Researchers from UC Irvine discover a DNA repair mechanism enabling Greenland sharks to maintain their vision for centuries despite extreme low-light conditions. The study challenges current understanding of aging, vision, and longevity, offering new insights into preserving vision as we age.
Researchers at UCI will conduct a first-in-humans safety and tolerability study of an embryonic stem cell-derived neural stem cell product for Huntington’s disease. The clinical trial aims to protect brain cells, repair damaged brain circuits, and slow or prevent disease progression.
UCI MIND is receiving $80 million in new commitments to build a state-of-the-art facility for Alzheimer's disease and related dementias research and patient care. The Quilter family donation has inspired others to pledge support, enabling the institute to advance its critical mission.
Researchers analyzed over 7,000 heat-related posts on X and linked them to local conditions using the Healthy Places Index. They found that residents in low-income areas expressed more negative sentiments about heat, while those in higher-income areas described coping strategies and relief. The study developed an AI-based tool to help ...
A global survey led by UC Irvine researchers found that 70% of oncology professionals use or recommend integrative approaches to manage cancer symptoms. However, these services remain underused due to cost, lack of insurance coverage, and limited training opportunities, particularly in low-income countries.
Researchers at UC Irvine have identified stormlike circulation patterns beneath Antarctic ice shelves causing aggressive melting of Thwaites and Pine Island glaciers. The study found that these ephemeral processes account for nearly a fifth of total submarine melt variance, with implications for global sea level rise projections.
Researchers created a practical tool to assess urban fossil fuel carbon dioxide patterns by analyzing radiocarbon in turfgrasses. The method allows cities to gauge the effectiveness of their emission-curbing initiatives and track progress toward decarbonization goals.
Researchers at UC Irvine have identified a molecular mechanism controlling the transition from acute to chronic pain. A newly proposed formula, which includes a modified diet rich in deficient nutrients, showed promise in blocking this transition in mouse models.
Researchers at UC Irvine have identified an exoplanet in the Milky Way Galaxy's habitable zone, which may support liquid water conditions. The super-Earth orbits an M-dwarf star just 18 light-years away, making it a prime target for future direct imaging studies.
Researchers at UC Irvine found that amyloid precursor proteins form a complex with voltage-gated proton channels in human brain immune cells, altering their operation and promoting neuroinflammation. The study suggests two specific mutations linked to early-onset Alzheimer's further increase channel activity.
Researchers at UC Irvine have developed a 3D human colon model integrated with bioelectronics to aid in colorectal cancer research and drug discovery. The model shows promising results in detecting resistance to chemotherapy drugs, making it a potential alternative to traditional animal testing.
Researchers at UC Irvine have identified a new way to protect the brain from cognitive decline caused by cranial radiation therapy. The study found that targeting a specific immune response pathway can improve memory and cognition in mice with and without brain cancer.
A new study by UC Irvine researchers found a clear association between children's exposure to wind-blown dust from the receding Salton Sea and poorer lung function. The study highlights the urgent need for targeted public health strategies to mitigate air pollution in the region.
A new survey by University of California, Irvine professor Nicholas Scurich found that 65% of Missouri voters believe Governor Mike Kehoe should commute Shockley's death sentence to life imprisonment. The survey revealed strong bipartisan support for clemency across all political affiliations.
Researchers used a new analytic method to analyze brain scans of over 2,600 adults, discovering that the inferior and anterior parts of the brain expanded outward, while the superior and posterior regions contracted inward. These shape changes were closely associated with declines in memory, reasoning, and other cognitive functions.
A new study from UC Irvine researchers explores a potential therapy for addressing aging in the eye and preventing diseases like age-related macular degeneration. Injecting polyunsaturated fatty acids into aged mice improved visual function, suggesting a possible way to reverse age-related vision decline.
A UC Irvine-led study reveals that indoor surfaces act as massive chemical sponges, absorbing volatile organic compounds for extended periods. Regular ventilation alone may not be sufficient to remove these contaminants, highlighting the importance of physical cleaning activities.
