A new UC Irvine study suggests that social media posts can reveal where Californians may be most vulnerable to extreme heat. Researchers analyzed 24,598 heat-related posts on Twitter, finding correlations between housing, transportation, and life impacts on the effects of heat.
Researchers at UC Irvine developed lab-grown brain tissue with defined regional identity, reproducing molecular characteristics of prenatal human cortex. The model helped investigate fragile X syndrome and autism, highlighting potential developmental processes that can be studied in human tissue models.
Researchers found that Treg infiltration speed is the critical factor in determining PD-1 blockade immunotherapy outcomes. The team developed a mathematical model that accurately predicted this factor and validated it experimentally, identifying a promising new strategy to improve treatment outcomes.
Researchers at UC Irvine propose a new framework to target mitochondrial dysfunction, a key contributor to immune effector cell-associated neurotoxicity syndrome, to make CAR T-cell therapy safer. The approach aims to repurpose existing drugs with established safety profiles, potentially accelerating the development of safer treatment ...
A new study analyzing 11,500 US neighborhoods over a decade found that unauthorized immigration does not drive crime rates. Neighborhoods with growing undocumented populations saw greater reductions in property crime and no significant change in violent crime.
Residents agree that buying a home is harder today than for their parents, with 69% saying hard work alone is no longer sufficient. Generational differences emerge, with Gen Z prioritizing freedom and personal independence over homeownership and family.
A UC Irvine psychologist is using a massive longitudinal dataset to investigate how daily social connections shape our bodies and minds over time. The researcher aims to understand the 'ripple effect' of small, everyday moments on long-term health outcomes.
A new survey finds Orange County's governor race virtually tied, with the top issue being the cost of housing. The poll also reveals an increasing divide by generation and gender, yet an electorate converging on fixing housing costs. This leaves Democrats and Republicans scrambling to assemble winning coalitions.
Researchers at UC Irvine analyzed 100,000 inspection records to identify key factors responsible for severe wildfires in California. The team developed a high-resolution fire risk map that highlights areas with the highest probability of property losses.
A UC Irvine-led study finds that childhood unpredictability is linked to depression, anxiety, and sleep disorders in children, even those without traditional adversity screenings. The research highlights the power of cross-institutional collaboration to translate neuroscience discoveries into clinical practice.
Physicists at UC Irvine have developed an AI system called Autonomous Model Builder that can autonomously design theoretical physics models, helping identify promising new explanations for the behavior of neutrinos. The system uses reinforcement learning and is designed to assist human physicists in narrowing down vast theory spaces.
Researchers at UCI and Mass General Brigham-affiliated McLean Hospital found that using biological and behavioral markers to guide antidepressant treatment selection boosted response rates by nearly 67 percent. The study suggests a new era of personalized depression treatment, where objective data helps guide treatment decisions.
A recent poll found that Orange County residents generally trust their local institutions, with 60% trusting the police department and 25% trusting the federal government. However, Independents express skepticism towards county government at just 32%, highlighting a concerning trend in the civic landscape.
A UC Irvine researcher has received a nearly $4 million NIH grant to advance a novel therapeutic vaccine strategy for genital herpes. The project aims to develop a safe and durable vaccine that strengthens protective immune cells and provides long-term immune surveillance, ultimately improving the lives of millions worldwide.
Researchers at UC Irvine have discovered a mechanism that combines DNA damage and inflammatory signaling in tumor cells, potentially improving cancer treatment response. The study found that a combination of PARP inhibitors and TOP1 blockers triggers an 'alarm signal' inside cancer cells, alerting the immune system to eliminate them.
Steward's groundbreaking research revealed protein-producing machinery located near synapses, demonstrating that neurons can manufacture proteins locally. His work has boosted comprehension of neurodevelopmental disabilities and opened new pathways for developing therapies to preserve cognitive function and restore neural connectivity.
A recent UC Irvine study analyzing health data from over 85,000 women found that access to healthcare and insurance coverage significantly influence whether women take recommended amounts of folic acid. Folic acid supplements were more commonly used by older pregnant women and non-Hispanic Black women.
