led to a potential treatment for multiple fibrotic human diseases. The study identified a specific cytokine as a key driver of cardiac fibrosis, paving the way for the development of first-in-class therapeutics.
A study from Oregon State University found that people who experience stigma are more likely to self-identify as disabled and develop pride in their disability. The researchers also discovered that severe impairments lead to greater stigma, which can increase the likelihood of self-identification. Developing disability pride is associa...
A post-hoc analysis of the SPRINT trial suggests that a universal blood pressure target may not be suitable for all patients. For those with high systolic blood pressure readings, intensive treatment might not always be beneficial, and the harms of aggressive treatment could outweigh the benefits.
The PATHWAY-2 study finds that salt retention is the main cause of drug-resistant hypertension and that older diuretic medications are the most effective treatment. The research discovered that spironolactone and amiloride work equally well in lowering blood pressure, offering new alternatives for patients with resistant hypertension.
A study of 183 participants found that those who lost a consistent number of pounds each week had better weight loss outcomes than those with high weight variability. This suggests that developing stable behaviors related to food intake and weight loss is crucial for maintaining changes in the long term.
Research has found that ancient coral reefs were bolstered by their bond with red algae, which also strengthens them today. The study suggests that understanding this relationship is crucial for preserving coral reefs in the face of climate change.
Researchers at Portland State University found a correlation between wildfires and warm weather fluctuations, known as the Southern Annular Mode (SAM), in fire-scarred trees dating back to 990 A.D. This study, published in PNAS, indicates that wildfires have become more frequent due to climate change.
A new study reveals a significant increase in US opioid-related overdose deaths and acute care costs, with nearly 4 million patients requiring critical care services over seven years. The study found a 34% increase in overdose-related ICU admissions, with mortality rates rising at the same rate.
A new study suggests that hydrophobic molecules like oil can be forced to dissolve in water when subjected to high pressure. Researchers applied immense pressure to methane and water, gaining insights into their interaction. This finding has implications for replacing hazardous industrial solvents and modeling planetary bodies.
Researchers found that a heat treatment under hydrogen doubles the life span of charge carriers in metal oxide photoelectrodes, leading to improved photocurrent under sunlight. This breakthrough could potentially reduce costs and increase stability for commercialization.
Researchers found that concurrent administration of anti-OX40 and anti-PD1 antibodies attenuated the effect of anti-OX40, resulting in poor treatment outcomes in mice. Sequential treatment with anti-OX40 followed by anti-PD1 improved therapeutic efficacy in some cases.
Researchers at Worcester Polytechnic Institute have developed liquid-metal membranes that appear to be lower in cost, more durable, and better at separating hydrogen than conventional membranes. This breakthrough could help reduce the cost of producing pure hydrogen for fuel-cell vehicles.
A new US nationally representative study found that romance and affection are the most appealing and common sexual behaviors, contrary to stereotypes. Researchers discovered a wide range of diverse behaviors, with men and women engaging in various romantic and affectionate acts.
A new study found that deep-sea dispersant injection improved air quality for responders at the Deepwater Horizon disaster site. The subsea injection may have broken up petroleum into smaller droplets, reducing volatile toxic compounds in the air and allowing responders to work longer without respirators.
Subsea dispersant injection during the Deepwater Horizon disaster mitigated environmental damage by reducing volatile organic compound emissions in the atmosphere. This led to a decrease in human health risks for response workers and accelerated the response effort.
The LSU Health New Orleans will investigate the effectiveness of the Adenowire in reversing coronary vasoconstriction and preventing no-reflow phenomenon. The technology has the potential to improve outcomes for millions of people worldwide affected by cardiovascular disease.
A collection of thirteen research papers addresses conservation strategies for elusive invertebrates in the European Union. Monitoring saproxylic beetles is feasible, and Citizen Science increases public awareness about Natura 2000 and saproxylic species in forests.
The EMANATE trial shows that apixaban lowers stroke risk in anticoagulation-naïve patients with atrial fibrillation scheduled for elective cardioversion. Patients treated with apixaban had fewer strokes than those receiving usual care, with similar bleeding rates to warfarin.