The researchers developed a new microscopy method that enables imaging of vibrations in specific directions at the atomic scale. This allows engineers to tailor materials for use in electronics, semiconductors, optics and quantum computing.
A new poll of California adults reveals overwhelming bipartisan support for stricter digital technology regulations, with 82% backing the Phone-Free Schools Act. Support for school smartphone restrictions and social media age limits is driven by concerns about classroom distractions, excessive tech use, and mental health.
A study published in Science found that total burned area declined globally from 2002 to 2021, but human exposures to wildfires surged by nearly 40%, with Africa accounting for 85% of all incidents. Proactive mitigation strategies are crucial to protect communities from the growing threat of wildfires.
The UCI-OC Poll found significant partisan and generational divides on immigration policy, with a majority supporting more open policies. Age is also a critical factor, with younger residents preferring legal status opportunities. The survey results suggest Orange County's evolving demographics are shaping its views on immigration.
A recent UC Irvine study reveals that women with Down syndrome exhibit advanced signs of Alzheimer's disease at the same average age of diagnosis as men. The research highlights the need for sex-specific approaches in treating Alzheimer's, particularly in clinical trials.
The UCI-OC Poll finds a strong preference for flexibility in work arrangements, with many workers willing to relocate for remote job opportunities. However, there is also concern about the impact of artificial intelligence on jobs, highlighting the need for thoughtful integration and policy considerations.
Researchers at UC Irvine and Japan's Okayama and Toho universities discovered a novel formation process for chitons' hard, magnetic teeth. The team learned how iron-binding proteins are transported into teeth through nanoscopic tubules, enabling the creation of highly aligned magnetite nanorods.
Researchers at UC Irvine have identified a combination of naturally occurring compounds - nicotinamide and epigallocatechin gallate - that can restore guanosine triphosphate levels in brain cells. This treatment reversed age-related cellular deficits and improved the brain's ability to clear damaging amyloid protein aggregates.
A team of UC Irvine researchers has identified a promising nonpharmaceutical treatment that can restore energy levels in aging brain cells, improving their ability to clear damaging amyloid protein aggregates. The treatment, which combines nicotinamide and epigallocatechin gallate, was found to reverse age-related cellular deficits and...
A multicenter clinical trial found gene therapy safe and effective for both children and adults with hereditary deafness. The treatment restores hearing within one month of delivery, showing potential for fast results in addressing congenital deafness and other forms of hearing loss.
The University of California, Irvine is selected for a national initiative to integrate evidence-based psychedelic-assisted therapy education into mainstream college courses. Nurse practitioner Christopher Cleary will lead the effort, aiming to equip advanced practice nurses with compassionate and holistic care in mental health treatment.
Researchers used NASA's TESS mission data to estimate the sizes of over 200 exoplanets and found that many are likely larger than previously thought. This discovery could impact the search for life on distant planets, as water worlds may harbor life but lack features that help life flourish on Earth.
A new study has found that residents' anxiety and stress about climate change is associated with increased disaster preparedness behaviors in Lake County, California. The research suggests that a certain level of anxiety may be adaptive, motivating important disaster preparedness actions.
A new survey finds Trump's disapproval ratings among Californians are nearly 2:1 higher than those for Gov. Gavin Newsom, with Newsom improving to a 56% somewhat favorable rating. Former VP Kamala Harris maintains an 11% net favorability rating and leads potential gubernatorial candidates.
A new study from UC Irvine reveals that airlines can make smarter tradeoff decisions to cut aviation's warming impact. The study found that even a 3-5% reduction in contrails or NOx emissions can outweigh a 1% increase in CO2 emissions over a 100-year period.
A new study by UC Irvine researchers offers a way for airlines and regulators to make informed decisions that balance climate change mitigation with economic costs. The Global Warming per Activity metric measures the full climate impact of each aviation activity, allowing for more accurate risk quantification and tradeoff analysis.