Researchers found that a father's health can influence a child's risk for obesity and related health conditions, even before conception. The study suggests that addressing obesity requires a family-centered approach that recognizes fathers as essential partners in building healthier futures.
A major real-world study by University of California, Irvine researchers found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Researchers discovered that some ADCs were linked to substantial rates of severe neutropenia and related complications.
Researchers have developed a wearable, wireless, battery-free sweat sensor that can track four clinically relevant biomarkers in real-time. The device's ability to regenerate its sensing surface and operate continuously over long timespans addresses key obstacles in long-term wearable biosensing.
A study by UC Irvine researchers found that renewable electrolytic hydrogen produces its greatest societal value when applied to steelmaking, transoceanic shipping, and long-haul heavy-duty trucking. The study suggests that these sectors can benefit from the transition to hydrogen, often offsetting additional costs.
Orange County residents hold broadly positive but carefully qualified views on immigration, recognizing its benefits while drawing distinctions around enforcement. The UCI-OC Poll found that Orange County residents are pragmatic about immigration, supporting targeted enforcement against human trafficking and limiting immigration from u...
Researchers found a higher risk of acute lymphoblastic leukemia among children exposed to PFAS compounds at birth. The study suggests that early-life exposure may contribute to cancer risk in children and highlights the need for further research on PFAS contamination.
A study led by UC Irvine researchers found that dopamine dysfunction in the entorhinal cortex contributes directly to impaired memory formation in Alzheimer's disease. Restoring dopamine levels using optogenetic techniques and Levodopa restored memory function in a mouse model of Alzheimer's disease.
A bidirectional brain-computer interface (BCI) allows individuals with spinal cord injuries to control a robotic exoskeleton using brain signals and receive artificial leg sensation. The system, developed by UC Irvine researchers, demonstrates high accuracy in step counting and sensory discrimination tasks.
A UC Irvine-led study reveals that the gut microbiome drives severe outcomes from foodborne infections in individuals with metabolic dysfunction-associated steatotic liver disease. Restoring a healthy microbiome may hold promise for protecting high-risk patients.
Researchers at UC Irvine have developed a method to reverse 'quantum scrambling', a phenomenon that causes information loss in quantum computers. By understanding the microscopic laws underlying this behavior, they found a way to counteract it with a precisely tuned intervention.
The UCI-OC Poll reveals nearly two-thirds of Orange County residents view Trump negatively, while Newsom fares only marginally better. A surge in independent support suggests a broader mood of pessimism and uncertainty, with voters hesitant to settle on their choices.
Researchers at UC Irvine have identified LENG8 as a crucial regulator of RNA quality control, enabling cells to retain or degrade specific RNAs. This discovery sheds light on the mechanisms underlying cellular processes such as gene expression and translation.
Researchers at the University of California, Irvine, have identified asprosin as a key biological target for obesity prevention in postmenopausal women. Higher levels of asprosin were linked to reduced weight gain in metabolically healthy women, suggesting its potential role in maintaining weight stability when metabolic health is intact.
A study by UC Irvine chemists reveals that a subtle chemical change in an eye lens protein can make it more likely to clump together over time, suggesting an early step in cataract formation. The research focuses on proteins called crystallins, which help keep the eye lens clear and are meant to last a lifetime.
Reports of child exploitation in Orange County have skyrocketed 700% over the past decade, with middle schoolers being targeted. Researchers stress the need for updated intervention strategies and training for professionals to identify and respond to exploitation effectively.
A 30-year study reveals 77% of Antarctica's coastline remains stable, but vulnerable sectors lose 5,000 sq mi of ice equivalent to 10 cities the size of LA every three years. Researchers use satellite data to measure glaciers and grounding lines, providing crucial benchmarks for ice sheet models and mass balance assessments.