A UC Irvine-led team has developed a multispectral composite material with adjustable visible and infrared properties, inspired by the structures found in squid skin cells. The material can dynamically adjust its color and reflectivity in response to environmental or mechanical stimuli.
Aileen Anderson, director of the stem cell center, has been named vice chancellor for research at UC Irvine. She will oversee the university's research strategy and operations, building partnerships with industry and community stakeholders.
A UC Irvine study reveals that extreme heat weakens the gut microbiome and immune function in older individuals, making them more susceptible to deadly waterborne bacteria like Vibrio vulnificus. This research identifies a potential avenue for treatment: supporting gut health through beneficial probiotics.
Researchers at UC Irvine have successfully tested a new replacement heart valve designed for toddlers and young children with congenital cardiac defects. The Iris Valve can be implanted via a minimally invasive catheter, allowing treatment to begin earlier in very young patients.
Researchers discover abnormal polyadenylation in ALS, affecting mRNA function and potentially leading to new therapeutic targets. The study suggests that correcting gene function through polyadenylation correction could prevent motor neuron dysfunction and death in ALS patients.
A national survey reveals that many home healthcare agencies have discontinued telehealth services, highlighting funding policy gaps and the need for Centers for Medicare & Medicaid Services reimbursement. The study's findings suggest that without reimbursement, providers may abandon telehealth opportunities to improve care and manage ...
A new study reveals that body lotion hinders the generation of key hydroxyl radical precursors, while ethanol in fragrances acts as a sink, reducing the human oxidation field. This finding has significant implications for indoor air chemistry and human health.
Researchers at UC Irvine have expanded a longstanding model governing slip banding in metals, discovering extended slip bands that challenge the classic Frank-Read theory. This finding provides new insight into collective dislocation motion and microscopic deformation instability in advanced materials.
Researchers at UC Irvine develop a cell-based platform to deliver disease-fighting proteins throughout the brain, reducing inflammation, preserving neurons, and reversing neurodegeneration in mice. The engineered microglia can detect disease-specific changes and release enzymes to break down toxic proteins.
A UC Irvine study found that machine learning algorithms using electronic health records can predict two-year dementia risk among American Indian/Alaska Native adults. The researchers identified novel predictors of all-cause dementia, including health service utilization.
A review of research on childhood adversity sheds light on its long-term consequences on brain development and introduces innovative methods for tackling mental health issues. Emerging factors like societal inequality and pollution are gaining recognition as potential contributors to adverse neurodevelopmental outcomes.
The UCI-OC Poll found that experiences shape perspectives on immigration, with significant differences across racial and ethnic groups. Generational ties to immigration are linked to both identity and political views in Orange County.
A recent study by UC Irvine researchers found that multicolored stickers can be used to confuse self-driving vehicle AI algorithms, leading to hazardous operations. The attack vectors were demonstrated to be easily deployable and inexpensive, with the potential to exploit spatial memorization designs in commercial TSR systems.
A UC Irvine-led study found associations between prenatal PFAS exposure and certain childhood cancers, including acute myeloid leukemia and Wilms tumors. Higher PFAS concentrations were linked to increased cancer risk in California children.
Researchers at UC Irvine have developed a new family of antibiotics that targets two key areas of bacterial cells, offering a potential solution to the growing threat of antibiotic resistance. The new drug candidates may help eliminate the need for continuous redesign of new antibiotics.
Lauren Albrecht, a UC Irvine assistant professor of pharmaceutical sciences, has been recognized as a 2025 Sloan Research Fellow for her groundbreaking work in cell and chemical biology. Her research on methylation in lysosomal proteolysis holds promise for new therapeutic strategies and implications in genetic heart disease.
Researchers found that white dwarf exoplanets could have more habitable surface area than previously thought due to their fast rotation periods. The study suggests these stars may present new avenues for exoplanet and astrobiology research.