Researchers identified an enzyme called PFKM, which helps control glucose processing in cells. By manipulating PFKM levels, they accelerated muscle building in laboratory models, potentially helping address age-related muscle decline and lean muscle loss in patients using weight-loss medications. This finding could lead to the developm...
A new book chronicles the impact of immigration enforcement on young adult families, revealing a geography of deportability where no space feels safe. The research highlights the pivotal role of young adults in coping strategies, including emotional labor and navigating legal processes, amidst rising mental health concerns.
Researchers from UC Irvine have discovered a critical security vulnerability in autonomous target-tracking drones that can be exploited using an ordinary umbrella. The team demonstrated how attackers could use the 'FlyTrap' attack framework to manipulate drones, drawing them close enough for capture or causing them to crash.
Researchers found that Southern California beaches experienced a significant widening of 10% between 1984 and 2024, while Northern California showed moderate growth, and Central California showed no significant trend. Beach growth was concentrated at human-made coastal structures.
A new pilot study in Long Beach found that heightened federal immigration enforcement is undermining democratic participation, even among U.S. citizens who fear for undocumented family members. The study identified three critical barriers: climate of fear, knowledge gaps, and practical constraints.
A UC Irvine-led team has developed the most detailed maps of gene regulation in Alzheimer's disease, revealing causal mechanisms and potential new targets for treatments. The study identifies key biological pathways and genes that may drive memory loss and brain degeneration.
The study examines California's Racial Justice Act implementation and impact on racial justice access for criminal defendants. The research team, led by UC Irvine Chancellor's Professor Mona Lynch, will investigate the act's effectiveness across diverse jurisdictions, with a focus on under-resourced areas.
The University of California, Irvine, has been awarded a $1.39 million grant to tackle non-point source pollution from agriculture and urbanization in the US and China. The research will focus on severe eutrophication and harmful algal blooms caused by agricultural runoff and urban pollutants.
A UC Irvine-led study suggests that high estrogen levels in the brain may increase women's risk of stress-related memory issues, such as post-traumatic stress disorder and dementia. Women are more likely to develop PTSD and face higher dementia risk due to hormonal fluctuations during stressful events.
Researchers at UC Irvine found that climate change is decreasing the atmospheric lifetime of nitrous oxide, a potent greenhouse gas, by 1.4 percent per decade. This decrease alters climate projections for the rest of the 21st century, introducing significant uncertainty.
Researchers at UC Irvine developed a multimodal bioelectronic wrist-worn device to track molecular stress biomarkers alongside physiological stress indicators. The device provides an accurate picture of how stress is experienced by humans, addressing a critical healthcare gap.
The UC Irvine School of Medicine has been awarded a $850,000 grant by the California Office of Traffic Safety to broaden the UC Traffic Safety Collaborative Program. The program aims to reduce traffic-related injuries and fatalities in California through education, research, and enforcement.
Researchers found structural and functional differences between mitral annular calcification and rheumatic mitral stenosis, which may lead to inaccurate diagnoses and treatment. The study suggests using disease-specific diagnostic criteria and management guidelines for patients with MAC-related stenosis.
Researchers at UC Irvine's Nanoscale Communication Integrated Circuits Labs developed a unique transceiver that operates in the F-band spectrum, enabling speeds of up to 120 gigabits per second. This technology offers massive bandwidths and can transform how machines, robots, and data centers communicate.
Researchers at UCI are developing a noninvasive way to assess lymphatic fluid flow using CT scans and blood-based markers, aiming to improve diagnosis and treatment of lymphatic diseases. The project could help physicians diagnose problems earlier and make more informed treatment decisions.
Researchers highlight climate-driven disruptions in food production and supply chains, leading to nutritional quality gaps. Dietary supplements may help fill these gaps, but more research is needed on their safety and effectiveness.
Researchers have spotted the largest-known stream of super-heated gas, a kiloparsec-scale jet, erupting from a nearby galaxy called VV 340a. The team used radio wave images to reveal the jet and its associated coronal line emission, which is equivalent to 10 quintillion hydrogen bombs going off every second.